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What Is The Number Needed To Treat When Exercise Training Heart Failure Patients?, Neil Smart
What Is The Number Needed To Treat When Exercise Training Heart Failure Patients?, Neil Smart
Neil Smart
Debate exists on the number needed to treat (NNT) to prevent one mortality with exercise training in heart failure patients. The primary aim of this work was to conduct a sensitivity analysis, removing outlying mortality data from a published meta-analysis of exercise training in heart failure patients. A sensitivity analysis was conducted by removing data from one randomized controlled trial that reported particularly high mortality rates and may be considered a data outlier. Annualized NNTs were subsequently calculated for mortality data from a meta-analysis of exercise training in heart failure patients. Sensitivity analysis showed that the mortality benefit reported by …
Systematic Review Of The Effect Of Aerobic And Resistance Exercise Training On Systemic Brain Natriuretic Peptide (Bnp) And N-Terminal Bnp Expression In Heart Failure Patients, N. Smart, M. Steele
Systematic Review Of The Effect Of Aerobic And Resistance Exercise Training On Systemic Brain Natriuretic Peptide (Bnp) And N-Terminal Bnp Expression In Heart Failure Patients, N. Smart, M. Steele
Neil Smart
Background: BNP and the N-terminal portion (NT-pro-BNP) have emerged as powerful tools in the diagnosis and prognosis of heart failure on acute presentation. The aim of this work was to systematically review the effect of exercise training on BNP and NT-pro-BNP levels in patients with left ventricular dysfunction. Methods: A systematic search was conducted of Medline (Ovid) (1950–July 2008), Embase.com (1974–current), Cochrane Central Register of Controlled Trials, CINAHL (1981–current) and Web of Science (2000–current) to identify randomized controlled trials of aerobic and/or resistance exercise training in heart failure patients that measured BNP and/or pro-BNP. Primary outcome measures were changes in …