Medicine and Health Sciences Commons^™

Does Attention-Deficit/Hyperactivity Disorder Increase The Risk Of Minor Blunt Head Trauma In Children?, Murat Pakyurek, Mohamed Badawy, Irma T Ugalde, Paul Ishimine, Pradip P Chaudhari, Kevan Mccarten-Gibbs, Ozra Nobari, Nathan Kuppermann, James F Holmes

Faculty, Staff and Student Publications

PROBLEM: It is unclear if attention-deficit hyperactivity disorder (ADHD) increases the risk of head trauma in children.

METHODS: We conducted a multicenter prospective observational study of children with minor blunt head trauma. Guardians were queried, and medical records were reviewed as to whether the patient had previously been diagnosed with ADHD. Enrolled patients were categorized based on their mechanism of injury, with a comparison of those with motor vehicle collision (MVC) versus non-MVC mechanisms.

FINDINGS: A total of 3410 (84%) enrolled children had ADHD status available, and 274 (8.0%; 95% confidence interval, CI: 7.1, 9.0%) had been diagnosed with ADHD. …

Meaningful Improvement In General Health Outcomes With Guselkumab Treatment For Psoriatic Arthritis: Patient-Reported Outcomes Measurement Information System-29 Results From A Phase 3 Study, Ana-Maria Orbai, Laura C Coates, Atul Deodhar, Philip S Helliwell, Christopher T Ritchlin, Evan Leibowitz, Alexa P Kollmeier, Elizabeth C Hsia, Xie L Xu, Shihong Sheng, Yusang Jiang, Yan Liu, Chenglong Han

Faculty, Staff and Student Publications

OBJECTIVE: The Phase 3 DISCOVER-1 study of guselkumab is the first randomized controlled trial to use Patient-Reported Outcomes Measurement Information System (PROMIS) measures to assess the effects of treatment on general health outcomes in patients with psoriatic arthritis (PsA).

METHODS: Patients (N = 381) with active PsA were randomized 1:1:1 to guselkumab 100 mg every 4 weeks (Q4W); guselkumab 100 mg at Week 0, Week 4, then every 8 weeks (Q8W); or placebo with Week 24 crossover to guselkumab Q4W. The PROMIS-29 Profile contains four items for each of seven domains (anxiety, depression, fatigue, pain interference, physical function, sleep disturbance, …

The Correlation Between Transformational Leadership And Mental Health Clinician Burnout, Rebekah E. Shutter

Electronic Theses and Dissertations

Mental health clinicians working in a hospital setting are at a high risk of experiencing burnout due to the stressful demands of their caseloads, compassion fatigue, limited resources, and unsupportive leadership. While there is ample research regarding the cause and effect of burnout on clinicians there is a gap in the literature when it comes to the impact leadership has on mental heath clinician burnout. The purpose of this quantitative, correlational study is to determine if and to what extent there is a correlation between Transformational Leadership and mental health clinician burnout. Participants for this study consisted of 200 mental …

Structural Brain Alterations Associated With Suicidal Thoughts And Behaviors In Young People: Results From 21 International Studies From The Enigma Suicidal Thoughts And Behaviours Consortium, Laura S Van Velzen, Maria R Dauvermann, Lejla Colic, Luca M Villa, Hannah S Savage, Yara J Toenders, Alyssa H Zhu, Joanna K Bright, Adrián I Campos, Lauren E Salminen, Sonia Ambrogi, Rosa Ayesa-Arriola, Nerisa Banaj, Zeynep Başgöze, Jochen Bauer, Karina Blair, Robert James Blair, Katharina Brosch, Yuqi Cheng, Romain Colle, Colm G Connolly, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Katharina Dohm, Janice M Fullerton, Ali Saffet Gonul, Ian H Gotlib, Dominik Grotegerd, Tim Hahn, Ben J Harrison, Mengxin He, Ian B Hickie, Tiffany C Ho, Frank Iorfino, Andreas Jansen, Fabrice Jollant, Tilo Kircher, Bonnie Klimes-Dougan, Melissa Klug, Elisabeth J Leehr, Elizabeth T C Lippard, Katie A Mclaughlin, Susanne Meinert, Adam Bryant Miller, Philip B Mitchell, Benson Mwangi, Igor Nenadić, Amar Ojha, Bronwyn J Overs, Julia-Katharina Pfarr, Fabrizio Piras, Kai G Ringwald, Gloria Roberts, Georg Romer, Marsal Sanches, Margaret A Sheridan, Jair C Soares, Gianfranco Spalletta, Frederike Stein, Giana I Teresi, Diana Tordesillas-Gutiérrez, Aslihan Uyar-Demir, Nic J A Van Der Wee, Steven J Van Der Werff, Robert R J M Vermeiren, Alexandra Winter, Mon-Ju Wu, Tony T Yang, Paul M Thompson, Miguel E Rentería, Neda Jahanshad, Hilary P Blumberg, Anne-Laura Van Harmelen, Enigma Suicidal Thoughts And Behaviours Consortium, Lianne Schmaal

Faculty, Staff and Student Publications

Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample …

Phubbing And Fear Of Missing Out As Mediators Between Problematic Social Media Use And Life Satisfaction Among Young Adults, Najeera Peer Meera Levai

Theses

Recent studies have shown certain risk indicators for young adults' decreased life satisfaction as a result of excessive social media use. However, few studies have looked at possible impact of problematic social media on life satisfaction, and less information is known about the mediating factors that contribute to this association. The purpose of the current study was to determine whether problematic social media use predicts life satisfaction among young adults. It also explored whether phubbing behaviour and fear of missing out might both serve as mediators in this relationship. A sample of 351 young adults (18–25, M_age = 19.74 …

Moderating Factors In The Relationship Between Bully Victimization And Psychosomatic Symptoms, Tonya Paulson

Theses and Graduate Projects

The purpose of this study was to investigate the relationship between bully victimization and psychosomatic symptoms, and to examine the protective influence of perceived parent and peer support across developmental age groups. Bully victimization frequency, somatic symptom severity, perceived parent support, and perceived peer support were assessed using archival data from 7,304 youth who participated in the 2009-2010 Health Behavior in School-Aged Children (HBSC) U.S. survey, excluding perpetrators of bullying. Bully victimization and somatic symptoms were significantly positively correlated. Older adolescents consistently reported more severe somatic symptoms, but age did not moderate the relationship between bullying and somatic symptoms. Higher …

Early Life Exposure To Unpredictable Parental Sensory Signals Shapes Cognitive Development Across Three Species, Elyssia Poggi Davis, Kari Mccormack, Hina Arora, Desiree Sharpe, Annabel K. Short, Jocelyne Bachevalier, Laura M. Glynn, Curt A. Sandman, Hal S. Stern, Mar Sanchez, Tallie Z. Baram

Psychology Faculty Articles and Research

Exposure to early life adversity has long term consequences on cognitive function. Most research has focused on understanding components of early life adversities that contribute to later risk, including poverty, trauma, maltreatment, and neglect. Whereas these factors, in the aggregate, explain a significant proportion of emotional and cognitive problems, there are serious gaps in our ability to identify potential mechanisms by which early life adversities might promote vulnerability or resilience. Here we discuss early life exposure to unpredictable signals from the caretaker as an understudied type of adversity that is amenable to prevention and intervention. We employ a translational approach …

Media Multitasking And Sustained Attention: An Experimental Investigation, Ryan Nix

Student Theses and Dissertations

Research exploring the cognitive effects of media multitasking show a lack of convergent findings among studies that utilize the Media Multitasking Index (MMI) and behavioral measures of sustained attention. All these studies approached media multitasking as a linear construct with solely cumulative effects. To investigate the possibility that media multitasking may have immediate, direct effects on sustained attention, a laboratory media multitasking simulation was implemented alongside the MMI and the Sustained Attention to Response Task (SART). Eighty-one participants completed all measures; half experienced the media multitasking simulation. It was predicted that experimental participants would exhibit more post-simulation SART NOGO errors …

The Development And Implementation Of Evidence-Based Preanesthesia Assessment Tools For Lvad Patients Undergoing Non-Cardiac Procedures, Tracey Rooney, Casey Weimer, Eileen Giardino, Kerry Shanklin, Pete Pelletier, Audrey Rosenblatt

Journal of Nursing & Interprofessional Leadership in Quality & Safety

Abstract

A university-affiliated tertiary medical center with a newly developed Advanced Heart Failure and Mechanical Circulatory Support program identified the need to implement a more systematic approach to the preanesthesia assessment process for patients with a Left Ventricular Assist Device (LVAD) undergoing noncardiac procedures and standardized guidelines to determine the best blood pressure monitoring system for patients with an LVAD during these noncardiac procedures. A multidisciplinary panel of clinical experts developed an LVAD Preanesthesia Toolkit using standard recommendations identified via evidence-based literature and expert opinion. The Toolkit included an LVAD Preanesthesia Assessment (VaPA) tool and an LVAD Blood Pressure Monitoring …

Contrafreeloading In Kea (Nestor Notabilis) In Comparison To Grey Parrots (Psittacus Erithacus), Gabriella E. Smith, Amalia P. M. Bastos, Martin Chodorow, Alex H. Taylor, Irene M. Pepperberg

Publications and Research

Contrafreeloading—working to access food that could be freely obtained—is rarely exhibited and poorly understood. Based on data from Grey parrots ( Psittacus erithacus ), researchers proposed a correlation between contrafreeloading and play: that contrafreeloading is more likely when subjects view the task as play. We tested that hypothesis by subjecting a relatively more playful parrot species, the kea ( Nestor notabilis ), to the same experimental tasks. Experiment 1 presented eight kea with container pairs holding more- or less-preferred free or enclosed food items, and examined three types of contrafreeloading: calculated (working to access preferred food over less-preferred, freely available …

Engagement For Good Or Ill: Comparing Characteristics Of Co-Creative And Co-Destructive Online Communities, Yimin Chen, Sarah Cornwell, Nicole Delellis, Dominique Kelly, Liu Yifan, Alex Mayhew, Victoria Rubin

Data and Test Instruments

Highly engaged online communities can be characterized in terms of level of user activity and the valence of those activities. Positively-valenced communities engage in co-construction through supportive, uplifting interactions, while negatively-valenced communities engage in co-destruction through shared animosity towards outside individuals and groups. Both types of engagement offer prosocial benefits to community members, but this benefit is achieved through antisocial means in co-destructive communities. This study examines the features of one positively-valenced and one negatively-valenced subreddit community to determine if the same engagement factors drive participation in each, and whether these factors may be influenced to promote positive, rather than …

Full Issue, Winthrop Mcnair Research Bulletin

The Winthrop McNair Research Bulletin

Winthrop McNair Research Bulletin Volume 5, Full Issue

The Impact Of Generalized Anxiety Disorder On Academic Performance In Undergraduate Students Following A Brief Guided Meditation, Ali Maclay

The Winthrop McNair Research Bulletin

Many undergraduate college students report high levels of anxiety, which can negatively impact their academic performance. Meditation is currently being explored as a method to reduce anxiety, with the duration and frequency under investigation to optimize outcomes. Therefore, this pilot study examined whether the severity of generalized anxiety disorder affected the influence of a brief, one-time, guided meditation on undergraduate academic performance. This study also investigated student perceptions of meditation and test anxiety. Students completed the GAD-7 to assess levels of anxiety, participated in a brief meditation, completed a lab quiz, and evaluated their meditation experience through a post-survey. We …

Cue-Induced Cocaine Craving Enhances Psychosocial Stress And Vice Versa In Chronic Cocaine Users, Ann-Kathrin Kexel, Bruno Kluwe-Schiavon, Markus R Baumgartner, Etna J E Engeli, Monika Visentini, Clemens Kirschbaum, Erich Seifritz, Beate Ditzen, Leila M Soravia, Boris B Quednow

Faculty, Staff and Student Publications

Stress and craving, it has been found, contribute to the development and maintenance of and relapse in cocaine use disorder. Chronic cocaine users (CU), previous research has shown, display altered physiological responses to psychosocial stress and increased vegetative responding to substance-related cues. However, how psychosocial stress and cue-induced craving interact in relation to the CU's physiological responses remains largely unknown. We thus investigated the interaction between acute psychosocial stress and cocaine-cue-related reactivity in 47 CU and 38 controls. In a crossed and balanced design, the participants were randomly exposed to a video-based cocaine-cue paradigm and the Trier Social Stress Test …

Molecular Pathways Of Major Depressive Disorder Converge On The Synapse, Gabriel R Fries, Valeria A Saldana, Johannes Finnstein, Theo Rein

Faculty, Staff and Student Publications

Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major systems under consideration include monoamines, stress, neurotrophins and neurogenesis, excitatory and inhibitory neurotransmission, mitochondrial dysfunction, (epi)genetics, inflammation, the opioid system, myelination, and the gut-brain axis, among others. This review aims at illustrating how these multiple signaling pathways and systems may interact to provide a more comprehensive view of MDD's neurobiology. In particular, considering the pattern of synaptic activity as the closest physical representation of mood, …

Psychophysiological Effects Of Increasing Awareness Of Nondual Consciousness In Young Adults With Depression And Anxiety, Milena Braticevic

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

Young adults increasingly suffer from anxiety and depression during the time of transition into adulthood. This research study examined the effects of increasing awareness of nondual consciousness in young adults who were experiencing various levels of anxiety and depression. The methodology was mixed-method and included four 1-hour group-based sessions over 4 weeks. Increasing awareness of nondual consciousness through educational, experiential, and behavioural components resulted in reduction in the average depression score from 19.4 (borderline clinical depression) to 10 (normal), and reduction in the average anxiety score from 12.7 (moderate anxiety) to 6.9 (mild). Participants reported increased mental, emotional, physical, and …

Description Des Stratégies Favorisant L'Adoption De Comportements Préventifs Chez Les Travailleurs Ayant Subi Une Lésion Professionnelle : Une Revue Critique De La Littérature, Alexandra Lecours, Marie-France Coutu, Marie-José Durand

Rapports de recherche scientifique

Contexte et objectif de la recherche

Certains travailleurs ayant subi une lésion professionnelle présentent des difficultés à se maintenir au travail à long terme au retour d’une période d’absence, et ce, même après avoir reçu des services de réadaptation. Les professionnels de la réadaptation ont un rôle à jouer pour favoriser ce maintien sain et durable au travail, notamment par le soutien au développement des comportements préventifs chez les travailleurs. En effet, de récentes études ont permis de développer le Modèle des comportements préventifs au travail (MCPT) qui décrit six comportements que les travailleurs peuvent adopter en interaction avec leur …

The Relationship Between Chronic Pain And Stress, Anxiety, And Depression In College Students

Journal of Interdisciplinary Undergraduate Research

The purpose of this study was to measure chronic pain levels as they relate to stress, anxiety, and depression in college students. This is a non-experimental, correlational research design, using a survey methodology. Eighty-four participants, over the age of 18, were recruited (men = 33.3%, women = 66.6%) to participate in this study. The participants were asked to complete a questionnaire which was a compilation of the Chronic Pain Grade Questionnaire (CPGQ) (Von Korff et al., 1992), the Perceived Stress Scale (Wickrama et al., 2013), the Beck Anxiety Inventory (BAI) (Beck et al., 1988), the Beck Depression Inventory-II (BDI-II) (Beck …

How To Survive College As An Acoa: The Effectiveness Of University Resources On Helping Acoas Socially And Psychologically Succeed During Their Academic Career, Kelly Buchan

Senior Theses

In 2019, 14.5 million people ages 12 and older had Alcohol Use Disorder (AUD), but only 10% received treatment (National Institute on Alcohol Abuse and Alcoholism [NIAAA], 2022). Parental drinking problems can directly affect children, or “Adult Children of Alcoholics.” Of the few studies targeting ACoAs, results show that ACoAs not only have higher risks of mental illness, but they also have lower GPAs and social health (Schroeder & Kelley, 2008). Thus, this study assessed the extent to which perceptions of the college drinking environment are related to higher depression rates in ACoAs, certain drinking motivations, and reluctance to use …

Accessibility Rating Form For Websites And Other Online Platforms, Ethan Wu, Jafra D. Thomas, Regina F. Hockert, Jasmine C. Wong, Samantha M. Ross

Kinesiology and Public Health

Background. This file provides a coding form developed to judge how accessible websites and other online platforms are to users. Accessibility may be defined as the ease to which a person can perceive content and navigate material (Ross & Ross, 2021). Users are encouraged to adapt this form for their use.

Purpose. The rating form can be used to judge the pages of online media, using 14 criteria under two areas: Accessible Media and Accessible Design. One of three grades could be assigned to each criterion: Not Accessible (0 point), Somewhat Accessible (1 point), Accessible (2 …

Correlations Between Peripheral Levels Of Inflammatory Mediators And Frontolimbic Structures In Bipolar Disorder: An Exploratory Analysis, Satyajit Mohite, Haitham Salem, Thiago Cordeiro, Jonika Tannous, Benson Mwangi, Sudhakar Selvaraj, Jair C Soares, Marsal Sanches, Antonio L Teixeira

Faculty, Staff and Student Publications

BACKGROUND: Altered peripheral immune/inflammatory system and brain volumetric changes have been implicated in the pathophysiology of bipolar disorder (BD). This study aimed to evaluate how peripheral levels of cytokines are related to volumetric brain changes in euthymic patients with BD.

METHODS: Euthymic patients with BD (n = 21) and healthy controls (n = 22) were enrolled in this exploratory study. Blood samples were collected on the same day of clinical assessment and neuroimaging. Cytokines were measured through cytometric bead array method. Neuroimaging data were acquired using a sagittal three-dimensional magnetic resonance imaging T1-weighted fast field echo sequence and was processed …

Altop (Alternatives To Opioids), Fall 2022, Dr. Susan L. Davis, Rn & Richard J. Henley College Of Nursing

News, Magazines and Reports

In this issue:

• New Principal Investigator (PI) ALTOP Grant
• 2021-2022 Graduating Class
• ANEW HRSA 2022-2023 Awardees
• Students Quality Improvement Projects
• April 9th, 2022, Preceptor Workshop Photos
• New Clinical Partner: The Bridgeport Rescue Mission/ Sage Health Care
• Save the Date: Annual DNP Colloquium

Risk Factors Of Cyberbullying Victimization: The Impact Of Developmental Trauma, Yuliya Mykytyn

Dissertations

Trauma has been considered as one of the significant causes of psychological distress, especially if the traumatic event occurred in the childhood. At the same time, due to wide popularity of social media as a source of communication, cyberbullying emerged as a new way to harass someone, with specific focus on adults and young adults. The area of focus of this research project is to investigate whether experienced trauma, specifically developmental trauma might serve as a risk factor for cyberbullying victimization. Additional focus was on the differences in traumatic experiences and their impact for people with diverse cultural and ethnic …

The Social Determinants Of Ideal Cardiovascular Health: A Global Systematic Review, Farah Qureshi, Kelb Bousquet-Santos, Sakurako S. Okuzono, Elaine Tsao, Scott Delaney, Anne-Josie Guimond, Julia K. Boehm, Laura D. Kubzansky

Psychology Faculty Articles and Research

This systematic review synthesizes research published from January 2010-July 2022 on the social determinants of ideal cardiovascular health (CVH) carried out around the world and compares trends in high-income countries (HICs) to those in low- and middle-income countries (LMICs). 41 studies met inclusion criteria (n = 28 HICs, n = 13 LMICs). Most were from the United States (n = 22) and cross-sectional (n = 33), and nearly all evaluated associations among adults. Among studies conducted in LMICs, nearly all were from middle-income countries and only one was carried out in low-income country. Education (n = …

Surveying The Stigma: How The Plhiv Stigma Index Acts As A Validated Framework To Measure Healthcare Discrimination And How It Can Be Adapted To Quantify Mental Health Stigma, Keeley Lariviere

Independent Study Project (ISP) Collection

The PLHIV Stigma Index is an ongoing, international study conducted by and for people living with HIV to measure the stigmatization that people living with HIV experience. As a model that has been proven successful in translating to targeted advocacy campaigns, this paper theorizes on how this Stigma Index could be broadened to capture other aspects of healthcare discrimination. With a growing demand for mental health support and a critically underdeveloped mental healthcare framework, understanding the stigma and discrimination that exist for people living with depression is a good place to start. Using mixed methods analysis from existing literature and …

“Living In Trauma 24/7”: A Qualitative Exploration Of Factors Contributing To Secondary Traumatic Stress And Burnout Among Student Services Professionals Working With Marginalized Student Populations, Delia Sanchez, Portia A. Jackson Preston, Christine Vu, Lucia Alcala

Journal of Human Services: Training, Research, and Practice

Higher education professionals are at risk of secondary traumatic stress (STS) as a result of supporting students experiencing trauma, while overwhelming workload, inadequate resources, and unclear role responsibilities may lead to burnout. This study explored contributing factors to STS and burnout and coping efforts among faculty, students, and staff working in a capacity in which they provide non-instructional support to programs or centers focusing on marginalized student populations. Participants (N=56) represented twenty-two U.S. regional universities, and were a subset of respondents to a larger mixed-methods study (n=559). Qualitative responses to three open-ended questions on challenges and coping efforts were analyzed …

Preconditioning By Voluntary Wheel Running Attenuates Later Neuropathic Pain Via Nuclear Factor E2-Related Factor 2 Antioxidant Signaling In Rats, Suzanne M Green-Fulgham, Michael E Harland, Jayson B Ball, Jiahe Li, Michael J Lacagnina, Heather D'Angelo, Renee A Dreher, Kendal F Willcox, Sabina A Lorca, Andrew J Kwilasz, Steven F Maier, Linda R Watkins, Peter M Grace

Faculty, Staff and Student Publications

Animal and human studies have shown that exercise prior to nerve injury prevents later chronic pain, but the mechanisms of such preconditioning remain elusive. Given that exercise acutely increases the formation of free radicals, triggering antioxidant compensation, we hypothesized that voluntary running preconditioning would attenuate neuropathic pain by supporting redox homeostasis after sciatic nerve injury in male and female rats. We show that 6 weeks of voluntary wheel running suppresses neuropathic pain development induced by chronic constriction injury across both sexes. This attenuation was associated with reduced nitrotyrosine immunoreactivity-a marker for peroxynitrite-at the sciatic nerve injury site. Our data suggest …

Development Of The International Spinal Cord Injury Basic Data Set For Informal Caregivers, Carol Haywood, Rebecca Martin, Kathryn Dent, M J Mulcahey

Faculty, Staff and Student Publications

STUDY DESIGN: Mixed-methods, including expert consensus for initial development and a multi-center repeated measures design for field testing.

OBJECTIVES: To develop an International Spinal Cord Injury Basic Data Set for caregivers of individuals with spinal cord injury/disorder (SCI/D) for use in research and clinical care settings.

SETTING: International, multi-disciplinary working group with field testing in five North American pediatric rehabilitation hospitals.

METHODS: The data set was developed iteratively through meetings and online surveys with a working group of experts in pediatric and adult SCI/D rehabilitation and caregivers of individuals with SCI/D. Initial reliability was examined through repeat administration of a …

Genetics And Epigenetics Of Self-Injurious Thoughts And Behaviors: Systematic Review Of The Suicide Literature And Methodological Considerations, Salahudeen Mirza, Anna R Docherty, Amanda Bakian, Hilary Coon, Jair C Soares, Consuelo Walss-Bass, Gabriel R Fries

Faculty, Staff and Student Publications

Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent need to advance research on its phenomenology and etiology. Epidemiological studies have demonstrated that suicidal behavior is heritable, suggesting that genetic and epigenetic information may serve as biomarkers for suicide risk. Here we systematically review the literature on genetic and epigenetic alterations observed in phenotypes across the full range of self-injurious thoughts and behaviors (SITB). We included 577 studies focused on genome-wide and epigenome-wide associations, candidate genes (SNP and methylation), noncoding RNAs, and histones. Convergence of specific genes is limited across units of analysis, although pathway-based …

Concerns About The Use Of Polygenic Embryo Screening For Psychiatric And Cognitive Traits, Todd Lencz, Maya Sabatello, Anna Docherty, Roseann E Peterson, Takahiro Soda, Jehannine Austin, Laura Bierut, David Crepaz-Keay, David Curtis, Franziska Degenhardt, Laura Huckins, Gabriel Lazaro-Munoz, Manuel Mattheisen, Bettina Meiser, Holly Peay, Marcella Rietschel, Consuelo Walss-Bass, Lea K Davis

Faculty, Staff and Student Publications

Private companies have begun offering services to allow parents undergoing in-vitro fertilisation to screen embryos for genetic risk of complex diseases, including psychiatric disorders. This procedure, called polygenic embryo screening, raises several difficult scientific and ethical issues, as discussed in this Personal View. Polygenic embryo screening depends on the statistical properties of polygenic risk scores, which are complex and not well studied in the context of this proposed clinical application. The clinical, social, and ethical implications of polygenic embryo screening have barely been discussed among relevant stakeholders. To our knowledge, the International Society of Psychiatric Genetics is the first professional …