Medicine and Health Sciences Commons^™

Is Melatonin An Effective Treatment For Sleep Problems In Autism?, Andrew J. Winkler

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not melatonin is an effective treatment for sleep problems in Autism.

STUDY DESIGN: Review of three English language, randomized controlled blinded trials published within peer-reviewed journals from 2006-2010 evaluating the efficacy of Melatonin as an oral sleep supplement in diagnosed autistic children.

DATA SOURCES: A double blind, randomized, placebo-controlled, crossover trial; a randomized controlled crossover trial; and a randomized controlled trial found using Cochrane, PubMed, and DynaMed.

OUTCOMES MEASURED: Total night’s sleep duration, number of awakenings, and sleep latency time were all measured …

Does Epigallocatechin Gallate Improve Mood In Heathly Adults?, Bethany J. Wong

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not epigallocatechin gallate (EGCG) improves mood in healthy adults.

STUDY DESIGN: A review of three peer-reviewed journal articles written in the English language published between 2009 and 2012.

DATA SOURCES: Three randomized, double-blind, placebo-controlled studies comparing the effect of EGCG to placebo on mood were found using PubMed and Cochrane databases.

OUTCOMES MEASURED: Outcomes measured in the studies included change in mood. Patient ratings of mood were measured using Mood Visual Analog Scales (Mood VAS), the University of Wales Institute of Science and …

A Study Of Authentic Leadership Adopting The Job Demands And Resources Approach In Predicting Work-Related Flow And Job Performance, Yiqing Wang

Theses & Dissertations

The authentic leadership model posits that authentic leaders can foster personal development of their subordinates in order to produce better job outcomes. The current study has investigated authentic leadership using the job demands and resources (JD-R) approach to examine how leaders’ authenticity can empower employees in terms of resources-building (e.g. PsyCap, supervisor support); and to examine how these resources can offset negative stressors (e.g. work overload, emotional demands) so that employees may achieve a peak psychological state of flow (Bakker, 2005, 2008) and better job performances. To date, very few studies have tried to explain authentic leader behaviors in the …

Anxiety Disorders And School-Based Treatments: Assessing School Pyschologists' Knowledge And Perceptions, Kelly A. Myhasuk

PCOM Psychology Dissertations

Anxiety disorders are common in children and youth. Despite high prevalence rates, most children with anxiety disorders do not receive treatment. In fact, for the few children who are receiving treatment, schools are the primary source of mental health care. When left untreated, children experience significant disruptions in their academic, social, emotional, and behavioral functioning. Therefore, it is important for those working in schools to recognize and treat children with anxiety disorders. The present study surveyed school psychologists (n = 178) to assess their knowledge about anxiety disorders and about empirically supported school-based treatments. Also, this study sought to investigate …

Grounded Labels From The Behavioral International Economic Development Growth Path Model On Economic Development Patterns From 2002-2012, Kenneth Thomas Davis

Walden Dissertations and Doctoral Studies

Economic models generally fail to adequately measure positive and negative growth paths in development through agrarian, industry, and service economies. The purpose of this grounded theory study was to design a new model that could accommodate both directions of growth and better measure development paths with particular attention to labors contributions. The theoretical foundation for this study was Walt Whitman Rostow's 5 economic stages of growth classifications. This Study attempted to find the most common economic growth path. While most development models use three to five classifications, this study used nine new classifications giving it a unique and specific look …

Dopamine And Glutamate Dysfunction In A Rodent Model Of Attention-Deficit/Hyperactivity Disorder: Implications For Future Neuropharmacology, Erin M. Miller

Theses and Dissertations--Neuroscience

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common disorders of childhood. It is theorized to be caused by catecholamine dysfunction in the striatum (Str) and frontal cortex (FC). The spontaneously hypertensive rat (SHR) has been used as a model for ADHD because of its attention deficits, impulsiveness, and hyperactivity. Prior studies of dopamine (DA) in the Str and FC have revealed conflicting results in the SHR compared to control, indicative of a need for a better understanding of DA dynamics in this model. In addition to the DA hypothesis, studies have begun implicating glutamate in the etiology of ADHD. …

The Effects Of A Compassion Focused Intervention On A Non-Clinical Student Population, Adrian Kunemund

EWU Masters Thesis Collection

Previous research has suggested that Compassion Focused Therapy (CFT) is beneficial for individuals suffering from a variety of mental health concerns including depression, shame, and self-criticism. The present study assessed the effects of a 10-week university Introduction to CFT course that includes a group orientation to CFT including exposure to CFT intervention exercises. It was hypothesized that those receiving the CFT course would show reductions in shame, self-criticism, and fears of compassion, and increases in gratitude, positive affect, and self-compassion relative to controls. While some differences were observed between the CFT and control groups, none of the hypothesized group X …

A Systems Biology Approach To Detect Eqtls Associated With Mirna And Mrna Co-Expression Networks In The Nucleus Accumbens Of Chronic Alcoholic Patients, Mohammed Mamdani

Theses and Dissertations

Alcohol Dependence (AD) is a chronic substance use disorder with moderate heritability (60%). Linkage and genome-wide association studies (GWAS) have implicated a number of loci; however, the molecular mechanisms underlying AD are unclear. Advances in systems biology allow genome-wide expression data to be integrated with genetic data to detect expression quantitative trait loci (eQTL), polymorphisms that regulate gene expression levels, influence phenotypes and are significantly enriched among validated genetic signals for many commonly studied traits including AD.

We integrated genome-wide mRNA and miRNA expression data with genotypic data from the nucleus accumbens (NAc), a major addiction-related brain region, of 36 …

Follow-Up Evaluation Of Treatment For Anxiety And Depression Provided In A University-Based Primary Care Clinic, Renée M. Grinnell

Theses and Dissertations

Although integrated primary care psychology services are becoming increasingly common, the literature lacks adequate research support for the longitudinal durability of treatment effects following the conclusion of brief primary care interventions. This study served as a follow-up program evaluation of psychological services for depression and anxiety provided at the Medical College of Virginia’s Ambulatory Care Center in Richmond, Virginia. Data were collected on 47 adult primary care patients who received treatment for depression and/or anxiety between six and 18 months prior to the follow-up telephone call. Data were collected on the trajectory of depression scores throughout and following treatment, treatment …

Caffeine And Human Perception Of Time, Trevor Fry

EWU Masters Thesis Collection

The purpose of this study was to investigate the effect of caffeine on several components of time perception in an attention-demanding task. Review of the current literature shows that the rhythm of the brain's internal clock, controlled by the suprachiasmatic nucleus (SCN), which is believed to mediate the perception of short durations, is sensitive to a variety of stimuli including stimulants. This study expands on previous research on the effect of caffeine on prospective time estimation by having participants estimate multiple short durations while completing a cognitively complex time estimation task involving math. The study included a moderate dose caffeine …

Examining Sexual Satisfaction And Pretending Orgasm, Chelsea Twiss

EWU Masters Thesis Collection

An article in popular women’s magazine, Cosmopolitan, recently revealed a startling admission from its readers: 86% of respondents reported pretending orgasm during intercourse with a partner (Kylstra, 2011). Despite its apparent frequency, there is yet to be a study conducted investigating the relationship between pretending orgasm and overall sexual satisfaction (Ippolito, 2012). Sexual satisfaction is linked with important facets of life such as overall relationship satisfaction and general wellbeing. The present study examines the relationship between experiencing orgasm, pretending orgasm and overall sexual satisfaction. Participants were Eastern Washington University college students recruited via an online survey website (Qualtrics), and who …

Injured Athletes' Preferences Regarding Source Of Emotional Support, Kristin Kutz

Honors Projects

Athletes often experience emotional distress as a result of an injury. Feelings of loss, decreased self-esteem, frustration, and anger are not uncommon. Athletic trainers (ATs) who work with injured athletes are focused on helping the progression of athletes' physical healing, but their role in helping athletes emotionally and psychologically is often unclear. There are twelve Athletic Training Education Competencies that the National Athletic Training Association requires to be taught to undergraduate AT students, one of them being psychosocial intervention and referral. However, little research has been done to define the exact role of ATs in this area, as well as …

The Effects Of Anxiety On Sensory Gating, Jonathon Meier

Honors Projects

Sensory gating is a proposed important physiological process of inhibiting neuronal responses of repetitious stimuli in the central nervous system to allocate more cognitive resources to additional salient information. Sensory gating is currently being studied to better understand psychiatric illnesses, especially those characterized by emotional changes and the inability to concentrate such as schizophrenia, ADHD, anxiety disorder, and Parkinson’s. Anxiety is a strong feeling of nervousness that occurs in all individuals at varying degrees and is associated with detrimental health effects as well as hindering concentration. Numerous brain regions are associated with anxiety levels such as the anterior limbic system, …

The Relationship Between Simple Pleasures And Trait Gratitude, Megan Shupe

EWU Masters Thesis Collection

Grateful disposition is associated with positive affect, happiness, high levels of overall well-being and an appreciation of simple pleasures. This study further examined the relationship between simple pleasures and trait gratitude. I hypothesized that people with higher trait gratitude scores would notice more simple pleasures in their lives and feel more gratitude for simple pleasures than less grateful people. I acquired data from 169 undergraduate students at Eastern Washington University. Results suggested that grateful people experienced the same number of simple pleasures as less grateful people but were more grateful for them. This suggests that although grateful people do not …

Stress Management For Cancer Survivors Using A Technologically Adapted Psychosocial Intervention: A Randomized Trial Determining The Effect Of Expressive Writing On Psychoneuroimmunology Based Outcomes, Utkarsh B. Subnis

Theses and Dissertations

Patients with cancer transitioning from completing their final cancer treatments to survivorship are particularly at risk for experiencing psychosocial stress, and the Institute of Medicine (IOM) has referred to these cancer patients as “lost in transition.” In this study, patients with cancer in their transition phase after completing their final radiation treatment were defined as cancer survivors (CS). CS must deal with chronic stressors such as the fear of cancer recurrence as well as the resumption of their roles in their family and work lives. Chronic stress impacts the nervous system and increases secretion of stress hormones (e.g. cortisol) from …

Predictors Of Hiv Testing Among Individuals Diagnosed With Bipolar Disorder, Marie Denise Decoline

Walden Dissertations and Doctoral Studies

Research on rates of HIV testing among individuals diagnosed with Bipolar Disorder (BPD) is limited, while HIV infection continues to rise among BPD individuals. The problem is that BPD individuals are at high risk for HIV infection due to non-adherence to treatment for bipolar disorder and manic episodes that can lead to high-risk behaviors. The goal of the study was to examine the association between selected demographic variables, having a bipolar diagnosis, engaging in high-risk behaviors, inability to afford treatment for bipolar disorder, non-adherence to treatment for bipolar disorder, and substance abuse, and their relationship to obtaining an HIV test …

Knowledge, Attitude, Lifestyle Practices, And Quality Of Life In Sporadic Lymphangioleiomyomatosis Patients, Shahpar Vafamand

Walden Dissertations and Doctoral Studies

Lymphangioleiomyomatosis (LAM) is a rare lung disease recognized by abnormal growth of smooth muscle cells proliferating in lungs parenchyma, developing benign tumors, migrating to the other organs, and ultimately leading to respiratory failure and death. Despite existing literature mainly on clinical aspects of LAM, there is a gap of literature in regards to the knowledge, attitude, and lifestyle practices (KAPs) of LAM patients and their effects on their quality of life. The purpose of this quantitative study was to investigate the KAPs of the sporadic LAM patients as measured by the Bristol Chronic Obstructive Pulmonary Disease Knowledge Questionnaire, Beliefs and …

Eating Disorder Onset In Young Girls: A Longitudinal Trajectory Analysis, Carolyn M. Pearson

Theses and Dissertations--Psychology

To investigate whether there are different patterns of development for binge eating and purging behavior among pre-adolescent and early adolescent girls, I conducted trajectory analyses of those behaviors in 938 girls across eight waves of data from the spring of 5^th grade (the last year of elementary school) through the spring of 9^th grade (the first year of high school). Analyses revealed four separate developmental trajectories for binge eating behavior (labeled none, increasing, decreasing, and high steady) and three separate developmental trajectories for purging behavior (labeled none, dabble, and increasing). Fifth grade scores on risk factors that were …

Identifying Functional Variation In Schizophrenia Gwas Loci By Pooled Sequencing, Erik Loken

Theses and Dissertations

Schizophrenia demonstrates high heritability in part accounted for by common simple nucleotide variants (SNV), rare copy number variants (CNV) and, most recently, rare SNVs Although heritability explained by rare SNVs and CNVs is small compared to that explained by common SNVs, rare SNVs in functional sequences may identify specific disease mechanisms. However, current exome methods do not capture a large proportion of potentially functional bases where rare variation may impact disease risk: as much as two-thirds of conserved sequences lie outside the exome in non-coding regions of cross-species evolutionary constraint. We reasoned that the candidate loci from the Psychiatric Genomics …

Examining The Appeal And Ascribed Meanings Of Complementary And Alternative Medicine (Cam) Use By Males: An Interpretative Phenomenological Analysis, Kathryn V. Hogan

Theses : Honours

Men are commonly and consistently underrepresented in global depression rates, however figure predominantly in rates for substance abuse and suicide. It has been suggested that men’s under-utilisation of mental health services accounts for the discrepancy between the genders and that hegemonic masculine stereotypes have created a barrier for males in seeking help for mood disorders. The use of Complementary and Alternative Medicines (CAM) has been expanding globally, with research showing in some instances of self-diagnosed depression and anxiety, CAM is being utilised more often than mainstream health care services. The present study explored the personal meanings of males who currently …

Physical, Emotional, And Competitive Aggression Tendencies In Contact And Non-Contact Collegiate Athletes, Samyra Rose Safraoui

Online Theses and Dissertations

Differences in aggression tendencies between athletes who play a contact sport and athletes who play a non-contact sport at the collegiate level were investigated. Specifically, emotional, physical, and competitive aggression tendencies were measured for both groups and then compared to each other using independent t tests and effect sizes. One hundred student-athletes from a medium sized midwestern university participated in the study, with an even split between contact and non-contact athletes. Student-athletes were sent an electronic survey via email and Survey Monkey; all materials were approved by the university's Institutional Review Board (IRB) and Athletics department.

It was determined that …

Depression In Children And Adolescents: The Role Of School Professionals, Emily Dawn Hoerman

Dissertations and Theses @ UNI

Depression in children and adolescents is a significant issue for schools. Research has indicated that most students who see mental health professionals do so within the school setting, indicating a need for effective school-based programs to address mental health issues in the schools. The symptoms of depression and short and long term effects are reviewed. The need for, and necessary components of, a comprehensive mental health system in the school setting is discussed.

Exercise Behavior Patterns In Emerging Adulthood: An Exploration Of Predictor Variables From Self-Determination Theory And Transtheoretical Model, Chad R. Johnson

Electronic Theses and Dissertations

During the transition from childhood to adulthood, young people establish patterns of behavior and make lifestyle choices that affect both their current and future health (NCHS, 2010). Emerging adulthood – a new conception of development for the period from the late teens through the twenties – focuses on individuals ages 18-25 who did not have a child, own a home, or have sufficient income to be fully independent (Arnett, 2000). Very little is known about social influence, motivational mediators, and motivation on exercise behavior within this developmental period. Therefore, the purpose of this study was to determine the influence of …

Cxcl12 Induces Camkii Synaptic Localization And Glutamate-Induced Hippocampal Cell Death, Robert M. Bragg Iii

WWU Graduate School Collection

Cerebral ischemia is known to induce cell death through hypoxia and oxidative stress following reperfusion. However, cell death can spread beyond the ischemic core when toxic glutamate levels act on NMDA receptors of surrounding regions. Levels of CXCL12, a chemokine primarily released from glia, reportedly elevate following ischemia. Acute activation of its receptor, CXCR4, appears to serve a neuroprotective function while prolonged activation results in cell death and this cell death was reported to be dependent on the combined release of calcium from intracellular stores as well as calcium influx through NMDARs. Calcium influx through NMDA receptor channels leads to …

Parent Adolescent Conflict Among Asian Indian Immigrant Families, Aparna Kumar

WWU Graduate School Collection

Acculturation can be a difficult process for immigrant families as parents and children adjust to different cultural value systems. Parents and adolescents may acculturate at different rates to the mainstream culture due to parents wanting to retain their heritage culture and adolescents immersion into mainstream Western culture. This seems to assume assimilation as the same process as acculturation when it is only one possible outcome. As a result of this, acculturation gaps between parents and adolescents result, which may lead to parent-adolescent conflict. The current study took a mixed methods approach to investigate how Asian Indian immigrant families experience parentadolescent …