Medicine and Health Sciences Commons^™

Fact Sheet: Methamphetamine, Aaron Hunt, Gabriela Murza, Jenna Hawks, Alyssa Ferrin

All Current Publications

Methamphetamine, or meth, is a powerful stimulant that speeds up the central nervous system, causing increases in heart rate, blood pressure, and how fast the body uses energy. This fact sheet explains how meth is habit-forming and addictive and what it does to your body. It also explains overamping and responding to such an emergency.

Adverse Childhood Experiences And The Impact Of Resiliency On Child Behavior: A Quality Improvement Project, Macy Kraft

Graduate Theses, Dissertations, and Capstones

Background: Adverse Childhood Experiences can have a significant impact on a person’s future health and wellness. Therefore, it is necessary for healthcare professionals to increase their understanding of possible mediating factors to lessen the impact of these experiences should they occur.

Purpose: The purpose of this project was to evaluate the effectiveness of an evidence-based quality improvement initiative designed to enhance the formal behavioral assessments of pre-school children following the participation of their caregivers in an ACEs and resiliency educational intervention.

Methods: Implementation of a two-armed intervention; a brief educational session aimed at providing an introduction to ACEs and a …

The Relationship Between Sexual Orientation, Anxiety, And Mental Health Access With Suicidal Ideation Among Veterans, Winsome R. Ashley

Walden Dissertations and Doctoral Studies

Prior studies have examined the connection between minority sexual orientation (MSO) and mental health; however, very little is known about the effect among veterans. The objective of this cross-sectional quantitative study aimed to determine the relationship between veteran status, sexual orientation, anxiety levels, access to mental health services, and suicidal ideation among veterans. More specifically, it addressed if veteran status modifies the association between anxiety and suicidal ideation, if marital status modifies the association between mental health care access and suicidal ideation, and if veteran status modifies the association between sexual orientation and suicidal ideation after controlling for age, gender, …

Improving Dietary Supplement Information Retrieval: Development Of A Retrieval-Augmented Generation System With Large Language Models, Yu Hou, Jeffrey R Bishop, Hongfang Liu, Rui Zhang

Faculty, Staff and Student Publications

Background: Dietary supplements (DSs) are widely used to improve health and nutrition, but challenges related to misinformation, safety, and efficacy persist due to less stringent regulations compared with pharmaceuticals. Accurate and reliable DS information is critical for both consumers and health care providers to make informed decisions.

Objective: This study aimed to enhance DS-related question answering by integrating an advanced retrieval-augmented generation (RAG) system with the integrated Dietary Supplement Knowledgebase 2.0 (iDISK2.0), a dietary supplement knowledge base, to improve accuracy and reliability.

Methods: We developed iDISK2.0 by integrating updated data from authoritative sources, including the Natural Medicines Comprehensive Database, the …

A Brief Commentary On Human-Ai Attachment And Possible Impacts On Family Dynamics, Brandon T. Mcdaniel Phd, Amanda Coupe, Allison Weston, Jessica A. Pater

Health Services and Informatics Research

Objective: In this brief commentary article, we outline an emerging idea that it may be possible that as Conversational Artificial Intelligence (CAI) becomes a part of an individual’s environment and interacts with them their attachment system may become activated, potentially leading to behaviors—such as seeking out the CAI to feel safe in times of stress—that have typically been reserved for human-to-human attachment relationships. We term this attachmentlike behavior, but future work must determine if these behaviors are driven by a Human-AI attachment or something else entirely. Background: CAI is an emerging technical advancement that is the cornerstone of many everyday …

A Narrative Review Of The Covid-19 Infodemic And Censorship In Healthcare, Mitchell Liester, Sohaib Ashraf, Patricia Callisperis, Hector Carvallo, Shankara Chetty, Robert Enzenauer, Carlos Franco-Paredes, Raul Pineda, Panagis Polykretis, Rachel Wilkenson, Peter Mccullough

Secrecy and Society

Ideological and financial motivations have undermined science for decades. In this narrative review, we explore how organizations and governments used misinformation, disinformation, censorship, and secrecy to manage the COVID-19 pandemic. Various rationales for employing censorship and secrecy during the COVID-19 pandemic are examined including how organizations and governments create confusion about the risks associated with their products and blame avoidance to shift responsibility and to avoid accountability for their actions. Methods of censorship employed during the COVID-19 pandemic are reviewed, examples are provided, and the consequences of these actions are reviewed. Information included in this review was obtained from scientific …

Gender Differences In Weight Perceptions And Intentions Among Hispanic Youth In The United States, Kristy Gregurek

Walden Dissertations and Doctoral Studies

Childhood obesity is a global epidemic and a serious issue for children and adolescents in the United States. Despite recognition of its dangers, obesity remains a public health concern, with both genetic and environmental factors contributing to its prevalence. Of particular concern is the higher obesity rates among Hispanic children, who face disproportionately significant psychological and physical health risks. Using the theory of planned behavior, this study aimed to investigate the lack of knowledge regarding gender differences in weight perceptions and intentions, the relationship between physical activity and weight perception, and the role each may play in obesity among Hispanic …

Using Ehr Reminders To Control Hypertension, Umme Kulsoom Ghous, Logan Mcculley, Danielle C. Hall, Linda Katherine Lambert, Laura Reed Dnp, Aprn, Fnp-Bc, Cne

Doctor of Nursing Practice Projects

Purpose/Background

Hypertension is a significant risk factor for cardiovascular and kidney diseases but is often under-diagnosed and poorly managed. Electronic Health Records (EHR) can help by providing automated reminders to recheck elevated blood pressure (BP) readings, ensuring accurate measurements, and guiding clinical interventions. This study aims to determine if EHR-based reminders improve BP control in adult patients aged 21 and older, focusing on hypertension diagnosis accuracy and timely management.

Methods

After a literature review, the study took place in a primary care clinic and only included patients with an existing diagnosis of hypertension. Thirty patients were included in the study. …

Older Women In The U.S. Were Lonelier Than Men During The Covid-19 Pandemic, Qiyu Deng

Population Health Research Brief Series

Loneliness damages health and quality of life. The COVID-19 pandemic increased social isolation and loneliness among some groups in the U.S. This data slice uses data from the 2020 Health and Retirement Study to examine gender and age differences in loneliness among older adults (50+) in the U.S. during the first year of the pandemic. The author finds that loneliness was more prevalent among women than among men, with the highest rate among women ages 80 and older.

Health System, Community-Based, Or Usual Dementia Care For Persons With Dementia And Caregivers: The D-Care Randomized Clinical Trial, David B Reuben, Thomas M Gill, Alan Stevens, Jeff Williamson, Elena Volpi, Maya Lichtenstein, Lee A Jennings, Rebecca Galloway, Jenny Summapund, Katy Araujo, David Bass, Lisa Weitzman, Zaldy S Tan, Leslie Evertson, Mia Yang, Katherine Currie, Aval-Na'ree S Green, Sybila Godoy, Sitara Abraham, Jordan Reese, Rafael Samper-Ternent, Roxana M Hirst, Pamela Borek, Peter Charpentier, Can Meng, James Dziura, Yunshan Xu, Eleni A Skokos, Zili He, Sherry Aiudi, Peter Peduzzi, Erich J Greene, D-Care Study

Faculty, Staff and Student Publications

Importance: The effectiveness of different approaches to dementia care is unknown.

Objective: To determine the effectiveness of health system-based, community-based dementia care, and usual care for persons with dementia and for caregiver outcomes.

Design, setting, and participants: Randomized clinical trial of community-dwelling persons living with dementia and their caregivers conducted at 4 sites in the US (enrollment June 2019-January 2023; final follow-up, August 2023).

Interventions: Participants were randomized 7:7:1 to health system-based care provided by an advanced practice dementia care specialist (n = 1016); community-based care provided by a social worker, nurse, or licensed therapist care consultant (n = 1016); …

An Exploration Of The Experiences Of Perinatal Depression And Anxiety Among Pregnant And Parenting Adolescents In The Tampa Bay Area Of Florida, Olajumoke Adetoun Ojeleye

USF Tampa Graduate Theses and Dissertations

Perinatal depression (PND) and perinatal anxiety (PNA) are increasing among pregnant and parenting adolescents (PPAs), with PNA often underrecognized. This leads to significant socioeconomic costs and adverse maternal consequences if untreated. Hence, this dissertation explores the experiences of PND and PNA among PPAs, focusing on their knowledge gaps, perception, mental health needs, care preferences, and access to PMH care. The research employs a qualitative design (free-listing and in-depth interviews) to gather participant insights. Key findings reveal that many PPAs possess limited knowledge about PNA when compared to PND. Lack of support from partners, family, and peers emerged as the topmost …

Rethinking Systematic Review Assignment Design In Graduate Health Science Education: Librarians' Perspectives, Laura Lipke, Carrie Price Mls

Library Scholarship

Background: This article examines the problematic phenomenon of faculty assigning graduate health science students systematic reviews as semester-based assignments while expecting a health science librarian to be a willing support system for those students. Despite published conduct and reporting guidelines establishing that systematic reviews require a team, time, and methodological expertise, some faculty still turn to full systematic review assignments in the classroom. The authors propose applying cognitive load theory and chunking the systematic review process into manageable steps, allowing both faculty and students to better understand the required methodologies and to enhance educational outcomes.

Experience: The authors have often …

The Autophagy Protein Atg14 Safeguards Against Unscheduled Pyroptosis Activation To Enable Embryo Transport During Early Pregnancy, Pooja Popli, Arin K Oestreich, Vineet K Maurya, Marina N Rowen, Yong Zhang, Michael J Holtzman, Ramya Masand, John P Lydon, Shizuo Akira, Kelle Moley, Ramakrishna Kommagani

Faculty, Staff and Students Publications

Recurrent pregnancy loss, characterized by two or more failed clinical pregnancies, poses a significant challenge to reproductive health. In addition to embryo quality and endometrial function, proper oviduct function is also essential for successful pregnancy establishment. Therefore, structural abnormalities or inflammation resulting from infection in the oviduct may impede the transport of embryos to the endometrium, thereby increasing the risk of miscarriage. However, our understanding of the biological processes that preserve the oviductal cellular structure and functional integrity is limited. Here, we report that autophagy-related protein ATG14 plays a crucial role in maintaining the cellular integrity of the oviduct by …

Emerging Clostridioides Difficile Ribotypes Have Divergent Metabolic Phenotypes, Firas S Midani, Heather A Danhof, Nathanael Mathew, Colleen K Ardis, Kevin W Garey, Jennifer K Spinler, Robert A Britton

Faculty, Staff and Students Publications

Clostridioides difficile is a gram-positive spore-forming pathogen that commonly causes diarrheal infections in the developed world. Although C. difficile is a genetically diverse species, certain ribotypes are overrepresented in human infections, and it is unclear if metabolic adaptations are essential for the emergence of these epidemic ribotypes. To identify ribotype-specific metabolic differences, we therefore tested carbon substrate utilization by 88 C. difficile isolates and looked for differences in growth between 22 ribotypes. As expected, C. difficile was capable of growing on a variety of carbon substrates. Further, C. difficile strains clustered by phylogenetic relationship and displayed ribotype-specific and clade-specific …

Author Correction: Generation Of A Tree Shrew Breast Cancer Model Using Lentivirus Expressing Pik3ca-H1047r, Li Zeng, Hong-Yan Zhang, Chuan-Yu Yang, Zhuo Cheng, Qiu-Yun Jiang, Yao Luo, Yi Li, Fu-Bing Li, Ce-Shi Chen

Faculty, Staff and Students Publications

No abstract provided.

Healthy Here Active Living Year 1 Summary, Camille R. Velarde, Courtney A. Fitzgerald, Theresa H. Cruz

Reports & Documents

No abstract provided.

Healthy Here Immunization Year 1 Summary, Camille R. Velarde, Courtney A. Fitzgerald, Theresa H. Cruz

Reports & Documents

No abstract provided.

Effects Of Exercise On Inflammation, Circulating Tumor Cells, And Circulating Tumor Dna In Colorectal Cancer, Justin C. Brown, Stephanie L. Compton, Andrew Kang, Anjana Jayaraman, L Anne Gilmore, Brian J. Kirby, Frank L. Greenway, Shengping Yang, Guillaume Spielmann

School of Medicine Faculty Publications

BACKGROUND: The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood. This trial tested the hypothesis that 12 wk of moderate-intensity aerobic exercise, when compared with a control group, would change inflammation, CTCs, and ctDNA in a manner consistent with an improved cancer prognosis. METHODS: This trial randomized Stages I-III colorectal cancer survivors to 12 wk of home-based moderate-intensity aerobic exercise or a waitlist control group. The co-primary endpoints were high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6), secondary endpoints were soluble tumor necrosis factor-α receptor 2 (sTNFαR2) and circulating tumor cells (CTCs), …

Healthy Here Healthy Eating Year 1 Summary, Camille R. Velarde, Courtney A. Fitzgerald, Theresa H. Cruz

Reports & Documents

No abstract provided.

Association Of Messenger Rna Coronavirus Disease 2019 (Covid-19) Vaccination And Reductions In Post Covid Conditions Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection In A Us Prospective Cohort Of Essential Workers, Josephine Mak, Sana Khan, Amadea Britton, Spencer Rose, Lisa Gwynn, Katherine D Ellingson, Jennifer Meece, Leora R Feldstein, Harmony Tyner, Laura J Edwards, Matthew S Thiese, Allison Naleway, Manjusha Gaglani, Natasha Solle, Jefferey L Burgess, Julie Mayo Lamberte, Meghan Shea, Taryn Hunt-Smith, Alberto Caban-Martinez, Cynthia Porter, Ryan Wiegand, Ramona Rai, Kurt T Hegmann, James Hollister, Ashley Fowlkes, Meredith Wesley, Andrew L Philips, Patrick Rivers, Robin Bloodworth, Gabriella Newes-Adeyi, Lauren E W Olsho, Sarang K Yoon, Sharon Saydah, Karen Lutrick

Center for Medical Ethics and Health Policy Staff Publications

Background: Data are limited on whether vaccination reduces post COVID conditions (PCCs) risk after less severe nonhospitalized coronavirus disease 2019 (COVID-19). This study assessed whether COVID-19 vaccination protected against PCCs in persons with mild initial infections during Delta and Omicron variant predominance.

Methods: This study utilized a case-control design, nested within the HEROES-RECOVER cohort. Participants aged ≥18 years with test-confirmed severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) between 28 June 2021 and 14 September 2022 were surveyed for PCCs, defined by symptoms lasting >4 weeks after initial infection. Cases self-reported PCCs and controls self-reported no PCCs. The exposure was …

Exploring Profiles Of Fathers Integrating Food And Physical Activity Parenting Practices, John A Jimenez-Garcia, Louise C Mâsse, Robert L Newton, Salma M Musaad, Alicia Beltran, Teresia M O'Connor

Children’s Nutrition Research Center Staff Publications

Objective: This study aims to identify fathers' profiles integrating food parenting practices (FPP) and physical activity parenting practices (PAPP).

Design: We analysed cross-sectional data. The fathers completed the reduced FPP and PAPP item banks and socio-demographic and family dynamics (co-parenting and household responsibility) questionnaires. We identified fathers' profiles via latent profile analysis. We explored the influence of social determinants, child characteristics and family dynamics on fathers' profiles using multinomial logistic regression.

Setting: Online survey in the USA.

Participants: Fathers of 5-11-year-old children.

Results: We analysed data from 606 fathers (age = 38 ± 8·0; Hispanic = 37·5 %). Most fathers …

Dengue Cases In Hanoi, Vietnam: Unseasonal Surge Foreshadows Increased Incidence That Demands Organized Preventive Action, Andrew W. Taylor-Robinson

Chulalongkorn Medical Journal

Letter to the Editor - Abstract not required.

Mobilizing Prevention And Early Detection Of Alzheimer's Disease And Related Dementias (Adrd) In Allegheny County Through The Area Agency On Aging (Aaa), Laiba N. Mirza

Public Health Capstone Projects

1. Objectives: In collaboration with the Department of Human Services (DHS): the Area Agency on Aging (AAA) using the Healthy Brain Initiative (HBI), my capstone project will involve the development of a comprehensive literature review examining the impacts of Alzheimer’s disease and related dementias (ADRD) on patients and their caregivers. The project aims to help the AAA focus on strategies to delay the onset of ADRD in Allegheny County. It also seeks to evaluate and enhance early detection programs for ADRD established by the AAA in communities within the county. Additionally, the project will explore how public health initiatives can …

Health Equity & Parental Leave: Addressing Gaps In Maternal Health Policy, Destiny L. Smith

Public Health Capstone Projects

Objective: This capstone project at Duquesne University will address health equity by focusing on employer-provided maternal and parental leave policies in the United States among underserved groups. It aims to address the gaps in these policies and analyze how disparities in leave policies across different industries can impact maternal and infant health outcomes.

Priority Population Served: This study will primarily target underserved employees who had to take some type of leave policy while working for an intended employer.

Methods: This project will engage in data analysis of the 2024 BIRTH survey results that the Pittsburgh Business Group on …

Aiding Counseling Services To Increase Cultural Knowledge About Black And Lgbtq+ Populations, Brianna L. Walden

Public Health Capstone Projects

OBJECTIVES: The capstone project I would like to undertake is the creation of a quality improvement plan for the counseling and social work department of The Children’s Home to help them expand to reach vulnerable populations. A quality improvement plan, along with graphics reflecting the current data about mental health, will be delivered to The Children’s Home which they will be able to use in future projects and grant applications.

METHODS: The methods and research will be based on the 2024 Community Health Needs Assessment (CHNA) and Community Counseling Needs Assessment conducted by The Children’s Home in August 2024 to …

Cortical Visual Impairment Awareness And Education, Sarah Kozosey

Public Health Capstone Projects

Objectives: This Capstone Project, conducted in collaboration with The Children’s Home (TCH), aims to raise awareness of the educational aspect of cortical visual impairment (CVI) by compiling the work already done in schools, hospitals, and the communities it serves. The focus is on raising awareness and education, interdisciplinary collaboration, diagnosis and early detection, public health implications, and strategic planning and implementation through secondary research. Methods: This project uses CH’s strategic plan to improve the flow of grand rounds already enforced. Meetings with multiple people on the Marketing & Development team and Pediatric VIEW team will answer how much progress has …

Cracking The Code Of Hbv Persistence: Cutting-Edge Approaches To Targeting Cccdna In Chronic Hepatitis B With Or Without Pyogenic Liver Abscesses, Umar Saeed, Zahra Zahid Piracha, Mahmood Khan, Muhammad Nouman Tariq, Syed Shahan Gilani, Muhammad Raza, Rakshana Munuswamy, Naveen Bose, Dilber Uzun Ozsahin, Ilker Özşahin, Surya M. Nauli

Pharmacy Faculty Articles and Research

Chronic Hepatitis B Virus (HBV) infection remains a formidable global health challenge, driving severe liver complications such as hepatocellular carcinoma (HCC) and pyogenic liver abscesses (PLA). At the core of HBV persistence lies covalently closed circular DNA (cccDNA), a viral reservoir that fuels ongoing infection despite antiviral treatments. This review highlights molecular mechanisms governing cccDNA formation, maintenance, and clearance, spotlighting innovative therapeutic strategies to disrupt this key viral element. We explore cutting-edge approaches, including epigenetic modulation to silence cccDNA, RNA interference (RNAi) for viral RNA degradation, and CRISPR/Cas genome editing to excise cccDNA directly. Additionally, emerging antiviral therapies and immunotherapies, …

Construct Validity, Test-Retest Reliability, And Inter-Rater Objectivity Of The Swimming Competence Assessment Scale (Scas), Jon Sundan, Håvard Lorås, Monika Haga

International Journal of Aquatic Research and Education

This study aimed to investigate the construct validity, test-retest reliability, and inter-rater reliability of a newly developed and comprehensive instrument for assessment of children’s swimming competence. The Swimming Competence Assessment Scale (SCAS) consists of six consecutive test items (entry, swim on front, surface dive, float, swim on back and exit) that aligns with the Norwegian curricular standard of swimming competence. The exploratory factor analysis retained a unidimensional model, supporting one underlaying statistical dimension with acceptable internal consistency (α = 0.79). Intraclass correlation coefficients (ICCs) between test and retest ranged from .84 to .98, and .97 for the total score. Strong …

"Feel For The Water": What Is It, Really?, Robert Keig Stallman, Kristine De Martelaer

International Journal of Aquatic Research and Education

The phrase, 'feel for the water,' is commonly used. But what does it really mean? The traditional idea of this 'feel' focuses on the sensation of touch and use of the hands to produce propulsion. But what about water resistance? Mastering a feel for how to reduce resistance is equally important as the unique relationship between aquatic propulsion and resistance is of great importance. While being in the water, the effects of gravity and buoyancy also need to be perceived by the learner and taught by the instructor. Reflection on the effects on propulsion-resistance and gravity-buoyancy requires relevant exercises to …

Water Orientation Skills And Basic Safety And Swimming Skills Of Children With Autism Spectrum Disorder, Kelle L. Murphy, Min Liu

International Journal of Aquatic Research and Education

Drowning is the leading cause of death among individuals with autism spectrum disorder (ASD). The current study examined water orientation (i.e., comfort level), water safety, and beginning swimming skills of individuals with ASD of ages ranging from 3 to 13 years using the Aquatic Orientation Checklist (AOC) (Kilian et al., 1984). Data were collected during consecutive Fall and Spring semesters. A total of 23 children (n = 15 boys; n = 8 girls) volunteered for the study. Lessons were conducted twice a week for 10 weeks continuously and each lesson was 45 minutes in length. Overall, the swimming program had …