Medicine and Health Sciences Commons^™

Gestational Diabetes Augments Group B Streptococcus Infection By Disrupting Maternal Immunity And The Vaginal Microbiota, Vicki Mercado-Evans, Marlyd E Mejia, Jacob J Zulk, Samantha Ottinger, Zainab A Hameed, Camille Serchejian, Madelynn G Marunde, Clare M Robertson, Mallory B Ballard, Simone H Ruano, Natalia Korotkova, Anthony R Flores, Kathleen A Pennington, Kathryn A Patras

Faculty, Staff and Student Publications

Group B Streptococcus (GBS) is a pervasive perinatal pathogen, yet factors driving GBS dissemination in utero are poorly defined. Gestational diabetes mellitus (GDM), a complication marked by dysregulated immunity and maternal microbial dysbiosis, increases risk for GBS perinatal disease. Using a murine GDM model of GBS colonization and perinatal transmission, we find that GDM mice display greater GBS in utero dissemination and subsequently worse neonatal outcomes. Dual-RNA sequencing reveals differential GBS adaptation to the GDM reproductive tract, including a putative glycosyltransferase (yfhO), and altered host responses. GDM immune disruptions include reduced uterine natural killer cell activation, impaired recruitment to placentae, …

Acceptability Of Personalized Lung Cancer Screening Program Among Primary Care Providers, Paul J Resong, Jiangong Niu, Gabrielle F Duhon, Lewis E Foxhall, Sanjay Shete, Robert J Volk, Iakovos Toumazis

Faculty, Staff and Student Publications

Current lung cancer screening (LCS) guidelines rely on age and smoking history. Despite its benefit, only 5%-15% of eligible patients receive LCS. Personalized screening strategies select individuals based on their lung cancer risk and may increase LCS's effectiveness. We assess current LCS practices and the acceptability of personalized LCS among primary care providers (PCP) in Texas. We surveyed 32,983 Texas-based PCPs on an existing network (Protocol 2019-1257; PI: Dr. Shete) and 300 attendees of the 2022 Texas Academy of Family Physicians (TAFP) conference. We analyzed the responses by subgroups of interest. Using nonparametric bootstrap, we derived an enriched dataset to …

Efficacy And Safety Of Autologous Tumor-Infiltrating Lymphocytes In Recurrent Or Refractory Ovarian Cancer, Colorectal Cancer, And Pancreatic Ductal Adenocarcinoma, Rodabe Amaria, Anne Knisely, David Vining, Scott Kopetz, Michael J Overman, Milind Javle, Mara B Antonoff, Ching-Wei D Tzeng, Robert A Wolff, Shubham Pant, Kathryn Lito, Kelly Rangel, Bryan Fellman, Ying Yuan, Karen H Lu, Donastas Sakellariou-Thompson, Cara L Haymaker, Marie-Andrée Forget, Patrick Hwu, Chantale Bernatchez, Amir A Jazaeri

Faculty, Staff and Student Publications

BACKGROUND: Tumor-infiltrating lymphocyte (TIL) therapy has shown efficacy in metastatic melanoma, non-small cell lung cancer, and other solid tumors. Our preclinical work demonstrated more robust CD8 predominant TIL production when agonistic anti-4-1BB and CD3 antibodies were used in early ex vivo TIL culture.

METHODS: Patients with treatment-refractory metastatic colorectal (CRC), pancreatic (PDAC) and ovarian (OVCA) cancers were eligible. Lymphodepleting chemotherapy was followed by infusion of ex vivo expanded TIL, manufactured at MD Anderson Cancer Center with IL-2 and agonistic stimulation of CD3 and 4-1BB (urelumab). Patients received up to six doses of high-dose IL-2 after TIL infusion. Primary endpoint was …

Chronic Respiratory Symptoms Following Deployment-Related Occupational And Environmental Exposures Among Us Veterans, Eric Garshick, Carrie A Redlich, Anna Korpak, Andrew K Timmons, Nicholas L Smith, Karen Nakayama, Coleen P Baird, Paul Ciminera, Farrah Kheradmand, Vincent S Fan, Jaime E Hart, Petros Koutrakis, Ware Kuschner, Octavian Ioachimescu, Michael Jerrett, Phillipe R Montgrain, Susan P Proctor, Emily S Wan, Christine H Wendt, Cherry Wongtrakool, Paul D Blanc

Faculty, Staff and Students Publications

Objectives: Characterise inhalational exposures during deployment to Afghanistan and Southwest Asia and associations with postdeployment respiratory symptoms.

Methods: Participants (n=1960) in this cross-sectional study of US Veterans (Veterans Affairs Cooperative Study 'Service and Health Among Deployed Veterans') completed an interviewer-administered questionnaire regarding 32 deployment exposures, grouped a priori into six categories: burn pit smoke; other combustion sources; engine exhaust; mechanical and desert dusts; toxicants; and military job-related vapours gas, dusts or fumes (VGDF). Responses were scored ordinally (0, 1, 2) according to exposure frequency. Factor analysis supported item reduction and category consolidation yielding 28 exposure items in 5 categories. Generalised …

Association Between Malaria Educational Message Exposure And Malaria Prevalence Among Children In Nigeria, Eberechukwu Jacob Ajiwe

Walden Dissertations and Doctoral Studies

No abstract provided.

Covid-19 Vaccine And Survival Of Diabetes Patient On Dialysis, Luis Guillermo De Jesús Iii Vega

Walden Dissertations and Doctoral Studies

No abstract provided.

African Americans’ Nutrition And Dietary Management Experiences To Mitigate Congestive Heart Failure, Chukwuemeke Joseph Onokwai

Walden Dissertations and Doctoral Studies

No abstract provided.

Patient Satisfaction With A Coach-Guided, Technology-Based Mental Health Treatment: Qualitative Interview Study And Theme Analysis, Ashley Helm Smith, Hilary Touchett, Patricia Chen, Terri Fletcher, Jennifer Arney, Julianna Hogan, Miryam Wassef, Marylene Cloitre, Jan A Lindsay

Faculty, Staff and Students Publications

Background: Technology-based mental health interventions address barriers rural veterans face in accessing care, including provider scarcity and distance from the hospital or clinic. webSTAIR is a 10-module, web-based treatment based on Skills Training in Affective and Interpersonal Regulation, designed to treat posttraumatic stress disorder and depression in individuals exposed to trauma. Previous work has demonstrated that webSTAIR is acceptable to participants and effective at reducing symptoms of posttraumatic stress disorder and depression when delivered synchronously or asynchronously (over 5 or 10 sessions).

Objective: This study explored factors that lead to greater patient satisfaction with webSTAIR, a web-based, coach-guided intervention.

Methods: …

Assessing Suboptimal Health Status In The Saudi Population: Translation And Validation Of The Shsq-25 Questionnaire, Mohamed A. Alzain, Collins O. Asweto, Sehar-Un-Nisa Hassan, Mohammed E. Saeed, Ahmed Kassar, Kamal E. M. Ali, Mouna Ghorbel, Rafat Zrieq, Bandar Alsaif, Wei Wang

Research outputs 2022 to 2026

Background: Suboptimal Health Status (SHS) is realised as a vital feature for improving global health. However, the Arabian world does not have a validated instrument for screening SHS in their population. Therefore, the study aimed to evaluate the psychometric properties of Arabic-translated SHS (ASHSQ-25) in the Saudi Arabian population. Methods: We conducted a cross-sectional study among the conveniently sampled 1590 participants from the Saudi population (with a 97.4% response rate). The data was gathered through an online survey and then exported into SPSS and AMOS version 26.0 for analysis. Mann-Whitney and Kruskal-Wallis tests were used to identify the median difference …

"I Live My Best Life In The Garden": Project Dig Summary Report, Tracy Boehm Barrett, University Of Montana Rural Institute

Health and Wellness

People with intellectual and developmental disabilities (IDD) are commonly overlooked in society because of a combination of social, economic, political, and cultural barriers. Due to such constraints, they also experience a wide range of health and community disparities that result in negative impact on their quality of life and well-being (Mpofu et al., 2020; Akyurek & Bumin, 2017). While many community-based organizations provide a variety of supports for people with disabilities, far less common are those providing therapeutic horticulture (TH) programs within the scope of their services. This report provides information about and recommendations for TH as an increased practice …

A Validation Study Of The Occupational Depression Inventory In Poland And Ukraine, Krystyna Golonka, Karine O. Malysheva, Dominika Fortuna, Bożena Gulla, Leon T. De Beer, Irvin Sam Schonfeld, Renzo Bianchi

Publications and Research

This study examined the psychometric and structural properties of the Polish and Ukrainian versions of the Occupational Depression Inventory (ODI). We relied on two samples of Polish employees (NSample1 = 526, 47% female; NSample2 = 164, 64% female) and one sample of Ukrainian employees (NSample3 = 372, 73% female). In all samples, the ODI exhibited essential unidimensionality and high total-score reliability (e.g., McDonald’s omegas > 0.90). The homogeneity of the scale was strong (e.g., 0.59 ≤ scale-level Hs ≤ 0.68). The ODI’s total scores thus accurately ranked individuals on a latent occupational depression continuum. We found evidence of complete measurement invariance …

Assessment Of Salivary Cadmium Levels And Breast Density In The Marin Women's Study, Michaela F. George, Shayne Paff, Jenyse Rojo, Mark Powell, Christopher Benz, Karl Pope, Karla Kerlikowske, John Shepard, Matthew Willis, Rochelle Ereman, Leeann Prebil

Global Public Health | Faculty Scholarship

Background: We aimed to determine if salivary cadmium (Cd) levels had any association with breast density, hoping to establish a less invasive cost-effective method of stratifying Cd burden as an environmental breast cancer risk factor.

Methods: Salivary Cd levels were quantified from the Marin Women's Study, a Marin County, California population composite. Volumetric compositional breast density (BDsxa) data were measured by single x-ray absorptiometry techniques. Digital screening mammography was performed by the San Francisco Mammography Registry. Radiologists reviewed mammograms and assigned a Breast Imaging-Reporting and Data System score. Early morning salivary Cd samples were assayed. Association analyses were then …

Impact Of Point-Of-Care Ultrasound Use On Patient Referral Decisions In Rural Kenya: A Mixed Methods Study., Grace Wanjiku, Gregory Bell, Sonja Kapadia, Benjamin Wachira

Emergency Medicine, East Africa

Background: Point-of-care ultrasound (POCUS) is recognized as a key imaging modality to bridge the diagnostic imaging gap in Low- and Middle-Income Countries (LMICs). POCUS use has been shown to impact patient management decisions including referral for specialist care. This study explored the impact of POCUS use on referral decisions among trained healthcare providers working in primary rural and peri-urban health facilities in Kenya.

Methods: A concurrent mixed methods approach was used, including a locally developed survey (N=38) and semistructured interviews of POCUS trained healthcare providers (N=12). Data from the survey was descriptively analyzed and interviews were evaluated through the framework …

Association Between Community Social Vulnerability And Preventable Hospitalizations, Rachel Hogg-Graham, Joseph A. Benitez, Mary E. Lacy, Joshua Bush, Juan Lang, Haritomane Nikolaou, Emily R. Clear, J. M. Mccullough, Teresa M. Waters

Public and Population Health Faculty Publications and Presentations

Preventable hospitalizations are common and costly events that burden patients and our health care system. While research suggests that these events are strongly linked to ambulatory care access, emerging evidence suggests they may also be sensitive to a patient’s social, environmental, and economic conditions. This study examines the association between variations in social vulnerability and preventable hospitalization rates. We conducted a cross-sectional analysis of county-level preventable hospitalization rates for 33 states linked with data from the 2020 Social Vulnerability Index (SVI). Preventable hospitalizations were 40% higher in the most vulnerable counties compared with the least vulnerable. Adjusted regression results confirm …

Alzheimer’S Disease And Inflammatory Biomarkers Positively Correlate In Plasma In The Uk-Adrc Cohort, Kate E. Foley, Zachary Winder, Tiffany L. Sudduth, Barbara J. Martin, Peter T. Nelson, Gregory Jicha, Jordan P. Harp, Erica M. Weekman, Donna M. Wilcock

Neurology Faculty Publications

INTRODUCTION: Protein-based plasma assays provide hope for improving accessibility and specificity of molecular diagnostics to diagnose dementia. METHODS: Plasma was obtained from participants (N = 837) in our community-based University of Kentucky Alzheimer’s Disease Research Center cohort. We evaluated six Alzheimer’s disease (AD)- and neurodegeneration-related (Aβ40, Aβ42, Aβ42/40, p- tau181, total tau, and NfLight) and five inflammatory biomarkers (TNF𝛼, IL6, IL8, IL10, and GFAP) using the SIMOA-based protein assay platform. Statistics were performed to assess correlations. RESULTS: Our large cohort reflects previous plasma biomarker findings. Relationships between biomarkers to understand AD–inflammatory biomarker correlations showed significant associations between AD and inflammatory …

The Effect Of Centering Pregnancy Group Antenatal Care On Maternal, Birth, And Neonatal Outcomes Among Low-Risk Women In The Netherlands: A Stepped-Wedge Cluster Randomized Trial, Mary-Ann Wagijo, Mathilde Crone, Birgit Bruinsma-Van Zwich, Jan Van Lith, Deborah Lynn Billings Phd, Marlies Rijnders

Publications

Introduction

This study was carried out to assess the effects of participating in CenteringPregnancy (CP) on maternal, birth, and neonatal outcomes among low-risk pregnant women in the Netherlands.

Methods

A total of 2124 pregnant women in primary care were included in the study. Data were derived from the Dutch national database, Perined, complemented with data from questionnaires completed by pregnant women. A stepwise-wedge design was employed; multilevel intention-to-treat analyses and propensity score matching were the main analytic approaches. Propensity score matching resulted in sample sizes of 305 nulliparous women in both the individual care (IC) and the matched control group …

A04: A Pilot Study On The Persistence Of Children's Online Sports Games, Haoye Shen, Xiaozan Wan, Meiyuan Chen, Mengke Kang, Hao Li, Yiang Yuan

International Journal of Physical Activity and Health

Purpose: In the post-epidemic era, children's physical activity has decreased sharply, and smart sports at home have gradually emerged, making online sports games an important path for children's sports participation. This pilot study was to explore the persistence of children's online sports game participation through exercise frequency recording and provided guidance for online sports game intervention programs. Methods: A total of 29 primary school children were enrolled, including 24 boys and 5 girls. Participants exercise autonomously through motion software. In this study, the movement of each participant was recorded through the background of the software system and exported to Excel. …

A01: A Pilot Study Of Student Cadres Mental Health At A Sport University During Covid-19, Yuan Yuan, Haijun Han, Hongwei Guan

International Journal of Physical Activity and Health

Purpose: Over 90% of college students have experienced negative mental health symptoms due to the pandemic, according to a survey from BestColleges.com. More than half (54%) of college students believe COVID-19 circumstances have impacted their mental health. Although the pandemic's influence on mental health expanded, not all students have felt its effects to the same degree. Physical activity has been reported to have many physical and mental health benefits. Students at sport universities tend to participate in more sport and physical activity. During the pandemic, student cadres are expected to take more responsibilities such as coordinating COVID-19 tests and interacting …

A10: Analyzing Perceptual Differences Toward Esports Among Students Across Various Educational Levels Of America, Xianhua Luo, Li Chen, Yong Yang, Hui Deng

International Journal of Physical Activity and Health

Purpose: Electronic sports (Esports) draw increasing attention in the world and become popular across institutions of American higher education. Scholars in Esports research have explored various findings and discussions related to education, marketing and promotion, organization and management, and sociology and psychology of sport. However, the perceptual differences of Esports participants remain unknown across educational levels across American institutions. The purposes of this study were to examine the perceptual differences toward Esports across educational levels in the United States. Methods: A total of 397 voluntary participates with various education levels took part in a reginal survey in the east coast …

A52: Practice Research On Orientation Movement Teaching In Primary School, Ziying Zeng, Haicheng Wen, Liyan Lao, Shunzhou Du, Yuntao Zeng

International Journal of Physical Activity and Health

Purpose: Sports shoulder the important task of improving the physical health of teenagers, is an indispensable part of the school quality education, more importantly, is to undertake the fundamental mission of moral cultivation. Orienteering is a new sports project integrating intelligence and physical strength. It not only strengthens the body, but also improves the students' self-control ability such as thinking and judging ability and solving difficulties by themselves, so as to truly realize the ideal effect of "sports people". Methods: From the perspective of the implementation of school-based orienteering curriculum in our school, this paper adopts experimental methods, mathematical statistics …

A56: Mediation Analysis Of Association Between Fundamental Motor Skills And Physical Activity In Elementary School Students, Jun Chen, Xiaozan Wang, Ouyi Chen, Haizhu Long

International Journal of Physical Activity and Health

Purpose: This study aimed to investigate the association of fundamental motor skills (FMS), perceived motor competence (PMC), physical activity (PA) in elementary school students, as well as to examine whether PMC mediated the relationship between FMS and PA. Methods: Participants were 470 3-6th grade students (210 boys vs. 242 girls; Mean age = 10.11 years old; SD = 1.19) at five elementary schools from the province of Hunan in China. The students’ FMS were assessed with The Test of Gross Motor Development-3, PMC was assessed using the perceived athletic competence sub-scale of Harter’s Self-perception profile for children and PA were …

A57: A Study On The Correlation Between Basic Motor Skills And Attention, Parent-Child Relationship And Behavior, Mengke Kang, Xiaozan Wang, Meiyuan Chen, Haoye Shen

International Journal of Physical Activity and Health

Purpose: In the Curriculum Standards of Physical Education and Health for Compulsory Education (2022 Edition) newly issued by China in 2022, basic motor skills are included in the curriculum, requiring students to learn, practice and experience mobility skills, control skills, manipulative skills, and other basic motor skills. The purpose of this study is to explore the correlation between basic motor skills and pupils' attention, parent-child relationship, and behavior, and to provide a theoretical basis for its further implementation. Methods: In this study, 45 primary school students from Malu Primary School, Jiading District, Shanghai, with an average age of 9.76 years …

A60: Gait Kinematics Characteristics Of The Overweight And Obese Elderly At Different Walking Speeds, Liu Min

International Journal of Physical Activity and Health

Purpose: Gait is associated with falls. Overweight, obesity and falls are prominent problems affecting the healthy life of the elderly in China. The purpose of this study is to measure the gait kinematic parameters of the overweight and obese elderly using BTS SMART DX Motion Capture System, and to analyze the gait characteristics of the overweight and obese elderly when walking with different speeds, so as to provide reference for the prevention of falls in the overweight and obese elderly. Methods: A total of 42 healthy old women (overweight or obese group: N = 20, age = 67.36±6.11 yrs.; normal …

A70: An Experimental Study Of Sports Vr Equipment On Cultivating High School Students' Interest In Sports, Zhang Rui

International Journal of Physical Activity and Health

Purpose: The incorporation of VR virtual teaching has garnered significant attention, with its applications spanning various disciplines and fields. Notably, in the realm of physical education, VR integration has not only contributed to the enhancement of instructional effectiveness but has also played a pivotal role in fostering the holistic development and personality growth of students. The primary objective of this study is to investigate whether VR virtual teaching can elevate the interest of high school students in the learning of physical education. Methods: Eighty students in high school were recruited and randomly divided into experimental and control groups (40 students …

A67: The Influence Of Physical Exercise On College Students' Psychological Pressure: A Chain Intermediary Effect, Zhenqi Zhou, Zhen Li

International Journal of Physical Activity and Health

Purpose: At this stage, the increasingly fierce social competition makes college students face significant challenges while striving for development opportunities. They will encounter various setbacks and challenges, causing excessive psychological pressure on college students, which will affect their mental health. As an effective means to promote people's physical and mental development, physical exercise plays an important role in the development of college students, It plays a very important role in relieving college students' psychological pressure. Therefore, it is particularly important to study how physical exercise affects college students' psychological pressure and the role of other factors. The purpose of this …

A111: Relationship Between Physical Activity And Mental Toughness: A Cross-Sectional Study Among Chinese College Students, Ke Wang, Jiaju Hu

International Journal of Physical Activity and Health

Purpose: Physical activity has favorable impacts on exercisers' stress levels, psychological distress and anxiety, emotional regulation, and mental wellness. In recent years, the global outbreak of COVID-19 has subtly altered college students' lifestyles. Studies have shown that the physical and mental health of students has deteriorated dramatically, which is alarming. Mental toughness refers to the ability to adapt well in the face of major pressures, setbacks, and adversity in life. The purpose of the present study was to examine variations in mental toughness depending on the intensity, length, and frequency of physical activity. Methods: A total of 3,120 Chinese college …

A127: Difficulties Facing And Coping Strategies Of Physical Education And Health Interdisciplinary Teaching In China, Jie Yang, Liping Xu, Zhihua Yin

International Journal of Physical Activity and Health

Purpose: In response to the national demand for compound talents, “Physical Education (PE) and Health Curriculum (2022 version) for Compulsory Education” proposes to include interdisciplinary teaching in five major courses in China. Due to the lack of course cases for reference, there’s a certain gap between interdisciplinary theory and practice. Therefore, it’s urgent to analyze the difficulties faced by interdisciplinary teaching and find out the coping strategies. Methods: By using keywords such as "interdisciplinary teaching," "PE and health curriculum," and "interdisciplinary," this study collected and studied 39 articles from CNKI, Web of Science, Scopus, and other databases, and analyzed the …

A123: Research Progress And Review Of Key Competencies Of Physical Education Curriculum In China, Liping Xue, Zhihua Yin

International Journal of Physical Activity and Health

Purpose: The introduction of the "Opinions on Comprehensively Deepening Curriculum Reform and Implementing the Fundamental Task of Establishing Virtues and Cultivating People" marked the initiation of comprehensive curriculum reform across all disciplines in our country, with a particular emphasis on key competencies. Among these competencies, those integral to the Physical Education (PE) curriculum have garnered increasing attention from scholars. Building upon this foundation, this paper systematically reviews and analyzes pertinent research on the key competencies within the PE curriculum. The exploration covers the development process, current research hotspots, and future prospects in this field, aiming to serve as a reference …

A143: Influence Of Sports Participation On Females’ Health In The Cold Cities Of Northeast China, Chenxu Zuo

International Journal of Physical Activity and Health

Purpose: People living in the northeastern, cold region of China have been enduring a severe climate. It’s well known that sports participation can promote health. However, there is a lack of research on sports participation among urban females in cold areas of China. Therefore, this study aims to analyze the influence of sports participation on urban females’ health in northeastern China. Methods: A total of 305 urban females (aged 39 years) from Harbin completed an online survey, which asks about demographic information, health status, and sports participation. Health status was assessed by measuring three dimensions of health-related indicators (BMI, chronic …

A153: The Relationships Between Physical Activity And Health-Related Quality Of Life In Parent-Child Dyads With Asd, Yu Song, Bo Shen

International Journal of Physical Activity and Health

Purpose: Researchers have found that the core and combined symptoms of autism spectrum disorder (ASD) negatively influence the health-related quality of life (HRQoL) of autistic children and their parents. Although it is supported that participation in physical activity (PA) can enhance the HRQoL and well-being in general, few studies have addressed the relationship between HRQoL with PA in the population with ASD. This study examines how much leisure-time physical activity participation is correlated to HRQoL in parent-child dyads with ASD. Method: Participants were recruited from two Rehabilitation Centers for neurodevelopmental disability children. Eighty-five ASD children and their parents participated in …