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Articles 391 - 397 of 397
Full-Text Articles in Medicine and Health Sciences
Consequences Of The Loss Of P53, Rb1, And Pten: Relationship To Gefitinib Resistance In Endometrial Cancer, L. Albitar, M. Carter, S. Davies, Kimberly Leslie
Consequences Of The Loss Of P53, Rb1, And Pten: Relationship To Gefitinib Resistance In Endometrial Cancer, L. Albitar, M. Carter, S. Davies, Kimberly Leslie
Kimberly K. Leslie
OBJECTIVE: These studies demonstrate how loss of function mutations or downregulation of key tumor suppressors missing from type I and type II endometrial cancer cells contributes to carcinogenesis and to resistance to the EGFR inhibitor gefitinib (ZD1839). METHODS: Cell models devoid of tumor suppressors PTEN and RB1 or PTEN were studied. PTEN, RB1 and p53 expression was reinstated, and the effects on cell cycle, apoptosis, and cell cycle regulators were evaluated. RESULTS: In Ishikawa H cells that model type I endometrial cancer in the loss of PTEN and RB1, re-expressing PTEN and RB1 increased the apoptotic and G1 phases and …
The Effect Of Work Shift And Sleep Duration On Various Aspects Of Police Officers' Health, Sandra Ramey, Elena Perkhounkova, M. Moon, L. Budde, H. Tseng, M. Clark
The Effect Of Work Shift And Sleep Duration On Various Aspects Of Police Officers' Health, Sandra Ramey, Elena Perkhounkova, M. Moon, L. Budde, H. Tseng, M. Clark
Elena Perkhounkova
Police officers are prone to cardiovascular disease, overweight, and obesity. Because night-shift work affects sleep, a modifiable risk factor linked to chronic disease, the researchers explored the relationship among shift work, sleep, and wellness for police officers. Sleep, C-reactive protein (CRP) levels, stress, fatigue, and body mass index were used to compare officers who worked primarily day shifts to those who worked primarily evening or night shifts, and officers who slept less than 6 hours per day to those who slept at least 6 hours per day. A cross-sectional study of 85 male officers, 20 to 63 years old, was …
Differences In Cervical Cytologic And Histologic Findings Between Women Using Depot-Medroxyprogesterone Acetate And Oral Contraceptives, Mary Clark, C. Stockdale, L. Railsback, S. Nichols
Differences In Cervical Cytologic And Histologic Findings Between Women Using Depot-Medroxyprogesterone Acetate And Oral Contraceptives, Mary Clark, C. Stockdale, L. Railsback, S. Nichols
M. Kathleen Clark
OBJECTIVE: This study aimed to compare cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate (DMPA) and oral contraceptives (OCs) referred for colposcopy and to determine whether there were differences in the occurrence of false-positive cytologic finding between the 2 contraceptive groups. MATERIALS AND METHODS: Retrospective cohort of 1,569 premenopausal women using either DMPA or OC who were evaluated for abnormal cervical cytologic findings. Cytologic and histologic data were collected in conjunction with routine gynecologic examinations or follow-up colposcopic evaluations. chi2 tests were used to determine differences in cervical cytologic and histologic findings and the proportion of false-positive results …
The Effect Of Work Shift And Sleep Duration On Various Aspects Of Police Officers' Health, Sandra Ramey, Elena Perkhounkova, M. Moon, L. Budde, H. Tseng, M. Clark
The Effect Of Work Shift And Sleep Duration On Various Aspects Of Police Officers' Health, Sandra Ramey, Elena Perkhounkova, M. Moon, L. Budde, H. Tseng, M. Clark
M. Kathleen Clark
Police officers are prone to cardiovascular disease, overweight, and obesity. Because night-shift work affects sleep, a modifiable risk factor linked to chronic disease, the researchers explored the relationship among shift work, sleep, and wellness for police officers. Sleep, C-reactive protein (CRP) levels, stress, fatigue, and body mass index were used to compare officers who worked primarily day shifts to those who worked primarily evening or night shifts, and officers who slept less than 6 hours per day to those who slept at least 6 hours per day. A cross-sectional study of 85 male officers, 20 to 63 years old, was …
Decoupling Of Stretch Reflex And Background Muscle Activity During Anticipatory Postural Adjustments In Humans, Siddharth Vedula, Robert Kearney, Ross Wagner, Paul Stapley
Decoupling Of Stretch Reflex And Background Muscle Activity During Anticipatory Postural Adjustments In Humans, Siddharth Vedula, Robert Kearney, Ross Wagner, Paul Stapley
Dr Paul J Stapley
We studied the evolution of stretch reXexes in relation to background electromyographic (EMG) activity in the soleus muscle preceding the onset of voluntary arm raise movements. Our objective was to investigate if changes in reXex EMG and muscle activity occur simultaneously and are similarly scaled in amplitude. Ten human subjects stood with each foot on pedals able to exert short dorsiXexor pulses during stance. Subjects were asked to product consistent voluntary arm raise movements to a target upon a visual cue. In ¼ of trials, no pulse perturbations were given, but in the remaining ¾’s of all trials pulses were …
Independent Control Of Limb Force Underlies Stability During Voluntary Head Movements In Standing Humans, Paul Stapley, Alicia Hilderley, Julia Leonard
Independent Control Of Limb Force Underlies Stability During Voluntary Head Movements In Standing Humans, Paul Stapley, Alicia Hilderley, Julia Leonard
Dr Paul J Stapley
Postural stability during voluntary head movements is maintained through the integration of vestibular and neck afferent inputs. These inputs combine to accurately estimate trunk position in space, relative to a turning head. In animals, a loss of vestibular information leads to an active destabilization of balance as neck afferent information is interpreted as a movement of the trunk under a stable head (Stapley et al. 2006).
Postural Adjustments For Online Corrections Of Arm Movements In Standing Humans, Julia Leonard, Valeriya Gritsenko, Ryan Ouckama, Paul Stapley
Postural Adjustments For Online Corrections Of Arm Movements In Standing Humans, Julia Leonard, Valeriya Gritsenko, Ryan Ouckama, Paul Stapley
Dr Paul J Stapley
The aim of this study was to investigate how humans correct ongoing arm movements while standing. Specifically, we sought to understand whether the postural adjustments in the legs required for online corrections of arm movements are predictive or rely on feedback from the moving limb. To answer this question we measured online corrections in arm and leg muscles during pointing movements while standing. Nine health right-handed subjects reached with their dominant arm to a visual target in front of them and aligned with their midline. In some trials, the position of the target would switch from the central target to …