Phrenic Afferent Activation Modulates Cardiorespiratory Output In The Adult Rat, Kristi A. Streeter, Michael D. Sunshine, Paul W. Davenport, David D. Fuller

Physical Therapy Faculty Research and Publications

Phrenic afferents project to brainstem areas responsible for cardiorespiratory control and the mid-cervical spinal cord containing the phrenic motor nucleus. Our purpose was to quantify the impact of small- and large-diameter phrenic afferent activation on phrenic motor output. Anesthetized and ventilated rats received unilateral phrenic nerve stimulation while contralateral phrenic motor output and blood pressure were recorded. Twelve currents of 40-Hz inspiratory-triggered stimulation were delivered (20 s on, 5 min off) to establish current response curves. Stimulation pulse width was varied to preferentially activate large-diameter phrenic afferents (narrow pulse width) and recruit small-diameter fibers (wide pulse width). Contralateral phrenic amplitude …

Accuracy Of Body Mass Index In Categorizing Weight Status In Children With Intellectual And Developmental Disabilities, Michele Polfuss, Bethany Forseth, Dale A. Schoeller, Chiang-Ching Huang, Andrea Moosreiner, Paula E. Papanek, Kathleen J. Sawin, Kimberley Zvara, Linda Bandini

Exercise Science Faculty Research and Publications

PURPOSE:

To identify the accuracy of Body Mass Index (BMI) to categorize body weight in a sample of children with spina bifida and Down syndrome as compared to typically developing peers.

METHODS:

A secondary analysis of 32 children with spina bifida, Down syndrome or no chronic illness. A calculated BMI was plotted on the Centers for Disease Control and Prevention age- and sex-specific BMI growth charts to determine each child’s weight status. Percentage of body fat, obtained by labeled water, was plotted on two different body fat percentile reference curves, one derived from a whole body measure (DXA) of body …

The Role Of Eye Movements, Attention, And Hand Movements On Age-Related Differences In Pegboard Tests, Brittany Heintz Walters, Wendy E. Huddleston, Kristian M. O'Connor, Jinsung Wang, Marie K. Hoeger Bement, Kevin G. Keenan

Physical Therapy Faculty Research and Publications

Well-documented manual dexterity impairments in older adults may critically depend on the processing of visual information. The purpose of this study was to determine age-related changes in eye and hand movements during commonly used pegboard tests and the association with manual dexterity impairments in older adults. The relationship between attentional deficits and manual dexterity was also assessed. Eye movements and hand kinematics of 20 young (20–38 yr) and 20 older (65–85 yr) adults were recorded during 9-Hole Pegboard, Grooved Pegboard, and a visuospatial dual test. Results were compared with standardized tests of attention (The Test of Everyday Attention and Trail …

Association Of The Psychological Response To The Acl-Sports Training Program And Self-Reported Function At 2 Years After Anterior Cruciate Ligament Reconstruction, Ryan Zarzycki, Jacob J. Capin, Elanna Arhos, Matthew Failla, Angel H. Smith, Lynn Snyder-Mackler

Physical Therapy Faculty Research and Publications

Background:

Psychological readiness to return to sport has emerged as an important factor associated with outcomes after anterior cruciate ligament reconstruction (ACLR). Psychological factors are potentially modifiable during the course of rehabilitation, and improving them may lead to better outcomes.

Purpose:

To determine whether athletes with a positive psychological response after participation in a neuromuscular training and second injury prevention program had better self-reported function and activity outcomes compared with athletes who did not have a meaningful change.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

After ACLR and the completion of formal rehabilitation, 66 level I/II athletes completed …

Exploring The Pain In Patellofemoral Pain: A Systematic Review And Meta-Analysis Examining Signs Of Central Sensitization, Kemery J. Sigmund, Marie K. Hoeger Bement, Jennifer E. Earl-Boehm

Physical Therapy Faculty Research and Publications

Background

Patellofemoral pain (PFP) has high recurrence rates and minimal long-term treatment success. Central sensitization refers to dysfunctional pain modulation that occurs when nociceptive neurons become hyperresponsive. Researchers in this area of PFP have been increasingly productive in the past decade.

Objective

To determine whether evidence supports manifestations of central sensitization in individuals with PFP.

Data Sources

We searched MeSH terms for quantitative sensory testing (QST) pressure pain thresholds (PPTs), conditioned pain modulation (CPM), temporal summation, sensitization, hyperalgesia, and anterior knee pain or PFP in PubMed, SPORTDiscus, CINAHL, Academic Search Complete, and EBSCOhost.

Study Selection

Peer-reviewed studies that were written …

Gait Mechanics Are Influenced By Quadriceps Strength, Age, And Sex After Total Knee Arthroplasty, Jesse C. Christensen, Jacob J. Capin, Lauren A. Hinrichs, Moiyad Aljehani, Jennifer E. Stevens-Lapsley, Joseph A. Zeni

Physical Therapy Faculty Research and Publications

Although most patients are satisfied with outcomes after total knee arthroplasty (TKA), many retain preoperative altered gait mechanics. Identifying patient characteristics associated with gait mechanics will improve rehabilitation strategies and enhance our understanding of movement disorders. Therefore, the purpose of this study was to identify which patient characteristics are related to gait mechanics in the surgical limb during walking post-TKA. Patient characteristics included age, body mass, sex, quadriceps strength, self-reported function, and knee pain. General linear regression was used to compare patient characteristics associated with gait mechanics, after controlling for gait speed, functional capacity and time from surgery. We tested …

Neuromuscular Function In Achilles Tendinopathy, Lauren K. Sara

Dissertations (1934 -)

Midportion Achilles tendinopathy (AT) is a chronic, painful condition of the long tendon that attaches the triceps surae muscle group (the soleus, medial and lateral gastrocnemius muscles), which are the primary plantar flexor muscles, to the calcaneus bone. There is incomplete understanding of the underlying pathophysiology, pain, and role of plantar flexor function (strength and fatigability) in functional impairment in AT. Deficits in plantar flexor muscle function are assumed, but evidence is sparce and inconclusive. There is no understanding of whether people with AT have deficits in neural drive to the plantar flexor muscles or altered contractile function, or the …

Influence Of The Bar Position On Joint-Level Biomechanics During Isometric Pulling Exercises, Nayun Ahn, Hoon Kim, John Krzyszkowski, Stuart Roche, Kristof Kipp

Exercise Science Faculty Research and Publications

The purpose of this study was to investigate the influence of the bar position on ankle, knee, and hip net joint moments (NJMs), relative muscular effort (RME), and vertical ground reaction forces (GRFs) during isometric pulling exercises, such as the isometric midthigh pull. Eight female lacrosse athletes performed maximal effort isometric pulls at 3 different bar positions (low: above patella, mid: midthigh, and high: crease of hip) while motion capture and GRF data were recorded. Net joint moments were calculated with inverse dynamics. Relative muscle effort was defined as the ratio between the inverse dynamics NJMs and the maximum theoretical …

Electroencephalography Resting-State Networks In People With Stroke, Dylan B. Snyder, Brian D. Schmit, Allison S. Hyngstrom, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Introduction

The purpose of this study was to characterize resting-state cortical networks in chronic stroke survivors using electroencephalography (EEG).

Methods

Electroencephalography data were collected from 14 chronic stroke and 11 neurologically intact participants while they were in a relaxed, resting state. EEG power was normalized to reduce bias and used as an indicator of network activity. Correlations of orthogonalized EEG activity were used as a measure of functional connectivity between cortical regions.

Results

We found reduced cortical activity and connectivity in the alpha (p < .05; p = .05) and beta (p < .05; p = .03) bands after stroke while connectivity …

An Updated Systematic Review Of Cost-Effectiveness Analyses Of Drugs For Osteoporosis, Nannan Li, Dennis Cornelissen, Stuart Silverman, Daniel Pinto, Lei Si, Ingrid Kremer, Sandrine Bours, Robin De Bot, Annelies Boonen, Silva Evers, Joop Van Den Bergh, Jean-Yves Reginster, Mickaël Hiligsmann

Physical Therapy Faculty Research and Publications

Background

Considering the heavy economic burden of osteoporotic fractures, the limits of healthcare resources, and the recent availability of new anti-osteoporosis drugs, there is continuing interest in economic evaluation studies of osteoporosis management strategies.

Objectives

This study aims to (1) systematically review recent economic evaluations of drugs for osteoporosis and (2) to apply an osteoporosis-specific guideline to critically appraise them.

Methods

A literature search was undertaken using PubMed, EMBASE, National Health Service Economic Evaluation database, and the Cost-Effectiveness Analysis Registry to identify original articles containing economic evaluations of anti-osteoporosis drugs, published between 1 July, 2013 and 31 December, 2019. A …

Clinical Update For Physical Therapists: Coagulopathy And Covid-19, Kathleen M. Lukaszewicz, Ellen Hillegass, Michael Puthoff, A. Kate Macphedran

Physical Therapy Faculty Research and Publications

Physical therapists have a unique role in both prevention of venous thromboembolism (VTE) through the promotion of early mobility and physical activity and diagnosis through discovery of signs and symptoms of VTE. This Perspective updates clinicians on the latest information regarding pathophysiology of coagulopathy associated with COVID-19 and applies VTE clinical practice guidelines to COVID-19 in order to provide guidance on physical therapist management.

Ampakines Stimulate Phrenic Motor Output After Cervical Spinal Cord Injury, L. B. Wollman, Kristi A. Streeter, A. F. Fusco, E. J. Gonzalez-Rothi, M. S. Sandhu, J. J. Greer, D. D. Fuller

Physical Therapy Faculty Research and Publications

Activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors increases phrenic motor output. Ampakines are a class of drugs that are positive allosteric modulators of AMPA receptors. We hypothesized that 1) ampakines can stimulate phrenic activity after incomplete cervical spinal cord injury (SCI), and 2) pairing ampakines with brief hypoxia could enable sustained facilitation of phrenic bursting. Phrenic activity was recorded ipsilateral (IL) and contralateral (CL) to C2 spinal cord hemisection (C2Hx) in anesthetized adult rats. Two weeks after C2Hx, ampakine CX717 (15 mg/kg, i.v.) increased IL (61 ± 46% baseline, BL) and CL burst amplitude (47 ± 26%BL) in 8 of 8 …

Two Weeks Of Remote Ischemic Conditioning Improves Brachial Artery Flow Mediated Dilation In Chronic Stroke Survivors, Allison Hyngstrom, Jennifer Nguyen, Michael Wright, Sergey Tarima, Brian Schmit, David D. Gutterman, Matthew J. Durand

Physical Therapy Faculty Research and Publications

Many stroke survivors have reduced cardiorespiratory fitness as a result of their stroke. Ischemic conditioning (IC) is a noninvasive, cost-effective, easy-to-administer intervention that can be performed at home and has been shown to improve both motor function in stroke survivors and vascular endothelial function in healthy individuals. In this study, we examined the effects of 2 wk of remote IC (RIC) on brachial artery flow mediated dilation (FMD) in chronic stroke survivors. We hypothesized that FMD would be improved following RIC compared with a sham RIC control group. This was a prospective, randomized, double-blinded, controlled study. Twenty-four chronic stroke survivors …

A Discrete-Choice Experiment To Assess Patients’ Preferences For Osteoarthritis Treatment: An Esceo Working Group, Mickael Hiligsmann, Elaine Dennison, Charlotte Beaudart, Gabriel Herrero-Beaumont, Jaime Branco, Olivier Bruyère, Philip G. Conaghan, Cyrus Cooper, Nasser Al-Daghri, Famida Jiwa, Willem Lems, Daniel Pinto, René Rizzoli, Thierry Thomas, Daniel Uebelhart, Nicolas Veronese, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

Objective

To evaluate the preferences of patients with osteoarthritis for treatment.

Methods

A discrete-choice experiment was conducted among adult OA patients who were presented with 12 choice sets of two treatment options and asked in each to select the treatment they would prefer. Based on literature reviews, expert consultation, patient survey and expert meeting, treatment options were characterized by seven attributes: improvement in pain, improvement in walking, ability to manage domestic activities, ability to manage social activities, improvement in overall energy and well-being, risk of moderate/severe side effects and impact on disease progression. Random parameters logit model was used to …

The Influence Of Autonomic Function On Pain Modulation Before And After Exercise And Cognitive Task In Fibromyalgia, Abdulaziz Awali

Dissertations (1934 -)

Fibromyalgia (FM) is a chronic pain condition characterized by widespread pain. People with FM have alterations in autonomic function compared to healthy individuals. Exercise can decrease pain in people with FM, however some people with FM experience pain exacerbation when initiating exercise. Whether variability in pain at rest and following exercise is related to altered autonomic function, including the potential implications with other stressful events such as mental math, is not known. This dissertation aimed at investigating: 1) the relation between cardiovascular autonomic function and central pain facilitation and inhibition, measured by temporal summation of pain (TS) and conditioned pain …

Pain Modulatory Effects Of Exercise In Chronic Pain, Giovanni Berardi

Dissertations (1934 -)

Exercise training is recommended as a first-line treatment in the management of fibromyalgia due to its ability to improve symptoms and function. However, many with fibromyalgia report limited tolerance to exercise due to exacerbation of pain and fatigue during and following participation of a single bout of exercise. The purpose of this dissertation was to determine the influence of contraction type on local and systemic experimental pain sensitivity, performance fatigue, and perceived pain and fatigue during exercise and through recovery in people with and without fibromyalgia.Experimental and perceived pain were measured before and after a single bout of submaximal intermittent …

Experimental & Simulation Approaches To Study Neuromuscular Control In People With Chronic Ankle Instability, Hoon Kim

Dissertations (1934 -)

Ankle sprains are among the most common musculoskeletal injuries, and up to 70% of people who sprain their ankles develop chronic ankle instability (CAI). Moreover, people who develop CAI have a significantly higher risk of developing ankle osteoarthritis. Recent research has identified neuromuscular deficits that may be responsible for the high recurrence rates of ankle sprains and for the progression towards ankle osteoarthritis in people with CAI. Unfortunately, current rehabilitation strategies are not completely successful because the mechanisms responsible for these deficits are not fully elucidated. Therefore, the purpose of this dissertation was to investigate individual muscle forces and force …

Direct Healthcare Costs Associated With Oligoarticular Juvenile Idiopathic Arthritis At A Single Center, Amit Thakral, Daniel Pinto, Michael Miller, Megan L. Curran, Marisa Klein-Gitelman, Dustin D. French

Physical Therapy Faculty Research and Publications

Oligoarticular juvenile idiopathic arthritis (JIA) is a common disease in pediatric rheumatology. The management of oligoarticular JIA can result in a considerable economic burden. This study is a four-year, retrospective cost identification analysis performed to determine the annual direct cost of care for patients with oligoarticular JIA and possible predictive clinical factors. Direct healthcare costs were defined as those associated with office visits, laboratory studies, hospital admissions, joint injections, medications, infusions, radiology tests, and emergency room visits. Disease characteristics and patient information included ANA status, gender, age at diagnosis, duration from diagnosis to initial visit during the study period, and …

Temporal Aspects Of Endogenous Pain Modulation During A Noxious Stimulus Prolonged For 1 Day, Marie K. Hoeger Bement, Kristian K. Petersen, Line B. Sørensen, Hjalte H. Andersen, Thomas Graven-Nielsen

Physical Therapy Faculty Research and Publications

Background

This study investigated (a) if a prolonged noxious stimulus (24‐hr topical capsaicin) in healthy adults would impair central pain inhibitory and facilitatory systems measured as a reduction in conditioned pain modulation (CPM) and enhancement of temporal summation of pain (TSP) and (b) if acute pain relief or exacerbation (cooling and heating the capsaicin patch) during the prolonged noxious stimulus would affect central pain modulation.

Methods

Twenty‐eight participants (26.2 ± 1.0 years; 12 women) wore a transdermal 8% capsaicin patch on the forearm for 24 hr. Data were collected at baseline (Day 0), 1 hr, 3 hr, Day 1 (post‐capsaicin …

Submaximal Isometric Force Steadiness In People With Multiple Sclerosis Under Single And Dual Task Conditions, Sheri Bunyan

Dissertations (1934 -)

Activities of daily living require steady, non-fatiguing, isometric muscular contractions to maintain postural control and stabilize body segments to facilitate interaction with the environment. Furthermore, typical activities often require simultaneous performance of cognitive and motor tasks. This may challenge people with multiple sclerosis, a chronic neurodegenerative disease of the central nervous system associated with motor and cognitive impairments. Despite functional relevance, isometric force steadiness in both the upper and lower extremities has not been explored in this population. Additionally, dual task experiments in multiple sclerosis have primarily used gait, a dynamic activity, as the motor task. Thus, the purpose of …

Energy Cost Of Slow And Normal Gait Speeds In Low And Normally Functioning Adults, Taylor W. Rowley, Chi Cho, Ann M. Swartz, John Staudenmayer, Allison S. Hyngstrom, Kevin G. Keenan, Whitney A. Welch, Scott J. Strath

Physical Therapy Faculty Research and Publications

Objective

Slow walking speed paired with increased energy cost is a strong predictor for mortality and disability in older adults but has yet to be examined in a heterogeneous sample (ie, age, sex, disease status). The aim of this study was to examine energy cost of slow and normal walking speeds among low- and normal-functioning adults.

Design

Adults aged 20–90 yrs were recruited for this study. Participants completed a 10-m functional walk test at a self-selected normal walking speed and were categorized as low functioning or normal functioning based on expected age- and sex-adjusted average gait speed. Participants completed two …

The Impact Of Isometric Exercise On Somatosensory Processing In People With Or Without Chronic Pain, Ali Mohammed Alsouhibani

Dissertations (1934 -)

Despite an increase in our understanding of the pathomechanisms of chronic pain and the advancement of new treatments, pharmacological management of chronic pain remains poor. This presents the need for non-pharmacological treatments and understanding their efficacy and mechanisms in managing pain. The purpose of this dissertation was to examine the effects of isometric exercise on the somatosensory system and other biopsychosocial aspects related to pain in individuals with and without fibromyalgia. The first aim was to determine whether isometric exercise improves pain inhibitory mechanisms and vibration sense. The second aim was to determine what biopsychosocial factors influence pain relief following …

Practical Guidance For Engaging Patients In Health Research, Treatment Guidelines And Regulatory Processes: Results Of An Expert Group Meeting Organized By The World Health Organization (Who) And The European Society For Clinical And Economic Aspects Of Osteoporosis, Osteoarthritis And Musculoskeletal Diseases (Esceo), Maarten De Wit, Cyrus Cooper, Peter Tugwell, Nathalie Bere, John Kirwan, Philip G. Conaghan, Charlotte Roberts, Isabelle Aujoulat, Nasser Al-Daghri, Islene Arajujo De Carvalho, Mary Barker, Nicola Bedlington, Maria Luisa Brandi, Olivier Bruyère, Nansa Burlett, Philippe Halbout, Mickaël Hiligsmann, Famida Jiwa, John A. Kanis, Andrea Laslop, Wendy Lawrence, Daniel Pinto, Concepción Prieto Yerro, Véronique Rabenda, René Rizzoli, Marieke Scholte-Voshaar, Mila Vlaskovska, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients’ needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated practical guidance to facilitate optimal patient engagement in clinical development and regulatory decisions. Patient engagement is a relational process. The …

Practical Guidance For Engaging Patients In Health Research, Treatment Guidelines And Regulatory Processes: Results Of An Expert Group Meeting Organized By The World Health Organization (Who) And The European Society For Clinical And Economic Aspects Of Osteoporosis, Osteoarthritis And Musculoskeletal Diseases (Esceo), Maarten De Wit, Cyrus Cooper, Peter Tugwell, Nathalie Bere, John Kirwan, Philip G. Conaghan, Charlotte Roberts, Isabelle Aujoulat, Nasser Al-Daghri, Islene Arajujo De Carvalho, Mary Barker, Nicola Bedlington, Maria Luisa Brandi, Olivier Bruyère, Nansa Burlett, Philippe Halbout, Mickaël Hiligsmann, Famida Jiwa, John A. Kanis, Andrea Laslop, Wendy Lawrence, Daniel Pinto, Concepción Prieto Yerro, Véronique Rabenda, René Rizzoli, Marieke Scholte-Voshaar, Mila Vlaskovska, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients’ needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated practical guidance to facilitate optimal patient engagement in clinical development and regulatory decisions. Patient engagement is a relational process. The …

The Role Of Movement Pattern In Relation To Running Related Injuries Risk Factors, Marwan Mahmoud A Aljohani

Dissertations (1934 -)

About 52.3 million American run on a regular basis. Up to 79% of runners get injured every year and the rate of injury has not declined over the past decades. Females have twice the risk of developing a running related injury (RRI). Rate of loading (ROL), tibial impact shock (TIS), and low movement variability may contribute to the development of RRI. Not much is known, however, about the relationships between impact kinetics (i.e. ROL, TIS) and movement variability. In addition, there is a lack of understanding about the effects of sex and speed on the aforementioned RRI risk factors. Therefore, …

Does Weight Status Impact Metabolic Health In Adolescents When Controlling For Physical Fitness?, Stacy Stolzman, Joseph Skelton, April L. Harkins, Marie K. Hoeger Bement

Physical Therapy Faculty Research and Publications

Purpose:

To determines whether adolescents who are fit with overweight/obesity are similar in their metabolic profile to adolescents who are fit and normal weight.

Methods:

Adolescents participated in 3 sessions: (1) resting vitals and anthropometrics; (2) maximal aerobic treadmill test () to determine physical fitness; and (3) dual-energy x-ray absorptiometry and fasting laboratory draw for analysis of insulin, glucose, high-density lipoprotein, triglycerides, and C-reactive protein.

Results:

Of the 30 fit adolescents who are normal weight and 16 adolescents who are fit and overweight/obese (OW/OB), metabolic syndrome was apparent in 1 adolescent who are normal weight and 4 adolescents who are …

The Effect Of A Portable Electrical Muscle Stimulation Device At Home On Muscle Strength And Activation Patterns In Locomotive Syndrome Patients: A Randomized Control Trial, Yuichi Nishikawa, Kohei Watanabe, Shuhei Kawade, Tetsuya Takahashi, Hiroaki Kimura, Hirofumi Maruyama, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

The aim of the present study was to quantify the effect of electrical muscle stimulation (EMS) intervention using a portable device on muscle strength and activation patterns in locomotive syndrome. Nineteen women were randomly assigned to the intervention group (n = 10; age = 71–82 years) and control group (n = 9; age = 70–84 years). Participants in the intervention group used a portable EMS device to stimulate the bilateral quadriceps muscles for 8 weeks (23 min/5 days/week). To understand the effects of EMS, the following measurements were made at baseline, 8 weeks, and 12 weeks: locomotive syndrome assessment score, …

Fatiguing Trunk Flexor Exercise Decreases Pain Sensitivity In Postpartum Women, Rita Deering, Tatyana Pashibin, Meredith Cruz, Sandra K. Hunter, Marie K. Hoeger Bement

Physical Therapy Faculty Research and Publications

Background: Low back pain (LBP) is common in the general population and among postpartum women. Abdominal muscle exercise is often used to treat LBP, but it is unknown if fatiguing abdominal muscle exercise can produce exercise-induced hypoalgesia (EIH).

Objectives: To assess pressure pain thresholds (PPTs) at rest and following fatiguing trunk flexor exercise (EIH) in (1) nulligravid and postpartum women to evaluate the impact of pregnancy and childbirth and (2) nulligravid women and men to examine sex differences.

Methods: Seventy healthy adults (31 postpartum women, 23 nulligravid women, 16 men) participated. Postpartum and nulligravid women were tested twice (16–18 weeks …

Two Weeks Of Ischemic Conditioning Improves Walking Speed And Reduces Neuromuscular Fatigability In Chronic Stroke Survivors, Matthew J. Durand, Timothy F. Boerger, Jennifer Nguyen, Saad Z. Alqahtani, Michael T. Wright, Brian D. Schmit, David D. Gutterman, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

This pilot study examined whether ischemic conditioning (IC), a noninvasive, cost-effective, and easy-to-administer intervention, could improve gait speed and paretic leg muscle function in stroke survivors. We hypothesized that 2 wk of IC training would increase self-selected walking speed, increase paretic muscle strength, and reduce neuromuscular fatigability in chronic stroke survivors. Twenty-two chronic stroke survivors received either IC or IC Sham on their paretic leg every other day for 2 wk (7 total sessions). IC involved 5-min bouts of ischemia, repeated five times, using a cuff inflated to 225 mmHg on the paretic thigh. For IC Sham, the cuff inflation …

Incremental Clinical Effectiveness And Cost Effectiveness Of Providing Supervised Physiotherapy In Addition To Usual Medical Care In Patients With Osteoarthritis Of The Hip Or Knee: 2-Year Results Of The Moa Randomised Controlled Trial, J. H. Abbott, R Wilson, Daniel Pinto, C. M. Chapple, A. A. Wright

Physical Therapy Faculty Research and Publications

Objective

To investigate the clinical- and cost-effectiveness at 2-year follow-up of providing individual, supervised exercise physiotherapy and/or manual physiotherapy in addition to usual medical care.

Method

People with hip or knee osteoarthritis meeting the American College of Rheumatology clinical diagnostic criteria were randomised (1:1, concealed, assessor-blinded) to four groups: usual medical care; supervised exercise physiotherapy; manual physiotherapy; or combined exercise and manual physiotherapy. Physiotherapy group participants were provided 10 50-min treatment sessions including booster sessions at 4 and 13 months, in addition to usual care. The primary outcome at 2-year follow-up was incremental cost-utility ratio (ICUR) of each physiotherapy intervention …