Medicine and Health Sciences Commons^™

Mice Deficient In Endothelial Α5 Integrin Are Profoundly Resistant To Experimental Ischemic Stroke, Jill Roberts, Leon De Hoog, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

Stroke is a disease in dire need of better therapies. We have previously shown that a fragment of the extracellular matrix proteoglycan, perlecan, has beneficial effects following cerebral ischemia via the α5β1 integrin receptor. We now report that endothelial cell selective α5 integrin deficient mice (α5 KO) are profoundly resistant to ischemic infarct after transient middle cerebral artery occlusion. Specifically, α5 KOs had little to no infarct 2–3 days post-stroke, whereas controls had an increase in mean infarct volume over the same time period as expected. Functional outcome is also improved in the α5 KOs compared with controls. Importantly, no …

Early Shifts Of Brain Metabolism By Caloric Restriction Preserve White Matter Integrity And Long-Term Memory In Aging Mice, Janet Guo, Vikas Bakshi, Ai-Ling Lin

Sanders-Brown Center on Aging Faculty Publications

Preservation of brain integrity with age is highly associated with lifespan determination. Caloric restriction (CR) has been shown to increase longevity and healthspan in various species; however, its effects on preserving living brain functions in aging remain largely unexplored. In the study, we used multimodal, non-invasive neuroimaging (PET/MRI/MRS) to determine in vivo brain glucose metabolism, energy metabolites, and white matter structural integrity in young and old mice fed with either control or 40% CR diet. In addition, we determined the animals’ memory and learning ability with behavioral assessments. Blood glucose, blood ketone bodies, and body weight were also measured. We …

Research Brief: "Impact Of Parents' Wartime Military Deployment And Injury On Young Children's Safety And Mental Health", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the relationship between the mental health of military children and parental deployment. In policy and practice, healthcare providers and teachers should understand the risks during the post-deployment period and the DoD should implement programs to help military families during the post-deployment period. Suggestions for future research include conducting a study over time on this topic, as well as expanding the sample to include longer and multiple deployments and various age groups of children within military families.

Association Between Childhood Sexual Abuse And Hiv-Related Risk Factors For Hiv-Positive Haitian Women, Marie Sandra Severe

FIU Electronic Theses and Dissertations

Childhood sexual abuse (CSA) is one of the least studied HIV-related risk factors in Haiti although research in the United States and Europe has clearly established the link between childhood trauma and HIV risk behaviors. Understanding the role and impact of CSA on HIV-positive Haitian women is likely to strengthen future HIV prevention and treatment efforts aimed at this vulnerable group.

The current study was a cross-sectional examination of baseline data collected during a randomized trial of a cognitive-behavioral stress management (CBSM) intervention in Haiti. The purpose of this study was to analyze the association between CSA and sexual risk …

How A Healthy Population Acquires Nutrition And Exercise Information: A Mixed Methods Study, Sally J. Hillis

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Faced with an overwhelming amount of available sources and different perspectives, researchers in the field of Nutrition and Health Sciences continually strive to identify key factors that shape a healthy lifestyle. Employing an exploratory sequential mixed methods design, phase one of this research utilized a constructivist grounded theory approach to develop a model explaining the process by which healthy individuals acquire nutrition and exercise information. Interested is studying a population identified by good nutrition and daily exercise, the researcher set the participant criteria to include daily consumption of 2-3 balanced meals, 45-60 minutes daily moderate-intensity exercise, and a normal BMI. …

The Perennial Purple Heart, Anonymous

SURGE

Let’s talk about Veterans’ sacrifices. I must admit that I didn’t know much myself about veterans until one of my siblings entered the Navy. I’m very proud of his service, sacrifice, and dedication to protecting the United States. It’s probably not a common thought to all of us, but I think often of what it is like to be away during wartime serving our country. Military folks sacrifice a ton – whether it be lower pay, moving around a lot, being away from family for a long time, going into risky military operations, etc. These men and women sacrifice comparatively …

Irish Gms Cost Projections And Its Implications Between 2016 And 2026, Aisling Conway Lenihan, Noel Woods

Dept. of Management & Enterprise Publications

Introduction: Ireland had one of the highest pharmaceutical spends per capita in the EU in 2012. The General Medical Services (GMS) scheme is the largest community drug scheme in Ireland with approximately 40% of the population eligible for free drugs and appliances in 2012. The total cost of GMS prescriptions increased by 414% between 1998 and 2012. This paper projects Irish GMS cost from 2016 to 2026 and examines the implications of the estimated impact on GMS expenditure.

Method: Central Statistics Office (CSO) population projections (2013) and HSE-PCRS GMS population prescription data (2012) were used to develop four variables; population, …

God, Human Nature, And Psychology, Mark Christians

Faculty Work Comprehensive List

"God created humans to think, act, and feel and to be in relationship with other humans."

Posting about exploring the many realms of human expression­­­­­­­­ from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.

http://inallthings.org/god-human-nature-and-psychology/

Estimating Health & Economic Gains From Public Health Delivery System Transformation, Glen P. Mays

Health Management and Policy Presentations

Objectives: The Affordable Care Act created new resources and incentives for hospitals, insurers, public health agencies, and others to contribute to disease prevention and health promotion activities, potentially changing the structure of public health delivery systems and expanding the implementation of strategies that improve population health. This study uses data from the 1998-2014 National Longitudinal Survey of Public Health Systems to examine: (1) the extent and nature of change in inter-organizational contributions to public health activities, which we use as indicators of public health system change; and (2) the effects of these changes on preventable mortality and resource use. Methods: …

Functional Differences Between Statistical Learning With And Without Explicit Training., Laura J Batterink, Paul J Reber, Ken A Paller

Brain and Mind Institute Researchers' Publications

Humans are capable of rapidly extracting regularities from environmental input, a process known as statistical learning. This type of learning typically occurs automatically, through passive exposure to environmental input. The presumed function of statistical learning is to optimize processing, allowing the brain to more accurately predict and prepare for incoming input. In this study, we ask whether the function of statistical learning may be enhanced through supplementary explicit training, in which underlying regularities are explicitly taught rather than simply abstracted through exposure. Learners were randomly assigned either to an explicit group or an implicit group. All learners were exposed to …

Residual Impact Of Previous Injury On Musculoskeletal Characteristics In Special Forces Operators, Jeffrey J. Parr, Nicholas C. Clark, John P. Abt, Julie Y. Kresta, Karen A. Keenan, Shawn F Kane, Scott M. Lephart

Physical Therapy Faculty Publications

Background: Musculoskeletal injuries are a significant burden to United States Army Special Operations Forces. The advanced tactical skill level and physical training required of Army Special Operators highlights the need to optimize musculoskeletal characteristics to reduce the likelihood of suffering a recurrent injury.

Purpose: To identify the residual impact of previous injury on musculoskeletal characteristics.

Study Design: Cross-sectional study; Level of evidence, 3.

Methods: Isokinetic strength of the knee, shoulder, and back and flexibility of the shoulder and hamstrings were assessed as part of a comprehensive human performance protocol, and self-reported musculoskeletal injury history was obtained. Subjects were stratified based …

Engaging Older Adults To Build Social Capital, Beverly K. Lunsford, Danielle Janes

Nursing Faculty Publications

Countries are considering the healthcare implications as the proportion of older adults increases, including rising healthcare costs and resources needed as more adults want to "age in place" or continue living in the community. More in home resources and support services will be needed for older adults to continue living independently at homes. Older adults are an incredibly untapped resource with a continuing need to contribute to society and a willingness to help others. Older adults are working longer than ever before, so they have the potential to build their own social capital for meeting the needs of aging colleagues. …

Rural Disabled Medicare Beneficiaries Spend More Out-Of-Pocket Than Their Urban Counterparts, Erika C. Ziller Phd, Jennifer D. Lenardson Mhs, Andrew F. Coburn Phd

Access / Insurance

The majority of Medicare beneficiaries experience gaps between the care they need and costs covered by Medicare and seek supplemental coverage to meet this gap, including private plans offered by former employers or purchased individually, or public coverage through Medicaid. Since rural beneficiaries are more likely to purchase supplemental indemnity coverage individually, to participate in Medicaid, or to go without supplemental coverage altogether, it is likely that their out-of-pocket spending differs from that of urban residents, although the magnitude and direction of these differences may vary for individual beneficiaries. This study used data from the 2006-2010 Medical Expenditure Panel Survey …

Out-Of-Pocket Spending Among Rural Medicare Beneficiaries, Erika C. Ziller Phd, Jennifer D. Lenardson Mhs, Andrew F. Coburn Phd

Access / Insurance

The majority of Medicare beneficiaries experience gaps between the care they need and costs covered by Medicare and seek supplemental coverage to meet this gap, including private plans offered by former employers or purchased individually, or public coverage through Medicaid. Since rural beneficiaries are more likely to purchase supplemental indemnity coverage individually, to participate in Medicaid, or to go without supplemental coverage altogether, it is likely that their out-of-pocket spending differs from that of urban residents, although the magnitude and direction of these differences may vary for individual beneficiaries. This study used data from the 2006-2010 Medical Expenditure Panel Survey …

Traditional Grain Alcohol (Bai Jiu, 白酒) Production And Use In Rural Central China: Implications For Public Health, Ling Qian, Ian M. Newman, Wen Xiong, Yanyu Feng

Department of Educational Psychology: Faculty Publications

Background: An estimated 25 % of the alcohol consumed in China is traditional unrecorded alcohol produced and distributed informally. Consequently there is concern about its safety and its contribution to public health risk. Little has been written about this type of alcohol in China.

Methods: Researchers observed the manufacture of traditional bai jiu in a rural area of Hubei Province, Central China. Two hundred fifty-nine individuals were interviewed, either individually or in small groups, about their use of and attitudes toward bai jiu. Individuals who made or sold bai jiu were interviewed about local production, distribution, and sale. Key community …

The Physiological Consequences Of Crib-Biting In Horses In Response To An Acth Challenge Test, S. Briefer Freymond, D. Bardou, Elodie F. Briefer, R. Bruckmaier, N. Fouché, J. Fleury, A.-L. Maigrot, A. Ramseyer, K. Zuberbühler, I. Bachmann

Physiology Collection

Stereotypies are repetitive and relatively invariant patterns of behavior, which are observed in a wide range of species in captivity. Stereotypic behavior occurs when environmental demands produce a physiological response that, if sustained for an extended period, exceeds the natural physiological regulatory capacity of the organism, particularly in situations that include unpredictability and uncontrollability. One hypothesis is that stereotypic behavior functions to cope with stressful environments, but the existing evidence is contradictory. To address the coping hypothesis of stereotypies, we triggered physiological reactions in 22 horses affected by stereotypic behavior (crib-biters) and 21 non-crib-biters (controls), using an ACTH challenge test. …

Behavioral, Perceptual, And Neural Alterations In Sensory And Multisensory Function In Autism Spectrum Disorder., Sarah H Baum, Ryan A Stevenson, Mark T Wallace

Brain and Mind Institute Researchers' Publications

Although sensory processing challenges have been noted since the first clinical descriptions of autism, it has taken until the release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013 for sensory problems to be included as part of the core symptoms of autism spectrum disorder (ASD) in the diagnostic profile. Because sensory information forms the building blocks for higher-order social and cognitive functions, we argue that sensory processing is not only an additional piece of the puzzle, but rather a critical cornerstone for characterizing and understanding ASD. In this review we discuss what …

Dual Optimization Method Of Radiofrequency And Quasistatic Field Simulations For Reduction Of Eddy Currents Generated On 7t Radiofrequency Coil Shielding., Yujuan Zhao, Tiejun Zhao, Shailesh B Raval, Narayanan Krishnamurthy, Hai Zheng, Chad T Harris, William B Handler, Blaine A Chronik, Tamer S Ibrahim

Brain and Mind Institute Researchers' Publications

PURPOSE: To optimize the design of radiofrequency (RF) shielding of transmit coils at 7T and reduce eddy currents generated on the RF shielding when imaging with rapid gradient waveforms.

METHODS: One set of a four-element, 2 × 2 Tic-Tac-Toe head coil structure was selected and constructed to study eddy currents on the RF coil shielding. The generated eddy currents were quantitatively studied in the time and frequency domains. The RF characteristics were studied using the finite difference time domain method. Five different kinds of RF shielding were tested on a 7T MRI scanner with phantoms and in vivo human subjects. …

Arkansas Animal Science Department Report 2015, Paul Beck, Jason Apple, Beth Kegley, Charles Rosenkrans Jr.

Arkansas Agricultural Experiment Station Research Series

No abstract provided.

Attachment And Pornography Use: The Influence Of Romantic Attachment Styles, Intimacy, And Pornography Use On Marital Satisfaction, Saudia Twine

Doctoral Dissertations and Projects

The current study sought to answer the following research questions: First, what is the relationship between attachment, intimacy, pornography use, and marital satisfaction? Second, in what ways does intimacy influence marital satisfaction among pornography users with insecure attachment? Finally, is pornography used to regulate attachment emotions among pornography users with insecure attachment? The study revealed that Pornography Use caused an interaction in the relationship between Intimacy and Marital Satisfaction for those higher in Attachment Avoidance. Pornography Use accounted for 3% unique variance on Marital Satisfaction after controlling for Intimacy and Attachment Avoidance. Results also revealed Intimacy had a direct effect …

Himmelfarb Headlines - November/December 2015, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on ORCiDs, the Himmelfarb strategic plan, community collaboration, and profiles on Stephen Bryant and Sean Robinson.

Fearless Friday: Fergan Imbert, Christina L. Bassler

SURGE

This week, SURGE is showcasing the fabulous Fergan Imbert ‘16 for Fearless Friday!

Fergan is a senior at Gettysburg studying Biology with a pre-med concentration.

Fergan and his bright smile can be found all over campus. He’s currently the residence coordinator for Patrick Hall and the new senior admissions intern for the admissions office. He also works in the campus bookstore, is part of the senior class gift committee, and shows off his dance skills through B.O.M.B. squad. [excerpt]

In Search Of Safety, Negotiating Everyday Forms Of Risk: Sex Work, Criminalization, And Hiv/Aids In The Slums Of Kampala, Serena Cruz

FIU Electronic Theses and Dissertations

This dissertation offers an in-depth descriptive account of how women manage daily risks associated with sex work, criminalization, and HIV/AIDS. Primary data collection took place within two slums in Kampala, Uganda over the course of fourteen months. The emphasis was on ethnographic methodologies involving participant observation and informal and unstructured interviewing. Insights then informed document analysis of international and national policies concerning HIV prevention and treatment strategies in the context of Uganda. The dissertation finds social networks and social capital provide the basis for community formation in the sex trade. It holds that these interpersonal processes are necessary components for …

Disabled Women’S Attendance At Community Women’S Groups In Rural Nepal, J. Morrison, T. Colbourn, B. Budhathoki, A. Sen, D. Adhikari, J. Bamjan, S. Pathak, A. Basnet, J. F. Trani, A. Costello, D. Manandhar, N. Groce

Brown School Faculty Publications

There is strong evidence that participatory approaches to health and participatory women’s groups hold great potential to improve the health of women and children in resource poor settings. It is important to consider if interventions are reaching the most marginalized, and therefore we examined disabled women’s participation in women’s groups and other community groups in rural Nepal. People with disabilities constitute 15% of the world’s population and face high levels of poverty, stigma, social marginalization and unequal access to health resources, and therefore their access to women’s groups is particularly important. We used a mixed methods approach to describe attendance …

Colon Cancer Care And Survival: Income And Insurance Are More Predictive In The Usa, Community Primary Care Physician Supply More So In Canada, Kevin M. Gorey, Sindu M. Kanjeekal, Frances C. Wright, Caroline Hamm, Isaac N. Luginaah, Emma Bartfay, Guangyong Zou, Erc J. Holowaty, Nancy L. Richter

Social Work Publications

Background: Our research group advanced a health insurance theory to explain Canada’s cancer care advantages over America. The late Barbara Starfield theorized that Canada’s greater primary care-orientation also plays a critically protective role. We tested the resultant Starfield-Gorey theory by examining the effects of poverty, health insurance and physician supplies, primary care and specialists, on colon cancer care in Ontario and California.

Methods: We analyzed registry data for people with non-metastasized colon cancer from Ontario (n = 2,060) and California (n = 4,574) diagnosed between 1996 and 2000 and followed to 2010. We obtained census tract-based socioeconomic data from population …

Characterization Of Fast-Scan Cyclic Voltammetric Electrodes Using Paraffin As An Effective Sealant With In Vitro And In Vivo Applications, Eric Ramsson, Albert Dionise, Daniel Cholger, Nicholas Poirer, Avery Andrus, Randi Curtiss

Funded Articles

Fast-scan cyclic voltammetry (FSCV) is a powerful technique for measuring sub-second changes in neurotransmitter levels. A great time-limiting factor in the use of FSCV is the production of high-quality recording electrodes; common recording electrodes consist of cylindrical carbon fiber encased in borosilicate glass. When the borosilicate is heated and pulled, the molten glass ideally forms a tight seal around the carbon fiber cylinder. It is often difficult, however, to guarantee a perfect seal between the glass and carbon. Indeed, much of the time spent creating electrodes is in an effort to find a good seal. Even though epoxy resins can …

Kentucky’S Public Health Strategic Plan: Strengthening Foundational Services & Improving Population Health, Glen P. Mays

Health Management and Policy Presentations

This session examines recent progress toward the 2012 Institute of Medicine recommendation to identify the components and costs of a "minimum package" of public health services and foundational capabilities to be available across the U.S. Research about the health and economic benefits of Foundational Public Health Services has begun to shape Kentucky's strategic plan for transforming the public health system.

Research Brief: "Receipt Of Employment Services Among Veterans Health Administration Users With Psychiatric Diagnoses", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This study found that about four percent (4.2%) of VHA users with psychiatric diagnoses accessed employment services in a given year. VHA patients with a psychiatric diagnosis of schizophrenia had higher odds of accessing employment services relative to VHA users with other psychiatric diagnoses, including PTSD, depression, and other anxiety disorders. In practice, veterans should be aware that receiving VHA employment services should not affect VA benefits and should discuss their medical and financial benefits with benefits advisors and other appropriate advisors. In policy, Policymakers could consider allocating funds to further study the efficacy and effectiveness of various employment services …

Poverty Indicators And Mental Health Functioning Among Adults Living With Hiv In Delhi, India, Ezer Kang

Department of Psychology Faculty Publications

Poor mental health functioning among persons living with HIV (PLHIV) has gained considerableattention particularly in low-income countries that disproportionately carry the global HIV/AIDSburden. Fewer studies, however, have examined the relationship between poverty indicators andmental health among PHLIV in India. Based on this cross-sectional study of 196 HIV-seropositiveadults who received medical services at Shalom AIDS Project in Delhi, India, structural equationmodeling and mediation analysis were employed to estimate the associations between povertyindices (household asset index, food security, unemployment, water treatment, sanitation), HIVhealthfactors (illness in the past 3 months, co-morbid medical conditions), and psychologicaldistress. In the final model, ownership of fewer household …

Differential Modification Of Cortical And Thalamic Projections To Cat Primary Auditory Cortex Following Early- And Late-Onset Deafness., Nicole Chabot, Blake E Butler, Stephen G Lomber

Brain and Mind Institute Researchers' Publications

Following sensory deprivation, primary somatosensory and visual cortices undergo crossmodal plasticity, which subserves the remaining modalities. However, controversy remains regarding the neuroplastic potential of primary auditory cortex (A1). To examine this, we identified cortical and thalamic projections to A1 in hearing cats and those with early- and late-onset deafness. Following early deafness, inputs from second auditory cortex (A2) are amplified, whereas the number originating in the dorsal zone (DZ) decreases. In addition, inputs from the dorsal medial geniculate nucleus (dMGN) increase, whereas those from the ventral division (vMGN) are reduced. In late-deaf cats, projections from the anterior auditory field (AAF) …