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Articles 6151 - 6180 of 33730
Full-Text Articles in Medicine and Health Sciences
Relation Between Fine And Gross Motor Skills And Observation Of Sociocultural Factors Across The First Year Of Infancy, Erika Garcia Mora
Relation Between Fine And Gross Motor Skills And Observation Of Sociocultural Factors Across The First Year Of Infancy, Erika Garcia Mora
LSU Doctoral Dissertations
The development of independent arms-free sitting, which frees an infant’s arms to explore objects in their environment (Soska & Adolph, 2014) is observed to propagate an increase in the frequency of manual and manipulatory actions (Marcinowski, et al., 2019; Mlincek, et. al., 2022). Active object exploration provides the infant with more sensory information of the fundamental characteristics of objects in their environment. Thus, this dissertation examined the quality and quantity of object exploration across seated postures.
Additionally, the literature claiming that infants raised in low-income households having fewer resources for effective development is being countered by considering a more holistic …
Medicine And Kindness, A Glorious Concurrence?, Araya Gautam
Medicine And Kindness, A Glorious Concurrence?, Araya Gautam
Patient Experience Journal
This article unfolds the journey of a 28-year-old junior doctor entangled in the throes of a pernicious anemia diagnosis during her travels abroad, a scenario exacerbated by the grip of a COVID-19 lockdown. Adrift without medical insurance and distant from her family, she found herself under the care of a compassionate on-call resident, emphasizing the crucial role of kindness and compassion in her predicament. Her treatment regimen encompassed a series of CBC tests meticulously tracking cobalamin and ferritin levels, complemented by extensive examinations for iron deficiency and a regimen of vital vitamin B12 injections, all carried out under vigilant scrutiny …
The Case For Patient-Reported Pleasure, Preston Long, Tanja Stamm
The Case For Patient-Reported Pleasure, Preston Long, Tanja Stamm
Patient Experience Journal
Pleasure is a cornerstone of human behavior. Its lack of consideration in the medical sciences has been to the detriment of all patients. The process of including pleasure as a medical outcome has multiple beginnings. A health-related pleasure scale must be developed for clinical purposes and original research must be conducted to establish the added value of measuring pleasure. Treatment comparisons, prediction models for recovery, side-effect investigations, and more may benefit from the collection of patient-reported pleasure. Furthermore, simply inquiring about a patient’s pleasure may serve as a positive intervention by giving them permission to discuss more than the illness …
Breaking The Transactional Mindset: A New Path For Healthcare Leadership Built On A Commitment To Human Experience, Kirsten Krull, Jerry Mansfield, Jennifer Gentry, Karen Grimley, Barbara Jacobs, Jason Wolf
Breaking The Transactional Mindset: A New Path For Healthcare Leadership Built On A Commitment To Human Experience, Kirsten Krull, Jerry Mansfield, Jennifer Gentry, Karen Grimley, Barbara Jacobs, Jason Wolf
Patient Experience Journal
Numerous health care publications have focused on the compelling need to improve patient experience and the associated improvements necessary to address workforce well-being. The COVID-19 pandemic exacerbated and illuminated long-standing problems in health care including workforce shortages, inequity in health care delivery outcomes, care provider burnout, and overall societal structural racism.1,2 The Beryl Institute’s Nursing Executive Council (NEC) manuscript Rebuilding a Foundation of Trust: A Call to Action in Creating a Safe Environment for Everyone3 focused on actions and behaviours to heal relationships and build trust between care providers and leaders with commitments to safety, empathy, shared decision …
Four Commitments For The Future Of Healthcare: Reflecting On A Decade Of Patient Experience Journal, Jason A. Wolf
Four Commitments For The Future Of Healthcare: Reflecting On A Decade Of Patient Experience Journal, Jason A. Wolf
Patient Experience Journal
This issue closes the first decade of Patient Experience Journal’s (PXJ) contribution to evidence and innovation, to sharing stories and research, to elevating the conversation and pushing the boundaries of the experience movement. We have never hesitated to nudge at the status quo or to respond with agility to the challenging moments we have faced. We have welcomed diverse voices as contributors, and we have seen an even more diverse readership. In reviewing the pages of PXJ over the last decade, we see a true evolution of the experience movement itself. The words of our contributors have provided a lens …
Improving Effective Care In Obese Patients In A Primary Care Clinic, Amy Miller
Improving Effective Care In Obese Patients In A Primary Care Clinic, Amy Miller
Journal of Interprofessional Practice and Collaboration
Background: Obesity is a preventable epidemic and costs the United States $200 billion annually. The leading causes of death are linked to obesity.
Local Problem: In a chart review, 53% of patients at a northeast Louisiana primary care clinic were obese. However, none were offered comprehensive lifestyle intervention. The aim was to increase the percentage of patients with BMI < 30 kg/m2 to 60% over 8 weeks.
Methods: A rapid-cycle quality improvement initiative was implemented using four Plan-Do-Study-Act cycles over 8 weeks. Each cycle produced tests of change related to screening, patient and team engagement, and assessing effective care. Run charts and aggregate tables were used to analyze …
Hmmelfarb Headlines - November/December 2023, George Washington University, Himmelfarb Health Sciences Library
Hmmelfarb Headlines - November/December 2023, George Washington University, Himmelfarb Health Sciences Library
Himmelfarb Headlines (2009 - present)
News, information, and resources relating to the Himmelfarb Library that is of interest to patrons
Vol. 13, Issue 2
Library Newsletter (2009-present)
This Fall Issue is all about the NEW at Krupp Library!
New Counseling Services Exhibit- 1
Meet our New Librarian - 2
New Vending Machine - 2
Baking Yesteryear Review New Book - 3
Historical Documents made New again - 4
New Graphic Novels Section - 5
Examining The Evidence Base For Burnout, Renzo Bianchi, Irvin Schonfeld
Examining The Evidence Base For Burnout, Renzo Bianchi, Irvin Schonfeld
Publications and Research
Burnout has elicited growing interest among occupational health specialists in recent decades. Since 2019, the World Health Organization has characterized burnout as a syndrome resulting from chronic, unmanageable workplace stress. Accordingly, three symptoms define the entity: (i) feelings of energy depletion or exhaustion; (ii) increased mental distance from one’s job or feelings of negativism or cynicism towards one’s job; and (iii) a sense of ineffectiveness and lack of accomplishment. We call into question the definition of burnout embodied in the Maslach Burnout Inventory and incorporated into the ICD-11. We draw stakeholders’ attention to the fact that burnout’s symptoms and etiology …
Himmelfarb Library Liaison Letter - November 2023, George Washington University, Himmelfarb Health Sciences Library
Himmelfarb Library Liaison Letter - November 2023, George Washington University, Himmelfarb Health Sciences Library
Himmelfarb Library Liaison Letters
No abstract provided.
A Phenomenological Exploration Of Women’S Lived Experiences During Their Pregnancy Lifecycle, Ashley J. Blount, Charmayne R. Adams, Kara M. Schneider, Gurudutt Pendyala, Ann L. Anderson-Berry, Corrine Hanson
A Phenomenological Exploration Of Women’S Lived Experiences During Their Pregnancy Lifecycle, Ashley J. Blount, Charmayne R. Adams, Kara M. Schneider, Gurudutt Pendyala, Ann L. Anderson-Berry, Corrine Hanson
Office of Health Promotion Scholarship
When considering peri-and-post natal health, there are several biopsychosocial risk factors at play. Biological, psychological, and social health factors are significant in contributing to maternal wellbeing and influencing maternal morbidity/mortality [1]. The Covid-19 pandemic had significant impacts on general populations and on vulnerable groups such as pre-peri-and-post natal women [2]. In previous epidemics, pregnant women were reluctant to attend hospitals and doctors’ appointments due to fear of infection [3]. Covid-19 has shown similar effects [2] and as such, risks associated with the pregnancy lifecycle have increased. A phenomenological investigation found themes of women experiencing negative healthcare, struggles with self-advocacy, heightened …
A Word From The Writing Team (November 2023), Pam Walter, Mfa, Liz Declan, Ma, Mfa
A Word From The Writing Team (November 2023), Pam Walter, Mfa, Liz Declan, Ma, Mfa
A Word From the Writing Team (Newsletter)
This issue includes:
- New!! Check Out Our OPWPC Resources Page in Canvas
- First Friday Writing Retreats Continue - This Friday
- The Annual Yeo Writing Prize is Back
- Learn How AI Impacts Scholarly Writing, Reviewing, and Publishing
- Publication Spotlight
- Reminders
- Consultations Available
- Scott Memorial Library Renovations
- Wiley Open Access Fees Waived for Jefferson Authors
2023 - The Fourth Annual Fall Symposium Of Student Scholars
2023 - The Fourth Annual Fall Symposium Of Student Scholars
Symposium of Student Scholars Program Books
The full program book from the Fall 2023 Symposium of Student Scholars, held in November 2023. Includes abstracts from the presentations and posters.
Examining The Evidence Base For Burnout, Renzo Bianchi, Irvin Sam Schonfeld
Examining The Evidence Base For Burnout, Renzo Bianchi, Irvin Sam Schonfeld
Publications and Research
Burnout has elicited growing interest among occupational health specialists in recent decades. Since 2019, the World Health Organization has characterized burnout as a syndrome resulting from chronic, unmanageable workplace stress. According to the ICD-11, three symptoms define the entity: feelings of exhaustion, increased mental distance from one’s job, and a sense of ineffectiveness at work, all of which correspond to the structure of the Maslach Burnout Inventory. The ICD-11 includes burnout among the factors that influence health status. This paper calls into question that conceptualization based on a number of lines of evidence. The evidence includes the following: burnout was …
Strategies For Culturally Safe Research With Native American Communities: An Integrative Review, Teresa Brockie, Kyle X. Hill, Patricia Davidson, Ellie Decker, Lydia Koh Krienke, Katie E. Nelson, Natalie Nicholson, Alicia M. Werk, Deborah Wilson, Deana Around Him
Strategies For Culturally Safe Research With Native American Communities: An Integrative Review, Teresa Brockie, Kyle X. Hill, Patricia Davidson, Ellie Decker, Lydia Koh Krienke, Katie E. Nelson, Natalie Nicholson, Alicia M. Werk, Deborah Wilson, Deana Around Him
Indigenous Health Faculty Publications
Background: A history of unethical research and deficit-based paradigms have contributed to profound mistrust of research among Native Americans, serving as an important call to action. Lack of cultural safety in research with Native Americans limits integration of cultural and contextual knowledge that is valuable for understanding challenges and making progress toward sustainable change. Aim: To identify strategies for promoting cultural safety, accountability, and sustainability in research with Native American communities. Method: Using an integrative review approach, three distinct processes were carried out: (1) appraisal of peer-reviewed literature (Scopus, PubMed, and ProQuest), (2) review of grey literature (e.g. policy documents …
Trauma-Informed Youth Sport: Identifying Program Characteristics And Challenges To Advance Practice, Kayla Hussey, Lindsey C. Blom, Zenzi Huysmans, Dana Voelker, Matt Moore, Thalia M. Mulvihill
Trauma-Informed Youth Sport: Identifying Program Characteristics And Challenges To Advance Practice, Kayla Hussey, Lindsey C. Blom, Zenzi Huysmans, Dana Voelker, Matt Moore, Thalia M. Mulvihill
Journal of Youth Development
This purpose of this qualitative study was to explore shared characteristics and local challenges of trauma-informed youth sport program design and implementation through the voices of ten program facilitators (e.g., director, trainer; 8 women, 2 men; average age of 36.2 years, SD = 6.03) across four U.S. regions. Within a postpositivist approach and through thematic analysis of semi-structured interviews (average length of 53 minutes), shared characteristics identified by facilitators included promoting a safe and supportive environment, cultivating healthy relationships among adults and peers, and intentional psychological and social skill-building (e.g., attentional cues). Facilitators also explained the importance of understanding the …
Characterizing How Food Advertising And Genetic Obesity Risk Factors Affect Neural Reward Reactivity And Eating In The Absence Of Hunger In Children, Dabin Yeum
Dartmouth College Ph.D Dissertations
The complex and multifactorial etiology of obesity involves the interaction of numerous risk factors. Assessing the gene-environment interaction of pediatric obesity can provide valuable insights for the characterization of key factors contributing to obesity and identification of potential points of intervention. The data used in this thesis comes from a single sample of young children recruited from the communities surrounding Dartmouth College. The primary objective of this thesis is to assess the impacts of complicated gene-environment interaction on pediatric obesity. First, we assessed the dynamic and static advertising of food cues to examine they lead to differential neural reward responsivity. …
Invisible In Plain Sight: A Qualitative Analysis Of The U.S. Public Health Service Syphilis Study And Contemporary Issues Of Iatrophobia In Black Women, Krystal Morgan
Undergraduate Student Research Fellowship
The U.S. Public Health Service Syphilis Study (USPHSSS) is the nation’s most infamous example of biomedical misconduct in the United States. Using the wives and the descendants of the USPHSSS as a case study, this project examines and conceptualizes how the lack of healthcare access and secondhand healthcare the wives and descendants received has had a cumulative impact on Black women and contemporary iatrophobia, using a Black feminist ethical and constructivist theoretical framework. Findings reflect two major themes for contemporary iatrophobia: systemic racism and what Muhjah Shakir terms the cultural constellation of silence.
Economic Equity And People With Disabilities: Development And Characterization Of A Novel Index, Bhavneet Walia, Katherine Mcdonald, Joy Hammel, Lex Frieden, Michael Morris, Barry Whaley, Vinh Nguyen
Economic Equity And People With Disabilities: Development And Characterization Of A Novel Index, Bhavneet Walia, Katherine Mcdonald, Joy Hammel, Lex Frieden, Michael Morris, Barry Whaley, Vinh Nguyen
Faculty, Staff and Student Publications
Here we develop two new social indices: The ADA PARC Absolute Economic Opportunity Index and the ADA PARC Relative Economic Opportunity Index. These indices allow us novel examinations of economic equity between people with and without disabilities within a U.S. State and between people with disabilities in different states using aggregations of multiple component economic indicators. These represent the first efforts to offer U.S. indices of this focus, an important development given the distinct economic needs of people with disabilities and the value in accounting for distinct national policies. The indices rely on U.S. Census and other data on economic …
Delivering Healthcare To The Underserved, Edward Booty
Delivering Healthcare To The Underserved, Edward Booty
Asian Management Insights
Non-profits, governments, and businesses need to come together and use a data-driven approach to improve local basic healthcare access.
Sun Protection Behaviors And Skin Cancer Risk Among Children Of Color, Williana Magloire
Sun Protection Behaviors And Skin Cancer Risk Among Children Of Color, Williana Magloire
Theses and Dissertations
Sun protection is beneficial for children of color as it decreases the risk for sunburns, hyperpigmentation, and most importantly, skin cancer. Invasive melanoma is commonly seen in children of color due to inadequate sun protection. Parental and caregiver modeling of sun protection behaviors may decrease the likelihood of skin cancer among children of color. The American Academy of Pediatrics (AAP, 2011) has suggested that pediatricians adopt the role of informing parents about the benefits of using sun protection products for their young children. They recommended that providers discuss sun protection behaviors with both the parent/child beginning at the age of …
Ambulatory Intensive Care For Medically Complex Patients At A Health Care Clinic For Individuals Experiencing Homelessness The Summit Randomized Clinical Trial, Brian Chan, Christina Nicolaidis, Meg Devoe, Priya Srikanth, P. Todd Korthuis, Samuel T. Edwards, Devan Kansagara, Rachel Solotaroff, Somnath Saha
Ambulatory Intensive Care For Medically Complex Patients At A Health Care Clinic For Individuals Experiencing Homelessness The Summit Randomized Clinical Trial, Brian Chan, Christina Nicolaidis, Meg Devoe, Priya Srikanth, P. Todd Korthuis, Samuel T. Edwards, Devan Kansagara, Rachel Solotaroff, Somnath Saha
School of Social Work Faculty Publications and Presentations
Importance Intensive primary care interventions have been promoted to reduce hospitalization rates and improve health outcomes for medically complex patients, but evidence of their efficacy is limited.
Objective To assess the efficacy of a multidisciplinary ambulatory intensive care unit (A-ICU) intervention on health care utilization and patient-reported outcomes.
Design, Setting, and Participants The Streamlined Unified Meaningfully Managed Interdisciplinary Team (SUMMIT) randomized clinical trial used a wait-list control design and was conducted at a health care clinic for patients experiencing homelessness in Portland, Oregon. The first patient was enrolled in August 2016, and the last patient was enrolled in November 2019. …
The Relationship Between Parental Trauma History And Perceptions Regarding Their Child’S Healthcare And Utilization Of Healthcare Services, Krishna Patel
Theses and Dissertations
Abstract
TITLE: The Relationship Between Parental Trauma History and Perceptions Regarding Their Child’s Healthcare and Utilization of Healthcare Services
Adverse child events (ACEs) have been associated with a number of physical and mental health problems and have also been linked to increased health care utilization. While parents who have an ACE history may tend to seek healthcare services for themselves, limited studies have examined the impact of their trauma history on seeking healthcare services for their child. Healthcare utilization may also depend on the parents’ level of health anxiety, as well as their anxiety about their child’s health status. This …
Mosaic Chromosomal Alterations In Blood Across Ancestries Using Whole-Genome Sequencing, Yasminka A Jakubek, Ying Zhou, Adrienne Stilp, Jason Bacon, Justin W Wong, Zuhal Ozcan, Donna Arnett, Kathleen Barnes, Joshua C Bis, Eric Boerwinkle, Jennifer A Brody, April P Carson, Daniel I Chasman, Jiawen Chen, Michael Cho, Matthew P Conomos, Nancy Cox, Margaret F Doyle, Myriam Fornage, Xiuqing Guo, Sharon L R Kardia, Joshua P Lewis, Ruth J F Loos, Xiaolong Ma, Mitchell J Machiela, Taralynn M Mack, Rasika A Mathias, Braxton D Mitchell, Josyf C Mychaleckyj, Kari North, Nathan Pankratz, Patricia A Peyser, Michael H Preuss, Bruce Psaty, Laura M Raffield, Ramachandran S Vasan, Susan Redline, Stephen S Rich, Jerome I Rotter, Edwin K Silverman, Jennifer A Smith, Aaron P Smith, Margaret Taub, Kent D Taylor, Jeong Yun, Yun Li, Pinkal Desai, Alexander G Bick, Alexander P Reiner, Paul Scheet, Paul L Auer
Mosaic Chromosomal Alterations In Blood Across Ancestries Using Whole-Genome Sequencing, Yasminka A Jakubek, Ying Zhou, Adrienne Stilp, Jason Bacon, Justin W Wong, Zuhal Ozcan, Donna Arnett, Kathleen Barnes, Joshua C Bis, Eric Boerwinkle, Jennifer A Brody, April P Carson, Daniel I Chasman, Jiawen Chen, Michael Cho, Matthew P Conomos, Nancy Cox, Margaret F Doyle, Myriam Fornage, Xiuqing Guo, Sharon L R Kardia, Joshua P Lewis, Ruth J F Loos, Xiaolong Ma, Mitchell J Machiela, Taralynn M Mack, Rasika A Mathias, Braxton D Mitchell, Josyf C Mychaleckyj, Kari North, Nathan Pankratz, Patricia A Peyser, Michael H Preuss, Bruce Psaty, Laura M Raffield, Ramachandran S Vasan, Susan Redline, Stephen S Rich, Jerome I Rotter, Edwin K Silverman, Jennifer A Smith, Aaron P Smith, Margaret Taub, Kent D Taylor, Jeong Yun, Yun Li, Pinkal Desai, Alexander G Bick, Alexander P Reiner, Paul Scheet, Paul L Auer
Faculty, Staff and Student Publications
Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers for a host of human diseases. Here, to gain a better understanding of mCA rates in genetically diverse populations, we analyzed whole-genome sequencing data from 67,390 individuals from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine program. We observed higher sensitivity with whole-genome sequencing data, compared with array-based data, in uncovering mCAs at low mutant cell fractions and found that individuals of European ancestry have the highest rates of autosomal mCAs and the lowest rates of chromosome X mCAs, compared with individuals of African or Hispanic ancestry. …
Benefits Of The Enhanced Recovery After Surgery (Eras) Pathway With Quadratus Lumborum Blocks For Minimally Invasive Gynecologic Surgery Patients: A Retrospective Cohort Study, Paul S Lee, Laurie L Brunette, Intira Sriprasert, Mohamed Eloustaz, Rasika Deshpande, Crystal Adams, Laila Muderspach, Lynda Roman, Shane Dickerson, Michael P Kim
Benefits Of The Enhanced Recovery After Surgery (Eras) Pathway With Quadratus Lumborum Blocks For Minimally Invasive Gynecologic Surgery Patients: A Retrospective Cohort Study, Paul S Lee, Laurie L Brunette, Intira Sriprasert, Mohamed Eloustaz, Rasika Deshpande, Crystal Adams, Laila Muderspach, Lynda Roman, Shane Dickerson, Michael P Kim
Faculty, Staff and Student Publications
STUDY OBJECTIVE: This study aimed to determine the effect of the implementation of the Enhanced Recovery After Surgery (ERAS) protocol among patients receiving minimally invasive gynecologic surgery.
DESIGN AND SETTING: This retrospective cohort study was performed in a tertiary care hospital.
PATIENTS: A total of 328 females who underwent minimally invasive gynecologic surgeries requiring at least one overnight stay at Keck Hospital of University of Southern California (USC), California, USA, from 2016 to 2020 were included in this study.
INTERVENTIONS: The institutional ERAS protocol was implemented in late 2018. A total of 186 patients from 2016 to 2018 prior to …
Mixed-Method Study Of Relationship Satisfaction Among African American Males With Or Without History Of Childhood Sexual Abuse, Sandra Webster Brown
Mixed-Method Study Of Relationship Satisfaction Among African American Males With Or Without History Of Childhood Sexual Abuse, Sandra Webster Brown
Dissertations
Relationship satisfaction among African American males is an important and feasible topic and underrepresented among scholarly literature. The purpose of this study was to explore relationship satisfaction and experiences among African American males who may be impacted by history of childhood sexual abuse. The study was guided by the theoretical frameworks of family systems theory. Using a concurrent mixed-methods triangulation design, the researcher collected data quantitatively and qualitatively from an online survey. Data were collected from 43 African American males recruited from Black organizations in the United States. The qualitative data collected by written narratives from the men were used …
Diversity, Equity, And Inclusion: Considerations In The Geriatric Emergency Department Patient, Anita N Chary, Lauren Cameron-Comasco, Kalpana N Shankar, Margaret E Samuels-Kalow
Diversity, Equity, And Inclusion: Considerations In The Geriatric Emergency Department Patient, Anita N Chary, Lauren Cameron-Comasco, Kalpana N Shankar, Margaret E Samuels-Kalow
Faculty, Staff and Students Publications
This article introduces core topics in health equity scholarship and provides examples of how diversity, equity, and inclusion impact the aging population and emergency care of older adults. It offers strategies for promoting diversity, equity, and inclusion to both strengthen the patient-clinician therapeutic relationship and to address operations and systems that impact care of the geriatric emergency department patient.
Regional Vulnerability Indices In Youth With Persistent And Distressing Psychoticlike Experiences, Nicole R Karcher, Hailey Modi, Peter Kochunov, Si Gao, Deanna M Barch
Regional Vulnerability Indices In Youth With Persistent And Distressing Psychoticlike Experiences, Nicole R Karcher, Hailey Modi, Peter Kochunov, Si Gao, Deanna M Barch
Faculty, Staff and Student Publications
IMPORTANCE: Distressing and persistent psychoticlike experiences (PLEs) in youth are associated with greater odds of developing psychiatric conditions in adulthood. Despite this risk, it is unclear whether early PLEs show similar brain patterns compared with adults with psychiatric and neurologic conditions.
OBJECTIVE: To examine the degree to which persistent and distressing PLEs exhibit neural metrics that show similarity to adults with chronic psychiatric and neurologic conditions.
DESIGN, SETTING, AND PARTICIPANTS: This cohort study used Adolescent Brain Cognitive Development (ABCD) Study examining the persistence and distress associated with PLEs across the first 3 waves of data with baseline structural magnetic resonance …
Pancreatic Replacement Therapy For Maladaptive Behaviors In Preschool Children With Autism Spectrum Disorder, Deborah A Pearson, Robert L Hendren, Matthew F Heil, William R Mcintyre, Shane R Raines
Pancreatic Replacement Therapy For Maladaptive Behaviors In Preschool Children With Autism Spectrum Disorder, Deborah A Pearson, Robert L Hendren, Matthew F Heil, William R Mcintyre, Shane R Raines
Faculty, Staff and Student Publications
IMPORTANCE: There is an urgent unmet need for a treatment addressing the core symptoms and associated maladaptive symptoms of autism spectrum disorder (ASD), especially in preschool populations.
OBJECTIVES: To evaluate whether treatment of children with ASD aged 3 to 6 years treated with high-protease pancreatic therapy produces long- and short-term improvements in autism-associated maladaptive behaviors.
DESIGN, SETTING, AND PARTICIPANTS: This cohort study at 32 sites across the US used a double-blind parallel group, delayed-start design comprising a 2-week blinded placebo run-in, and a double-blind, randomized, placebo-controlled segment (12 weeks). Children were recruited into the study in 2015, with data collection …
Arginase Deficiency Masked By Cerebral Palsy And Coagulopathy-Three Varied Presentations Of Latin American Origin, Shelby L Mills, Paige Roberts, Myla Ashfaq, Kathryn Leal, Hope Northrup, Deborah L Brown, David Rodriguez-Buritica, Laura S Farach
Arginase Deficiency Masked By Cerebral Palsy And Coagulopathy-Three Varied Presentations Of Latin American Origin, Shelby L Mills, Paige Roberts, Myla Ashfaq, Kathryn Leal, Hope Northrup, Deborah L Brown, David Rodriguez-Buritica, Laura S Farach
Faculty, Staff and Student Publications
Arginase deficiency (ARG1‐D) is an autosomal recessive inborn error of metabolism that is often misdiagnosed. Classic presentation of ARG1‐D includes progressive symptoms of spasticity, delayed development, cognitive impairment, protein avoidance, and seizures. Patients who present atypically may evade diagnosis and require a thoughtful diagnostic workup. Here, we discuss three females of Latin American origin with differing clinical presentations, but who all have the same intronic pathogenic variant in ARG1. Importantly, we found that each case included elevated coagulopathy on laboratory testing and discussed one case in particular with manifestation of bleeding. When diagnosed early, treatment is favorable and can …