Medicine and Health Sciences Commons^™

Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L. Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G. Gorenstein, David E. Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Faculty Publications

Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45 immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast tumors. While CD45 level was significantly elevated in DOX-treated wildtype mice, it remained unchanged in DOX-treated tumors from E-selectin null mice. Similarly, intravenous administration of anti-E-selectin aptamer (ESTA) resulted in a significant reduction in CD45 immune cell density in DOX-treated residual tumors, which coincided with a delay in tumor growth and lung metastasis in MMTV-pyMT mice. Additionally, both …

How To Stop Touching Your Face To Minimize Spread Of Coronavirus And Other Germs, Stephen D. Benning, Brian Labus, Kimberly Barchard

Psychology Faculty Research

Public health officials consistently promote hand-washing as a way for people to protect themselves from the COVID-19 coronavirus. However, this virus can live on metal and plastic for days, so simply adjusting your eyeglasses with unwashed hands may be enough to infect yourself. Thus, the Centers for Disease Control and Prevention and the World Health Organization have been telling people to stop touching their faces.

First Aid First: Implementation And Evaluation Of A Community-Based First Aid Training Course, Luke Wesemann

Medical Student Research Symposium

In 2018, medical students at Wayne State University School of Medicine (WSUSOM) created a first aid training initiative called First Aid First (FAF). FAF is a comprehensive community-based training program that teaches lifesaving skills tailored for Detroit. The objective of this initiative was to improve the confidence and basic first aid skills of those who attend trainings.

Pre- and post-test surveys were used to measure knowledge, confidence and skill level. The survey data gathered from March 2018-October 2019 consisted of 5 Likert scale questions for self-evaluation component and 23-25 multiple choice questions, number depending on time of administration due to …

Evaluation Of The Impact Of Social Collaborations On Sexual And Reproductive Health Knowledge, Lucki Word, Jaila Campbell, Manar T. Edriss, Destiny Stroman, Jewel Evans, Melanie Hanna-Johnson, Md, Anil N. F. Aranha, Phd

Medical Student Research Symposium

Introduction: Developments in technology, such as the popularity of mobile devices and social media outlets, have enhanced the ability of individuals to communicate. Currently, search engines allow for easy exploration of information related to every topic of interest. Our study purpose was to evaluate the impact of technological and social collaborations on sexual and reproductive health knowledge (SRHK).

Methods: A 50-item survey instrument, integrating factors of sociodemographics, number/type of social collaborations, technological communication use, and SRHK, was developed to assess familiarity with sexual and reproductive health perceptions. The survey was provided to consenting patients in an ambulatory, primary care setting. …

Covid-19 Update, Wku Staff Senate

Staff Council

COVID-19 update issued by WKU Staff Senate.

We Need Sex Ed, Too! : Addressing The Sexual Risk Behaviors Of System Involved Youth, Nadine Finigan-Carr

National Youth Advocacy & Resilience Conference

System involved youth (e.g., youth in child welfare or juvenile services) are a vulnerable population with increased risk for unintended pregnancy, HIV, and STIs. This workshop is designed to (1) identify their sexual reproductive health risk behaviors; (2) describe the related determinants; and, (3) improve awareness of how educators can promote the development of positive sexual risk behaviors among them.

Pharmacist-Prescribed Birth Control: A Policy Analysis, Brianna Full

UNO Student Research and Creative Activity Fair

Although unintended pregnancy in the United States has steadily decreased from 2008, rates are still unacceptably high as almost half (42%) of all pregnancies are not wanted or timed correctly (Finer & Zolna). In 2011, 2.8 million of the 6.1 million pregnancies in the United States each year were unintended. Public health professionals are worried about unintended pregnancy because research shows that unwanted or mistimed pregnancies come with associations to adverse maternal and child health outcomes, such as delayed prenatal care, premature birth, and negative physical and mental health effects for children (Frost, Frohwirth & Zolna, 2016). Also, two-thirds (68%) …

A Brief Report On A Facilitated Approach To Connect Cooperative Extension Southern Region State-Level Health Specialists, Samantha M. Harden, Lisa Washburn, Alison Berg, Ninfa Pena-Purcell, Heather Norman-Burgdolf, Nancy Franz

Dietetics and Human Nutrition Faculty Publications

Improving the nation’s health will require collaboration among many stakeholders and systems, including representatives from Cooperative Extension Services (CES). This paper describes the process of establishing a multistate collaboration and discusses initial outcomes of a third-party facilitated participatory planning meeting. State-level specialists with expertise and responsibilities in “health” promotion participated. Satisfaction with meeting format; feasibility, acceptability, and appropriateness of the proposed approach to public health impact; and general meeting feedback were collected through a survey and cultural artifacts (e.g., notes, worksheets). Preparation and attendance costs were captured. Seventeen of the 20 attendees (85%) responded to the survey and reported the …

Comparing Self-Reported Medication Adherence Measures With Hair Antiretroviral Concentration Among People Living With Hiv In Guangxi, China, Quan Zhang, Xiaoming Li Ph.D., Shan Qiao Ph.D., Zhiyong Shen, Yuejiao Zhou

Faculty Publications

Background: Antiretroviral adherence is essential to HIV treatment efcacy. Various self-reported measures are commonly used for assessing antiretroviral adherence. Limited data are available regarding the validity of those selfreported measures in comparison with long-term objective biomarkers of adherence measures such as hair measures.

Methods: Self-reported adherence (frequency, percentage, and visual analog scale [VAS]) and hair tenofovir concentration were evaluated at a single time point from 268 people living with HIV in China. The responses to each of three self-reported measures were converted into percentage and then dichotomized as “optimal” (100%) vs. “suboptimal” (less than 100%) adherence. Two composite adherence scores …

Preparing For Shortages Of Future Covid-19 Drugs: A Data-Based Model For Optimal Allocation, Charlie L. Sy, Kathleen Aviso, Christina D. Cayamanda, Anthony F. Chiu, Rochelle Irene Lucas, Michael Angelo Promentilla, Luis F. Razon, Raymond R. Tan, John Frederick Tapia, Ador Torneo, Aristotle T. Ubando, Derrick Ethelbhert C. Yu

Angelo King Institute for Economic and Business Studies (AKI)

Drugs for the treatment of Covid-19 are currently beign tested, and those that are apporved for use are likely to be in short supply due to the global scale of the pandemic. This policy brief proposes a model for optimally allocating future Covid-19 drugs to patients to minimize deaths under conditions of resource scarcity. A linear programming model is developed that estimates the potential number of deaths that may result from Covid-19 under two scenarios: with antivirals and without antivirals. It takes into account patient risk level, the severity of their symptoms, resource availability in hospitals (i.e. hospital beds, critical …

Fluoridation: Our History, Our Legacy, James Wieland Dds

The Journal of the Michigan Dental Association

2020 marks the 75th anniversary of one of the world’s most dramatic public health initiatives, a public health project that dramatically improved the oral health of millions of people, not only in the United States but throughout the world. On Jan. 25, 1945, the Grand Rapids Study was launched and the Furniture City became the world’s first to adjust the fluoride level of its public water supply.

This landmark trial established the use of fluoridation as a safe, effective, and economical public health measure to prevent tooth decay.

How the Grand Rapids Study began is a fascinating story. Even though …

The Flint Water Crisis And Community Water Fluoridation: A Lesson In Communication. Communicating With The Public And Connecting With Community Leaders, Traci J. Dantzler Dds, Raymond Gist Dds

The Journal of the Michigan Dental Association

This article presents how not only was Flint’s water compromised lead contamination of residential waterlines during the Flint Water Crisis, but area dentists had to work hard to refute unsubstantiated claims that adding fluoride to the community water supply increased the level of lead in the water. Oral health advocacy to reassure citizens and build confidence in the community water supply following remediation efforts required sharing the best evidence while most importantly actively listening to assure that community members were heard; that they felt that they have a voice, and to know that we are here to listen to their …

Celebrate! The Legacy Of Community Water Fluoridation Continues In Grand Rapids, James Wieland Dds

The Journal of the Michigan Dental Association

Michigan dentistry continues to tell the world about the great advance in public health that began in Grand Rapids 75 years ago. This article looks back at past commemorations, and a tribute to those who worked so hard to make a permanent monument to community water fluoridation.

Community Water Fluoridation’S Legacy: Protect It Or Lose It, Johnny Johnson Dmd, Ms

The Journal of the Michigan Dental Association

This article presents advocacy strategies to promote and preserve community water fluoridation initiatives. The American Fluoridation Society, patterned after the British Fluoridation Society, brings dentists, health experts, and other allies and provides evidence-based resources to address a broad spectrum of assertion by fluoridation opponents.

Increasing Healthy Lifestyle Behaviors In Cargo Drivers, Ronda L. Bell

Electronic Theses and Dissertations

The purpose of this project was to examine the extent to which lifestyle behaviors of transportation drivers in North Texas can be improved with health education. This research study was conducted to examine the health behaviors of transportation drivers as a result of an educational partnership between nursing and the transportation industry. The goal was to improve healthy lifestyles through education to decrease chronic illness and comorbid conditions of a significantly at-risk occupational population. The impact of this education was immediate and verified with quantitative measurement and statistical analysis. Results demonstrated that after nurse-led health education, transportation drivers reported significant …

The Studies That Shaped A Science-Based Profession, Christopher J. Smiley

The Journal of the Michigan Dental Association

Editorial on science-based public health policy and the lessons of the Grand Rapids Study.

Health Risk Behaviors: Smoking, Alcohol, Drugs, And Dating Among Youths In Rural Central Java, Zahroh Shaluhiyah, Syamsulhuda Budi Musthofa, Ratih Indraswari, Aditya Kusumawati

Kesmas

Adolescents are more likely to adopt risky health behaviors, such as smoking, alcohol use, and sexual activity. This study examined the links betweensmoking, alcohol use, and risky dating behavior and analyzed how these factors influenced risky dating and other behaviors. It is expected that this studywould be used as a foundation for developing appropriate integrated intervention for multiple risk behaviors among youths. This study was an explanatory research study with a cross-sectional approach. It involved 160 youths aged 15-24 years randomly selected from purposive villages. Participants completedself-administrated questionnaires with an enumerator present. Data were analyzed using univariate, chi-square, and multiple …

Evaluation Of Program For Overcoming Intestinal Worm Infections Among Children, Henny Febriyanti, Haerawati Idris

Kesmas

Prevalence of intestinal worm infection in generall is extremely high in Indonesia among the poor population with poor sanitation. One of the government programs to address this problem is the distribution of medicines to prevent intestinal worm infections. However, the coverage of the achievement for this program is still low in several areas of public health centers in Palembang. Therefore, this study was conducted to evaluate the efficacy of the national program for preventing intestinal worm infections. The qualitative research design used evaluation model approach Context, Input, Process, and Product (CIPP) model. This study was conducted in one of health …

Effects Of Diabetes On The Output Of Farmer And Its Policy Implications, Syed Asif Ali Naqvi, Bilal Hussain, Syed Ale Raza Shah, Muhammad Sohail Amjad Makhdum

Kesmas

This study investigated the impact of diabetes on work performance of different farming communities from Punjab, Pakistan. This study was based on cross-sectional data. A representative sample of 374 farmers was collected from five selected districts. Three types of respondents were analyzed in the study e.g.,laborer, small and large growers. Poisson and logistic regression techniques were used for the sake of analysis. According to the investigated results for thelabor category, respondents with more age, less qualification, low earning per month (Rupees), and having positive record of family diabetes, would havemore leave per month. In the same way, findings for small …

Qualitative Exploration Of Experiences And Consequences Of Health-Related Stigma Among Indonesians With Hiv, Leprosy, Schizophrenia And Diabetes, Sarju Sing Rai, Irwanto Irwanto, Ruth M.H. Peters, Elena V. Syurina, Annisa Ika Putri, Altana Mikhakhanova, Denise Naniche, Marjolein B.M. Zweekhorst

Kesmas

Health-related stigma causes a negative impact on the lives of affected people and undermines the effectiveness of public health programs. This study aimedto explore experiences and consequences of stigma among people affected by four health conditions relevant in Indonesia– HIV (Human ImmunodeficiencyVirus), leprosy, schizophrenia and diabetes. In this qualitative study 40 people affected by the four health conditions in Jakarta and West Java, Indonesia–,were interviewed between March and June 2018. Data were analyzed thematically by following an integrative inductive-deductive approach. The experiencesand consequences of people with stigma were similar, but such experience were more severe among people affected by HIV, …

Entomological Index And Home Environment Contribution­ ­To Dengue Hemorrhagic Fever In Mataram City, Indonesia, Tri Baskoro Tunggul Satoto, Nur Alvira Pascawati, Tri Wibawa, Roger Frutos, Sylvie Maguin, I Kadek Mulyawan, Ali Wardana

Kesmas

Indonesia is a member of Southeast Asia Regional Office (SEARO) ranked the first in dengue hemorrhagic fever (DHF) problem based on incidence rate (IR) and case fatality rate (CFR). Several provinces in Indonesia experience an outbreak, one of which is the Mataram City in West Nusa Tenggara Province. Mataram City is an endemic area of DHF because the DHF cases are always found in three consecutive years with the number of cases that fluctuate and tend to increase. This study aimed to obtain factors that could be used to improve early warning systems in controlling DHF. This study used a …

Utilization Of Family Planning Contraceptives Among Women Inthe Coastal Area Of South Buru District, Maluku, 2017, Christiana Rialine Titaley, Ninik Sallatalohy

Kesmas

Maluku Province is one among provinces in Indonesia with a contraceptive prevalence rate (CPR) lower than the national average. This study aimed toexamine factors associated with the utilization of family planning contraceptives among women of reproductive age living in the coastal area of South BuruDistrict, Maluku, Indonesia. Data were derived from a household health survey conducted in five subdistricts in South Buru, e.g., Namrole, Leksula, Waesama,Kapala Madan and Ambalau Subdistricts on November 2017 by the Faculty of Medicine, Pattimura University in Ambon. Information on contraceptive usewere collected from 390 married women aged 20 - 49 years. Bivariate and multivariate logistic …

Determinants Of Stunted Children In Indonesia: A Multilevel Analysis At The Individual, Household, And Community Levels, Febri Wicaksono, Titik Harsanti

Kesmas

This study aimed to examine the risk factors of childhood undernutrition in Indonesia. Determinants of childhood stunting were examined by using the 2013 Indonesia Basic Health Research Survey dataset. A total of 76,165 children aged under 5 years were included in this study. The analysis used multivariate multilevel logistic regression to determine adjusted odds ratios (aORs). The prevalence of stunting in the sample population was 36.7%. The odds of stunting increased significantly among the under-five boys, children living in slum area, and the increase of household member (aOR = 1.11, 95 %CI: 1.06–1.15; 1.09, 95%CI: 1.04–1.15; and 1.03, 95%CI: 1.02–1.04 …

A Qualitative Study Of The Genesis Of A Community Food Pantry For Students Of Higher Education, Elizabeth Fast

Theses and Dissertations

Objective: The purpose of this case study was to understand the development of a food pantry for students of higher education at a Midwestern university.

Methods: The researchers recruited 11 individuals on the food pantry’s board using a snowball sampling method to participate in a 30-minute interview about the food pantry’s development from conception to implementation. The interviews were transcribed and then qualitatively analyzed by two researchers. The researchers coded interviews separately to identify frequent commonalities between participant responses. The researchers then organized the codes into themes, which were then summarized in the results of this study.

Results: The first …

Woodi Health Hub: Promoting Health Information Literacy To Students In The Atlanta University Center, Rosaline Y. Odom

Georgia International Conference on Information Literacy

“Health Literacy is defined as the degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions.” National initiatives call for improved health literacy as a means of addressing ongoing health disparities in the U.S. Low health literacy is linked to a poorer overall health status and higher risk of death among at-risk populations. Vulnerable populations include older adults, immigrant populations, minority populations and low income populations. College years are a time when young adults transition from parental control to independence and face new challenges, stressors and messages …

Icope A Multi-Level, Cluster Randomized, 36-Month, Parallel-Group Study To Assess The Efficacy Of Hiv Disclosure Intervention In Hiv Parental Disclosure Among Parents Living With Hiv In China, Xiaoming Li Ph.D., Shan Qiao Ph.D., Yuejiao Zhou

Faculty Publications

Objectives: Parents living with HIV who disclose their HIV status to their children could benefit from the parental HIV disclosure. However, it is also very challenging because of persistent stigma and discrimination against HIV. This report describes the study design and protocol of the “Interactive Communication with Openness, Passion, and Empowerment (iCOPE)” randomized controlled trial aimed at assisting parents living with HIV in conducting culturally and developmentally appropriate disclosure to their uninfected children in China through trainings among both parents living with HIV and healthcare providers.

Methods: A total of 791 parents living with HIV with children aged between 6 …

Development Of A Diabetes Self-Management + Mhealth Program: Tailoring The Intervention For A Pilot Study In A Low-Income Setting In Mexico, Robin Whittemore, Mireya Vilar-Compte, Soraya Burrola-Méndez, Annel Lozano-Marrufo, Roberta Delvy, Mariana Pardo-Carrillo, Selene De La Cerda, Ninfa Pena-Purcell, Rafael Pérez-Escamilla

Department of Public Health Scholarship and Creative Works

Background: Type 2 diabetes (T2D) is a public health pandemic disproportionately affecting low- and middle-income countries. The purpose of this formative research was to adapt evidence-based diabetes self-management education programs to the context of Seguro Popular clinics in Mexico. A theory-based mHealth (pictorial text messaging) component was developed.

Method: Our formative research and development of the program protocol consisted of six phases: (1) interviews and focus groups with stakeholders on the challenges to T2D management, curriculum content needs, and the use of mHealth as a supplement to a DSME program; (2) review of the theoretical underpinning, curriculum, and interactive strategies …

Promoting Bike Safety And Physical Activity In The Community: The Kenton-Hardin County Family Bike Program, Jamie Hunsicker

Ada Chats

No abstract provided.

Condom Use And Related Factors Among Rural And Urban Men Who Have Sex With Men In Western China: Based On Information-Motivation-Behavioral Skills Model, Ling Hu, Yetao Luo, Xiaoni Zhong, Rongrong Lu, Yang Wang, Manoj Sharma, Mengliang Ye

Environmental & Global Health Faculty Research

This study aimed to determine the differences in condom use and related factors among rural–urban men who have sex with men (MSM) in Western China. A cross-sectional survey was conducted in Chongqing, Sichuan, and Guangxi, which recruited MSM by non-probability sampling. Data were collected through an anonymous, standardized, and self-reported questionnaire guided by an information–motivation–behavioral skills model. Structural equation model was applied to analyze the related factors. Out of the 1141 MSM included in this analysis, 856 (75%) and 285 (25%) were from urban and rural areas, respectively. The median age was 27 years for both groups. Self-reported consistent condom …

Is The Coronavirus A Pandemic, And Does That Matter? 4 Questions Answered, Brian Labus

Environmental & Global Health Faculty Research

Editor’s note: The new coronavirus has now affected more than 20,000 people in China and claimed more lives as of Feb. 4 than the SARS epidemic from 2002 to 2004. Hong Kong has reported its first death. Some public health officials have said the outbreak is likely to soon be a pandemic, but the World Health Organization said Feb. 4 that it isn’t, yet. Just what is a pandemic anyway? An epidemiologist and public health researcher explains.