Medicine and Health Sciences Commons^™

Laboratory Analysis Of Risky Driving At 0.05% And 0.08% Blood Alcohol Concentration, Nicholas A. Van Dyke, Mark T. Fillmore

Psychology Faculty Publications

Background—The public health costs associated with alcohol-related traffic crashes are a continuing problem for society. One harm reduction strategy has been to employ per se limits for blood alcohol concentrations (BACs) at which drivers can legally operate motor vehicles. This limit is currently 0.08% in all 50 US states. Recently, the National Transportation Safety Board proposed lowering the legal limit to 0.05 % (NTSB, 2013). While research has well-validated the ability of alcohol to impair driving performance and heighten crash-risk at these BACs, relatively little is known about the degree to which alcohol might increase drivers’ risk-taking.

Methods—Risk-taking …

An Examination Of The Moderating Effect Of Proactive Coping In Nicu Nurses, Britan M. Moore

Loma Linda University Electronic Theses, Dissertations & Projects

The NICU environment is unique in that the patient population consists of critically ill neonates. Research has revealed that there are increased levels of depression, secondary traumatic stress, and burnout in nurses. Problem solving and support seeking coping strategies have been shown to be associated with lower levels of burnout and increased patient and job satisfaction in general staff nurses. Multiple linear regression and a hierarchical stepwise technique was used to conduct moderator analyses assessing whether the use of problem solving or support seeking strategies moderated the relationship between secondary traumatic stress levels and burnout as well as between depressive …

Coping As A Mediator Between Symptom Burden And Distress In Lung Cancer Patients, Spring F. Gehring

Loma Linda University Electronic Theses, Dissertations & Projects

Lung cancer is considered the leading cause of cancer death worldwide. An estimated 224,390 new cases of lung cancer are expected to be diagnosed and 158,080 Americans are expected to die from lung cancer in 2016 (National Institutes of Health, 2016; Siegel, Miller, & Jemal, 2016). Lung cancer patients also report the highest levels of psychological distress and symptom burden than any other forms of cancer (Linden, Vodermaier, MacKenzie, & Greig, 2012). Given the prevalence and impact of lung cancer, it is imperative to address the emotional toll this diagnosis can have on those suffering with the disease to develop …

Dyadic Research In Couple Therapy: The Link Between Attachment And Relationship Satisfaction, Bryson Greaves

Loma Linda University Electronic Theses, Dissertations & Projects

Couple therapy ranks among the most frequently and diligently researched topics in Marital and Family therapy (MFT). Additionally, intimate partner relationships are a key focal point for clinical intervention with increasingly more couples seeking therapy to address relational conflict, repair emotional injury, and increase intimacy (Lebow, Chambers, Christensen, & Johnson 2012). Rigorous empirical inquiry has suggested that attachment theory is a crucial foundation to understanding relationship distress and increasing relationship satisfaction (Wiebe & Johnson, 2016). Secure attachment between intimate partners can lead to an increase in trust (Pistole, 1993), healthy emotion regulation (Kobak & Hazan, 1991), and positive conflict resolution …

Cancer Center Regional Benchmarks For Psychosocial Care, Desiree R. Azizoddin

Loma Linda University Electronic Theses, Dissertations & Projects

The American College of Surgeons (ACoS) Commissions on Cancer (CoC) formulated and implemented standard 3.2 for Psychosocial Distress Screening. This standard requires that all accredited cancer centers evaluate psychosocial distress and provide appropriate triage and intervention for all cancer patients. Over the past decade, Loma Linda University Medical Oncology Center (LLUMOC) administration, physicians, nurses, psychosocial care staff, and chaplaincy collaborated to implement a psychosocial screening and referral program throughout cancer patient services. This current research includes qualitative analysis assessing strengths and barriers of the psychosocial program at LLUMOC from the perspective of LLUMOC providers and two directors of Supportive Care …

Neurophysiological Capacity In A Working Memory Task Differentiates Dependent From Nondependent Heavy Drinkers And Controls, Michael J. Wesley, Joshua A. Lile, Mark T. Fillmore, Linda J. Porrino

Behavioral Science Faculty Publications

Background—Determining the brain-behavior profiles that differentiate heavy drinkers who are and are not alcohol dependent will inform treatment efforts. Working memory is linked to substance use disorders and can serve as a representation of the demand placed on the neurophysiology associated with cognitive control.

Methods—Behavior and brain activity (via fMRI) were recorded during an N-Back working memory task in controls (CTRL), nondependent heavy drinkers (A-ND) and dependent heavy drinkers (A-D). Typical and novel step-wise analyses examined profiles of working memory load and increasing task demand, respectively.

Results—Performance was significantly decreased in A-D during high working memory load …

Clinical Social Workers’ Perspectives On Illicit Drug Use And The Development Of Psychotic Disorders, Asma Naseer

Electronic Theses, Projects, and Dissertations

This purpose of this study was to explore social workers’ perspectives of drug-induced psychosis. More specifically, it sought to determine how knowledgeable clinical social workers are on the impact illicit drug use on the development of psychotic disorders. The study also aimed to discover clinical social workers’ perspectives regarding the influence of illicit drug use on the development of psychotic illnesses. This study used mixed methods approach in attempt to solve the research question. The quantitative portion of the research, an anonymous survey, allowed for the assessment of social workers’ knowledge of drug-induced psychosis. The qualitative portion of the research, …

Towards Unobtrusive Mental Well-Being Monitoring For Independent-Living Elderly, Sinh Huynh, Hwee-Pink Tan, Youngki Lee

Research Collection School Of Computing and Information Systems

It is essential to proactively detect mental health problems such as loneliness and depression in the independently-living elderly for timely intervention by caregivers. In this paper, we introduce an unobtrusive sensor-enabled monitoring system that has been deployed to 50 government housing ats with the independent-living elderly for two years. Then, we also present our initial findings from the 6-month sensor data between August 2015 and April 2016 as well as the survey data to measure the subjective well-being indicator. Our study showed the promising results that "room-level movements within a house" and "going out" behavior captured by our simple sensor …

Ultrasonography In Acupuncture: Uses In Education And Research, Mabel Qi He Leow, Shu Li Cui, Mohammad Taufik Bin Mohamed Shah, Taige Cao, Shian Chao Tay, Peter Kay Chai Tay, Chin Chin Ooi

Research Collection School of Social Sciences

This study aims to explore the potential use of ultrasound in locating the second posterior sacral foramen acupuncture point, quantifying depth of insertion and describing surrounding anatomical structures. We performed acupuncture needle insertion on a study team member. There were four steps in our experiment. First, the acupuncturist located the acupuncture point by palpation. Second, we used an ultrasound machine to visualize the structures surrounding the location of the acupuncture point and measure the depth required for needle insertion. Third, the acupuncturist inserted the acupuncture needle into the acupuncture point at an angle of 30°. Fourth, we performed another ultrasound …

A Descriptive Study Of The Elderly In California Substance Abuse Treatment Programs, David Berenschot

Electronic Theses, Projects, and Dissertations

As gerontologists may know, there are a great deal of studies and a variety of academic literature on the misuse of alcohol and prescription medication amongst the elderly population. While there is a plethora of information on alcohol and prescription misuse, there is little reported data about the prevalence of other substance misuse experienced by this population. This study aims to help to fill that gap in the data by using quantitative methods to describe the scope of substance abuse of individuals 55-years or older. This study utilizes data from the Treatment Data Set Admission (TEDS-A). The TEDS-A is a …

Community Living Integration Club For Women In Recovery From Sex Trafficking, Toni Thompson

Occupational Therapy Program Student Theses, Dissertations and Capstones

Sex trafficking is one form of human trafficking, a heinous human rights violation that transcends international borders. People who have been trafficked often present with complex neurobehavioral, psychological, emotional, physiological, sensory, and developmental difficulties. The United Nations developed the international 3 p protocol to guide governmental agencies, non-governmental groups, and individuals in developing programs and legal actions of trafficking prevention, protection, and prosecution. Protection encompasses the recovery of trafficking survivors and community integration has been identified as an essential foundation for successful recovery. Measurable components of community integration include safe housing, stable employment, and vocation-focused education. This Capstone describes the …

Determined Wellness: The Influence Of Mental Illness Models Upon Treatment Outcome Expectancies And Treatment Engagement, Francisco I. Surace

Graduate Doctoral Dissertations

Multiple campaigns geared towards reducing public and self-stigma associated with depression, and increasing help-seeking behaviors have been launched in the past two decades. There has been an increase in promoting psychoeducation on the biological bases of mental illness. Recent international studies have documented that this increase in public knowledge has not reduced stigma. Indeed, growing evidence suggests that biological models, in comparison to other causal models of mental illness, decrease people’s sense of self-efficacy and self-control, and decrease positive expectancies of treatments and prognosis–among those with and without mental illness. Individuals who have come in contact with health services, however, …

Digital Mindfulness: An Emerging Field Of Inquiry And Practice, Sherri Henderson

Mindfulness Studies Theses

This two-part paper explores digital mindfulness as an emerging field of inquiry and practice into the integration of technology and contemplative practices. The first part surveys the growing research on the effects of technology on health and well-being. Investigating Buddhist teachings leads to a more balanced and aware approach towards integrating mindfulness with the digital world. Digital mindfulness encourages meaningful engagement while online. It also encourages thoughtfulness, awareness and intention. Digital mindfulness also reshapes and encourages conversations in our homes, schools, and proposes digital responsibility and digital citizenship. The second part of the paper proposes a framework for a workshop …

Black, Woman And Alive: Black Women’S Practices Of Nontraditional Healing And Freedom, Hythia Phifer

Expressive Therapies Capstone Theses

This thesis explores the implications of nontraditional healing methods on Black women’s psychological and holistic health. It includes a critical literature review of existing research by Black Feminist theorists and other Black women scholars on Black women who use nontraditional healing methods, particularly to overcome the violent and pervasive experience of gendered racism and misogynoir. A brief autoethnographic analysis of my own art-based practice is included, with ties to the effectiveness of Literature and Poetry as a nontraditional healing method used by Black women. This thesis is my attempt to create space for myself in academia, in social science, in …

Employing Polyethnography To Navigate Researcher Positionality On Weight Bias, Nancy Arthur, Darren E. Lund, Shelly Russell-Mayhew, Sarah Nutter, Emily Williams, Monica Sesma Vazquez, Anusha Kassan

The Qualitative Report

Researchers often focus on the content of their research interests but, depending on the research approach, may pay less attention to the process of locating themselves in relation to the research topic. This paper outlines the dialogue between an interdisciplinary team of researchers who were at the initial stages of forming a research agenda related to weight bias and social justice. Using a polyethnographic approach to guide our discussion, we sought to explore the diverse and common life experiences that influenced our professional interests for pursuing research on weight bias. As a dialogic method, polyethnography is ideally suited for the …

Flesh And Blood, Clayton Petras

Graduate School of Art Theses

In my work, I look for ways to visualize and document the degenerative mental disease of Parkinson’s and transform it into portrayals of the disease itself, its effects, and those it afflicts. Being a physical breakdown of the body, both popular culture and my own corporal understanding influence my interpretation and representation. This document outlines those influences and their buildup towards a shared understanding of the interests behind the work, as well as implies what the work does through these contexts.

How do we give identity to a disease that is difficult to diagnose or view on medical technology, currently …

Dynamic Modeling Of Problem Drinkers Undergoing Behavioral Treatment, Rebecca A. Everett

Biology and Medicine Through Mathematics Conference

No abstract provided.

Increasing Access To Aba Intervention For Children With Developmental Disabilities In Taiwan, Noel Hsu

Master's Projects and Capstones

Applied Behavior Analysis (ABA) uses a behavioral approach to help clients and their behavioral challenges. This treatment has been proven to be a highly effective intervention for children with developmental disabilities, such as autism spectrum disorders. It is widely practiced in the United States and many other developed countries; however, this intervention is not widely available in Taiwan. This phenomenon requires our investigation because it raises questions about the available supports and interventions for children with special needs in Taiwan. This project is to explore factors that influence the development of ABA intervention in Taiwan. The goal of this project …

Down Syndrome, The Image Of God, And Personhood, Paris Webb

Dialogue & Nexus

People with Down syndrome help Christians understand what being made in the image of God truly means. After describing Down syndrome, we will examine the different views of the image of God and how these relate to people with Down syndrome. Another approach will be to define personhood in light of God’s image and relate it to Down syndrome. We will use the principles held by the L’Arche community as an exemplar in this discussion to demonstrate that those with Down syndrome encourage us to expand our understanding of the image of God. Consequently, Down’s persons allow us to apply …

Computational Modeling Of Contrast Sensitivity And Orientation Tuning In Schizophrenia, Steven M. Silverstein, Docia L. Demmin, James A. Bednar

MODVIS Workshop

Computational modeling is being increasingly used to understand schizophrenia, but, to date, it has not been used to account for the common perceptual disturbances in the disorder. We manipulated schizophrenia-relevant parameters in the GCAL (gain control, adaptation, laterally connected) model (Stevens et al., 2013), run using the Topographica simulator (Bednar, 2012), to model low-level visual processing changes in the disorder. Our models incorporated: separate sheets for retinal, LGN, and V1 activity; gain control in the LGN; homeostatic adaptation in V1 based on a weighted sum of all inputs and limited by a logistic (sigmoid) nonlinearity; lateral excitation and inhibition in …

Easi-Crispr: A Robust Method For One-Step Generation Of Mice Carrying Conditional And Insertion Alleles Using Long Ssdna Donors And Crispr Ribonucleoproteins., Rolen M Quadros, Hiromi Miura, Donald W Harms, Hisako Akatsuka, Takehito Sato, Tomomi Aida, Ronald Redder, Guy P Richardson, Yutaka Inagaki, Daisuke Sakai, Shannon M Buckley, Parthasarathy Seshacharyulu, Surinder K Batra, Mark A Behlke, Sarah A Zeiner, Ashley M Jacobi, Yayoi Izu, Wallace B Thoreson, Lisa D Urness, Suzanne L Mansour, Masato Ohtsuka, Channabasavaiah B Gurumurthy

Journal Articles: Munroe-Meyer Institute

BACKGROUND: Conditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic studies and comprise over 90% of mouse models created. Conditional knockout mice are generated using labor-intensive methods of homologous recombination in embryonic stem cells and are available for only ~25% of all mouse genes. Transgenic mice generated by random genomic insertion approaches pose problems of unreliable expression, and thus there is a need for targeted-insertion models. Although CRISPR-based strategies were reported to create conditional and targeted-insertion alleles via one-step delivery of targeting components directly to zygotes, these strategies are quite inefficient. …

Serious Mental Illness Among Young Adult Women Who Use Drugs In The Club Scene: Co-Occurring Biopsychosocial Factors, Maayan Lawental, Hilary L. Surratt, Mance E. Buttram, Steven P. Kurtz

Center for Health Services Research Faculty Publications

Young women who regularly attend nightclubs are at risk for numerous health and social consequences, including mental distress, sexual and physical victimization and substance dependence. This paper uses a biopsychosocial framework to examine co-occurring mental health problems, victimization, substance dependence, sexual risk and physical pain among a sample of young women who use drugs (N = 222) in Miami’s club scene. The majority of women were under 24 years old, Hispanic, and identified as heterosexual. Almost all the women reported past 90-day use of alcohol, ecstasy/MDMA, marijuana, cocaine and prescription opioids and benzodiazepines; 32% of women reported being in a …

The Effects Of Nicotine In The Neonatal Quinpirole Rodent Model Of Psychosis: Neural Plasticity Mechanisms And Nicotinic Receptor Changes, Daniel J. Peterson, W. Drew Gill, John M. Dose, Donald B. Hoover, James R. Pauly, Elizabeth D. Cummins, Katherine C. Burgess, Russell W. Brown

Pharmaceutical Sciences Faculty Publications

Neonatal quinpirole (NQ) treatment to rats increases dopamine D2 receptor sensitivity persistent throughout the animal’s lifetime. In Experiment 1, we analyzed the role of α7 and α4β2 nicotinic receptors (nAChRs) in nicotine behavioral sensitization and on the brain-derived neurotrophic factor (BDNF) response to nicotine in NQ- and neonatally saline (NS)-treated rats. In Experiment 2, we analyzed changes in α7 and α4β2 nAChR density in the nucleus accumbens (NAcc) and dorsal striatum in NQ and NS animals sensitized to nicotine. Male and female Sprague-Dawley rats were neonatally treated with quinpirole (1 mg/kg) or saline from postnatal days (P)1–21. Animals were given …

Relationships Of Weight-Related Dissatisfaction, Body Image Flexibility, And Coping In Women, Pooja Shah

Electronic Theses and Dissertations

Purpose: The present study examined the relationships between body image flexibility, body image dissatisfaction, body image evaluation, and specific coping factors based on the WEIGHTCOPE measure. Body image flexibility was also examined as a mediator of the relationship between body image dissatisfaction and weight-related coping factors in women. Methods: An online link of the survey (Qualtrics Research Software Program) was distributed through social media and word of mouth to women of all body shapes and sizes (N= 267). The survey included the BICS as a measure of body image dissatisfaction, the MBSR (AE) as a measure of body …

Mindfulness Meditation As A Stress Reactivity Intervention: An Event-Related Potential Study, Jessica L. Trottier, Barry S. Oken

Student Research Symposium

The biological and neural mechanisms of stress have been extensively studied and supported, but are still unclear. Event-related potentials (ERP’s) emitted by neurons in the brain are a useful tool in measuring stress because they reflect neural response in real-time, to the millisecond, versus typical biological markers, which are typically evaluated before and after a stress test. The neurobiological relationship between ERP’s and stress originates in the anterior cingulate cortex, which in turn activates the hypothalamic–pituitary–adrenal axis; the main physiological cascade fueling the stress response and its chronically harmful symptoms. Malfunctions in the stress response, as in the cases of …

Unreplicable: The Unscientific Nature Of Science Journals, Ernest M. Oleksy

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Academia shapes the way our species looks at veracity and defines what is deemed as well-founded science. The platform for researchers to make their work known is academic journals. The prerogative of these journals is to disseminate technically sound work so that the public may be informed of up-to-date advances in scientific fields. However, these journals are products on the market whose ultimate purpose is to garner a following that will make the producers money. This results in research that does not have statistically significant findings, or replications of past experiments which are integral to supporting the findings of the …

Representation Of Multiple Body Parts In The Missing-Hand Territory Of Congenital One-Handers., Avital Hahamy, Scott N Macdonald, Fiona Van Den Heiligenberg, Paullina Kieliba, Uzay Emir, Rafael Malach, Heidi Johansen-Berg, Peter Brugger, Jody C Culham, Tamar R Makin

Brain and Mind Institute Researchers' Publications

Individuals born without one hand (congenital one-handers) provide a unique model for understanding the relationship between focal reorganization in the sensorimotor cortex and everyday behavior. We previously reported that the missing hand's territory of one-handers becomes utilized by its cortical neighbor (residual arm representation), depending on residual arm usage in daily life to substitute for the missing hand's function [1, 2]. However, the repertoire of compensatory behaviors may involve utilization of other body parts that do not cortically neighbor the hand territory. Accordingly, the pattern of brain reorganization may be more extensive [3]. Here we studied unconstrained compensatory strategies under …

Effect Of Activity Trackers And Text Messaging On Exercise, Fitness, And Physical Activity Self-Efficacy Of Middle School Students, Alison F. Pittman

Nursing Theses and Dissertations

A decrease in physical activity as children age is a contributing factor to the U.S. obesity epidemic. Middle school children are particularly vulnerable to sedentary activities. Activity trackers show promise as a means to motivate children and adults to increase physical activity (PA). This study examined the effect of a text messaging intervention and use of activity trackers with a companion social website on the body mass index (BMI), body fat percentage, physical fitness, and PA self-efficacy of middle school children. Children aged 11-14 (n=102) were randomly assigned to one of three groups for a 10-week intervention: activity tracker group; …

Coordinated Pluralism As A Means To Facilitate Integrative Taxonomies Of Cognition, Jacqueline Anne Sullivan

Brain and Mind Institute Researchers' Publications

© 2017 Informa UK Limited, trading as Taylor & Francis Group. The past decade has witnessed a growing awareness of conceptual and methodological hurdles within psychology and neuroscience that must be addressed for taxonomic and explanatory progress in understanding psychological functions to be possible. In this paper, I evaluate several recent knowledge-building initiatives aimed at overcoming these obstacles. I argue that while each initiative offers important insights about how to facilitate taxonomic and explanatory progress in psychology and neuroscience, only a “coordinated pluralism” that incorporates positive aspects of each initiative will have the potential for success.

The Role Of Simulation In Mixed-Methods Research: A Framework & Application To Patient Safety, Jeanne-Marie Guise, Matthew Hansen, William E. Lambert, Kerth O'Brien

Psychology Faculty Publications and Presentations

Background: Research in patient safety is an important area of health services research and is a national priority. It is challenging to investigate rare occurrences, explore potential causes, and account for the complex, dynamic context of healthcare - yet all are required in patient safety research. Simulation technologies have become widely accepted as education and clinical tools, but have yet to become a standard tool for research.

Methods: We developed a framework for research that integrates accepted patient safety models with mixed- methods research approaches and describe the performance of the framework in a working example of a large …