Medicine and Health Sciences Commons^™

Pathogen-Driven Crispr Screens Identify Trex1as A Regulator Of Dna Self-Sensing During Influenza Virus Infection, Cason R King, Yiping Liu, Katherine A Amato, Grace A Schaack, Clayton Mickelson, Autumn E Sanders, Tony Hu, Srishti Gupta, Ryan A Langlois, Judith A Smith, Andrew Mehle

Faculty, Staff and Student Publications

Host:pathogen interactions dictate the outcome of infection, yet the limitations of current approaches leave large regions of this interface unexplored. Here, we develop a novel fitness-based screen that queries factors important during the middle to late stages of infection. This is achieved by engineering influenza virus to direct the screen by programming dCas9 to modulate host gene expression. Our genome-wide screen for pro-viral factors identifies the cytoplasmic DNA exonuclease TREX1. TREX1 degrades cytoplasmic DNA to prevent inappropriate innate immune activation by self-DNA. We reveal that this same process aids influenza virus replication. Infection triggers release of mitochondrial DNA into the …

"I Believe More In The Ability Of The Small Person To Make Big Changes": Innovation And Social Entrepreneurship To Promote Public Health In Israel., Keren Dopelt, Nila Mordehay, Shir Goren, Aviya Cohen, Paul Barach

College of Population Health Faculty Papers

Social entrepreneurship has grown worldwide in recent decades as it attempts to create and implement innovative solutions to social and environmental issues through business strategies. The aim of this study was to explore what motivates public health social entrepreneurs to act, the challenges and barriers they face, achievements, and competencies required for success. As such, we interviewed 15 social entrepreneurs in Israel. Budget issues, regulatory barriers, and struggles against powerful companies were the frequent barriers to success. The interviewees indicated several achievements at the health policy level by positioning and becoming an authority in the field, positively influencing other people's …

The Impact Of Online Education On Families During Covid-19, Meghal Shah, Duaa Zahid, Heather Butts

Discovery Day

In the year 2020, the whole world was hit by a pandemic name COVID-19. It resulted in school closures across the world, which has impacted millions of children’s education. As a result, education has transitioned online via digital platforms. For many families, these transformations to online education have been difficult. For low-income families, people couldn’t afford or may not have had access to supplies needed for online education like high-speed internet and a computer. National Education Association (NEA) reports that 13.5 million children aged 5-7 years have no access to these technologies. It can be difficult for parents to understand …

The Effect Of Long Covid Syndrome On Physical Activity, Patrisha Hanna Villarmea

Master of Science in Kinesiology

Long covid syndrome is a condition where individuals experience persistent symptoms and functional limitations that can last about three months to two years after the initial Covid-19 infection. While long-term health consequences of Covid-19 have garnered significant attention,the impact of long covid syndrome symptoms is poorly understood. The purpose of the study is to explore the effect of long covid syndrome symptoms to an individual’s physical activity. Furthermore, this research aims to provide an overview of the existing literature on the effect of long covid syndrome symptoms on physical activity. The research would invite participants to answer two surveys that …

Public Health Ai Assignment, Amber Lyon-Colbert

AI Assignment Library

This assignment utilizes course foundational knowledge: Explain the social, political and economic determinants of health and how they contribute to population health and health inequities. This assignment addresses and strengthens our CEPH Competency #5 D2-11 Select methods to evaluate public health programs.

Innovations In Health-Care Service Delivery During The Pandemic, Taryn Vian, Ankita Meghani Phd

Nursing and Health Professions Faculty Research and Publications

The COVID-19 pandemic disrupted health service delivery as countries implemented lockdowns and issued stay-at-home orders. Despite attempts to make essential health services available throughout, the pandemic strained health systems and resulted in rampant shortages of health commodities, beds and health-care staff. There were concomitant declines in tuberculosis screening, HIV testing, and maternal and child health services.2 However, the global pandemic also accelerated the pace of innovation. Some initiatives served as stopgap measures implemented to maintain health services, whereas others helped leapfrog progress in the areas of health information systems, telemedicine, and regulatory policy, bringing efficiencies that could be applied even …

Perceptions Of Facilitators And Barriers To Smoking Cessation Among Patients And Providers In A Cancer Center: A Single Institution Qualitative Exploratory Study, Luke M. Shenton, Udara Perera, Amy Leader, Ann C. Klassen

College of Population Health Faculty Papers

PURPOSE: Cancer patients who remain tobacco users have poorer outcomes, including increased mortality and decreased treatment tolerance; however, cessation post-diagnosis is challenging. Our formative research explored cessation-related perspectives among patients and staff at one National Cancer Institute-designated cancer center, to inform improving cessation services within oncology care.

METHODS: Using a descriptive phenomenological approach, a purposive sample of current cancer patients (n = 13) and cancer center physicians and cessation program staff (n = 9) were recruited to complete one-on-one audio-recorded in-depth qualitative interviews, to explore experiences providing or receiving cessation support, and perspectives on patients' readiness and needs regarding cessation. …

Social Inequalities And The Adoption Of Health Misinformation In Cameroon: Implications On Health Behaviour, Eugene Nche Che

Library Philosophy and Practice (e-journal)

Public health restrictions in response to the COVID-19 pandemic resulted in an increase in the reliance on social media for peer interactions. This resulted in the proliferation of medical misinformation and conspiracy theories that undermined public support for disease control measures, and influenced negative health attitudes such as vaccine denial. The aim of this study was to determine how social inequalities influence the adoption of health related misinformation, and the extent to which the adoption of health misinformation results in poor health behaviours. The study employed an exploratory survey design, and relied on both quantitative and qualitative methods to collect …

An Evolutionary Pathway For Coping With Emerging Infectious Disease, Scott Lyell Gardner, Daniel R. Brooks, Walter A. Boeger, Eric P. Hoberg

Zea E-Books Collection

Emerging infectious disease (EID) represents an existential threat to humanity. EIDs are increasing in frequency and impact because of climate change and other human activities. We are losing the battle against EIDs because of improper assessment of the risk of EID. This stems from adherence to a failed paradigm of pathogen-host associations that suggests EIDs ought to be both unpredictable and rare. That, in turn, leads to policies suggesting that crisis response is the best we can do. Real-time and phylogenetic assessments show EIDs to be neither rare nor unpredictable—this is the parasite paradox that shows the failures of the …

Nutrition-Related Experiences Of Women With Perinatal Depression During The Covid-19 Pandemic: A Qualitative Study, Dahlia Stott, Cynthia Klobodu, Lisa A. Chiarello, Bobbie Posmontier, Mona Egohail, Pamela A. Geller, June Andrews Horowitz, Brandy-Joe Milliron

College of Nursing Faculty Papers & Presentations

Women with perinatal depression are at a high risk for unhealthy dietary behaviors but whether the coronavirus disease 2019 (COVID-19) pandemic has exacerbated this risk is unknown. Here we report the findings of a qualitative study exploring the impact of the COVID-19 pandemic on nutrition-related experiences of women with perinatal depression. Using a qualitative descriptive approach, in-depth interviews were conducted with 18 women with a history of perinatal depression and 10 healthcare providers. A semistructured format elicited how food and nutrition-related behaviors of women with perinatal depression were affected by the COVID-19 pandemic. Thematic analysis identified 4 themes related to …

The Public Health Impact Of Paxlovid Covid-19 Treatment In The United States, Yuan Bai, Zhanwei Du, Lin Wang, Eric H. Y. Lau, Isaac Fung, Petter Holme, Ben Cowling, Alison Galvani, Robert Krug, Lauren Ancel Meyers

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

The antiviral drug Paxlovid has been shown to rapidly reduce viral load. Coupled with vaccination, timely administration of safe and effective antivirals could provide a path towards managing COVID-19 without restrictive non-pharmaceutical measures. Here, we estimate the population-level impacts of expanding treatment with Paxlovid in the US using a multi-scale mathematical model of SARS-CoV-2 transmission that incorporates the within-host viral load dynamics of the Omicron variant. We find that, under a low transmission scenario (Re∼1.2) treating 20% of symptomatic cases would be life and cost saving, leading to an estimated 0.26 (95% CrI: 0.03, 0.59) million hospitalizations averted, 30.61 (95% …

A Pre-Medical Student’S Reconciliation Of Feminist Narratives Regarding Women’S Health: A Consideration Of Perspectives On Childbirth In The U.S., Laura Clayton

sprinkle: an undergraduate journal of feminist and queer studies

Many feminists argue that one major negative aspect of reproductive healthcare in the U.S. is the common over-medicalization of women during childbirth, including potentially unnecessary procedures such as cesarean-section and episiotomy. As a solution, they advocate for increased involvement of midwives in childbirth practices, as midwives allow women to give birth at home with minimal medical intervention. This paper analyzes the benefits of midwifery as well as the current increased risk associated with homebirth in the U.S. Additionally, it questions the damaging stigma associated with assumptions of cesarean-section as a suboptimal outcome. A false dichotomy has developed in our culture …

Hospitalizations For Hepatitis C In Mississippi, 2014-2018 – A Hidden Epidemic, Manuela Staneva Md, Mph, Thomas Dobbs Md, Mph, Paul Byers Md, Meg Pearson Pharmd, Ms, Jonathan Hubanks Pharmd

Journal of Public Health in the Deep South

Goal: Utilizing Mississippi’s hospital discharge data (HDD), we examined trends, demographics, comorbidities, in-hospital deaths, and hospital charges for hospitalizations with diagnoses for hepatitis C virus (HCV).Methods: We conducted a retrospective study of hospitalizations with primary or secondary HCV diagnoses. We performed descriptive and inferential statistical analyses using SAS 9.4. We compared categorical variables with chi-square tests and continuous variables with t-tests.Results: Between 2014 and 2018, patients hospitalized with an HCV diagnosis were more likely to have coexisting intravenous drug use (IDU) diagnoses compared to all other hospitalized patients (20.3% versus 3.3%, p < 0.001). From 2014 to 2018, hepatitis C infections associated with IDU spiked by 53.8%, fueling the overall increase in the number of hepatitis C hospitalizations in Mississippi. Almost one-third (31.8%) of all hepatitis C stays had a severe liver condition and 48.2% had nicotine dependence. The average charges for stays with coexisting HCV and decompensated cirrhosis were $65,975.Conclusions: In Mississippi, there has been a rapid increase in HCV hospitalizations associated with IDU. In addition, HCV hospitalizations were associated with severe morbidity burden and high economic expense. These findings underscore the need for measures aimed at containing the spread of this dangerous but preventable infection.

Prevalence Of Probable Hoarding And Associated Consequences At The Scene Of Mississippi Fires, 2009-2019, Mary E. Dozier Phd, Ben Porter Phd

Journal of Public Health in the Deep South

Background: Increased risk for fire is an often-discussed consequence of hoarding disorder; however, the source of this association has been largely through clinicians’ accounts or hoarding patients’ self-reports.Purpose: The purpose of this study was to investigate the association between probable hoarding and incidence of fires using archival data from Mississippi.Methods: Incidents of residential fires from 2009-2019 were provided by the Mississippi State Fire Marshal’s Office. Fires that were classified as having “a significant amount of fire load present” were classified as probable hoarding fires for analysis.Results: Of the 5,194 unique residential fires identified across the study period, 96 fires (1.9% …

Assessment Of Knowledge And Attitudes Toward Determinants Of Infant Mortality In Head Start Teachers, Teacher Aides, Caregivers, And Family Support Workers, Susan Mayfield-Johnson Phd, Mches, Danielle Fastring Phd, Stephanie T. Mcleod Mph

Journal of Public Health in the Deep South

IMR (11.9 infant deaths per 1,000 live births) almost twice the rate observed in (6.2 infant deaths per 1,000 live births). Objectives. The purpose of this project was to assess Head Start teachers’, teacher aides’, caregivers’, and family support workers’ perceptions, knowledge, attitudes, values and beliefs on topics (nutrition, exercise, breastfeeding, safe sleep, smoking, stress, postpartum depression, and mental health) related to infant mortality prevention in a Mississippi Gulf Coast Head Start consortium. Methods. A 47-item questionnaire was developed that focused on areas associated with primary prevention of infant mortality. Results. Participants (n=82) ages were 25 to 44 years of …

Factors Associated With History Of Unintended Pregnancy Among Mothers In Mississippi, Stephanie T. Mcleod Mph, Morgan Bradwell, Lei Zhang, Olivia Hogan Ismail, Eden Blackwell, Tanya Funchess, Jerome R. Kolbo

Journal of Public Health in the Deep South

Background: Mississippi has the highest rate of unintended pregnancy in the nation. Accessibility, availability, and affordability of women’s health services and effective contraceptive methods are key in preventing unintended pregnancies. Purpose: The purpose of this study was to identify factors associated with history of unintended pregnancy among parous women of childbearing age in Mississippi in order to improve understanding of these relationships and to fill a gap in literature about the state. Methods: Through a multi-stage, probability sample, mothers of students in childcare facilities were selected to participate in a survey about health care and contraceptive use. Chi-square tests of …

Adaptability In Community-Based Participatory Research: Comparisons Of Coalitions In The Deep South, Candace Forbes Bright Phd

Journal of Public Health in the Deep South

Background: Health inequities in the Gulf states are complex issues to resolve, and no single solution or strategy can improve the health rankings in each state. Yet, using grassroots approaches and building community partnerships are promising strategies to identify important health issues and opportunities for policy change. Purpose: This paper illustrates how the Gulf States Health Policy Center coalitions in four different locations used the same community-based participatory research model, but with distinct differences in processes, across nine projects to address issues that negatively affected population health. Methods: Recognizing that communities have unique needs, resources, and complementary health efforts, we …

Ocular Biomarkers Of Disease: Employing Routine Eye Exams To Promote Better Health Surveillance, Dawn S. Mclendon, Kenneth R. Butler Phd, Michael A. Welsch Phd, Facsm

Journal of Public Health in the Deep South

America’s burden of vision impairment, Alzheimer’s disease and related dementias (ADRD), and cardiovascular disease will continue to rise over the next 40 years. The burden of these diseases will be greater for women, Hispanics, African-Americans, and those from lower socio-economic regions. A key challenge is to develop strategies to deny the organization of the pathologies that eventually lead to the manifestation of the disease. An important feature within this battle is the development of appropriate tools and biomarkers for early reconnaissance of the enemy. Recent advances in Optical Coherence Tomography Angiography (OCTA) present a unique opportunity to examine physiological features …

Rural Medical Scholars Program: Filling The Gap For Health-Care And Public Health Leaders In Mississippi, Ann Sansing, David R. Buys, Marion W. Evans Phd, Mches, Laura Downey, Jasmine Harris-Speight

Journal of Public Health in the Deep South

The Rural Medical & Science Scholars program aims to help rising high school seniors determine if they want to pursue health-related careers. The program shapes students’ interest in and understanding of medicine, health-related disciplines, and other science, technology, engineering, and mathematics (STEM) fields. The program combines didactic, observational, and practical learning during a summer semester. Participants earn seven college credits to jumpstart a health or STEM career. We report on descriptive statistics since the program’s inception in 1998. The program has matriculated 401 students, of whom approximately 71% have chosen health-related careers in nursing, physical or occupational therapy, dentistry, pharmacy, …

Policies On Hand-Held Mobile Device Use While Driving: Considerations For Mississippi, Amy Radican-Wald

Journal of Public Health in the Deep South

Background: Mississippi enacted a texting/accessing social networking sites ban for all drivers in 2015; this ban is due for reauthorization in 2018. Purpose: Examine state policies prohibiting mobile device use while driving and changes in behaviors, attitudes, and opinions over time for Mississippi adults regarding distracted driving. Methods: Review literature and enacted policies. Analyze traffic, death, and survey data statewide from 2010 to 2017. Results: Mississippi’s crash death rate rose significantly (22.7 to 25.6 per 100,000; p < .01) from 2010 to 2015. Mississippi adults surveyed said they had talked on a mobile device (75.4%), texted (45.5%), or emailed (10.1%) while driving in 2017. Each reported risky driving behavior increased significantly (p < 0.05) from 2010. Most Mississippians support bans on texting (95%) and hand-held device use (89%) while driving. Support for these types of bans significantly (p < 0.05) increased from 2010 to 2017. Enacted policies vary among states and include mobile device use bans for novice drivers (n = 38) and texting (n = 47) and hand-held (n = 14) bans for all drivers. While safety campaigns coupled with aggressive enforcement are found effective, officials cite enforcement difficulties. Only three texting citations were issued to Mississippi drivers during 2016. Conclusions: Enforcement of policies addressing drivers’ mobile device use is a key factor to consider in reducing crash-related deaths.

Training The Next Generation Of Primary-Care Physicians: Are Student-Run Free Clinics (Srfcs) The Way To Go?, Tobe Momah

Journal of Public Health in the Deep South

Background: The consensus over the last 20 years is that increased availability of primary care reduces the overall cost of healthcare and improves mortality and morbidity rates by as much as 1.44 fewer deaths per 10,000 people (American College of Physicians, 2008; Shi, Starfield, Kennedy, & Kawachi, 1999). However, not enough physicians are going into primary care to meet the need for improved and increased access. By 2020, the expanded Title VII program goal is to produce a physician workforce that is at least 40 percent primary care (Jackson et al., 2014). Estimates show that 74% of U.S. medical school …

Speech-Language Pathologists And Respiratory Therapists: Team Approach To Caring For Patients With Long-Term Tracheotomy, Javis M. Knott

Journal of Public Health in the Deep South

Background: Recent technological advances, together with growing social acceptance of patients with disabilities, has led to a realization of the importance of long-term management of technologically dependent and chronically ill patients with tracheostomies. This includes tracheostomy patients who are ventilator dependent, neurological patients, patients with severe illness such as stroke, and so forth. These patients are able to have a higher quality of life and communicate verbally due to advances in health care. One of the major advancements is communicating via a tracheostomy. Hence, this study will provide ways in which respiratory therapists (RTs) and speech-language pathologists (SLPs) can work …

Maternal, Child, And Parenting Factors Associated With Obesity Among Pre-Kindergarten Children In Mississippi, Jerome R. Kolbo

Journal of Public Health in the Deep South

Background: Obesity among children and youth has been consistently assessed among public school students in Mississippi since 2005. Significant declines in the prevalence of obesity among elementary students over the past decade suggest that changes may be occurring prior to entry into public school. Purpose: The purpose was to collect anthropometric data on a weighted, representative sample of children ages 3 to 5 years in licensed childcare facilities across Mississippi, and to correlate maternal, child, and parenting characteristics to obesity. Methods: The Body Mass Index was calculated using measured height and weight data. Results: A total of 14.12% of the …

Remaining In The Workforce After Motherhood: Does The Family Medical Leave Act Play A Role In The Decisions Of Mississippi Mothers?, Danielle Fastring

Journal of Public Health in the Deep South

Background: Increased maternity leave has been shown to have a positive impact on maternal and child health, and to increase the length of time mothers breastfeed their infants. After childbirth, working women must decide if and when they will return to the workforce. Purpose: To determine the impact of current U.S. family leave policies on Mississippi mothers’ decisions to return to work after the birth of their first child. Methods: A survey was developed to collect information about factors influencing mothers’ decisions to return to work after the birth of their first child. The survey collected study eligibility information, demographics, …

Using Medicaid Data To Identify Factors That Predict Reinstitutionalization Of Mississippians With Disabilities And Elderly People, Hwanseok Choi

Journal of Public Health in the Deep South

Background: Mississippi Bridge to Independence (B2I) was Mississippi’s Money Follows the Person (MFP) program seeking to rebalance the state’s long-term care system by transitioning Medicaid beneficiaries from institutional living to home- and community-based settings (HCBS). Success of initial transitions has been documented in state cost-savings and participants’ quality of life increases. However, reinstitutionalization poses a challenge to sustaining a positive outcome for the initiative. Purpose: Therefore, the purpose of this research is to identify the underlying causes of participants’ reinstitutionalization. Methods: The Quality of Life (QoL) survey designed by Mathematica Policy Research was used to measure variables in 7 categories. …

The Relationship Between Obesity And Depression Among Federally Qualified Health Center Patients, Hwanseok Choi

Journal of Public Health in the Deep South

Background: Obesity has reached epidemic levels in Mississippi. In the shadow of these skyrocketing obesity levels, there are comorbid high levels of depression. Both obesity and depression complicate and, in many cases, compromise critical health outcomes. A significant association between obesity and depression has been suspected for decades. Purpose: The purpose of this study is to examine the relationship between obesity and depression among patients receiving medical care from a Federally Qualified Health Center (FQHC) in a southern state. Methods: The sample was comprised of 3,272 subjects. The Patient Health Questionnaire (PHQ-9) was used to measure the severity of depression, …

Effects Of In Utero Etoh Exposure On 18s Ribosomal Rna Processing: Contribution To Fetal Alcohol Spectrum Disorder, Nune Darbinian, Gary L Gallia, Armine Darbinyan, Ekaterina Vadachkoria, Nana Merabova, Amos Moore, Laura Goetzl, Shohreh Amini, Michael E Selzer

Faculty, Staff and Student Publications

Fetal alcohol spectrum disorders (FASD) are leading causes of neurodevelopmental disability. The mechanisms by which alcohol (EtOH) disrupts fetal brain development are incompletely understood, as are the genetic factors that modify individual vulnerability. Because the phenotype abnormalities of FASD are so varied and widespread, we investigated whether fetal exposure to EtOH disrupts ribosome biogenesis and the processing of pre-ribosomal RNAs and ribosome assembly, by determining the effect of exposure to EtOH on the developmental expression of 18S rRNA and its cleaved forms, members of a novel class of short non-coding RNAs (srRNAs). In vitro neuronal cultures and fetal brains (11–22 …

Strategies For Strengthening The Resilience Of Public Health Systems For Pandemics, Disasters, And Other Emergencies, Benjamin Ryan, Mayumi Kako, Rok Fink, Perihan Şimşek, Paul Barach, Jose Acosta, Sanjaya Bhatia, Mark Brickhouse, Matthew Fendt, Alicia Fontenot, Nahuel Arenas Garcia, Shelby Garner, Abdülkadir Gunduz, D Mike Hardin, Tim Hatch, Lashonda Malrey-Horne, Makiko Macdermot, Ryoma Kayano, Joshua Mckone, Chaverle Noel, Shuhei Nomura, Jeremy Novak, Andrew Stricklin, Raymond Swienton, Ismail Tayfur, Bryan Brooks

College of Population Health Faculty Papers

OBJECTIVE: The aim of this study was to identify and prioritize strategies for strengthening public health system resilience for pandemics, disasters, and other emergencies using a scorecard approach.

METHODS: The United Nations Public Health System Resilience Scorecard (Scorecard) was applied across 5 workshops in Slovenia, Turkey, and the United States of America. The workshops focused on participants reviewing and discussing 23 questions/indicators. A Likert type scale was used for scoring with zero being the lowest and 5 the highest. The workshop scores were analyzed and discussed by participants to prioritize areas of need and develop resilience strategies. Data from all …

Design, Analysis, And Interpretation Of Treatment Response Heterogeneity In Personalized Nutrition And Obesity Treatment Research, Roger S. Zoh, Bridget H. Esteves, Xiaoxin Yu, Amanda J. Fairchild, Ana I. Vazquez, Andrew G. Chapple, Andrew W. Brown, Brandon George, Derek Gordon, Douglas Landsittel, Gary L. Gadbury, Greg Pavela, Gustavo De Los Campos, Luis M. Mestre, David B. Allison

School of Public Health Faculty Publications

It is increasingly assumed that there is no one-size-fits-all approach to dietary recommendations for the management and treatment of chronic diseases such as obesity. This phenomenon that not all individuals respond uniformly to a given treatment has become an area of research interest given the rise of personalized and precision medicine. To conduct, interpret, and disseminate this research rigorously and with scientific accuracy, however, requires an understanding of treatment response heterogeneity. Here, we define treatment response heterogeneity as it relates to clinical trials, provide statistical guidance for measuring treatment response heterogeneity, and highlight study designs that can quantify treatment response …

Critical Issues In Community Health Course At Kingsborough Cc (Coh 1200) - Fall 2023, Jose Nanin

Open Educational Resources

This syllabus includes OER materials and college policies for a fully online course that exposes students to a range of topics and methods that health specialists use to research health disparities in affected communities. Through readings and videos, as well as online course assignments and discussions, students learn about library/database research methods, credibility of health information, and the health disparities most commonly occurring in modern society.