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Veterinary Medicine

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2003

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Articles 31 - 52 of 52

Full-Text Articles in Medicine and Health Sciences

Abundant PrpCwd In Tonsil From Mule Deer With Preclinical Chronic Wasting Disease, Katherine I. O'Rourke, Dongyue Zhuang, Amy Lyda, Gabriel Gomez, Elizabeth S. Williams, Wenbin Tuo, Michael W. Miller Jan 2003

Abundant PrpCwd In Tonsil From Mule Deer With Preclinical Chronic Wasting Disease, Katherine I. O'Rourke, Dongyue Zhuang, Amy Lyda, Gabriel Gomez, Elizabeth S. Williams, Wenbin Tuo, Michael W. Miller

Zoonotics and Wildlife Disease: Publications

A monoclonal antibody dot-blot assay was used to evaluate detergent lysates of tonsil tissue from mule deer to detect PrPCWD, the marker for the cervid transmissible spongiform encephalopathy chronic wasting disease (CWD). Samples of formalin-fixed brain and tonsil tissues from mule deer were examined for PrPCWD using immunohistochemistry (IHC) with Mab F99/97.6.1, the gold standard for diagnosis of preclinical CWD. The contralateral tonsil from each of the 143 deer was prepared for confirmatory IHC and as a 10% (wt/vol) detergent lysate without purification or enrichment steps for monoclonal antibody dot-blot assay. PrPCWD was detected by dot-blot …

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Immunohistochemical Detection And Distribution Of Prion Protein In A Goat With Natural Scrapie, Reginald A. Valdez, Matthew J. Rock, Anne K. Anderson, Katherine I. O'Rourke Jan 2003

Immunohistochemical Detection And Distribution Of Prion Protein In A Goat With Natural Scrapie, Reginald A. Valdez, Matthew J. Rock, Anne K. Anderson, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Formalin-fixed, paraffin-embedded tissue sections from a 3-year-old female Angora goat suffering from clinical scrapie were immunostained after hydrated autoclaving using a monoclonal antibody (mAb, F99/ 97.6.1; IgG1) specific for a conserved epitope on the prion protein. Widespread and prominent deposition of the scrapie isoform of the prion protein (PrPSc) was observed in the brain, brainstem, spinal cord, retina, postganglionic neurons associated with parasympathetic ganglia of myenteric and submucosal plexuses, Peyer’s patches, peripheral lymph nodes, and pharyngeal and palatine tonsils. The goat was homozygous for PrP alleles encoding 5 octapeptide repeat sequences in the N-terminal region of the prion …

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A Prion Protein Epitope Selective For The Pathologically Misfolded Conformation, Eustache Paramithiotis, Marc Pinard, Trebor Lawton, Sylvie Laboissiere, Valerie I. Leathers, Wen-Quan Zou, Lisa A. Estey, Julie Lamontagne, Marty T. Lehto, Leslie H. Kondejewski, Gregory P. Francoeur, Maria Papadopoulos, Ashkan Haghighat, Stephen J. Spatz, Mark Head, Robert Will, James Ironside, Katherine I. O'Rourke, Quentin Tonelli, Harry C. Ledebur, Avi Chakrabartty, Neil R. Cashman Jan 2003

A Prion Protein Epitope Selective For The Pathologically Misfolded Conformation, Eustache Paramithiotis, Marc Pinard, Trebor Lawton, Sylvie Laboissiere, Valerie I. Leathers, Wen-Quan Zou, Lisa A. Estey, Julie Lamontagne, Marty T. Lehto, Leslie H. Kondejewski, Gregory P. Francoeur, Maria Papadopoulos, Ashkan Haghighat, Stephen J. Spatz, Mark Head, Robert Will, James Ironside, Katherine I. O'Rourke, Quentin Tonelli, Harry C. Ledebur, Avi Chakrabartty, Neil R. Cashman

Zoonotics and Wildlife Disease: Publications

Conformational conversion of proteins in disease is likely to be accompanied by molecular surface exposure of previously sequestered amino-acid side chains. We found that induction of β-sheet structures in recombinant prion proteins is associated with increased solvent accessibility of tyrosine. Antibodies directed against the prion protein repeat motif, tyrosine-tyrosinearginine, recognize the pathological isoform of the prion protein but not the normal cellular isoform, as assessed by immunoprecipitation, plate capture immunoassay and flow cytometry. Antibody binding to the pathological epitope is saturable and specific, and can be created in vitro by partial denaturation of normal brain prion protein. Conformation-selective exposure of …

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Properties Of A Disease-Specific Prion Probe, Guy Gorochov, Jean-Phillippe Deslys, Eustache Paramithiotis, Marc Pinard, Trebor Lawton, Sylvie Laboissiere, Valerie L. Leathers, Wen-Quan Zou, Lisa A. Estey, Julie Lamontagne, Marty T. Lehto, Leslie H. Kondejewski, Gregory P. Francoeur, Maria Paoadopoulos, Ashkan Haghighat, Stephen J. Spatz, Mark Head, Robert Will, James Ironside, Katherine I. O'Rourke, Quentin Tonelli, Harry C. Ledebur, Avi Chakrabartty, Neil R. Cashman Jan 2003

Properties Of A Disease-Specific Prion Probe, Guy Gorochov, Jean-Phillippe Deslys, Eustache Paramithiotis, Marc Pinard, Trebor Lawton, Sylvie Laboissiere, Valerie L. Leathers, Wen-Quan Zou, Lisa A. Estey, Julie Lamontagne, Marty T. Lehto, Leslie H. Kondejewski, Gregory P. Francoeur, Maria Paoadopoulos, Ashkan Haghighat, Stephen J. Spatz, Mark Head, Robert Will, James Ironside, Katherine I. O'Rourke, Quentin Tonelli, Harry C. Ledebur, Avi Chakrabartty, Neil R. Cashman

Zoonotics and Wildlife Disease: Publications

In a recently published article, Paramithiotis et al. describe antibodies specific for the prion Tyr-Tyr-Arg (YYR) repeat motif. These antibodies interact with the pathological isoform of the prion protein (PrPSC), but not with the normal cellular isoform (PrpC). Because of this restricted specificity, they suggest that YYR-specific antibodies could be useful for the diagnosis and treatment of prion diseases (Fig. O. The monoclonal antibodies, all of the IgM isotype, were produced by immunizing mice with a synthetic peptide (CYYRRYYRYY). When coupled to magnetic beads, these YYR-specific antibodies immunoprecipitate Prpsc much more efficiently than PrpC …

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A Priori Prediction Of Disease Invasion Dynamics In A Novel Environment, Colin A. Russell, David L. Smith, Lance A. Waller, James E. Childs, Leslie A. Real Jan 2003

A Priori Prediction Of Disease Invasion Dynamics In A Novel Environment, Colin A. Russell, David L. Smith, Lance A. Waller, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Directly transmitted infectious diseases spread through wildlife populations as travelling waves away from the sites of original introduction. These waves often become distorted through their interaction with environmental and population heterogeneities and by long-distance translocation of infected individuals. Accurate a priori predictions of travelling waves of infection depend upon understanding and quantifying these distorting factors. We assess the effects of anisotropies arising from the orientation of rivers in relation to the direction of disease-front propagation and the damming effect of mountains on disease movement in natural populations. The model successfully predicts the local and large-scale prevaccination spread of raccoon rabies …

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Ehrlichia Chaffeensis: A Prototypical Emerging Pathogen, Christopher D. Paddock, James E. Childs Jan 2003

Ehrlichia Chaffeensis: A Prototypical Emerging Pathogen, Christopher D. Paddock, James E. Childs

Zoonotics and Wildlife Disease: Publications

In April 1986, a medical intern scanning the peripheral blood smear of a severely ill man with an unexplained illness observed peculiar intracytoplasmic inclusions in several of the patient’s monocytes. The patient described multiple tick bites sustained approximately 2 weeks earlier during a visit to a rural area in northern Arkansas, and a presumptive diagnosis of Rocky Mountain spotted fever had been made (104, 174). Clinicians and scientists subsequently identified these inclusions as clusters of bacteria belonging to the genus Ehrlichia, previously known in the United States solely as veterinary pathogens (174). Within the next 5 years, the organism …

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Monte Carlo Assessments Of Goodness-Of-Fit For Ecological Simulation Models, Lance A. Waller, David Smith, James E. Childs, Leslie A. Real Jan 2003

Monte Carlo Assessments Of Goodness-Of-Fit For Ecological Simulation Models, Lance A. Waller, David Smith, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

One often develops stochastic ecologic simulation models based on local interactions between individuals or groups and bases systemic conclusions on trends summarized over multiple data sets generated from the model. In many cases, such models generate data sets (“realizations”) each violating the usual assumptions associated with traditional statistical tests of goodness-of-fit, most notably that of independent observations. Monte Carlo hypothesis tests applied to multiple realizations from such models provide appropriate goodness-of-fit tests regardless of within-model peculiarities. The Monte Carlo tests address the question “Do the observed data appear consistent with the model?” in contrast to the usual question “Does the …

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Cd21-Positive Follicular Dendritic Cells A Possible Source Of PrpSc In Lymph Node Macrophages Of Scrapie-Infected Sheep, Lynn M. Herrmann, William P. Cheevers, William C. Davis, Donald P. Knowles, Katherine I. O'Rourke Jan 2003

Cd21-Positive Follicular Dendritic Cells A Possible Source Of PrpSc In Lymph Node Macrophages Of Scrapie-Infected Sheep, Lynn M. Herrmann, William P. Cheevers, William C. Davis, Donald P. Knowles, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Natural sheep scrapie is a prion disease characterized by the accumulation of PrPSc in brain and lymphoid tissues. Previous studies suggested that lymph node macrophages and follicular dendritic cells (FDC) accumulate PrPSc. In this study, lymph nodes were analyzed for the presence of PrPSc and macrophage or FDC markers using dual immunohistochemistry. A monoclonal antibody (mAb) to the C-terminus of PrP reacted with CD172a+ macrophages and CD21+ FDC processes in secondary follicles. However, a PrP N-terminus- specific mAb reacted with CD21+ FDC processes but not CD172a+ macrophages in secondary follicles. Neither the PrP N-terminus nor C-terminus-specific …

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The Risk Of Disease Transmission To Livestock Posed By Contamination Of Farm Stored Feed By Wildlife Excreta, M. J. Daniels, M. R. Hutchings, A. Greig Jan 2003

The Risk Of Disease Transmission To Livestock Posed By Contamination Of Farm Stored Feed By Wildlife Excreta, M. J. Daniels, M. R. Hutchings, A. Greig

Michigan Bovine Tuberculosis Bibliography and Database

Livestock feed is susceptible to contamination from wildlife excreta during on farm storage. Pathogens associated with diseases such as paratuberculosis, salmonella and cryptosporidiosis are present in wild rodent and bird excreta. Feed stores on four farms in the east of Scotland were monitored monthly over the winter of 1998/9 to quantify the levels of wildlife faecal contamination. A mean of 79.9 rodent (95% confidence interval: 37.5–165.9) and 24.9 (14.3–41.7) bird faeces were deposited per m2 of stored feed per month. It was estimated that individual cattle and sheep could encounter 1626 and 814 wildlife faeces over the winter.

A …

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Spatial And Temporal Spread Of Bovine Tuberculosis In Wild White-Tailed Deer In Michigan, Graham J. Hickling, Stephen M. Schmitt, Daniel J. O'Brien Jan 2003

Spatial And Temporal Spread Of Bovine Tuberculosis In Wild White-Tailed Deer In Michigan, Graham J. Hickling, Stephen M. Schmitt, Daniel J. O'Brien

Michigan Bovine Tuberculosis Bibliography and Database

In 1975, a wild white-tailed deer infected with bovine tuberculosis was shot in the northeastern Lower Peninsula, Michigan. The shooting of a second infected deer in the same area in 1994 triggered ongoing disease surveillance in the region. By 2002, bovine tuberculosis had been confirmed in 12 Michigan counties: from 449 deer; two elk; 41 non-cervid wildlife; one captive cervid facility and 28 cattle herds. We analyzed geographic spread of disease since the surveillance began and investigated factors influencing the prevalence of disease within the infected area. These analyses reveal that 78 percent of tuberculous deer came from within a …

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Aerosol Exposure Of White-Tailed Deer (Odocoileus Virginianus) To Mycobacterium Bovis, Mitchell V. Palmer, W. Ray Waters, Diana L. Whipple Jan 2003

Aerosol Exposure Of White-Tailed Deer (Odocoileus Virginianus) To Mycobacterium Bovis, Mitchell V. Palmer, W. Ray Waters, Diana L. Whipple

Michigan Bovine Tuberculosis Bibliography and Database

Tuberculosis due to Mycobacterium bovis affects both captive and free-ranging Cervidae in the United States. Various animal models have been developed to study tuberculosis of both humans and animals. Generally, tuberculosis is transmitted by aerosol and oral routes. Models of aerosol exposure of large animals to M. bovis are uncommon. In order to develop a reliable method of aerosol exposure of white-tailed deer (Odocoileus virginianus) to M. bovis, 12 healthy white-tailed deer, aged 8–10 mo, were infected by aerosol exposure to 2x105 to 1x106 colony forming units (CFU) (high dose, n=4) of M. bovis or …

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Mycobacterial Diseases In Wildlife, Gary Witmer, Thomas J. Deliberto, Kurt C. Vercauteren, Peter Butchko Jan 2003

Mycobacterial Diseases In Wildlife, Gary Witmer, Thomas J. Deliberto, Kurt C. Vercauteren, Peter Butchko

Michigan Bovine Tuberculosis Bibliography and Database

Mycobacterium infections occur in numerous wildlife species worldwide and this bacterial genus can also cause disease in humans and livestock. Two Mycobacterium species and one subspecies that infect wildlife are important from a wildlife damage management perspective. Mycobacterium avium, avian tuberculosis, is a ubiquitous and cosmopolitan disease of wild and domestic birds. Wild and domestic ruminants are host to M. avium paratuberculosis, also known as Johne’s disease. Finally, Mycobaterium bovis, bovine tuberculosis, is primarily associated with domestic and wild bovines and ungulates, but also infects many other species of mammals. Eradicating these diseases from wildlife populations is …

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Roles Of Mycobacterium Smegmatis D-Alanine:D-Alanine Ligase And D-Alanine Racemase In The Mechanisms Of Action Of And Resistance To The Peptidoglycan Inhibitor D-Cycloserine, Zhengyu Feng, Raul G. Barletta Jan 2003

Roles Of Mycobacterium Smegmatis D-Alanine:D-Alanine Ligase And D-Alanine Racemase In The Mechanisms Of Action Of And Resistance To The Peptidoglycan Inhibitor D-Cycloserine, Zhengyu Feng, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

D-Cycloserine (DCS) targets the peptidoglycan biosynthetic enzymes D-alanine racemase (Alr) and Dalanine: D-alanine ligase (Ddl). Previously, we demonstrated that the overproduction of Alr in Mycobacterium smegmatis determines a DCS resistance phenotype. In this study, we investigated the roles of both Alr and Ddl in the mechanisms of action of and resistance to DCS in M. smegmatis. We found that the overexpression of either the M. smegmatis or the Mycobacterium tuberculosis ddl gene in M. smegmatis confers resistance to DCS, but at lower levels than the overexpression of the alr gene. Furthermore, a strain overexpressing both the alr and ddl …

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Herpes Simplex Virus Type 1 And Bovine Herpesvirus 1 Latency, Clinton J. Jones Jan 2003

Herpes Simplex Virus Type 1 And Bovine Herpesvirus 1 Latency, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

A high percentage of the world’s population are infected with herpes simplex virus type 1 (HSV-1), and infection can cause a variety of disorders (35, 187). Recurrent ocular HSV-1 is the leading cause of infectious corneal blindness in industrialized nations (190). In a murine model, ocular infection induces autoimmune disorders, leading to corneal antigen destruction and stromal keratitis (275). HSV-1 infections also cause gastrointestinal disorders, esophageal disorders, and approximately 25% of the genital herpes infections (67, 158). HSV-1 infections can cause sporadic encephalitis, but this is relatively rare compared to other diseases resulting from infection. Further evidence for its involvement …

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Isovolumetric Regulation In Mammal Cells: Role Of Taurine, B. Ordaz, R. Franco, National University Of Mexico Tuz Jan 2003

Isovolumetric Regulation In Mammal Cells: Role Of Taurine, B. Ordaz, R. Franco, National University Of Mexico Tuz

School of Veterinary and Biomedical Sciences: Faculty Publications

The ability to regulate cell volume is an ancient conserved trait present in essentially all species through evolution. The maintenance of a constant cell volume is a homeostatic imperative in animal cells. Changes in cell water content affecting the concentration of intracellular messenger molecules impair the complex signaling network, crucial for cell functioning and intercellular communication. Although the renal homeostatic mechanisms exert a precise control of extracellular fluid osmolarity, this is challenged in a variety of pathological situations. The intracellular volume constancy is continuously compromised by the generation of local and transient osmotic microgradients, associated with nutrients uptake, secretion, cytoskeleton …

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Osmosensitive Taurine Release: Does Taurine Share The Same Efflux Pathway With Chloride And Other Amino Acid Osmolytes?, Rodrigo Franco Jan 2003

Osmosensitive Taurine Release: Does Taurine Share The Same Efflux Pathway With Chloride And Other Amino Acid Osmolytes?, Rodrigo Franco

School of Veterinary and Biomedical Sciences: Faculty Publications

Swelling subsequent to hyposmotic conditions activates a process of volume regulation present in most cell types. This volume adjustment is accomplished by osmolyte translocation toward the extracellular space to reach a new osmotic equilibrium. Molecules involved in this homeostatic mechanism have been broadly classified into two categories: organic and inorganic osmolytes. Inorganic osmolytes comprise mainly the intracellular ions K+ and Cl–. Cell swelling–induced activation of separate K+ and Cl– channels has been described in most preparations. Organic osmolytes are grouped in three categories: amino acids, polyalcohols, and methylamines. These osmolytes, particularly taurine, are present in …

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Role Of Activator Protein-1 In The Down-Regulation Of The Human Cyp2j2 Gene In Hypoxia, Nicole Y. Marden, Eva Fiala-Beer, Shi-Hua Xiang, Michael Murray Jan 2003

Role Of Activator Protein-1 In The Down-Regulation Of The Human Cyp2j2 Gene In Hypoxia, Nicole Y. Marden, Eva Fiala-Beer, Shi-Hua Xiang, Michael Murray

School of Veterinary and Biomedical Sciences: Faculty Publications

The cytochrome P450 (CYP) 2J2 arachidonic acid epoxygenase gene was down-regulated at a pre-translational level in human hepatoma-derived HepG2 cells incubated in a hypoxic environment; under these conditions, the expression of c-Jun and c-Fos mRNA and protein was increased. The 5′-upstream region of the CYP2J2 gene was isolated by amplification of a 2341 bp fragment and putative regulatory elements that resembled activator protein-1 (AP-1)-like sequences were identified. From transient transfection analysis, c-Jun was found to strongly activate a CYP2J2–luciferase reporter construct, but co-transfection with plasmids encoding c-Fos or c-Fos-related antigens, Fra-1 and -2, abrogated reporter activity. Using a series …

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Mucosal Priming Of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses In Rhesus Macaques By The Salmonella Type Iii Secretion Antigen Delivery System, David T. Evans, Li-Mei Chen, Jacqueline Gillis, Kuei-Chin Lin, Brian Harty, Gail P. Mazzara, Ruben O. Donis, Keith G. Mansfield, Jeffrey D. Lifson, Ronald C. Desrosiers, Jorge E. Galán, R. Paul Johnson Jan 2003

Mucosal Priming Of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses In Rhesus Macaques By The Salmonella Type Iii Secretion Antigen Delivery System, David T. Evans, Li-Mei Chen, Jacqueline Gillis, Kuei-Chin Lin, Brian Harty, Gail P. Mazzara, Ruben O. Donis, Keith G. Mansfield, Jeffrey D. Lifson, Ronald C. Desrosiers, Jorge E. Galán, R. Paul Johnson

School of Veterinary and Biomedical Sciences: Faculty Publications

Nearly all human immunodeficiency virus (HIV) infections are acquired mucosally, and the gut-associated lymphoid tissues are important sites for early virus replication. Thus, vaccine strategies designed to prime virus-specific cytotoxic T lymphocyte (CTL) responses that home to mucosal compartments may be particularly effective at preventing or containing HIV infection. The Salmonella type III secretion system has been shown to be an effective approach for stimulating mucosal CTL responses in mice. We therefore tested ∆phoP-phoQ attenuated strains of Salmonella enterica serovar Typhimurium and S. enterica serovar Typhi expressing fragments of the simian immunodeficiency virus (SIV) Gag protein fused to the …

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Method To Detect The Presence Of A Microorganism Or Agent In An Animal, David R. Smith, Laura L. Hungerford, Rodney A. Moxley, Susanne Hinkley, Terry Klopfenstein, Jeff Gray Jan 2003

Method To Detect The Presence Of A Microorganism Or Agent In An Animal, David R. Smith, Laura L. Hungerford, Rodney A. Moxley, Susanne Hinkley, Terry Klopfenstein, Jeff Gray

School of Veterinary and Biomedical Sciences: Faculty Publications

The present invention provides a method to detect the presence of a microorganism or agent in an animal. The method encompasses placement of devices at various locations where the animal resides so as to induce the animal to initiate contact with the device. As a result of this contact, the animal deposits various microorganisms and agents on the device. The device is then tested for the presence of the particular microorganism or agent of interest.

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Experimental Mycobacteriosis In Striped Bass Morone Saxatilis, D. T. Gauthier, M. W. Rhodes, W. K. Vogelbein, H. Kator, C. A. Ottinger Jan 2003

Experimental Mycobacteriosis In Striped Bass Morone Saxatilis, D. T. Gauthier, M. W. Rhodes, W. K. Vogelbein, H. Kator, C. A. Ottinger

Biological Sciences Faculty Publications

Striped bass Morone saxatilis were infected intraperitoneally with approximately 105 Mycobacterium marinum, M. shottsii sp. nov., or M. gordonae. Infected fish were maintained in a flow-through freshwater system at 18 to 21°C, and were examined histologically and bacteriologically at 2, 4, 6, 8, 17, 26, 36 and 45 wk post-infection (p.i.). M. marinum caused acute peritonitis, followed by extensive granuloma development in the mesenteries, spleen and anterior kidney. Granulomas in these tissues underwent a temporal progression of distinct morphological stages, culminating in well-circumscribed lesions surrounded by normal or healing tissue. Mycobacteria were cultured in high numbers from …

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Placental Expression Of Estrogen Receptor Beta And Its Hormone Binding Variant – Comparison With Estrogen Receptor Alpha And A Role For Estrogen Receptors In Asymmetric Division And Differentiation Of Estrogen-Dependent Cells, Antonin Bukovsky, Michael R. Caudle, Maria Cekanova Ms, Rndr, Phd, Romaine I. Fernando, Jay Wimalasena, James S. Foster, Donald C. Henley, Robert F. Elder Jan 2003

Placental Expression Of Estrogen Receptor Beta And Its Hormone Binding Variant – Comparison With Estrogen Receptor Alpha And A Role For Estrogen Receptors In Asymmetric Division And Differentiation Of Estrogen-Dependent Cells, Antonin Bukovsky, Michael R. Caudle, Maria Cekanova Ms, Rndr, Phd, Romaine I. Fernando, Jay Wimalasena, James S. Foster, Donald C. Henley, Robert F. Elder

Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology

During human pregnancy, the production of 17-beta-estradiol (E2) rises steadily to eighty fold at term, and placenta has been found to specifically bind estrogens. We have recently demonstrated the expression of estrogen receptor alpha (ER-alpha) protein in human placenta and its localization in villous cytotrophoblast (CT), vascular pericytes, and amniotic fibroblasts. In vitro, E2 stimulated development of large syncytiotrophoblast (ST) aggregates. In the present study we utilized ER-beta affinity purified polyclonal (N19:sc6820) and ER-alpha monoclonal (clone h-151) antibodies. Western blot analysis revealed a single ~52 kDa ER-beta band in chorionic villi (CV) protein extracts. In CV, strong cytoplasmic ER-beta immunoreactivity …

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Elastomeric Hoof Boots, John Hanley Jan 2003

Elastomeric Hoof Boots, John Hanley

Masters

The design, manufacture and testing of a prototype elastomeric equine boot is described in this thesis. Thoroughbred horses may suffer from a number of serious hoof disorders. These include stone bruising, navicular syndrome and hoof wall separation. Excessive concussion in the equine hoof is a major contributory factor in most of the problems horses experience in their lower limbs. Bandaging of a horses foot after injury is time consuming as well as being labour intensive. The proposed boot serves a number of purposes; by replacing bandages during poulticing it plays a part in faster healing of foot ailments. It can …

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