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S-Antigen In A Hereditary Visual Cell Disease. Immunocytochemical And Immunological Studies, Gustavo D. Aguirre, K Long, N Philp, I Gery
S-Antigen In A Hereditary Visual Cell Disease. Immunocytochemical And Immunological Studies, Gustavo D. Aguirre, K Long, N Philp, I Gery
Gustavo D. Aguirre, VMD, PhD
S-antigen is a photoreceptor-specific and potentially autoantigenic protein. Using light microscopic immunocytochemistry, the localization of S-antigen was studied in the retinas of normal dogs and Irish setters affected with rod-cone dysplasia, a hereditary retinal degeneration characterized by abnormal cGMP metabolism and arrested outer segment differentiation. Normal and affected dogs were also tested for the presence of humoral and cellular immunity to S-antigen. S-antigen was present in both rods and cones during inner and outer segment differentiation, but there was an apparent loss of immunoreactivity in cones as the retina matured. The developmental appearance and localization of S-antigen in affected retinas …