Medicine and Health Sciences Commons^™

Alzheimer's Disease: Risk And Protective Factors To Improve Detection And Prevention, Darryl Clay Nevels

Walden Dissertations and Doctoral Studies

Alzheimer’s disease (AD) is a growing epidemic and is the sixth-leading cause of death in the United States. Individuals with AD often have comorbidities due to the aging process. There is a lack of research on comorbidities as associated risk factors for AD. The leading hypothesis indicates that cardiovascular health issues, environmental exposure, social isolation, and amyloid-beta plaques influence cognitive health and are associated with AD. This study, guided by Finch and Kulminski’s AD exposome, is a caveat to explore a patient’s physical history of cardiovascular health, modifiable behavior, social isolation, and an AD diagnosis. Participants provided health information collected …

Can Children Catch Up From The Consequences Of Undernourishment? Evidence From Child Linear Growth, Developmental Epigenetics, And Brain And Neurocognitive Development, Jef L. Leroy, Edward A. Frongillo Jr., Pragya Dewan, Maureen M. Black, Robert A. Waterland

Faculty Publications

Recovery from nutritionally induced height deficits continues to garner attention. The current literature on catch-up growth, however, has 2 important limitations: wide-ranging definitions of catch-up growth are used, and it remains unclear whether children can recover from the broader consequences of undernutrition. We addressed these shortcomings by reviewing the literature on the criteria for catch-up in linear growth and on the potential to recover from undernutrition early in life in 3 domains: linear growth, developmental epigenetics, and child brain and neurocognitive development. Four criteria must be met to demonstrate catch-up growth in height: after a period in which a growth-inhibiting …

The Effects Of Exercise On Cognition, Mobility, And Neuroimaging Outcomes In Older Adults Without Dementia, Narlon Cassio Boa Sorte Silva

Electronic Thesis and Dissertation Repository

Cognitive decline is increasing with the aging population and, at present, there is no effective pharmacologic treatment available. Exercise interventions may impart protection against cognitive decline. A novel exercise approach is multiple-modality exercise (MME; aerobic, resistance, and balance exercise) with mind-motor training. Mind-motor training is a promising intervention in the study of cognitive function. Combining MME with mind-motor training may improve or maintain cognition and provide prevention of dementia early in the course of cognitive decline. Individuals with subjective cognitive complaints (SCC) comprise an at-risk group early in the spectrum of cognitive decline that could be targeted for prevention. The …

Positive Behavior Support-Based In-Home Services For Traumatic Brain Injury, Charles Jack

Walden Dissertations and Doctoral Studies

Researchers have demonstrated the effectiveness of positive behavior support (PBS) services in the in-home (IH) setting but few studies examined its use with traumatic brain injury (TBI) clients, and most of these were small sample cases. Additional research on IH PBS services for TBI clients was recommended, in particular using larger samples. The purpose of this study was to address that need by examining the effectiveness of IH PBS services in treating TBI-related challenging behaviors on a larger sample. The theoretical foundations for PBS, behaviorism, cognitive constructivism, social learning theory, and the biopsychosocial model of behavior, are described. The research …

Flowers Or Flora?: Understanding The Effects Of Probiotics On Depression, Nicole Collopy

Senior Theses

The human gut is populated with hundreds of types of bacteria and fungi. In North America, both intestinal and mood disorders are prevalent, presenting health problems that challenge health care professionals and patients alike. A scholarly literature review was conducted to explore this important relationship.

The investigation of the literature revealed that there is an association between gut health disorders and mood disorders, mainly anxiety and depression. This is due to bi-directionality between the brain-gut pathways, meaning that gastrointestinal health may have an effect on mental health and vice versa.

This connection between gut and mood can have substantial implications …

Smokers' Neurological Responses To Novel And Repeated Health Warning Labels (Hwls) From Cigarette Packages, Johann F. Fridriksson, Chris Rorden, Roger D. Newman-Norlund, Brett Froeliger, Jim Thrasher

Faculty Publications

Graphic health warning labels (HWLs) depicting bodily injury due to smoking are effective for producing changes in affect, cognition and smoking behavior in adult smokers. However, little is known about the effects of repeated presentation of graphic HWL’s on the aforementioned processes. The goal of this study was to examine neural and behavioral responses to graphic HWL’s and evaluate whether the repeated presentation of graphic HWL’s leads to repetition suppression (RS). Smokers (N = 16) performed an event-related HWL cue task while blood oxygen level dependent (BOLD) signal was collected during a functional magnetic resonance imaging (fMRI) experimental session. Consistent …

The Public Health Harms Of Pornography: The Brain, Erectile Dysfunction, And Sexual Violence, John D. Foubert

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.

Low Level Lead Exposure And Inflammatory Markers In The Brains Of C57bl/6j Mice, Miguel A. Cervantes

Open Access Theses & Dissertations

Background and Significance: Prior studies have indicated that early chronic low-level lead exposure may be associated with adverse effects on motor and cognitive functions. The mechanisms by which low-level lead affects brain function are unknown. Objectives: The current study aimed to (1) determine whether early chronic low-level lead exposure altered the expression of pro- or ant-inflammatory cytokines and markers of oxidative stress in mouse brain studied at two ages, pre-adolescence (PND 28) and early adulthood (PND 40); and (2) in the same pre-adolescent and early adulthood mice, compare and contrast the levels of pro- or ant-inflammatory markers in three brain …