Medicine and Health Sciences Commons^™

Jacuzzi-Induced Pneumoperitoneum: Case Report And Literature Review, Obteene Azimi-Ghomi, Dieter Brummund, Vasiliy Ovakimyan, Gerardo Kahane

HCA Healthcare Journal of Medicine

Radiographically-detected pneumoperitoneum in the setting of acute onset abdominal pain is a classic case among surgical emergencies. The spectrum of etiology ranges from benign to catastrophic, and the ability to differentiate depends in large part on the history and physical exam findings. Included among non-surgical types of pneumoperitoneum are (1) post-operative, (2) diagnostic/experimental, (3) gynecologic tract air entry, (4) the difference in intra- and extra-alveolar pressures, pneumothorax-associated and (5) miscellaneous. Jacuzzi-induced pneumoperitoneum is an extremely rare form of non-surgical pneumoperitoneum. We discuss a case of a 32-year-old female presenting with pneumoperitoneum and acute onset abdominal pain secondary to vaginal insertion …

Factors Affecting Renal Function On Ileostomy In Dr. Cipto Mangunkusumo General Hospital: A Cross-Sectional Study, Lam Sihardo, Agi S. Putranto

The New Ropanasuri Journal of Surgery

Introduction. Every year, about 30—60 ileostomy with various underlying diseases and indications were created in Dr. Cipto Mangunkusumo General Hospital (CMGH). There were a lot of complications attributable to these creations; one is the decline of renal function. The study goal was to find out factors influencing the renal function of ileostomy in CMGH.

Method. A cross-sectional study was conducted using medical records in April – May 2021. Samples were taken using the purposive sampling method. Inclusion criteria include male or female patients who underwent ileostomy closure in CMGH in the last four years with complete BMI, ileostomy creation and …

Prognostic And Predictive Factors Of Mortality In Burn Patients At Dr. Cipto Mangunkusumo General Hospital, Indonesia, Muhamad Irfan A. Hasibuan, Yefta Moenadjat

The New Ropanasuri Journal of Surgery

Introduction. Some prognostic– and predictive factors in burn have never been investigated in Indonesian specific characteristics, which is delayed treatment. A study was conducted to determine prognostic and predictive factors in this specific characteristic.

Method. A retrospective cohort focused on burn mortality in extensive burns managed in CMGH from 1998–2010. Some known prognostic– and predictive factors and unknown ones were the variables of interest. Bivariate and multivariate using logistic regression analysis proceeded to find out these factors.

Results. Out of all factors investigated, the variables that showed a significant correlation were: TBSA, inhalation injury, Baux score, revised …

Survival Rate Of Critically Ill Coronavirus Disease 2019 Patients On Tracheostomy In Indonesia, Aris Ramdhani, Dita Aditianingsih, Raihanita Zahra, Muhammad A. Putra, Wuryantoro Soeharto, Melvin D.B. Kwa

The New Ropanasuri Journal of Surgery

Introduction. During COVID-19 global pandemic, tracheostomy is often performed on critically ill COVID-19 patients. There is no available data on the survival rate of critically ill COVID-19 patients on tracheostomy in Indonesia. This study aimed to find the survival rate of critically ill COVID-19 patients on tracheostomy in Indonesia.

Methods. A descriptive survival analysis study enrolled critically ill COVID-19 patients in RSUI who underwent a tracheostomy procedure. Baseline data, including clinical characteristics and laboratory findings before tracheostomy, were recorded. Survival analysis was conducted using the Kaplan-Meier plot.

Results. Forty-two subjects were enrolled in the study: 25 males (59.5%) and 17 …

Different Approaches Of Suspected Unilateral And Bilateral Maxillary Sinus Myxoma, Two Rare Cases Report, Marlinda Adham, Ferucha Moulanda

The New Ropanasuri Journal of Surgery

Maxillary sinus myxoma is a rare benign tumor with locally aggressive behavior and can infiltrate surrounding structures. Surgical intervention is considered the primary procedure with several approaches for wider tumor exposure, complete tumor removal, and better wound healing. In this article, two cases of suspected unilateral and bilateral maxillary sinus myxoma were presented with different approaches applied for both cases. We managed two patients, a 37-year-old male with mass at right maxilla and a 60-year-old male with mass at both maxillae. Physical examination, radiology imaging, and pre-operative histopathology examination showed maxillary sinus myxoma. The total maxillectomy procedure with Weber Ferguson …

Cutaneous Horn On The Right Supraclavicular Region In An Adolescent Female, A Rare Case Report, Rohit Gupta, Manoj Kumar, Ruchi Sinha, Reva Shankar Sahu

The New Ropanasuri Journal of Surgery

Cutaneous horn (CH) is an outgrowth from the skin surface, composed of keratin, and associated with benign to malignant skin lesions. We report a case of CH in a 15-year-old female associated with Keratoacanthoma. It is uncommon in young people and is associated with a good prognosis because of its benign nature. This case needs to be reported as it highlights the rare occurrence of this condition in the younger age group and its good prognosis. Surgical excision is the treatment of choice, with histopathologic diagnosis playing a critical role in determining the nature and further treatment of this condition …

The New Version Of Accreditation For Higher Education In Health, Yefta Moenadjat

The New Ropanasuri Journal of Surgery

No abstract provided.

Consequential Surgeries Limit Recurrence Of Skin Malignancies In Xeroderma Pigmentosum: A Case Report, Ahmad Kurnia, Diani Kartini, Novinda Herwirastri, Zoya M. Adyasa

The New Ropanasuri Journal of Surgery

Xeroderma Pigmentosum (XP) is a rare inherited skin malignancy with no causative treatment options. Reporting a 23-year-old woman with xeroderma pigmentosum who underwent several surgical tumor removals followed by further five procedures to apply tissue expander, facial resurfacing using full-thickness skin grafts with a donor from abdominal. The next series was tumor resection in the chin, forehead, nasal reconstruction, tumor removal on bilateral third digits, and defect closure. No recurrence after nine years of postoperative monitoring with an aesthetically acceptable result.

Intraoperative Acoustics: Auditory Cues In Hip Reconstructive Surgery, Jeffrey M. Henstenburg, Walaa Abdelfadeel, Anthony J. Boniello, Joseph Schmitz, Jeffrey J. Vakil, Andrew M. Star

Rothman Institute Faculty Papers

Background: Orthopaedic surgeons rely on visual and tactile cues to guide performance in the operating room (OR). However, there is very little data on how sound changes during orthopaedic procedures and how surgeons incorporate audio feedback to guide performance. This study attempts to define meaningful
changes in sound during vital aspects of total hip arthroplasty (THA) within the spectrum of human hearing.

Methods: 84 audio recordings were obtained during primary elective THA procedures during sawing of the femoral neck, reaming of the acetabulum, acetabular cup impaction, polyethylene liner impaction, femoral broaching, planning of the femoral calcar and press-fit of a …

Candida Pericarditis Presenting With Cardiac Tamponade And Multiple Organ Failure After Combined Damage Control Thoracotomy And Laparotomy With Splenectomy In A Trauma Patient: Case Report And Review Of Literature, R. A. Siller, Jeffrey Skubic, J. L. Almeda, Adolfo E. Kaplan

School of Medicine Publications and Presentations

Candida pericarditis is a rare condition which has previously been described after cardiothoracic surgery and immunosuppressive states (Geisler et al., 1981; Eng et al., 1981; Kraus et al., 1988; Kaufman et al., 1988; Tang et al., 2009; Glower et al., 1990; Carrel et al., 1991; Rabinovici et al., 1997; Canver et al., 1998; Farjah et al., 2005; Gronemeyer et al., 1982 [1-11]). We describe the case of a 19-year-old male blunt trauma patient, who survived a damage control thoracotomy and laparotomy with splenectomy, who later developed a loculated Candida pericardial effusion, complicated with cardiac tamponade and multiple organ failure, and …

Thyroidectomy In Mechanical Circulatory Support - A Salvage Treatment For Thyrotoxicosis-Induced Cardiogenic Shock: Case Series, Rody G. Bou Chaaya, Lauren M. Saint, Onyedika J. Ilonze Md, Mph

The VAD Journal

Amiodarone is frequently used to treat arrhythmias in patients supported with left ventricular assist devices. Long term amiodarone use can cause hyperthyroidism ultimately leading to cardiomyopathy and sometimes thyrotoxicosis-induced cardiogenic shock (CS). We describe two cases of thyrotoxicosis-induced CS rescued by successful thyroidectomy under mechanical circulatory support (MCS) – one with a Heartmate III (Abbott Laboratories) and another supported with veno-arterial extracorporeal membrane oxygenation (V-A ECMO). In refractory CS, the initiation of V-A ECMO as a bridge to recovery is critical. In thyrotoxicosis-induced CS that is refractory to medical therapy requiring MCS, thyroidectomy is feasible, and a growing body of …

Decreasing Pre-Procedural Fasting Times: A Benchmark Study, Sheila Gasparek

MSN Capstone Projects

On a busy Surgical Trauma unit, scheduled procedures and operations are often delayed for priority emergent cases. Patients admitted to the unit with delayed procedures often endure extended fasting times beyond the six-hour intention of standard nothing by mouth (NPO) after midnight fasting order. With prolonged fasting times, patients inquire about pending surgery times and dietary options. Some providers may allow ice chips, but most doctors prefer patients to remain NPO in case Operating Room availability opens for surgery, leaving already anxious and uncomfortable patients more frustrated as prolonged fasting affects patients’ physical and psychological well-being (Anderson & Comrie, 2009). …

Reduced Risk Of Reoperations With Modern Deep Brain Stimulator Systems: Big Data Analysis From A United States Claims Database, Chengyuan Wu, Sean J Nagel, Rahul Agarwal, Monika Pötter-Nerger, Wolfgang Hamel, Ashwini Sharan, Allison T Connolly, Binith Cheeran, Paul S Larson

Department of Neurosurgery Faculty Papers

Objective: There have been significant improvements in the design and manufacturing of deep brain stimulation (DBS) systems, but no study has considered the impact of modern systems on complications. We sought to compare the relative occurrence of reoperations after de novo implantation of modern and traditional DBS systems in patients with Parkinson's disease (PD) or essential tremor (ET) in the United States.

Design: Retrospective, contemporaneous cohort study.

Setting: Multicenter data from the United States Centers for Medicare and Medicaid Services administrative claims database between 2016 and 2018.

Participants: This population-based sample consisted of 5,998 patients implanted with a DBS system, …

Augmentation Of Pedicle Screws Using Bone Grafting In Patients With Spinal Osteoporosis, Andrey Evgenievich Bokov, Anatoliy Bulkin, I S. Bratsev, Svetlana Ya Kalinina, Sergey G. Mlyavykh, David G. Anderson

Department of Neurosurgery Faculty Papers

The aim of the study was to develop a new method of vertebral augmentation based on autologous and allogeneic bone chips to be used in pedicle screw fixation and to compare this method with the technique based on polymethyl methacrylate (PMMA). Materials and Methods. This prospective non-randomized study included 164 patients with degenerative pathologies or traumatic injuries of the lumbar spine and transitional thoracolumbar segments; 153 of the operated patients were followed up for 18 months. In these patients, radiodensity of the cancellous bone tissue was below 110 HU by the Hounsfield scale. Patients with degenerative spinal disorders underwent pedicle …

Clinical Applications Of Magnetic Resonance Imaging Based Functional And Structural Connectivity, Chengyuan Wu, Francisca Ferreira, Michael Fox, Noam Harel, Jona Hattangadi-Gluth, Andreas Horn, Saad Jbabdi, Joshua Kahan, Ashwini Oswal, Sameer A Sheth, Yanmei Tie, Vejay Vakharia, Ludvic Zrinzo, Harith Akram

Department of Neurosurgery Faculty Papers

Advances in computational neuroimaging techniques have expanded the armamentarium of imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in vivo brain MRI structural and functional network mapping has been used to identify therapeutic targets, define eloquent brain regions to preserve, and gain insight into pathological processes and treatments as well as prognostic biomarkers. These tools have the real potential to inform patient-specific treatment strategies. Nevertheless, a realistic appraisal of clinical utility is needed that balances the growing excitement and interest in the field with important limitations associated with these techniques. Quality of the raw data, minutiae of the …

Outcomes Of Mechanical Thrombectomy For Patients With Stroke Presenting With Low Alberta Stroke Program Early Computed Tomography Score In The Early And Extended Window, Eyad Almallouhi, Sami Al Kasab, Zachary Hubbard, Eric C Bass, Guilherme Porto, Ali Alawieh, Reda Chalhoub, Pascal Jabbour, Robert M Starke, Stacey Q Wolfe, Adam S Arthur, Edgar Samaniego, Ilko Maier, Brian M Howard, Ansaar Rai, Min S Park, Justin Mascitelli, Marios Psychogios, Reade De Leacy, Travis Dumont, Michael R Levitt, Adam Polifka, Joshua Osbun, Roberto Crosa, Joon-Tae Kim, Walter Casagrande, Shinichi Yoshimura, Charles Matouk, Peter T Kan, Richard W Williamson, Benjamin Gory, Maxim Mokin, Isabel Fragata, Osama Zaidat, Albert J Yoo, Alejandro M Spiotta

Department of Neurosurgery Faculty Papers

Importance: Limited data are available about the outcomes of mechanical thrombectomy (MT) for real-world patients with stroke presenting with a large core infarct.

Objective: To investigate the safety and effectiveness of MT for patients with large vessel occlusion and an Alberta Stroke Program Early Computed Tomography Score (ASPECTS) of 2 to 5.

Design, setting, and participants: This retrospective cohort study used data from the Stroke Thrombectomy and Aneurysm Registry (STAR), which combines the prospectively maintained databases of 28 thrombectomy-capable stroke centers in the US, Europe, and Asia. The study included 2345 patients presenting with an occlusion in the internal carotid …

Genetic Susceptibility To Hepatocellular Carcinoma In Chromosome 22q13.31, Findings Of A Genome-Wide Association Study., Zhanwei Wang, Anuradha S Budhu, Yi Shen, Linda Lou Wong, Brenda Y Hernandez, Maarit Tiirikainen, Xiaomei Ma, Melinda L Irwin, Lingeng Lu, Hongyu Zhao, Joseph K Lim, Tamar Taddei, Lopa Mishra, Karen Pawlish, Antoinette Stroup, Robert Brown, Mindie H Nguyen, Jill Koshiol, Maria O Hernandez, Marshonna Forgues, Hwai-I Yang, Mei-Hsuan Lee, Yu-Han Huang, Motoki Iwasaki, Atsushi Goto, Shiori Suzuki, Koichi Matsuda, Chizu Tanikawa, Yoichiro Kamatani, Dean Mann, Maria Guarnera, Kirti Shetty, Claire E Thomas, Jian-Min Yuan, Chiea Chuen Khor, Woon-Puay Koh, Harvey Risch, Xin Wei Wang, Herbert Yu

Surgery Faculty Publications

Background and Aim: Chronic hepatitis C virus (HCV) infection, long-term alcohol use, cigarette smoking, and obesity are the major risk factors for hepatocellular carcinoma (HCC) in the United States, but the disease risk varies substantially among individuals with these factors, suggesting host susceptibility to and gene-environment interactions in HCC. To address genetic susceptibility to HCC, we conducted a genome-wide association study (GWAS).

Methods: Two case-control studies on HCC were conducted in the United States. DNA samples were genotyped using the Illumian microarray chip with over 710 000 single nucleotide polymorphisms (SNPs). We compared these SNPs between 705 HCC cases and …

Increased Use Of Opioids Perioperatively Leads To Unmanaged Postoperative Pain, Halida Sehic

Nursing | Senior Theses

Background: Total knee and total hip joint arthroplasty are two frequently preformed surgeries, with 5.2 million total knee arthroplasties performed the United States between the year 2000 and 2010 (Williams et al., 2015). Opioids are widely used to manage pain for patients undergoing total joint arthroplasty. However, use of opioids is associated with undesirable adverse effects, such as nausea and respiratory depression, (Johnson et al., 2011). In postoperative patients following total joint replacement, 75 % of the patients complain of inadequately controlled moderate to severe pain (De Luca et al., 2018). Increased use and overprescribing increase tolerance to opioids …

Giant Abdominal Aortic Aneurysms, Joshua I Ng, Tuong Nguyen, Anand Tarpara, Dawn Salvatore, Paul J Dimuzio, Babak Abai

Department of Surgery Faculty Papers

Giant abdominal aortic aneurysms (AAAs) are defined as AAAs >10 to 13 cm in the maximum transverse diameter. We have described a case of a patient who had presented for open repair of an 18-cm AAA and a review of reported cases of giant AAAs >10 cm in the maximum transverse diameter. Forty cases were compiled. The average maximum AAA diameter was 14.5 ± 4.1 cm. The AAA was ruptured on presentation in 12 patients (30%). Of the 40 cases, 34 (85%) were repaired with open surgery. The reported mortality was 15%. Despite the case complexity, five endovascular repairs were …

Laparoscopic Assisted Robotic Radical Prostatectomy With Pelvic Lymph Node Dissection Using Viable Cryopreserved Umbilical Tissue To Improve Cavernosal Nerve Function., Joshua Volin, Brett Watson, Lior Kopel, Samantha Kraemer, Jason Hafron

Conference Presentation Abstracts

Radical prostatectomy is the preferred treatment for patients with clinically localized prostate cancer and is typically performed using a robotic approach. Surgical techniques that preserve the neurovascular bundle minimize the risk of incontinence and erectile dysfunction post-operatively. Umbilical cord tissue is a relatively new technique, which has been shown to reduce inflammation and promote regenerative healing. In this video we show a robotic radical prostatectomy with bilateral nerve sparing technique utilizing a cryopreserved umbilical cord allograft nerve wrap.

Robotic Spleen Preserving Distal Pancreatectomy (Warshaw Techniqe) In A 12-Year-Old Female., Rachel Harvey, Begum Akay, Pavan Brahmamdam

Conference Presentation Abstracts

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare entity seen in young females. Complete surgical resection is often curative. This video shows a robotic spleen preserving distal pancreatectomy for a SPN in a 12-year-old female using the Warshaw technique. This technique preserves the short gastric and left gastroepiploic vessels allowing for splenic survival after ligation of the splenic vessels. This video demonstrates the feasibility of using the robot to perform this procedure in a pediatric patient. MRI at 18 months follow up showed that the spleen was completely perfused, with no evidence of recurrence or metastasis.

Generation, Analysis, And Evaluation Of Patient-Specific, Osteoligamentous, Spine Meshes, Austin R. Tapp

Biomedical Engineering Theses & Dissertations

Scoliosis, an abnormal curvature of the spine, is traditionally corrected with bracing treatments or by a highly invasive posterior spinal fusion (PSF) operation. These correction strategies are constrained by current imaging modalities, which fail to elucidate the soft tissue anatomy that is known to play a critical role in spinal stiffness and overall structure. Osteoligamentous segmentations of the spinal column offer a foundation for downstream finite element (FE) studies seeking to optimize bracing treatments or determine ideal surgical approaches.

This thesis presents methods for automatically and semi-automatically segmenting vertebrae and surrounding soft tissues of the spinal column using X-ray computed …

Hook Plating Versus Tension Band Wiring In Treatment Of Displaced Lateral End Clavicle Fracture, Alaa Elmohamady, Ehab Elzahed, Ismail Hammouda

Al-Azhar International Medical Journal

Abstract Background: Lateral end clavicular fractures represent about 15% of clavicular fractures. Nonunion rate is about 22 to 44% due to interacting forces between arm weight and trapezius muscle . Objective: To assess the clinical and radiological outcomes of fixation by HP versus TBW and to determine which technique provides enough stability to permit early range of motion. Patients and Methods: A prospective comparative study on 40 patients( 20 patients fixed by HP and others 20 by TBW) was done and followed up at Al-Azhar University Hospitals between December 2019 to April 2021. Results: The mean age of patients is …

Pectoral Etching In Early Grades Gynecomastia, Elsayed Shaaban, Mostafa Mikki, Hazem Dahshan

Al-Azhar International Medical Journal

Background: Nowadays there is a great introduction of 3D,4D and high-definition body contouring. Applicability and evaluation of such techniques in gynecomastia surgery needs more investigation. Objective: The aim of this study was to assess high definition liposculpture to get masculinized appearance of the chest for treatment of early grades gynecomastia. Patients and methods: 30 patients with grade I&II gynecomastia were selected with age group between 18 and 50 years old with mean 24.73 ± 2.62. It was a prospective observational cohort study to assess the applicability of pectoral etching in early grades gynecomastia. The study was conducted at Al-Azhar university …

Neurophysiologic Study In Children With End Stage Renal Disease On Regular Hemodialysis, ‪Mohamed ‬ Hasan, Moftah Rabeea, Hassan Hassan, Ann Abd-Elkader, Eman Elzamarany

Al-Azhar International Medical Journal

Background: Patients undergoing hemodialysis for chronic kidney disease (CKD) commonly have neurological problems. Both the central and peripheral nerve systems may be affected by these problems. Uremic encephalopathy, cognitive impairment, peripheral neuropathies, and uremic myopathy are all common neurological consequences in CKD. Aim of the study: to detect neurophysiologic changes using electroencephalography (EEG), nerve conduction velocity (NCV) and electromyography (EMG) in children with CKD on regular hemodialysis and to correlate these changes with duration of dialysis and duration of disease. Patients and Methods: thirty patients with CKD who are on regular hemodialysis at pediatric nephrology unit at Al-azher university hospital. …

Assessment Of Platelet Rich Plasma (Prp) Therapy In Prevention Of Chronic Wound Complications, Mahmoud Shehata, Amr Rezk

Al-Azhar International Medical Journal

Background: Delayed wound healing is a key factor in the development of chronic wound complications so we can utilize the wound healing promotion properties of platelet rich plasma in decreasing the incidence of these complications. Patients and Methods: A total number of 50 patients with open wounds resulting after surgical debridement of various types of soft tissue infection were included in this study, two groups with 25 patients for each were divided randomly. Group A patients were treated with PRP while group B was the control group treated with ordinary dressing. The two groups were monitored every other day for …

Surgical Management Of Subclavian And Proximal Axillary Artery Injuries, Zia Ur Rehman, Suleman Yousaf, Tehmeed Ahmad

Department of Surgery

Subclavian and proximal axillary arterial injuries are rare and difficult to manage. Eight patients were managed from January 2008 to December 2018 at The Aga Khan University Hospital, Karachi, Pakistan with mean age of 36.13 ± 14.48 years. All patients had penetrating injuries, from gunshot in 5 (62.5%), bomb blast in 2 (25%), and stab wound in 1 (12.5%) case. Six (75%) patients presented in haemodynamically stable condition. The mean time between the injury and patient presentation was 28 ± 8.39 hours. The injuries were approached via supraclavicular incision in 3 (37.5%) patients, infraclavicular incisions in 2 (25%) patients and …

Strocss 2021: Strengthening The Reporting Of Cohort, Cross-Sectional And Case-Control Studies In Surgery, Ginimol Mathew, Riaz Agha, Strocss Group, Joerg Albrecht, Prabudh Goel, Indraneil Mukherjee, Prathamesh Pai, Anil K. D'Cruz, Ather Enam, Hammad Ather

Section of Neurosurgery

Introduction: Strengthening The Reporting Of Cohort Studies in Surgery (STROCSS) guidelines were developed in 2017 in order to improve the reporting quality of observational studies in surgery and updated in 2019. In order to maintain relevance and continue upholding good reporting quality among observational studies in surgery, we aimed to update STROCSS 2019 guidelines.
Methods: A STROCSS 2021 steering group was formed to come up with proposals to update STROCSS 2019 guidelines. An expert panel of researchers assessed these proposals and judged whether they should become part of STROCSS 2021 guidelines or not, through a Delphi consensus exercise.
Results: 42 …

The Effect Of Saline Flush After Rocuronium Bolus On Intubating Conditions In Adult Patients Undergoing Elective Surgery: A Randomized Controlled Trial, Ian Odari, Vitalis Mung’Ayi, Rajpreet Bal, David Odaba

Anaesthesiology, East Africa

Background: In emergency surgeries requiring endotracheal intubation, the time to effect of neuromuscular blocking drugs is a crucial time to avoid hypoxia and aspiration into the lungs. Various strategies have been undertaken to shorten this time. All these methods have positive results but some are associated with side effects. The effectiveness of a muscle relaxant can either be assessed using the train of four or intubating conditions on the Goldberg scale. In this study, we investigated the effects of a 20 ml saline bolus following intravenous rocuronium at 0.6 mg/kg on the proportions of patients with excellent intubating conditions …

Cdk5 Drives Formation Of Heterogeneous Pancreatic Neuroendocrine Tumors, Angela M. Carter, Nilesh Kumar, Brendon Herring, Chunfeng Tan, Rachael Guenter, Rahul Telange, Wayne Howse, Fabrice Viol, Tyler R. Mccaw, Hayden H. Bickerton, Priyanka Gupta, Frank Gillardon, Eugene A. Woltering, Deepti Dhall, John Totenhagen, Ronadip R. Banerjee, Elizabeth M. Kurian, Sushanth Reddy, Herbert Chen, Joerg Schrader

School of Medicine Faculty Publications

Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous population of neoplasms that arise from hormone-secreting islet cells of the pancreas and have increased markedly in incidence over the past four decades. Non-functional PanNETs, which occur more frequently than hormone-secreting tumors, are often not diagnosed until later stages of tumor development and have poorer prognoses. Development of successful therapeutics for PanNETs has been slow, partially due to a lack of diverse animal models for pre-clinical testing. Here, we report development of an inducible, conditional mouse model of PanNETs by using a bi-transgenic system for regulated expression of the aberrant activator of Cdk5, …