Medicine and Health Sciences Commons^™

Conflicts Of Interest And The Quality Of Recommendations In Clinical Guidelines, Lisa Cosgrove, Allen F. Shaughnessy, Deborah R. Erlich, Emily E. Wheeler, Harold J. Bursztajn

Counseling and School Psychology Faculty Publication Series

Background: There is increasing concern that conflicts of interest affect the development process of clinical practice guidelines. We evaluated The American Psychiatric Association's Practice Guideline for the Treatment of Patients with Major Depressive Disorder to determine the existence of financial and intellectual conflicts of interest and examine their possible effects. We selected this guideline because of its influence on clinical practice and because this guideline recommends pharmacotherapy for all levels of depression, despite controversies over the evidence base.

Methods and Findings: We determined the number and type of financial conflicts of interest for members of the guideline development group as …

The Association Between A Medical History Of Depression And Gestational Diabetes In A Large Multi-Ethnic Cohort In The United States, Katherine Bowers, S. Katherine Laughon, Sungduk Kim, Sunni L. Mumford, Jennifer Brite, Michele Kiely, Cuilin Zhang

Publications and Research

Background: Both major depression and gestational diabetes mellitus (GDM) are prevalent among women of reproductive age. Our objective was to determine whether a medical history of depression is related to subsequent development of GDM.

Methods: The Consortium on Safe Labor was a US retrospective cohort study of 228 562 births between 2002 and 2008. Exclusion criteria for the present analysis included multiple gestation pregnancies (n = 5059), pre-existing diabetes (n = 12 771), deliveries(n = 395), site GDM prevalence (

Results: The final analytic population included 121 260 women contributing 128 295 pregnancies, of which 5606 were affected by GDM. …

Restoring Effort-Related Functions In Models Of Depression Symptoms: Reversing Fatigue Symptoms Induced By Catecholamine Depleting Agent Tetrabenazine With The Adenosine A2a Antagonist Msx-3, Charlotte Freeland

Honors Scholar Theses

Motivational symptoms related to effort expenditure have been associated with major depression and other disorders that afflict millions of individuals worldwide. In an effort to identify potential therapeutic agents and characterize the underlying biochemical mechanisms related to these behaviors, recent research has utilized animal models to study and characterize such behavior. Previous work in the Salamone lab produced evidence that rats with impaired dopamine (DA) transmission show changes in response allocation in tasks that measure effort-related choice behavior, which are characterized by a decrease in selection of the high-effort choice but increased selection of the low-effort alternative. The present work …

Adjunctive Atypical Antipsychotic Treatment For Major Depressive Disorder: A Meta-Analysis Of Depression, Quality Of Life, And Safety Outcomes, Glen I. Spielmans, Margit I. Berman, Eftihia Linardatos, Nicholas. Z. Rosenlicht

Dartmouth Scholarship

Atypical antipsychotic medications are widely prescribed for the adjunctive treatment of depression, yet their total risk-benefit profile is not well understood. We thus conducted a systematic review of the efficacy and safety profiles of atypical antipsychotic medications used for the adjunctive treatment of depression.

Associations Of Childhood Family Adversity And Pubertal Timing With Depressive Symptomotology In Adulthood, Jeffrey P. Winer

Masters Theses 1911 - February 2014

To date, no prior research has examined the combined roles of childhood family adversity and pubertal timing in longitudinal pathways to depressive symptomatology in adulthood. The present study was conducted with 225 men and 225 women to explore the unique and combined roles of childhood family adversity and pubertal timing on depressive symptoms in a community sample of married adults. Results for both men and women indicated significant main effects of a cumulatively risky family environment on depressive symptoms, as well as main effects of families with higher levels of abuse and neglect, chaos and disorganization, and interpersonal family conflict. …

Gene X Environment Effects Of Serotonin Transporter, Dopamine Receptor D4, And Monoamine Oxidase A Genes With Contextual And Parenting Risk Factors On Symptoms Of Oppositional Defiant Disorder, Anxiety, And Depression In A Community Sample Of 4-Year-Old Children, John V. Lavigne, Laura B.K. Herzing, Edwin H. Cook, Susan A. Lebailly, Karen R. Gouze, Joyce Hopkins, Fred B. Bryant

Psychology: Faculty Publications and Other Works

Genetic factors can play a role in the multiple level of analyses approach to understanding the development of child psychology. The present study examined gene-environment correlations and Gene x Environment interactions for polymorphisms of three target genes, the serotonin transporter gene, the D4 dopamine reactor gene, and the monoamine oxidase A gene in relation to symptoms of anxiety, depression, and oppositional behavior. Saliva samples were collected from 175 non-Hispanic White, 4-year-old children. Psychosocial risk factors included socioeconomic status, life stress, caretaker depression, parental support, hostility, and scaffolding skills. In comparison with the short forms (s/s, s/l) of the serotonin transporter …

Analysis Of Gender Differences In Self-Statements And Mood Disorders, Robert Devore, Mary E. Pritchard

Psychological Sciences Faculty Publications and Presentations

Over 25% of adult Americans suffer from a mental disorder each year, with depression and anxiety being some of the most commonly reported issues. Researchers estimate that between 10% and 50% of adult Americans will suffer from a depressive episode at some point in their life, and cognitive theorists argue that mental states, including disorders, are generated and maintained by personal, subjective beliefs, and that events can only be appropriately labeled by the individual experiencing them. Thus, cognitive theorists suggest a strong link between self-talk (ST) and behavior and note that the automatic use of ST is associated with disordered …

An Exploration Of Comorbid Symptoms And Clinical Correlates Of Clinically Significant Hoarding Symptoms, Brian J. Hall, David F. Tolin, Randy O. Frost, Gail Steketee

Psychology: Faculty Publications

Background Hoarding disorder (HD) is currently being considered for inclusion in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), yet remains poorly understood. Consensus is building that hoarding may constitute a separate disorder, although comorbidity remains high and complicates the diagnostic picture. The purpose of this investigation was to explore patterns of comorbidity among people who engage in hoarding behavior in order to better understand its clinical presentation and phenomenology. Methods Data were collected from a large internet sample (N = 363) of people who self-identified as having hoarding problems, met criteria for clinically significant hoarding, and …