Medicine and Health Sciences Commons^™

Characteristic And Survival Analysis Of Infants With Critical Congenital Heart Disease, Suprohaita Rusdi Talib, Johanes Edy Siswanto, Mulyadi M. Djer, Nurzalia Safanta, Syifa Nurhakiki, Khobir Abdul Karim Taufiqurahman, Asri Adisasmita

Kesmas

Congenital heart disease (CHD) is a major health concern worldwide. This study focused on survival analysis and the factors influencing survival in infants with critical congenital heart disease (CCHD). A total of 79 infants diagnosed with CCHD were identified, with 48.1% (n=38) exhibiting duct-dependent pulmonary circulation, 35.6% (n=28) exhibiting duct-dependent systemic circulation, 6.3% (n=5) exhibiting critical non-duct-dependent, and 10.2% (n=8) exhibiting parallel circulation issues. Of the infants studied, 55.7% (n=44) were male, 78.5% (n=62) had a gestational age of ≥37 weeks, 62% (n=49) had a birth weight of ≥2,500 grams, 59.5% (n=47) exhibited normal fetal growth, 93.7% (n=74) experienced no …

Adolescent Reproductive Health Promotion For Senior High School Students, Niken Meilani, Sunarru Samsi Hariadi, Fransiskus Trisakti Haryadi

Kesmas

Adolescence is a vulnerable period to reproductive health problems, especially regarding issues of sexuality. Healthy adolescent behavior is needed to achieve the SDGs targets by 2030. This study aimed to analyze personal factors such as attitudes, perceptions, and self-efficacy, as well as environmental factors like family, school, friends, community, and social media's role in adolescent reproductive health behavior and health promotion models. This quantitative analysis was conducted using the survey method with 326 respondents at 32 senior high schools, involving 159 male and 167 female adolescents, as samples taken through a multistage random sampling technique. This study used a questionnaire …

Prevalence Of Low Back Pain Among Office Workers During The Covid-19 Pandemic In Various Countries: A Systematic Review, Yosephine Roma Intan, Ririn Arminsih Wulandari, Popy Yuniar

Kesmas

The COVID-19 pandemic has led to the implementation of work from home policies in almost all parts of the world. This policy has increased the onset of musculoskeletal disorders in workers, such as low back pain (LBP). This study aimed to examine the prevalence of LBP among office workers during the COVID-19 pandemic after implementing WFH policies. This study was performed using data from various countries to determine the relationship between LBP and several risk factors, specifically age, sex, physical activity, ergonomic factors, as well as work environment factors such as temperature, humidity, lighting, noise, and work duration. A systematic …

Exploring Physician Well-Being: A Bibliometric Analysis Of Mental Health, Suriya Kumareswaran, Bala Murali Sundram, Vanitha Thurairasu

Kesmas

This bibliometric study examined the evolving research landscape on physician mental health from 2010 to 2023, analyzing key themes, publication trends, and global contributions. A total of 3,360 articles, including 3,137 original research and 223 reviews, were sourced from Web of Science and Scopus. Findings revealed a significant increase in research output, particularly during the COVID-19 pandemic, with burnout, depression, and anxiety emerging as dominant themes. The US accounted for most publications, while research from low- and middle-income countries remains limited, indicating a substantial global disparity. Thematic analysis highlighted variations in burnout assessment methodologies, underscoring the need for standardized evaluation …

Determinants Of Adolescent Resilience Levels In Surabaya City, East Java Province, Indonesia, Riris Diana Rachmayanti, Fatwa Sari Tetra Dewi, Diana Setiyawati, M Dody Izhar, Andrei Ramani

Kesmas

Assessing adolescent resilience may provide valuable insights into adult resilience. This study aimed to analyze the relationship between determinants and adolescent resilience in Surabaya City. The participants of this cross-sectional study were 277 adolescents aged 12–19 years who were in senior high school. The outcome was the resilience levels. This study's findings indicated relationships between resilience levels and stress experience (p-value = 0.01), access to mental health information (p-value = 0.00), life satisfaction (p-value = 0.00), family harmony (p-value = 0.03), presence of adults to share (p-value = 0.04), feeling safe at home, school, and community (p-value = 0.00), perception …

Five-Year Journey Of Technical Assistance In Health Governance Reforms: A Case Report, Popy Yuniar, Indang Trihandini, Ibnu Muyassar, Latifatul Khoiriyah, Minawati Minawati, Fathiyya Aliyah Birjaman, Tyra Septi Diana, Annabel Serafina, Hertina Raisa Putri, Rana Maimunah, Riko Setiawan, Nadazaira Alifia Ramadhianisa, Aris Diyanto

Kesmas

Many districts and cities in Indonesia continue to have Public Health Development Index scores below the national average, highlighting the need for improved health governance. This study assessed the five-year impact (2019–2023) of a mentoring program for 149 District Health Offices in preparing annual work plans, focusing on stagnation or performance declines. Using a qualitative approach, the study analyzed annual work plan scores before and after technical assistance, conducted focus group discussions, and carried out in-depth interviews to identify challenges. Key barriers included data management issues, weak advocacy, knowledge transfer gaps, and poor cross-sectoral coordination, which hindered decision-making and program …

Help-Seeking Behavior And Related Mental Health Promotion Programs In Southeast Asian Youth: A Systematic Literature Review, Gladys Octavia, James A. Doorbar, Kallista Chan

Kesmas

Mental health issues are a prominent burden among adolescents and young adults in Southeast Asia, compounded by reluctance to seek help and low treatment rates. This mixed-method systematic review analyzed help-seeking profiles (preference, facilitators, and barriers) and evaluated implemented help-seeking programs. Data were sourced from electronic databases, hand-searched local databases, conference proceedings, and grey literature. Study selection followed PRISMA 2020 guidelines, focusing on 1) adolescents (10–19 years) and young adults (18–26 years) in Southeast Asia who were not receiving mental health care, 2) assessing help-seeking behavior, and 3) evaluating programs to increase help-seeking. A total of 16 articles were identified. …

Public Health Entrepreneurship In Indonesia: What Is Next?, Hadi Pratomo, Roy Darmawan, Karina Samaria

Kesmas

Public health has been demanded to search for ways to improve well-being by tackling societal and ecological factors that influence health through cooperative strategies and partnerships across various fields. More interdisciplinary, interprofessional, and action-oriented approaches toward sustainable public health programs are recommended to be made. Therefore, public health entrepreneurship is an indispensable approach to creating new interventions that address future public health problems. The Indonesian Ministry of Health conceptualized five public health entrepreneurship skills as standard competence for public health personnel. In addition, the Association of Indonesian Public Health Higher Education Institutions has identified several study materials and learning outcomes …

Reducing Burnout Among Physiatry Trainees During The Pandemic: Instituting A Wellness Retreat, Edwin Amirianfar, Oliver Acosta, Eduard Tiozzo, Joslyn Gober, Monica Verduzco-Gutierrez

Journal of Wellness

Introduction: Burnout has been described as “a state of mental and physical exhaustion related to work or caregiving activities.” Among resident physicians, burnout is a serious concern that can lead to medical errors and negative patient outcomes. To combat burnout among physiatry trainees during the COVID-19 pandemic, an innovative wellness retreat was created and implemented at the University of Miami’s Physical Medicine and Rehabilitation (PM&R) Residency Program in March 2021 and February 2022.

Methods: The retreat curriculum was designed by the PM&R Residency Wellness Committee and supported by departmental funding. The retreat(s) consisted of three strategies: education and discussion on …

Pornography, Problematic Use And Academic Outcomes In College Students: A Cross-Sectional Analysis, Promise Tewogbola, Victoria Bodunde, Deborah Odaudu

Journal of Graduate Education Research

Background: The prevalence of pornography consumption among college students has raised concerns about its potential impact on academic performance. This study aims to examine the relationships between pornography use, academic outcomes, and problematic pornography use among university students.

Methods: A cross-sectional study was conducted with 739 students from a Midwestern U.S. state university. Participants completed an online survey assessing demographics, grade point average (GPA), pornography consumption frequency, Academic Success Inventory (ASI) scores, and Problematic Pornography Use (PPU) scale scores. Logistic and linear regression analyses were used to examine associations between variables.

Results: Pornography consumers had 41% lower odds of …

More Than Numbers: Black Adolescents’ Journey With Type 1 Diabetes Management, Vanessa Di Felice

Walden Dissertations and Doctoral Studies

Black adolescents with Type 1 diabetes mellitus (T1DM) face significant health disparities, yet their unique treatment journeys remain largely underreported. This phenomenological qualitative study explored the lived experiences of Black adolescents with T1DM. The study addressed two research questions examining how these individuals experience and navigate T1DM self-management, self-efficacy beliefs, and perceived barriers and facilitators to optimal self-care. Virtual semi-structured interviews were conducted with 15 Black adolescents with T1DM recruited from a pediatric hospital in Washington, DC. The study utilized Bandura's social cognitive theory as the theoretical framework. Thematic data analysis identified four key themes: (1) character development through knowledge …

Analysis Of Interprofessional Education Perceptions At The Team Level: A Study Across Three Student Cohorts, Tina Gunaldo, Kelsey Witmeier, Harun Mazumder, Sharon Duffy, Colette Baudoin, Henry Sauviac, Susanne Straif-Bourgeois, Scott Edwards

Center for Interprofessional Education and Collaborative Practice Papers

The interprofessional education (IPE) literature showcases many studies reporting results at the all-student and academic program levels. However, if the purpose of IPE is to develop collaborative-practice ready professionals, analysis at the team level would better support the advancement of the IPE literature and future health care goals. Pre-licensure students engaged in a two-year IPE curriculum and individually completed the Student Perceptions of Interprofessional Clinical Education-Revised survey, version 2 (SPICE-R2), at the end of the first and second year. Teams were comprised of health profession students from 12 academic programs associated with the university. Exploratory and longitudinal analyses of the …

Interim Estimates Of 2024-2025 Seasonal Influenza Vaccine Effectiveness - Four Vaccine Effectiveness Networks, United States, October 2024-February 2025., Aaron M. Frutos, Seana Cleary, Emily L. Reeves, Haris M. Ahmad, Ashley M. Price, Wesley H. Self, Yuwei Zhu, Basmah Safdar, Ithan D. Peltan, Kevin W. Gibbs, Matthew C. Exline, Adam S. Lauring, Sarah W. Ball, Malini Desilva, Sara Y. Tartof, Kristin Dascomb, Stephanie A. Irving, Nicola P. Klein, Brian E. Dixon, Toan C. Ong, Ivana A. Vaughn, Stacey L. House, Kiran A. Faryar, Mary Patricia Nowalk, Manjusha Gaglani, Karen J. Wernli, Vel Murugan, Olivia L. Williams, Rangaraj Selvarangan, Geoffrey A. Weinberg, Mary A. Staat, Natasha B. Halasa, Leila C. Sahni, Marian G. Michaels, Janet A. Englund, Marie K. Kirby, Diya Surie, Fatimah S. Dawood, Benjamin R. Clopper, Heidi L Moline, Ruth Link-Gelles, Amanda B. Payne, Elizabeth Harker, Kristina Wielgosz, Zachary A. Weber, Duck-Hye Yang, Nathaniel M. Lewis, Jennifer Decuir, Samantha M. Olson, Jessie R. Chung, Brendan Flannery, Lisa A. Grohskopf, Carrie Reed, Shikha Garg, Sascha Ellington, Cdc Influenza Vaccine Effectiveness Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim influenza vaccine effectiveness (VE) was calculated among patients with acute respiratory illness-associated outpatient visits and hospitalizations from four VE networks during the 2024-25 influenza season (October 2024-February 2025). Among children and adolescents agedyears, VE against any influenza was 32%, 59%, and 60% in the outpatient setting in three networks, and against influenza-associated hospitalization was 63% and 78% in two networks. Among adults aged ≥18 years, VE in the outpatient setting was 36% and 54% in two networks and was 41% and 55% against hospitalization …

Complement Activity And Autophagy Are Dysregulated In The Lungs Of Patients With Nonresolvable Covid-19 Requiring Lung Transplantation, Pooja Shivshankar, Stacey L Mueller-Ortiz, Aleksey Y Domozhirov, Weizhen Bi, Scott D Collum, Marie-Francoise Doursout, Manish Patel, Isabella N Lefebvre, Bindu Akkanti, Simon Yau, Howard J Huang, Rahat Hussain, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced nonresolvable lung disease. While the complement system is involved in opsonization and phagocytosis of the invading pathogens, uncontrolled complement activation also leads to aberrant autophagic response and tissue damage. Our recent study revealed unique pathologic and fibrotic signature genes associated with epithelial bronchiolization in the lung tissues of patients with nonresolvable COVID-19 (NR-COVID-19) requiring lung transplantation. However, there is a knowledge gap if complement components are modulated to contribute to tissue …

Interim Estimates Of 2024-2025 Seasonal Influenza Vaccine Effectiveness - Four Vaccine Effectiveness Networks, United States, October 2024-February 2025, Aaron M Frutos, Seana Cleary, Emily L Reeves, Haris M Ahmad, Ashley M Price, Wesley H Self, Yuwei Zhu, Basmah Safdar, Ithan D Peltan, Kevin W Gibbs, Matthew C Exline, Adam S Lauring, Sarah W Ball, Malini Desilva, Sara Y Tartof, Kristin Dascomb, Stephanie A Irving, Nicola P Klein, Brian E Dixon, Toan C Ong, Ivana A Vaughn, Stacey L House, Kiran A Faryar, Mary Patricia Nowalk, Manjusha Gaglani, Karen J Wernli, Vel Murugan, Olivia L Williams, Rangaraj Selvarangan, Geoffrey A Weinberg, Mary A Staat, Natasha B Halasa, Leila C Sahni, Marian G Michaels, Janet A Englund, Marie K Kirby, Diya Surie, Fatimah S Dawood, Benjamin R Clopper, Heidi L Moline, Ruth Link-Gelles, Amanda B Payne, Elizabeth Harker, Kristina Wielgosz, Zachary A Weber, Duck-Hye Yang, Nathaniel M Lewis, Jennifer Decuir, Samantha M Olson, Jessie R Chung, Brendan Flannery, Lisa A Grohskopf, Carrie Reed, Shikha Garg, Sascha Ellington, Cdc Influenza Vaccine Effectiveness Collaborators

Faculty, Staff and Students Publications

Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim influenza vaccine effectiveness (VE) was calculated among patients with acute respiratory illness–associated outpatient visits and hospitalizations from four VE networks during the 2024–25 influenza season (October 2024–February 2025). Among children and adolescents aged <18 years, VE against any influenza was 32%, 59%, and 60% in the outpatient setting in three networks, and against influenza-associated hospitalization was 63% and 78% in two networks. Among adults aged ≥18 years, VE in the outpatient setting was 36% and 54% in two networks and was 41% and 55% against hospitalization in two networks. Preliminary estimates indicate that receipt of the 2024–2025 influenza vaccine reduced the likelihood of medically attended influenza and influenza-associated hospitalization. CDC recommends annual receipt of an age-appropriate influenza vaccine by all eligible persons aged ≥6 months as long as influenza viruses continue to circulate locally.

Jc Polyomavirus Pooled Seropositivity Prevalence In Healthy Subjects, Lenka J. Kimla

Walden Dissertations and Doctoral Studies

JC polyomavirus (JCV) causes progressive multifocal leukoencephalopathy in immunocompromised individuals and has been linked to cancer development. To-date, no information is available about the JCV seroprevalence in the healthy (nondiseased) population or whether this virus is ecologically connected to humans. The aim of this systematic literature review and meta-analysis was to the estimate the overall seroprevalence of JCV in the healthy human population by age, region, and testing method. A meta-analysis conducted on 24 studies revealed a pooled JCV seroprevalence of 60% (95% CI, 55% - 65%) with statistically significant effect size (z = 32.93, p < 0.001). Meta-regression and subgroup analyses with STATA18 showed that age and region had a strong positive predictive value on prevalence (R = .578, R2 = 0.334, F(2,52) = 12.543, p < 0.001) whereas the testing method had no significant effect on prevalence. The theories that grounded this study were the ecological model and the systems theory, which support the study result that JCV appears to be ubiquitous in the human population with JCV being acquired very early in life. The results of the systematic literature review indicated that JCV is transmitted via fecal-oral and respiratory routes within and outside of families. Most infants are infected with JCV by the age of 6 months and JCV seronegativity may not be indicative of a lack of an underlying JCV infection. JCV seropositivity increases with age, which is most probably by viral reactivation due to immune senescence. These findings have positive social change implications with JCV treatment, screening, and vaccine development.

Improving Financial Sustainability Through A 990n-Sized Charity’S Fundraising-Activity Audit, Eileen Callejas

Walden Dissertations and Doctoral Studies

Current scholarly literature has asserted that large non-profit organizations benefit from conducting fundraising-activity audit portfolio analyses. However, suitable techniques and tools that ultra-small nonprofits (990N-sized charities) can use to improve their fundraising-activity analyses have not been clearly established. The research problem was in modifying tools that work efficiently for hyper-localized charities to compare the effectiveness of their fundraising-activities. Preferred tools were needed to reinforce ideation and align improvements within the charities’ known constraints. The purpose of this study was to explore three suitably modified instruments that could be used for fundraising-activity auditing. Based on Ostrom’s institutional analysis and development framework, …

Implementing A Comprehensive Care Model To Improve Diabetes Management In Underserved Communities, Hector Trejo, Leticia Rodriguez

MEDI 9331 Scholarly Activities Clinical Years

Diabetes is a major public health issue, particularly in underserved communities with limited healthcare access. This study evaluates the effectiveness of the Comprehensive Care Model (CCM) in improving diabetes management at three Area Health Education Center (AHEC) sites in the Rio Grande Valley (RGV). A retrospective analysis was conducted on 858 patients, categorized as prediabetic (A1C 5.7-6.4) or diabetic (A1C ≥6.5). Of these, 54 patients in each group had confirmed follow-up A1C values after a minimum of three months. The study assessed the impact of three core CCM interventions—Primary Health Services (PHS), Diabetes Education (DE), and Community Health Worker (CHW) …

Associations Of Parental Perceived Health With Child Movement Behaviors Within Two-Parent Households, You Fu, Hayley Almes, Nora Constantino, Doria Schmidt, Ryan D. Burns

International Journal of Physical Activity and Health

This study aimed to examine how perceived parental mental and physical health status was associated with child physical activity, screen time, and sleep. Participants were 6- to 17-year-old minors (N = 20,156; 47.9% female) from the 2022 US National Survey of Children’s Health. Dependent variables were children’s physical activity frequency, screen time, and sleep. Independent variables were parents’ physical and mental health status. Using the Actor-Partner Interdependence Model, two adjusted path models were constructed. One for parent mental health associating with parental physical health, another for parent physical health associating with parental mental health–both further associating with child movement behaviors. …

Survey Of Mosquito Larval Habitats At The Ksu Field Station, Rose Sofia, Eli Lovvorn, Aspen Hartman, Andrew Haddow

Symposium of Student Scholars

The greater Atlanta metropolitan area hosts numerous mosquito species that are nuisance biters and can transmit arthropod-borne diseases to humans. We surveyed the Kennesaw State University (KSU) Field Station – an incredibly biodiverse location – where student, staff, and faculty-led groups engage in outdoor research and teaching activities. The KSU Field Station located in Cobb County, GA is a heavily trafficked 25-acre property that may attract various mosquito species capable of transmitting pathogens to humans and animals alike. On August 27th, 2024, our team investigated the KSU Field Station to quantify and record potential water-holding containers that serve as mosquito …

Relationship Between Prevalence Of Disability And Receiving The Covid-19 Vaccine Abstract, Brady Beard, Michael Treichler, Kevin Gittner

Symposium of Student Scholars

COVID-19 vaccines were developed to reduce the spread and severity of the virus, particularly among vulnerable populations. People with disabilities are at higher risk of severe outcomes from COVID-19 due to underlying health conditions, limited access to healthcare, and potential barriers to preventive measures like social distancing. Despite their vulnerability, disabled individuals may face challenges in accessing vaccines, such as physical barriers, transportation issues, or a lack of tailored information. Additionally, vaccine hesitancy may be influenced by concerns about potential side effects harming existing disabilities. This study investigates the research question: "Is there a relationship between receiving the COVID-19 vaccine …

Statistical Analysis Of Sex And Adolescent E-Vapor Product Use, Madison Caroline Weeks, Anna Kate Lane, Kevin Gittner

Symposium of Student Scholars

This study aims to examine the relationship between sex and electronic vapor product use among adolescent high school students aged 12 to 17. As the use of electronic vapor products, commonly known as e-cigarettes or vapes, continues to rise among youth, understanding demographic trends is crucial for the creation of public health interventions. A quantitative approach was utilized to create appropriate visuals and analyze the data, providing a clear representation of the patterns observed. This study utilizes the Centers for Disease Control and Prevention’s (CDC) Youth Risk Behavior Surveillance System (YRBSS). The sample size of the dataset being used in …

Addressing Obesity In Cancer Survivorship: Referral Gaps And Patient Engagement In Nutrition And Lifestyle Interventions, Brian Dinh, Kelly Nguyen, Whittney Thoman, Katherine Gilmore, Ying Qiao, Kathy Carpenter, Zayed Razouki, David Santos, Michael Roth

Cancer Survivorship Research Retreat

No abstract provided.

Pitavastatin Is Well-Tolerated With No Detrimental Effects On Physical Function, Kristine M Erlandson, Triin Umbleja, Heather J Ribaudo, Jennifer A Schrack, Edgar T Overton, Carl J Fichtenbaum, Kathleen V Fitch, Jhoanna C Roa, Marissa R Diggs, Kenneth Wood, Markella V Zanni, Gerald S Bloomfield, Carlos Malvestutto, Judith A Aberg, Maria C Rodriguez-Barradas, Rosalba Gomez Morones, Katherine Breaux, Pamela S Douglas, Steven K Grinspoon, Todd T Brown

Faculty, Staff and Students Publications

Background: Little is known about the potential benefits or harms of statins on physical function among people with human immunodeficiency virus (PWH).

Methods: REPRIEVE was a double-blind randomized controlled trial evaluating pitavastatin for primary prevention of major adverse cardiovascular events in PWH. Time to complete 10 chair rises, 4-m gait speed, grip strength, and a modified short physical performance test were assessed annually for up to 5 years in the ancillary study PREPARE and analyzed using linear mixed models.

Findings: Of 602 PWH, 52% were randomized to pitavastatin and 48% to placebo. Median age was 51 years; 18% were female …

A Disparities Analysis Of Cancer Patients’ Access To Depression Treatment By Health Insurance Status And Type, Stephanie Minbiole-Snider

Walden Dissertations and Doctoral Studies

Research has demonstrated that comorbid conditions like depression in cancer patients reduce quality of life, prolong recovery, and reduce survival time of the cancer patient. Although other studies have investigated the issue of depression among cancer patients, there is a dearth of studies looking at differences in taking depression medication with health insurance as a source of disparity. Using survey data from the National Health Interview Survey (NHIS), and the health belief model as the theoretical framework, this study had two purposes. The first was to determine if there were differences in the likelihood of taking medication for depression based …

Hurricane Irma's Impact On Mortality Among The Chronically Ill Populations In Florida, Cody Ray Thornton

Walden Dissertations and Doctoral Studies

Natural disasters pose significant risks to individuals with chronic diseases, exacerbating health disparities through disruptions in healthcare access and systemic vulnerabilities. This study investigated the association between chronic disease-related mortality occurring within 2 months of Hurricane Irma, and whether demographic variables, including age, sex, race, Hispanic ethnicity, poverty, urbanicity, and educational attainment, modified this relationship. This cross-sectional study used the social-ecological model to analyze secondary mortality data from the National Vital Statistics System. Bivariate and multivariate logistic regression revealed that deaths from chronic illnesses, occurring between September 2017 and October 2017, were 2.694 times higher, compared to the same period …

Invasion And Metastasis In Cancer: Molecular Insights And Therapeutic Targets, Yongxing Li, Fengshuo Liu, Qingjin Cai, Lijun Deng, Qin Ouyang, Xiang H-F Zhang, Ji Zheng

Faculty, Staff and Students Publications

The progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting their quality of life and survival rates. Research efforts have consistently focused on the intricate mechanisms underlying this process and the corresponding clinical management strategies. Consequently, a comprehensive understanding of the biological foundations of tumor metastasis, identification of pivotal signaling pathways, and systematic evaluation of existing and emerging therapeutic strategies are paramount to enhancing the overall diagnostic and treatment capabilities for metastatic tumors. However, current research is …

Analisis Faktor Penyebab Komplain Pasien Pada Pelayanan Rawat Inap: Studi Kasus Di Rumah Sakit X Tahun 2024, Tasmiati Manzilah, Risky Kusuma Hartono

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Complaints from patients are often used as an indicator of the quality of health services. The causes of complaints from inpatients are related to factors that cause dissatisfaction or discomfort experienced by patients during their hospitalization. This study aims to see the causes of patient complaints about inpatient services. In addition, researchers also examine the relationship between several variables and complaints and analyze further to determine the main factors causing complaints from patients about inpatient services. This study uses a sequential explanatory approach. The study design is cross-sectional for inpatients at Hospital X who are willing to be respondents and …

Association Between The Lack Of Health Insurance, Income, And The Severity Of Negative Perinatal Outcomes Among Native Spanish- And English-Speaking Women Living In Florida, Khadijeh Ashktorab

Walden Dissertations and Doctoral Studies

Evidence indicates that non-English-speaking mothers, particularly Spanish-only speakers, experience worse maternal health outcomes compared to their mainstream counterparts. Language barriers often hinder communication and negatively affect perinatal care. This study used data from the Centers for Disease Control and Prevention Pregnancy Risk Assessment Monitoring System from Florida (2019–2020) to examine associations between health insurance, income, and perinatal outcomes among Spanish and English-speaking women. Krieger’s eco-social theory guided this cross-sectional, quantitative analysis. Chi-square tests were used for bivariable analysis, and multivariable models were used to adjust for confounders. Results showed that native language alone significantly predicted specific outcomes such as large-for-gestational-age …

The Mutational Landscape And Functional Effects Of Noncoding Ultraconserved Elements In Human Cancers, Recep Bayraktar, Yitao Tang, Mihnea P Dragomir, Cristina Ivan, Xinxin Peng, Linda Fabris, Jianhua Zhang, Alessandro Carugo, Serena Aneli, Jintan Liu, Mei-Ju M Chen, Sanjana Srinivasan, Iman Sahnoune, Emine Bayraktar, Kadir C Akdemir, Meng Chen, Pranav Narayanan, Wilson Huang, Leonie Florence Ott, Agda Karina Eterovic, Oscar Eduardo Villarreal, Mohammad Moustaf Mohammad, Michael D Peoples, Danielle M Walsh, Jon Andrew Hernandez, Margaret B Morgan, Kenna R Shaw, Jennifer S Davis, David Menter, Constantine S Tam, Paul Yeh, Sarah-Jane Dawson, Laura Z Rassenti, Thomas J Kipps, Tanja Kunej, Zeev Estrov, Simon A Joosse, Luca Pagani, Catherine Alix-Panabières, Klaus Pantel, Alessandra Ferajoli, Andrew Futreal, Ignacio I Wistuba, Milan Radovich, Scott Kopetz, Michael J Keating, Giulio F Draetta, John S Mattick, Han Liang, George A Calin

Faculty, Staff and Student Publications

The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNAs (ncUCEs), and their functional relevance in cancers remain poorly characterized. Here, we perform a systematic analysis of whole-genome and in-house targeted UCE sequencing datasets from more than 3000 patients with cancer of 13,736 UCEs and demonstrate that ncUCE somatic alterations are common. Using a multiplexed CRISPR knockout screen in colorectal cancer cells, we show that the loss of several altered ncUCEs significantly affects cell proliferation. In-depth functional studies in vitro and in vivo further reveal that specific ncUCEs can be enhancers of tumor suppressors (such as ARID1B) …