Medicine and Health Sciences Commons^™

The Role Of Flumazenil In Generalised Anxiety Disorder: A Pilot Naturalistic Open-Label Study With A Focus On Treatment Resistance, Alexander T. Gallo, Stephen Addis, Vlad Martyn, Hishani Ramanathan, Grace K. Wilkerson, Kellie S. Bennett, Sean D. Hood, Hans Stampfer, Gary K. Hulse

Research outputs 2022 to 2026

Background: Anxiety disorders are highly prevalent and chronic disorders with treatment resistance to current pharmacotherapies occurring in approximately one in three patients. It has been postulated that flumazenil (FMZ) is efficacious in the management of anxiety disorders via the removal of 4 2 gamma-aminobutyric acid A receptors. Objective: To assess the safety and feasibility of continuous low-dose FMZ infusions for the management of generalised anxiety disorder (GAD) and collect preliminary efficacy data. Design: Uncontrolled, open-label pilot study. Method: Participants had a primary diagnosis of generalised anxiety disorder (GAD) and received two consecutive subcutaneous continuous low-dose FMZ infusions. Each infusion contained …

Survey Of Attitudes Toward Performing And Reflecting On Required Team Service-Learning (Sasl): Psychometric Data And Reliability/Validity For Healthcare Professions Students In Preclinical Courses, Lon J. Van Winkle, Shane L. Rogers, Bradley O. Thornock, Brian D. Schwartz, Alexis Horst, Jensen A. Fisher, Nicole Michels

Research outputs 2022 to 2026

Purpose: Previously we assessed healthcare professional students’ feelings about team-based learning, implicit bias, and service to the community using an in-house paper survey. In this study, we determined whether this survey is a reliable and valid measure of prospective medical students’ attitudes toward required service-learning in an Immunology course. To our knowledge, no published questionnaire has been shown to be dependable and useful for measuring such attitudes using only eight survey items. Methods: Fifty-eight prospective medical students in Colorado (CO) and 15 in Utah (UT) completed the same Immunology course using remote technology. In addition to the usual course content, …

Community Approaches To Veterans And Active-Duty Service Member Suicide Prevention Through Public Health Outreach: A Commentary, Joe Bohn, Tommy Childers, Christopher Baglivo

Florida Public Health Review

We discuss insights on a West Central Florida community-based Veterans suicide prevention effort- a series of Veterans coffee socials. Noted as a public health crisis which has been well documented, the article provides an overview of the importance of public health approaches and academic public health engagement at a local level to addressing suicide prevention at community levels. An active-duty service member’s perspective is provided that points to common pain points that that extend to the Veterans community with reintegration challenges. A community-based participatory research methodology has been applied which stressed the importance of community partners (e.g., public, private and …

Successful Treatment Of Myofascial Pain Syndrome (Mps) With Surgical Cauterization Of Temporalis Muscle Trigger Points: A Case Report, Craig Pearl, Brendan Moxley, Andrew Perry, Nagi Demian

Faculty, Staff and Student Publications

For patients suffering from myofascial pain syndrome (MPS) affecting muscles of mastication, traditional trigger point therapy treatment regimens can prove inconvenient, due to the short duration of pain relief after each injection and expense of repeated visits which are often not covered by insurance. We present a case of a patient treated using an alternative technique that could develop into an additional modality for treating MPS patients who are refractory to conservative treatment. This technique involves identifying and marking the patient's trigger points and surgically cauterizing each location using a Bovie electrosurgical unit. While traditional trigger point injection therapy for …

Occupational Depression In Italy: Associations With Health, Economic, And Work-Life Characteristics, Renzo Bianchi, Caterina Fiorilli, Giacomo Angelini, Nicoletta Dozio, Carlo Palazzi, Gloria Palazzi, Benedetto Vitiello, Irvin Sam Schonfeld

Publications and Research

Background: The Occupational Depression Inventory (ODI) reflects a new approach to job-related distress centered on work-attributed depressive symptoms. The instrument was developed with reference to the characterization of major depression found in the DSM-5. The ODI has been validated in English, French, and Spanish. This study (a) investigated the psychometric and structural properties of the ODI’s Italian version and (b) inquired into the nomological network of occupational depression. Methods: A convenience sample of 963 employed individuals was recruited in Italy (69.9% female; mean age = 40.433). We notably relied on exploratory structural equation modeling bifactor analysis, common-practice …

A Forehead Wearable Sensor For The Objective Measurement Of Chronic Pain, Marcus Orzabal, Ramo Naidu, Kasra Amirdelfan, Alireza Akhbardeh

Faculty, Staff and Student Publications

Chronic pain impacts one in five Americans and is difficult to manage, costing ~USD 600 billion annually. The subjective experience of pain is a complex processing of central nervous system input. Recent advances in magnetic resonance imaging revealed the prefrontal cortex as vital to the perception of pain and that changes in the cerebral hemodynamics can be used to detect painful sensations. Current pain monitoring is dependent on the subjective rating provided by patients and is limited to a single time point. We have developed a biomarker for the objective, real-time and continuous chronic pain assessment using proprietary algorithms termed …

Using Wearable Sensors To Measure Goal Achievement In Older Veterans With Dementia, Jennifer Freytag, Ram Kinker Mishra, Richard L Street, Angela Catic, Lilian Dindo, Lea Kiefer, Bijan Najafi, Aanand D Naik

Faculty, Staff and Students Publications

Aligning treatment with patients’ self-determined goals and health priorities is challenging in dementia care. Wearable-based remote health monitoring may facilitate determining the active participation of individuals with dementia towards achieving the determined goals. The present study aimed to demonstrate the feasibility of using wearables to assess healthcare goals set by older adults with cognitive impairment. We present four specific cases that assess (1) the feasibility of using wearables to monitor healthcare goals, (2) differences in function after goal-setting visits, and (3) goal achievement. Older veterans (n = 17) with cognitive impairment completed self-report assessments of mobility, then had an …

An Updated Look At Mental Health Services In American Public And Private Prisons, Lieren E. Tyira

Student Theses

People residing in American prisons have the legal right to mental health care while incarcerated (Justia, 2021). This is important, as the prevalence of mental disorders is high in this population (Prins, 2014), and incarceration is a psychologically damaging experience, which hinders a person’s success at rehabilitation. Numerous of issues related to the mental health services (MHSs) in both public and private prison facilities have been reported in recent years, which warrants systematic exploration. The little existing research comparing the presence of MHSs in these facilities has produced mixed results, it uses out-of-date datasets, and none has explored MHSs in …

Mental Health Benefits Of Physical Activity In Older Adults, Adrian Kurt Zitzmann

Master of Science in Nursing Family Nurse Practitioner

Physical activity is the fountain of youth, strengthening both the physical body as well as the mind, leading to better emotional stability and a general sense of well-being. The population over age 65 is nearing retirement age and are transitioning from a high paced work and family life to a slower and less active “empty nest” lifestyle. Among adults over age 65, will implementing an exercise program for 30 minutes per day increase mental well-being? The benefits of physical activity will be supported by gathering a group of older adults ages 65 and up from a local retirement community to …

Tiam1-Mediated Synaptic Plasticity Underlies Comorbid Depression-Like And Ketamine Antidepressant-Like Actions In Chronic Pain, Qin Ru, Yungang Lu, Ali Bin Saifullah, Francisco A Blanco, Changqun Yao, Juan P Cata, De-Pei Li, Kimberley F Tolias, Lingyong Li

Faculty, Staff and Students Publications

Chronic pain often leads to depression, increasing patient suffering and worsening prognosis. While hyperactivity of the anterior cingulate cortex (ACC) appears to be critically involved, the molecular mechanisms underlying comorbid depressive symptoms in chronic pain remain elusive. T cell lymphoma invasion and metastasis 1 (Tiam1) is a Rac1 guanine nucleotide exchange factor (GEF) that promotes dendrite, spine, and synapse development during brain development. Here, we show that Tiam1 orchestrates synaptic structural and functional plasticity in ACC neurons via actin cytoskeleton reorganization and synaptic N-methyl-d-aspartate receptor (NMDAR) stabilization. This Tiam1-coordinated synaptic plasticity underpins ACC hyperactivity and drives chronic pain-induced depressive-like behaviors. …

Analisis Faktor Risiko Keluhan Fatigue Pada Pramudi Brt (Bus Rapid Transit) Transjakarta Tahun 2022, Stefany Avelliana Megaranti, Chandra Satrya

National Journal of Occupational Health and Safety

There were 508 cases of Transjakarta Bus accidents in 2021. Investigation results by the National Transportation Safety Committee (KNKT) revealed that one of the causes was driver fatigue. This study aims to describe fatigue complaints and analyze fatigue-related risk factors in Drivers of Transjakarta BRT (Bus Rapid Transit) and Non-BRT in 2022. This research is a quantitative study with an analytical descriptive research design. The research sample was 124 Drivers of Transjakarta BRT and Non-BRT. The independent variables in this study are work-related risk factors (Work Duration, Shift Work, Rest Time, Commuting Time, and Workload). The covariates in this study …

Gambaran Faktor Psikososial Dan Distress Pada Guru Sekolah Luar Biasa (Slb) Di Kota Depok Saat Pandemi Covid-19 Tahun 2022, Azka Hafia, Dadan Erwandi

National Journal of Occupational Health and Safety

This study aims to obtain an overview of psychosocial factors and distress among special education teachers in Depok during the COVID-19 pandemic in 2022. This study used a cross-sectional study design with a semi-quantitative approach through filling out questionnaires and interviews. A total of 67 special education teachers in Depok participated in this study. The results showed that 34.3% of teachers experienced moderate distress, and 16.4% of teachers experienced significant distress. Then, it was found that distress is more experienced by female teachers (52.7%), aged > 30 years (52.4%), came from non-PLB study programs (52.5%), did not have personality type A …

Analisis Stres Kerja Pada Pengemudi Truk Pengantar Produk Pt Xyz Tahun 2022, Riska Oktaviana, Hendra Hendra

National Journal of Occupational Health and Safety

Drivers are one of the occupational groups with the highest risk of experiencing workplace stress. This can happen to truck drivers who play an important role in the PT XYZ product delivery process. This study aims to describe the work stress level in PT XYZ product delivery truck drivers and the risk factors associated with work stress. The factors studied include individual factors (age, marital status, place of residence, number of children, and length of service), psychosocial factors related to job context (job control, social support, and home-work interface), and job content (physical environment of the cabin, workload, and working …

Gambaran Faktor Kegagalan Laten Dan Kegagalan Aktif Pada Kecelakaan Transportasi Darat Di Indonesia Tahun 2019 – 2021, Rahma Laili Khairina, Dadan Erwandi

National Journal of Occupational Health and Safety

Road transportation accidents are the eighth leading cause of death worldwide, reaching 1.35 million people annually (WHO, 2021). Data from the NTMC Korlantas Polri for 2019-2021 shows that the number of road transportation accidents in Indonesia is above 100 thousand every year. This study identifies latent and active failure factors contributing to Indonesia's land transportation accidents to determine the causes of accidents comprehensively. This study uses secondary data with 320,084 traffic accident case reports in 2019-2021 belonging to the NTMC Korlantas Polri. The method used is qualitative by analyzing based on the Swiss Cheese Model. The results of this study …

Analisis Faktor Yang Berhubungan Dengan Fatigue Pada Pegawai Dinas Kesehatan Provinsi Dki Jakarta Tahun 2022, Halimatuzzahra Halimatuzzahra, Dadan Erwandi

National Journal of Occupational Health and Safety

In 2020 cases of Covid-19 were found in various parts of the world, one of which was in Indonesia. Since it was first discovered, this case has continued to increase, with DKI Jakarta Province being the highest contributor to daily positive cases of Covid-19 in Indonesia. The Indonesian government continues to make efforts and cooperation between institutions. One of the institutions it has is the Health Agency. However, the arrangements and working conditions that have changed following the development of the Covid-19 case can cause fatigue for employees of the DKI Jakarta Health Agency.. This study aims to analyze the …

Contributions Of Semantic And Phonological Working Memory To Narrative Language Independent Of Single Word Production: Evidence From Acute Stroke, Rachel Zahn, Tatiana T Schnur, Randi C Martin

Faculty, Staff and Student Publications

Neuropsychological case studies have provided evidence that individuals with semantic, but not phonological, working memory (WM) deficits have difficulty producing phrases containing several content words. These findings supported the claim of a phrasal scope of planning at the grammatical formulation stage of production, where semantic WM supports the maintenance of lexical-semantic representations as they are inserted into slots in phrasal constituents. Recent narrative production results for individuals at the acute stage of stroke supported the role for semantic WM in phrasal elaboration while suggesting a role for phonological WM at a subsequent phonological encoding stage in supporting fluent, rapid speech. …

Personality Disorder Predisposing To Alcohol Dependence, Samarchitha S Ms., Venkatesh Babu Dr., Megha Sadashiv Dr., Sudeep Pk Mr.

Digital Journal of Clinical Medicine

No abstract provided.

Testing Wickelgren's Model Of Interference And Decay, Gabriel Hull, Isabella Lacy

Undergraduate Research Symposium Posters

Two explanations have been proposed to explain forgetting: decay (forgetting occurs as a function of time) and interference (the mental activity can impinge on the consolidation of a recently acquired memory). Wickelgren (1974) proposed a model of forgetting which suggests that forgetting is a function of both decay and interference, best expressed as a power-exponential function. The present research will be the first to directly examine whether Wickelgren’s model accurately predicts the observed effects of these two components on forgetting. This research will further the study of human memory by improving current models, and helping to resolve the debate surrounding …

Self-Blame Associated With Sexual Maltreatment, Jessica Castillo, Mallory Constantine

Undergraduate Research Symposium Posters

Sexually maltreated youth are at increased risk for developing thoughts of self-blame associated with their traumatic experiences (Melville et al., 2014). Self-blame increases risk of maladaptive emotion regulation strategies and self-harming behaviors (Gorgi et al., 2019). Self-blame can cause negative side effects in development and adulthood, changing the trajectory of the child who was affected by sexual assault (Ullman et al., 2014). Recent studies suggest we must continue to investigate the role in shame in producing meaning making progress, and how it affects other emotions, cognitive learning, and emotion regulating strategies (McElvaney et al., 2022). In order to continue to …

You're So Harsh On Me: Meanness In Psychopathy And Perceived Family Criticism, Jordan E. Hayes, Kayla Mcginty

Undergraduate Research Symposium Posters

Overall, the lack of research on percieved criticism, especially within populations that display meanness, show a need for research because just like mood, percieved criticism may change throughout the day. Understanding the relationship between psychopathic meanness and momentary patterns of percieved criticism among family members could provide helpful insight into social interactions and elucidating patterns of family dysfunction involved in the most antagonistic features of psychopathy.

Understanding The Contributions Of Hormonal Contraceptives And Cortisol Levels To Fear Learning In Women, Sahil Bardai

Symposium of Student Scholars

Women are twice as likely to be diagnosed with an anxiety disorder than men. Eighty-five percent of women in the US will use hormonal contraceptives at some point in their lifetime. Women who use hormonal contraceptives show heightened startle reactivity to a threatening stimulus. Previous results from our lab showed a significant increase in fear-potentiated startle (FPS) in women who were on hormonal contraceptives compared to women who were naturally cycling. These results stayed consistent throughout three acquisition trials. Others have shown that the use of OCPs (oral contraceptive pills) is related to the dysregulation of the HPA-axis and elevated …

Correlation Of Psychospiritual Factors And Suicide In The Military, Michael Odinaka Ugbor

Doctoral Dissertations and Projects

Military is a profession that requires stable mental state as a prerequisite for active military life. However, suicide rate among active members and veterans has significantly increased despite traditional measures such as psychotherapies, medications and government sponsored incentives. The purpose of this quantitative study was to examine the correlation of psychospiritual factors (spiritual, religious factors and psychological beliefs) and suicide risks among military members. Participants were 18 years or older and members of the United States military base stationed in Kentucky. Data collection involved the used a paper-based survey to measure spiritual and religious affiliations and activities, church attendance, prayer …

Suicide Among South Asians In The United States: A Growing Public Health Problem, Aruna Jha, Manik Ahuja, Rajvi J. Wani

ETSU Faculty Works

This research study quantifies and describes suicide among South Asian Americans (SAAs), an emerging population that are underrepresented group in suicide research. The purpose of this study was to examine key characteristics of suicide deaths among SAAs. Data were employed from DuPage County, IL, a county with a large SAA population. Following federal recommendations for disaggregating Asian American data at a granular level, four SAA researchers used name recognition to identify all SAA cases classified as suicide in the DuPage County coroner’s database from 2001 to 2017 (N = 38). Coroner’s reports were analyzed for contextual details and correlating …

The Ins And Outs Of Undergraduate Research And Leadership: A Student's Perspective, Regina F. Hockert

Kinesiology and Public Health

This manuscript is a reflective write-up of Regina Hockert’s experience in completing KINE 462, Honors Kinesiology Senior Project, during the 2022 Fall Quarter. It describes their experience as an undergraduate research leader, including specific milestones and artifacts related to a broader replication study and the daily activities of Dr. Jafrā Thomas’ lab. This essay was designed to be a written reflection around their senior project presentation and the insights shared through that medium about the senior project experience. It is created to showcase lessons learned in relationship with the tasks and responsibilities required of working in-depth on student-led research. …

Barriers And Facilitators In Implementing Multiplatform Remote Patient Monitoring Of Heart Failure Patients In Clinical Settings, Zachary Andrew Reilly

All Theses

Remote patient monitoring (RPM), which provides continuous monitoring of vital signs, has become increasingly utilized in patients with heart failure (HF). As this condition impacts more than 26 million Americans each year, it is important to determine the barriers and facilitators of RPM to both improve patient care and help medical professionals make more informed medical decisions. To determine these barriers and facilitators, our research team partnered with Prisma Health-Upstate to interview healthcare professionals working at Carolina Cardiology Consultants--Greenville, which uses multiple RPM systems to monitor heart failure patients.

The twelve interviews conducted support that healthcare professionals would benefit from …

Les Facteurs Qui Influencent L'Émergence D'Un Sentiment D'Injustice Suite À Un Accident Du Travail, Michael J. L. Sullivan, Manon Truchon, Pierre Coté, Marie Achille

Rapports de recherche scientifique

De nombreuses études ont rapporté que des niveaux élevés de sentiment d’injustice sont associés à un rétablissement problématique chez les personnes souffrant d’un large éventail de problèmes débilitants de santé et de santé mentale. On en sait peu actuellement sur les facteurs déterminants du sentiment d’injustice dans les suites immédiates d’un accident du travail, ou sur les facteurs déterminants des changements dans le sentiment d’injustice.

L’objectif principal de cette recherche était d’identifier les déterminants du sentiment d’injustice dans les premières semaines suivant un accident du travail. L’échantillon de participants comprenait 187 personnes (92 hommes et 95 femmes) ayant subi une …

Multilingualism And Memory: Investigating Possible Differences In The Abilities Of Monolingual And Multilingual College Students, Clara E. Barned

Honors Projects

This study investigated whether there is a difference in the memories of monolingual and multilingual undergraduate students using simple memorization tasks. There were 46 participants, 30 of which were monolingual (only knew one language) and 16 of which were multilingual (knew two or more languages). There was found to be no significant difference between the performance of the two groups, with the data generating a p-value of 0.557. This study further suggests related avenues of research and ways in which the study could be improved in the future.

Disharmony Of The Soul: A Philosophical Analysis Of Psychological Trauma And Flourishing, Adam Blehm

Graduate Theses and Dissertations

In this dissertation I argue that psychological trauma hinders human flourishing by disrupting psychic harmony and hindering virtuous relationships. Given the negative symptomology of posttraumatic stress related disorders (i.e., PTSD) this conclusion may seem a bit obvious to some. However, making the case for trauma as a hindrance to human flourishing is more complicated than it may first appear.

First, in the extant literature, trauma as a concept tends to be unclear. In much of the empirical and philosophical literature, trauma can include a certain kind of event, experience, effect, or a combination of all three. Furthermore, because of practical …

Therapists’ Demonstrated Multicultural Competence In Treating Latinx Immigrants, Dulce Diaz Benitez

Graduate Theses and Dissertations

Studies suggest that health disparities occur when people from marginalized communities receive care that is inadequate based on their cultural needs (USDHHS, 2011). Multicultural competence (MCC) models have been proposed to provide a framework of the competencies that therapists should develop to work with multicultural populations (Sue et al., 1992). Researchers have questioned the validity of measures, which are mostly based on therapist self-report (Cartwright, 2008). The multicultural case conceptualization ability task has been used in previous studies as a measure of demonstrated cultural competence using a vignette to assess case conceptualization abilities (Ladany et al., 1997). However, it has …

Good Faith: Surveillance And Evaluation Of 911 Good Samaritan Laws In The United States, Shane W. Reader

Dissertations and Theses (Open Access)

To fight soaring overdose mortality rates in the United States, lawmakers adopted a variety of harm reduction tools. Among these, 911 Good Samaritan Laws (GSLs) derive their name from the biblical parable of the Good Samaritan, a bystander who broke cultural convention to come to the aid of a man beset by thieves. These laws provide limited criminal immunity for bystanders in possession of controlled substances to encourage them to report drug overdoses. While previous studies associate GSLs with a modest reduction in opioid mortality, analyses often model them as equivocal or divide them coarsely across individual provisions. Evaluating these …