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Full-Text Articles in Medicine and Health Sciences

"Challenging The Known." 16th Annual Research Week: Event Proceedings, University Of The Incarnate Word Apr 2023

"Challenging The Known." 16th Annual Research Week: Event Proceedings, University Of The Incarnate Word

Excellence Summit (Research Week) Archived Proceedings

Presentations of completed and ongoing research activity conducted by graduate students, undergraduate students, and faculty at University of the Incarnate Word. Includes poster, podium, visual arts, interactive demo, and creative and performing arts presentations. Coordinated and presented by the Office of Research and Graduate Studies.


Time Of Day Preferences And Daily Temporal Consistency For Predicting The Sustained Use Of A Commercial Meditation App: Longitudinal Observational Study, Vincent Berardi, Ryan Fowers, Gavriella Rubin, Chad Stecher Apr 2023

Time Of Day Preferences And Daily Temporal Consistency For Predicting The Sustained Use Of A Commercial Meditation App: Longitudinal Observational Study, Vincent Berardi, Ryan Fowers, Gavriella Rubin, Chad Stecher

Psychology Faculty Articles and Research

Background: The intensive data typically collected by mobile health (mHealth) apps allows factors associated with persistent use to be investigated, which is an important objective given users’ well-known struggles with sustaining healthy behavior.

Objective: Data from a commercial meditation app (n=14,879; 899,071 total app uses) were analyzed to assess the validity of commonly given habit formation advice to meditate at the same time every day, preferably in the morning.

Methods: First, the change in probability of meditating in 4 nonoverlapping time windows (morning, midday, evening, and late night) on a given day over the first 180 days …


Fruit And Vegetable Intake And Home Nutrition Environment Among Low-Income Minority Households With Elementary-Aged Children, Brittni Naylor Metoyer, Ru-Jye Chuang, Minjae Lee, Christine Markham, Eric L Brown, Maha Almohamad, Jayna M Dave, Shreela V Sharma Apr 2023

Fruit And Vegetable Intake And Home Nutrition Environment Among Low-Income Minority Households With Elementary-Aged Children, Brittni Naylor Metoyer, Ru-Jye Chuang, Minjae Lee, Christine Markham, Eric L Brown, Maha Almohamad, Jayna M Dave, Shreela V Sharma

Faculty, Staff and Student Publications

Racial/ethnic and socioeconomic differences were shown to have an influence on child fruit and vegetable intake. This study examined the associations between parent and child fruit and vegetable intake and the home nutrition environment among Hispanic/Latino and African American families. Through a cross-sectional study design, self-reported surveys (


“They’Re Still Trying To Wrap Their Head Around Forever”: An Anatomy Of Hope For Spinal Cord Injury Patients, William A. Lucas Apr 2023

“They’Re Still Trying To Wrap Their Head Around Forever”: An Anatomy Of Hope For Spinal Cord Injury Patients, William A. Lucas

USF Tampa Graduate Theses and Dissertations

This dissertation draws on ethnographic data to investigate the nature of spinal cord injury (SCI) rehabilitation in Central Florida, using participant observation and interview data to understand how people with SCI (pwSCI) conceptualize their own disabilities after experiencing such radical alterations in their subjectivities. Using case studies and ethnographic vignettes, it argues that the extreme double binds in which pwSCI find themselves (where they are personally ordinarily disabled and socially extraordinarily novel; and where they are enabled resources to pursue “hopeful” therapy modalities while being designated as hopelessly disabled) is further polarized by the various legislative regimes of truth in …


Co-Exploring Meaning In Everyday Life For People In Mental Health Recovery: A Photovoice Study, Siw H. Tønnessen, Ottar Ness, Trude G. Klevan Apr 2023

Co-Exploring Meaning In Everyday Life For People In Mental Health Recovery: A Photovoice Study, Siw H. Tønnessen, Ottar Ness, Trude G. Klevan

The Qualitative Report

Research on mental health recovery points to an interdependent relationship between experiences of meaning and experiences of recovery; meaning in everyday life promotes recovery, and recovery promotes meaning in everyday life. In this study we address the following question: What do people with mental challenges find meaningful in their everyday life? To explore this question, we offered disposable cameras to people with mental health challenges and asked them to photograph whatever makes their life meaningful. As part of the collaborative procedure of the study, a competence group contributed to different stages of the research process and the visual data were …


A Scoping Review Of Risk And Protective Factors For Negative Cannabis Use Consequences, Timothy J. Grigsby, Andrea Lopez, Larisa Albers, Christopher J. Rogers, Myriam Forster Apr 2023

A Scoping Review Of Risk And Protective Factors For Negative Cannabis Use Consequences, Timothy J. Grigsby, Andrea Lopez, Larisa Albers, Christopher J. Rogers, Myriam Forster

Social and Behavioral Health Faculty Research

Objective:

Numerous reviews have examined risk and protective factors for alcohol-related negative consequences, but no equivalent review of risk and protective factors exists for cannabis-related negative consequences (CRNCs)-a gap filled by the present study. This scoping review examined survey-based research of risk and protective factors for CRNCs such as neglecting responsibilities, blacking out, or needing more cannabis.

Methods:

Three databases (PubMed, PsycINFO, and Google Scholar) were searched for peer-reviewed manuscripts published between January 1, 1990, and December 31, 2021. A qualitative synthesis was performed using the matrix method and the results were organized using the socioecological model as a framework. …


Progressive Muscle Relaxation Exercises In Patients With Covid-19: Systematic Review And Meta-Analysis, Abubeker Alebachew Seid, Ahmed Adem Mohammed, Aragaw Asfaw Hasen Apr 2023

Progressive Muscle Relaxation Exercises In Patients With Covid-19: Systematic Review And Meta-Analysis, Abubeker Alebachew Seid, Ahmed Adem Mohammed, Aragaw Asfaw Hasen

Faculty, Staff and Student Publications

BACKGROUND: Patients with COVID-19 will experience high levels of anxiety and depression and poor levels of sleep and quality of life (QoL) due to isolation treatment and uncertain outcomes. Progressive muscle relaxation (PMR) exercises show promising treatment effects on mental health and sleep problems and overall QoL in COVID-19 patients. This study aimed to evaluate the efficacy and safety of PMR exercises in patients with COVID-19.

METHODS: Both experimental and non-experimental studies related to PMR and COVID-19 were systematically searched in the PubMed, Cochrane Library, PEDro and HINARI databases for studies published from the occurrence of the pandemic to December …


Geriatric Depression Screening And Chief Complaint: What Is The Risk For 30- And 90-Day Readmission?, Eric James, Joan Michelle Moccia, Victoria Lucia Apr 2023

Geriatric Depression Screening And Chief Complaint: What Is The Risk For 30- And 90-Day Readmission?, Eric James, Joan Michelle Moccia, Victoria Lucia

Journal of Geriatric Emergency Medicine

Abstract

Background:

Readmission to the hospital within 30-days has a high cost and represents a gap in care for older adults. Older adults are at significant risk for depression, particularly given their medical comorbidities and social factors such as isolation due to SARS-CoV-2. Many patients who screen positive for depression may have no known history of depression. This investigation examines the relationship between a positive geriatric depression screen and chief complaint as a function of 30- and 90-day readmission risk.

Methods:

We examined the electronic medical record of 329 older adults aged 65 and older from February 1, 2020, to …


Technology Implementation For Mental Health End Users: A Model To Guide Digital Transformation For Inpatient Mental Health Professionals, Jessa Lin Westheimer, Nidal Moukaddam, Jan A Lindsay, Ashutosh Sabharwal, Bijan Najafi, Peter A Iacobelli, Robert J Boland, Michelle A Patriquin Apr 2023

Technology Implementation For Mental Health End Users: A Model To Guide Digital Transformation For Inpatient Mental Health Professionals, Jessa Lin Westheimer, Nidal Moukaddam, Jan A Lindsay, Ashutosh Sabharwal, Bijan Najafi, Peter A Iacobelli, Robert J Boland, Michelle A Patriquin

Faculty, Staff and Students Publications

Digital transformation is the adoption of digital technologies by an entity in an effort to increase operational efficiency. In mental health care, digital transformation entails technology implementation to improve the quality of care and mental health outcomes. Most psychiatric hospitals rely heavily on "high-touch" interventions or those that require in-person, face-to-face interaction with the patient. Those that are exploring digital mental health care interventions, particularly for outpatient care, often copiously commit to the "high-tech" model, losing the crucial human element. The process of digital transformation, especially within acute psychiatric treatment settings, is in its infancy. Existing implementation models outline the …


Implementation Of A Hospital-Wide Surge Plan To Reduce Emergency Department Length Of Stay, Laura Massey Apr 2023

Implementation Of A Hospital-Wide Surge Plan To Reduce Emergency Department Length Of Stay, Laura Massey

Student Scholarly Projects

Practice Problem: Suboptimal patient flow throughout the hospital has resulted in an increased length of stay (LOS) for emergency department patients and the potential for adverse events.

PICOT: In admitted and discharged emergency room patients (P), how does a hospital-wide surge plan (I) compared to current throughput plan (C) affect the length of stay (O) within 8 weeks?

Evidence: The literature evidence reviewed supported the implementation of a hospital-wide surge plan approach positively impacts the emergency room length of stay and patient outcomes.

Intervention: The primary intervention for this project was the implementation of a hospital-wide surge policy. Targeted …


Beyond The Bmi: Expanding Quantitative Methods To Study Health For All Bodies, Kieran Chase, Daniel Oron Apr 2023

Beyond The Bmi: Expanding Quantitative Methods To Study Health For All Bodies, Kieran Chase, Daniel Oron

OHSU-PSU School of Public Health Annual Conference

The public health field is beginning to reckon with its role in perpetuating and reinforcing systemic anti-fatness. Emerging evidence for the devastating health impacts of stigma call into question decades of research and policy that labels the size of people’s bodies as diseased. However, even as we acknowledge the harmful effects of stigma, the field is materially and institutionally invested in a health paradigm that centers weight loss and size-related proxies for health, such as the BMI. Public health scholars interested in questions related to nutrition, chronic disease, and exercise must begin to expand their research focus to imagine non-stigmatizing …


(Un)Weighted Assumptions: Anti-Fatness & Health, Kieran Chase, Nell Carpenter, Madysen Schreiber Apr 2023

(Un)Weighted Assumptions: Anti-Fatness & Health, Kieran Chase, Nell Carpenter, Madysen Schreiber

OHSU-PSU School of Public Health Annual Conference

This lecture/discussion session aims to expand and add nuance to public health students’, professors’, and practitioners’ understanding of the interplay between body size and health. We will begin by naming and challenging common assumptions about the relationship between bodyweight and health outcomes. We will then argue for the consideration of weight-related stigma as a Fundamental Cause of Disease as defined by Phelan and Link, and for institutionally embedded anti-fat bias at the policy level (e.g., insurance policy, medical equipment) as a cause of population health inequity as defined in Whitehead’s Health Equity Framework. We offer these frameworks in contrast to, …


Determinants Of Modern Contraceptive Use Among Young Women In Ghana: A Mixed-Methods Study Design, Adjoa N. Manu Apr 2023

Determinants Of Modern Contraceptive Use Among Young Women In Ghana: A Mixed-Methods Study Design, Adjoa N. Manu

OHSU-PSU School of Public Health Annual Conference

Background: Only 20% of sexually active women aged 15-24 in Ghana used contraception during their last sexual intercourse. Young women are highly exposed to the risks associated with having unprotected sexual intercourse, such as unintended pregnancy and sexually transmitted infections.

Objective: To use an explanatory sequential mixed-methods design to examine the determinants of modern contraceptive use among young women in Ghana using population-based data and identify the types of contraceptive methods the population know and use.

QUAN Design: Analysis of the 2017 Ghana Maternal Health Survey data, a nationally representative cross-sectional survey.

QUAN Findings: The male …


Investing In Family Planning, Education, And Empowering Of Women And Girls To Mitigate The Impact Of Climate Change: An Exemplary Case Of Rwanda., Adjoa N. Manu Apr 2023

Investing In Family Planning, Education, And Empowering Of Women And Girls To Mitigate The Impact Of Climate Change: An Exemplary Case Of Rwanda., Adjoa N. Manu

OHSU-PSU School of Public Health Annual Conference

Countries where population growth is high are often highly impacted by the climate crisis despite not being a significant contributor to historical greenhouse gas emissions. This has created a global inequality in that countries with poorly developed infrastructure are 15 times more likely to have deaths due to climate related disasters such as floods, droughts, and storms compared to wealthy countries that can better protect against similar events. While the climate crisis impacts everyone, women and girls are at a higher risk because of their unique health needs and roles in the community. The effects of climate change can be …


Impact Of Industrial Disasters On The Mental Health Of Vietnamese Americans On The Gulf Coast, Vivian L. Duong Apr 2023

Impact Of Industrial Disasters On The Mental Health Of Vietnamese Americans On The Gulf Coast, Vivian L. Duong

OHSU-PSU School of Public Health Annual Conference

An explosion on the Deepwater Horizon oil rig caused 200 million gallons of crude oil to spill on the Gulf Coast over a five-month span. About 16,000 miles of coastline, ecosystem and marine life along Alabama, Florida, Louisiana, Mississippi, and Texas were contaminated. This disaster and the recovery process caused social, financial, and ecological shocks, resulting in adverse psychosocial and physical health outcomes, health disparities, and socioeconomic inequality. Among the oil spill's most affected and vulnerable populations are the Vietnamese American communities that settled on the Gulf Coast after the end of the Vietnam War in 1975. The plight of …


Are They Still Determining? Analysis Of Associations Among Gender, Ethnicity, Socioeconomic Status, Neighborhood Factors And Covid-19 Vaccination, Bokyung Kim, Seoyeon Celine Hong, Sojung Kim Apr 2023

Are They Still Determining? Analysis Of Associations Among Gender, Ethnicity, Socioeconomic Status, Neighborhood Factors And Covid-19 Vaccination, Bokyung Kim, Seoyeon Celine Hong, Sojung Kim

College of Communication & Creative Arts Departmental Research

Introduction: This study explores associations among adult vaccination, ethnicity, gender, and socioeconomic variables such as educational attainment and income, as well as neighborhood factors. Methods: A telephone quota sample of New Jersey adults (N = 1,984) was used to text associations among proposed predictors of vaccination behaviors. Results: Our multivariate logistic regression analyses found that certain races/ethnicity, respondents' household income, and perceived safety of one's community were the strongest predictors of COVID-19 vaccination. The odds of COVID-19 vaccination were 52% lower for Black/African American respondents compared to white/Caucasian respondents (p = 0.001) and 44% lower for Hispanic/Latino respondents compared to …


The What And When Of Psychomotor Retardation: A Multimodal Approach, Ole Edvard Granrud Apr 2023

The What And When Of Psychomotor Retardation: A Multimodal Approach, Ole Edvard Granrud

LSU Master's Theses

Psychomotor retardation (PMR) is a diagnostic criterion that reflects a gross slowing of movement, speech, and thought. More so, PMR is a transdiagnostic, pervasive source of impairment and distress that can be observed across disorders, such as Major Depressive Disorder (MDD), Schizophrenia (SZ), and Bipolar Disorder (BD). In clinical settings, PMR is associated with more severe psychopathology and is used to both inform treatment and predict long-term treatment outcomes. However, despite being clinically meaningful, PMR is poorly understood and is often conceptualized as a motor disturbance that happens in isolation from, rather than concurrently with, higher-order cognitive-emotional processes – such …


The Effect Of Lockdowns On The Status Of Women In The World, Angelika B. Magno Apr 2023

The Effect Of Lockdowns On The Status Of Women In The World, Angelika B. Magno

Angelo King Institute for Economic and Business Studies (AKI)

Coronavirus disease (COVID-19) is an infectious respiratory illness that causes moderate to severe symptoms that can be fatal to older people or those with other underlying health concerns. Considered a global pandemic, this disease spreads rapidly across the world, calling for a need for the implementation of lockdowns. This study examines the effects of lockdowns on joblessness among women, controlling for household conditions, namely, perceived household responsibility, hours allotted for household chores, and safety at home. Data for lockdowns were sourced from Google’s Community Mobility reports, whereas joblessness among women and household conditions were sourced from Facebook’s Survey on Gender …


Reproductive Justice Teaching In Undergraduate Medical Education: An Opportunity To Partner With Communities Beyond Traditional Medicine To Influence Health, Tiwadeye I. Lawal, Miriam R. Singer, Deborah Bartz Apr 2023

Reproductive Justice Teaching In Undergraduate Medical Education: An Opportunity To Partner With Communities Beyond Traditional Medicine To Influence Health, Tiwadeye I. Lawal, Miriam R. Singer, Deborah Bartz

Feminist Pedagogy

No abstract provided.


A Review Of The Implications Of The Love Canal Disaster And The Subsequent Actions Of The State And Federal Government, Hannah Albright, Brooklyn Hurtt, Douglas Mock Apr 2023

A Review Of The Implications Of The Love Canal Disaster And The Subsequent Actions Of The State And Federal Government, Hannah Albright, Brooklyn Hurtt, Douglas Mock

2023 Celebration of Student Scholarship - Poster Presentations

There is much literature written about environmental law and policy. The one focused on in this poster presentation is “Love Canal: A Toxic History from Colonial Times to the Present” by Richard S. Newman. The novel focuses on the Love Canal tragedy in upstate New York, where a chemical plant caused housewives to turn into activists after their neighbors, friends, and even their own families became extremely ill or succumbed because of the toxic waste. The tragedy at Love Canal was the precursor to grassroots movements across the United States.


Enhancing Telomerase Activity In Saccharomyces Cerevisiae Through A Genetic Screen For Gain-Of-Function Mutations, Keenan Conley, Hailey Rietz, Mackenzie Neal, Melissa Mefford Apr 2023

Enhancing Telomerase Activity In Saccharomyces Cerevisiae Through A Genetic Screen For Gain-Of-Function Mutations, Keenan Conley, Hailey Rietz, Mackenzie Neal, Melissa Mefford

2023 Celebration of Student Scholarship - Poster Presentations

Telomeres are located at the ends of eukaryotic linear chromosomes and are composed of repeated nucleotide sequences. The main function of telomeres is to protect chromosomal ends. However, telomeres cannot be copied entirely during DNA replication leading to a gradual shortening known as the “end-replication problem”. To counteract this problem, the RNA-dependent enzyme complex telomerase works to extend telomeres and maintain the chromosomal ends which helps to prevent senescence. Understanding the structure and function of telomerase could have important implications for the development of anti-cancer therapeutics, since telomerase is over-active in >85% of all human cancers. While the general role …


Collapse: The History Of How We Fail, And What We Can Do To Save Ourselves, David Ace, Grace Funke, Aj Abdel-Rahman, Nate Floccare, Kristen Russell, Madison Ingram, Douglas Mock Apr 2023

Collapse: The History Of How We Fail, And What We Can Do To Save Ourselves, David Ace, Grace Funke, Aj Abdel-Rahman, Nate Floccare, Kristen Russell, Madison Ingram, Douglas Mock

2023 Celebration of Student Scholarship - Poster Presentations

Using Diamond's Five point framework for how societies have collapsed in the past allow us in the present to recognize these signs in modern societies. We have the gift of hindsight in which we now know that factors such as climate change, impact on the environment, decline on friendly contact, increase in hostile contact, and a conservative outlook have all contributed to past societies' collapse. We now recognize these issues in modern societies such as China, Australia, Rwanda, and Haiti. This allows these societies to reevaluate their current environmental standards on whether they are compatible with their survival or collapse. …


The Impact Of Nursing Skill Competency On Patient Outcomes: A Quality Improvement Project, Abby Blair, Riley Boling, Natalie Crace, Jascie Greene, Peyton Kennedy, Andrew Morris, Joseph Sewell, Abigail Wesselkamper, Suzi White Apr 2023

The Impact Of Nursing Skill Competency On Patient Outcomes: A Quality Improvement Project, Abby Blair, Riley Boling, Natalie Crace, Jascie Greene, Peyton Kennedy, Andrew Morris, Joseph Sewell, Abigail Wesselkamper, Suzi White

2023 Celebration of Student Scholarship - Poster Presentations

45 out of 50 facilities that implemented continued education saw improved patient outcomes. This presentation focuses on the importance of nurse participation in continued professional development programs because it is a shortcoming that we noticed in clinical practice.


The Diversity Of Life By E.O. Wilson, Emma Collins, Matthew Grace, Brady Lawson, Michelle Lopez, Zane Rousey, Douglas Mock Apr 2023

The Diversity Of Life By E.O. Wilson, Emma Collins, Matthew Grace, Brady Lawson, Michelle Lopez, Zane Rousey, Douglas Mock

2023 Celebration of Student Scholarship - Poster Presentations

In The Diversity of Life, E. O. Wilson tells a tale about how our earth is on track for another extinction event and humans are at fault. Wilson discusses various topics such as environmental preservation, biodiversity and its importance, and how life has evolved over time. Wilson views biodiversity differently than many as he focuses on all species found in the ecosystem rather than narrowing his focus on one. He mentions how new species can be created by groups evolving and developing new skills or existing in new environments. Species are going extinct and being created constantly; these extinctions don't …


Age And Growth Of The Highland Shiner (Notropis Micropteryx) In Rockcastle County, Kentucky, Caitlyn Senters, Zoe Baker, Shelbie Black, Jared Vise, David J. Eisenhour Apr 2023

Age And Growth Of The Highland Shiner (Notropis Micropteryx) In Rockcastle County, Kentucky, Caitlyn Senters, Zoe Baker, Shelbie Black, Jared Vise, David J. Eisenhour

2023 Celebration of Student Scholarship - Poster Presentations

Notropis micropteryx, the Highland Shiner, is common in small to large streams of the Cumberland, Tennessee, and upper Green River drainages. It usually inhabits rocky riffles (Eisenhour and Eisenhour 2004)). While their population size was assessed as stable by the IUCN in 2012, little is known about the age and growth of this minnow species. Despite being a small fish, attention must be given to the health of its population as it serves an ecological niche and impact on the surrounding ecosystem.


Age And Growth Of The Popeye Shiner (Notropis Ariommus) In The Rockcastle River, Shelbie Black, Jared Vise, Zoe Baker, Caitlyn Senters, David J. Eisenhour Apr 2023

Age And Growth Of The Popeye Shiner (Notropis Ariommus) In The Rockcastle River, Shelbie Black, Jared Vise, Zoe Baker, Caitlyn Senters, David J. Eisenhour

2023 Celebration of Student Scholarship - Poster Presentations

The Popeye Shiner (Notropis ariommus), occupies clear, gravel runs and flowing pools of creeks and small rivers throughout the Ohio River basin, but has declined in many areas. This species is a small silvery minnow with an unusually large eye. Despite being a candidate for the endangered species list (Department of the Interior, 2011), little life-history data have been published, which are needed to make conservation management decisions.


A Search For The Time Variability In The Population Of X-Ray Binary Systems In The Galaxy Ic 342, Bannon Jones, Thomas Pannuti Apr 2023

A Search For The Time Variability In The Population Of X-Ray Binary Systems In The Galaxy Ic 342, Bannon Jones, Thomas Pannuti

2023 Celebration of Student Scholarship - Poster Presentations

X-ray binaries (XRBs) are comprised of a neutron star (NS) or stellar-mass black hole (BH) that is accreting material from a stellar companion. Studies of these sources yield insights into the properties of NSs and BHs as well as the dynamics of mass transfer and stellar evolution in binary star systems with sources at stages of advanced stellar evolution. Studies of X-ray binaries in the Galaxy are compromised by massive absorption extinction along Galactic lines of sight and by significant uncertainties in the distances to these sources. In contrast, studies of XRBs in nearby face-on galaxies with high current rates …


Period Analyses Of Variable Stars Alpha Orionis And Beta Lyrae, Gianna Federico, Jennifer Birriel Apr 2023

Period Analyses Of Variable Stars Alpha Orionis And Beta Lyrae, Gianna Federico, Jennifer Birriel

2023 Celebration of Student Scholarship - Poster Presentations

Variable stars change in brightness over regular or semiregular periods of time. Causes of variability include pulsation (changes in size) or the presence of a companion star or planet that eclipses part of the stellar surface. We examine period changes of the bright variable stars Alpha Orionis (Betelgeuse) and Beta Lyrae using data from the American Association of Variable Star Observers (AAVSO). Periods were analyzed by applying Fourier and weighted wavelet z-transforms to the light curves of each star over a 30-year time span. Our analyses showed that both the short and long secondary periods of Betelgeuse changed with time. …


The Thrombin Cleavage Of Protein Tags Of Co-Repressors Umudab And Ddrr Of The Pathogen Acinetobacter Baumaniihave Been Optimized For Cross-Linkage, Mercy Hailu, Deborah Cook, Janelle Hare Apr 2023

The Thrombin Cleavage Of Protein Tags Of Co-Repressors Umudab And Ddrr Of The Pathogen Acinetobacter Baumaniihave Been Optimized For Cross-Linkage, Mercy Hailu, Deborah Cook, Janelle Hare

2023 Celebration of Student Scholarship - Poster Presentations

The Acinetobacter baumannii strain 17978 is a Gram-negative and nosocomial ESKAPE pathogen which utilizes its unique SOS genes, umuDAb and ddrR, to inhibit cell division and control mutagenesis in response to DNA damage.


Challenges In Creating Circularized Versions Of Linear Chromosomes, Tanner Hamilton, Melissa A. Mefford Apr 2023

Challenges In Creating Circularized Versions Of Linear Chromosomes, Tanner Hamilton, Melissa A. Mefford

2023 Celebration of Student Scholarship - Poster Presentations

Prokayotic and eukarotic chromosome structure differs. Generally prokaryotes have a single circular chromosome, while eukaryotes have multiple linear chromosomes. Linear chromosomes contain telomeres, composed of repeated DNA sequences, at the ends of the chromosome. While telomeres play crucial roles in capping telomeres, they create an end-replication problem. To overcome this issue, most eukaryotes possess the ribonucleoprotein enzyme complex telomerase. Despite the existence of telomerase, telomeres nonetheless shorten with aging and are thought to be a major contributor to this phenomenon. On the other hand, telomerase is upregulated in >85% of human cancers in order to allow the uncontrolled cell proliferation …