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Low Level Lead Exposure And Inflammatory Markers In The Brains Of C57bl/6j Mice, Miguel A. Cervantes
Low Level Lead Exposure And Inflammatory Markers In The Brains Of C57bl/6j Mice, Miguel A. Cervantes
Open Access Theses & Dissertations
Background and Significance: Prior studies have indicated that early chronic low-level lead exposure may be associated with adverse effects on motor and cognitive functions. The mechanisms by which low-level lead affects brain function are unknown. Objectives: The current study aimed to (1) determine whether early chronic low-level lead exposure altered the expression of pro- or ant-inflammatory cytokines and markers of oxidative stress in mouse brain studied at two ages, pre-adolescence (PND 28) and early adulthood (PND 40); and (2) in the same pre-adolescent and early adulthood mice, compare and contrast the levels of pro- or ant-inflammatory markers in three brain …