Medicine and Health Sciences Commons^™

Dopaminergic Modulation Of Memory And Affective Processing In Parkinson Depression, Lee X. Blonder, John T. Slevin, Richard J. Kryscio, Catherine A. Martin, Anders H. Andersen, Charles D Smith, Frederick A. Schmitt

Magnetic Resonance Imaging and Spectroscopy Center Faculty Publications

Depression is common in Parkinson's disease and is associated with cognitive impairment. Dopaminergic medications are effective in treating the motor symptoms of Parkinson's disease; however, little is known regarding the effects of dopaminergic pharmacotherapy on cognitive function in depressed Parkinson patients. This study examines the neuropsychological effects of dopaminergic pharmacotherapy in Parkinsonian depression. We compared cognitive function in depressed and non-depressed Parkinson patients at two time-points: following overnight withdrawal and after the usual morning regimen of dopaminergic medications. A total of 28 non-demented, right-handed patients with mild to moderate idiopathic Parkinson's disease participated. Ten of these patients were depressed according …

Epidemiology News, Georgia Southern University

Epidemiology News (2012-2018)

• Social Contacts and Depression

Generalizing Anxiety, Center For Public Service

SURGE

As she began reading the list of symptoms, I was making mental check marks next to the ones that applied to me.

Fear of interacting with strangers- check. Fear that others will notice that you look anxious- check. Avoiding doing things or talking to people out of fear of embarrassment- check. Fear of situations in which you may be judged- check. Anxiety that disrupts your daily routine, work or school activities- check, check, check. [excerpt]

Trauma History And Depression Predict Incomplete Adherence To Antiretroviral Therapies In A Low Income Country, Kathryn Whetten, Kristen Shirey, Brian Wells Pence, Jia Yao, Nathan Thielman, Rachel Whetten, Julie Adams, Bernard Agala, Jan Ostermann, Karen O'Donnell, Amy Hobbie, Venance Maro, Dafrosa Itemba, Elizabeth Reddy, Chat Research Team

Faculty Publications

Background: As antiretroviral therapy (ART) for HIV becomes increasingly available in low and middle income countries (LMICs), understanding reasons for lack of adherence is critical to stemming the tide of infections and improving health. Understanding the effect of psychosocial experiences and mental health symptomatology on ART adherence can help maximize the benefit of expanded ART programs by indicating types of services, which could be offered in combination with HIV care. Methodology: The Coping with HIV/AIDS in Tanzania (CHAT) study is a longitudinal cohort study in the Kilimanjaro Region that included randomly selected HIV-infected (HIV+) participants from two local hospital-based HIV …

Recommendations For High-Priority Research On Cancer-Related Fatigue In Children And Adults., Andrea M. Barsevick, Michael R. Irwin, Pamela Hinds, Andrew Miller, Ann Berger, Paul Jacobsen, Sonia Ancoli-Israel, Bryce B Reeve, Karen Mustian, Ann O'Mara, Jin-Shei Lai, Michael Fisch, David Cella

Department of Medical Oncology Faculty Papers

Over the past decades, some scientific progress has been made in understanding and treating cancer-related fatigue (CRF). However, three major problems have limited further progress: lack of agreement about measurement, inadequate understanding of the underlying biology, and problems in the conduct of clinical trials for CRF. This commentary reports the recommendations of a National Cancer Institute Clinical Trials Planning Meeting and an ongoing National Cancer Institute working group to address these problems so that high-priority research and clinical trials can be conducted to advance the science of CRF and its treatment. Recommendations to address measurement issues included revising the current …

El Estigma De La Depresión Y Cómo Está Influenciado Por La Percepción De La Enfermedad En Santiago, Chile, Elena Michaels

Independent Study Project (ISP) Collection

Over the past century, as a greater understanding has been developed regarding the brain and mental health disorders, a stigma surrounding the field of mental health has emerged. The goal of this study was to analyze how the public perception of depression relates to the stigma surrounding mental illness and define the relationship between the two. This investigation took place at the Pontifical Catholic University of Chile in Santiago.

In Chile, one of the consequences of the stigma regarding mental health disorders is usage of the mental health services offered. Not uncommonly, a medic would give a mental health evaluation …

Parent Need And Impact On Family For Parents Whose Children Have Special Healthcare Needs, Jennifer Emilie Mannino Ph.D., R.N.

Faculty Works: NUR (2010-2023)

Statement of the Problem: Parenting a child with special healthcare needs adds to the everyday parenting challenges as parents become caregivers. When providing care for a child with special healthcare needs often the increasing needs of parents are overlooked. Unmet parental needs may lead to stress, anxiety, and depression.
Purpose: To examine the relationship among a child’s special healthcare need, parent need, and family impact; and to identify attributes that mitigate parent risk and maladaptive behaviors.
Subjects: A convenience sample of 33 parents/guardians of children enrolled in a mid-Atlantic coordinated health service plan has been identified, invited and signed consents. …

Vitamin B12 Supplementation In Trea Ting Major Depressive Disorder: A Randomized Controlled Trial, Ehsan Ullah Syed, Mohammad Wasay, Safia Awan

Department of Medicine

Recent literature has identified links between vitamin B12 deficiency and depression. We compared the clinical response of SSRI-monotherapy with that of B12-augmentation in a sample of depressed patients with low normal B12 levels who responded inadequately to the first trial with the SSRIs. Methods: Patients with depression and low normal B12 levels were randomized to a control arm (antidepressant only) or treatment arm (antidepressants and injectable vitamin B12 supplementation). Results: A total of 199 depressed patients were screened. Out of 73 patients with low normal B12 levels 34 (47%) were randomized to the treatment group while 39 (53%) …

Out Of The Night, Riley Gryc

SURGE

I did not graduate.

After four years of college, waiting for the day I could shake President Riggs’ hand, receive my diploma, and depart our campus with pride and honor, that day never came. One of the hardest things I’ve ever had to do was watch from the back row of the audience as everyone I had attended school with for the last four years, my classmates, my friends, all received their diplomas and moved on without me. The stares from teachers I knew, the surprised looks from underclassmen, the careful tact with which everyone avoided the subject of not …

Research Brief: "Mental Health Diagnosis And Occupational Functioning In National Guard/Reserve Veterans Returning From Iraq", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the employment or enrollment in school of recently returned National Guard and Reserve OIF/OEF veterans who have a mental health diagnosis compared to those veterans without a mental health diagnosis. In policy and practice, the US military should implement pre- to post-deployment programs to help adjustment into work/school role functioning, and policymakers should partner with universities to help veterans cope with academic stress. Suggestions for future research include using a larger and more comprehensive sample of National Guard/Reserve OIF veterans and studying the effectiveness of programs and support for veterans.

Conflicts Of Interest And The Quality Of Recommendations In Clinical Guidelines, Lisa Cosgrove, Allen F. Shaughnessy, Deborah R. Erlich, Emily E. Wheeler, Harold J. Bursztajn

Counseling and School Psychology Faculty Publication Series

Background: There is increasing concern that conflicts of interest affect the development process of clinical practice guidelines. We evaluated The American Psychiatric Association's Practice Guideline for the Treatment of Patients with Major Depressive Disorder to determine the existence of financial and intellectual conflicts of interest and examine their possible effects. We selected this guideline because of its influence on clinical practice and because this guideline recommends pharmacotherapy for all levels of depression, despite controversies over the evidence base.

Methods and Findings: We determined the number and type of financial conflicts of interest for members of the guideline development group as …

Barriers To Depression Treatment Among Low-Income, Latino Emergency Department Patients, Anjanette A. Wells, Isabel T. Lagomasino M.D., Lawrence A. Palinkas, Jennifer Green, Diana Gonzalez Msw

Brown School Faculty Publications

Objectives. Low-income and Latinos use the emergency department (ED) as a primary source of care. Also, the depression prevalence in ED patients is high, making the ED a compelling venue for depression screening and intervention. This study examined barriers and facilitators to depression treatment among low-income, predominantly Latino ED patients. Methods. We conducted telephone interviews with 24 ED patients (18-62 years of age, 79% female) who dropped out of a depression treatment intervention. Using grounded theory, we analyzed perceptions of depression and treatment, and barriers and facilitators to mental health treatment. Results. Although most patients acknowledged signs of depression, there …

An Overview Of The Predictors Of Depression Among Adult Pakistani Women, Aysha Zahidie, Tanzil Jamali

Community Health Sciences

Diseases of women that are due to their gender specific roles and responsibilities result from cultural and social factors prevalent in the environs. World Health Organization has put special emphasis on research need regarding gender related factors for diseases disproportionately affecting women in developing countries. The objective of this write up was to determine the prevalence of depression and the associated risk factors among adult women in Pakistan. PubMed was searched using key words depression, risk factors, women and Pakistan. Out of 20 initially retrieved articles, 12 were directly related to depression and its risk factors among Pakistani women within …

The Association Between A Medical History Of Depression And Gestational Diabetes In A Large Multi-Ethnic Cohort In The United States, Katherine Bowers, S. Katherine Laughon, Sungduk Kim, Sunni L. Mumford, Jennifer Brite, Michele Kiely, Cuilin Zhang

Publications and Research

Background: Both major depression and gestational diabetes mellitus (GDM) are prevalent among women of reproductive age. Our objective was to determine whether a medical history of depression is related to subsequent development of GDM.

Methods: The Consortium on Safe Labor was a US retrospective cohort study of 228 562 births between 2002 and 2008. Exclusion criteria for the present analysis included multiple gestation pregnancies (n = 5059), pre-existing diabetes (n = 12 771), deliveries(n = 395), site GDM prevalence (

Results: The final analytic population included 121 260 women contributing 128 295 pregnancies, of which 5606 were affected by GDM. …

Spirituality, Religiosity, Depression, Anxiety, And Drug-Use Consequences During Methadone Maintenance Therapy, Linda B. Piacentine

College of Nursing Faculty Research and Publications

Substance addiction is damaging to the health of persons, families, and society. Often the person with addiction has decreased spirituality and religiosity and suffers from anxiety, depression, or both, increasing the risk for continued substance use and its concomitant negative consequences. The study purpose was to describe spirituality and religiosity, among persons enrolled in methadone maintenance therapy and to examine associations between spirituality, religiosity, anxiety, depression, and drug-use consequences. Using a descriptive and cross-sectional correlational design, 108 participants completed questionnaires assessing the study variables. Spiritual well-being was similar to other addiction samples and lower than healthy person samples. Most participants …

Metabolic Syndrome And Depression: A Systematic Review Of The Association, Michael S. Robinson

Student Works

Purpose: To explore whether there is an association between metabolic syndrome (MetS) and depression, the nature of the relationship, and implications for practicing health care professionals. Data Sources: Peer reviewed articles obtained through electronic database search in: CINAHL, The Cochrane Library, MEDLINE, and PsychINFO between the years of 2006 and 2013. Results: MetS and depression have a bidirectional association; MetS leads to depression and vice-versa. More severe depression has a stronger association with MetS. Increased waist circumference (AKA: abdominal obesity, body mass index [BMI]), elevated triglycerides, and low HDL cholesterol are the MetS components most commonly/strongly associated depression. Though not …

Leisure-Time Physical Activity In Relation To Depressive Symptoms In African-Americans: Results From The National Survey Of American Life, Elisa R. Torres, Carolyn M. Sampselle, David L. Ronis, Harold W. Neighbors, Kimberlee A. Gretebeck

College of Nursing Faculty Research and Publications

Objective

To examine the frequency of leisure-time physical activity (LTPA) in relation to depressive symptoms in a nationally representative sample of African American (AA) women and AA men with guidance by Stokols' Social Ecological Framework.

Method

A secondary analysis of AA women (n = 1811) and AA men (n = 1038) was performed on the National Survey of American Life, where a four stage national area probability sampling was conducted. Interviews were conducted 2001–2003. Clinically depressed AA were excluded from the current study. LTPA was measured by self-report frequency (never, rarely, sometimes, often) of participation in sports/exercise. Depressive symptoms were …

Restoring Effort-Related Functions In Models Of Depression Symptoms: Reversing Fatigue Symptoms Induced By Catecholamine Depleting Agent Tetrabenazine With The Adenosine A2a Antagonist Msx-3, Charlotte Freeland

Honors Scholar Theses

Motivational symptoms related to effort expenditure have been associated with major depression and other disorders that afflict millions of individuals worldwide. In an effort to identify potential therapeutic agents and characterize the underlying biochemical mechanisms related to these behaviors, recent research has utilized animal models to study and characterize such behavior. Previous work in the Salamone lab produced evidence that rats with impaired dopamine (DA) transmission show changes in response allocation in tasks that measure effort-related choice behavior, which are characterized by a decrease in selection of the high-effort choice but increased selection of the low-effort alternative. The present work …

Just Another Girl, Julia D. Marshella

Student Publications

A non-fiction piece that explores the causes of the author’s depression while in college. While she is able to pinpoint specific events that have led to her unhappiness, she realizes that accepting her life in spite of these obstacles will allow her to move forward.

Research Brief: "A Prospective Study Of Ptsd And Early-Age Heart Disease Mortality Among Vietnam Veterans: Implications For Surveillance And Prevention", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is a summary of PTSD being prospectively associated with HD mortality among veterans free of HD at baseline.

Religious Commitment And Depression During Pregnancy, Tifani R. Fletcher, Andrea D. Clements, Lana Mcgrady, Beth A. Bailey

ETSU Faculty Works

Abstract available through the Annals of Behavioral Medicine.

Adjunctive Atypical Antipsychotic Treatment For Major Depressive Disorder: A Meta-Analysis Of Depression, Quality Of Life, And Safety Outcomes, Glen I. Spielmans, Margit I. Berman, Eftihia Linardatos, Nicholas. Z. Rosenlicht

Dartmouth Scholarship

Atypical antipsychotic medications are widely prescribed for the adjunctive treatment of depression, yet their total risk-benefit profile is not well understood. We thus conducted a systematic review of the efficacy and safety profiles of atypical antipsychotic medications used for the adjunctive treatment of depression.

Associations Of Childhood Family Adversity And Pubertal Timing With Depressive Symptomotology In Adulthood, Jeffrey P. Winer

Masters Theses 1911 - February 2014

To date, no prior research has examined the combined roles of childhood family adversity and pubertal timing in longitudinal pathways to depressive symptomatology in adulthood. The present study was conducted with 225 men and 225 women to explore the unique and combined roles of childhood family adversity and pubertal timing on depressive symptoms in a community sample of married adults. Results for both men and women indicated significant main effects of a cumulatively risky family environment on depressive symptoms, as well as main effects of families with higher levels of abuse and neglect, chaos and disorganization, and interpersonal family conflict. …

Gene X Environment Effects Of Serotonin Transporter, Dopamine Receptor D4, And Monoamine Oxidase A Genes With Contextual And Parenting Risk Factors On Symptoms Of Oppositional Defiant Disorder, Anxiety, And Depression In A Community Sample Of 4-Year-Old Children, John V. Lavigne, Laura B.K. Herzing, Edwin H. Cook, Susan A. Lebailly, Karen R. Gouze, Joyce Hopkins, Fred B. Bryant

Psychology: Faculty Publications and Other Works

Genetic factors can play a role in the multiple level of analyses approach to understanding the development of child psychology. The present study examined gene-environment correlations and Gene x Environment interactions for polymorphisms of three target genes, the serotonin transporter gene, the D4 dopamine reactor gene, and the monoamine oxidase A gene in relation to symptoms of anxiety, depression, and oppositional behavior. Saliva samples were collected from 175 non-Hispanic White, 4-year-old children. Psychosocial risk factors included socioeconomic status, life stress, caretaker depression, parental support, hostility, and scaffolding skills. In comparison with the short forms (s/s, s/l) of the serotonin transporter …

Treating Severely Depressed Adolescents With Integrated, Relational, Cognitive Therapy, Gary A. Sibcy

Faculty Publications and Presentations

No abstract provided.

Predictors Of Treatments Acceptable To Patients For Late-Life Depression, Gerald J. Jogerst, Shimin Zheng, Erik Vanderlip

ETSU Faculty Works

Objectives. Describe older patients’ perceptions about depression and characteristics associated with acceptance of treatments. Design. Cross-sectional study. Setting. Three primary care clinics in Iowa. Participants. Consecutive sample of 529 primary care patients. Measurements. Depression screening tool (a 9-item patient health questionnaire [PHQ-9]) and questionnaire including sociodemographic data, patient attitudes about depression, and acceptability of different treatments. Results. Mean age was 71.9 years (range 60–93 years), 314 (59%) female. Among the 529 participants, 93 (17.5%) had history of depression and 60 (11.3%) had PHQ-9 scores of 10 or greater. Participants believed depression is a disease for which they would use medication …

Leveraging Family Values To Decrease Unhealthy Alcohol Use In Aging Latino Day Laborers, Homero E. Del Pino, Carolyn Méndez-Luck, Georgiana Bostean, Karina Ramírez, Marlom Portillo, Alison A. Moore

Sociology Faculty Articles and Research

In one Los Angeles study, 20% of day laborers reported excessive drinking. Older adults are more sensitive to alcohol’s effects, yet heavy drinking persists among Latinos until they are in their 60s. No interventions to reduce heavy drinking exist for aging day laborers. We recruited 14 day laborers aged 50 and older in Los Angeles. We identified their unhealthy alcohol use behaviors and comorbidities and conducted semi-structured interviews to understand their perceptions of unhealthy alcohol use. We found social disadvantages and conditions exacerbated by alcohol use, like depression. Participants were concerned with dying and premature aging, and reported that family …

Control Group Design: Enhancing Rigor In Research Of Mind-Body Therapies For Depression, Patricia Anne Kinser, Jo Lynne W. Robins

School of Nursing Publications

Although a growing body of research suggests that mind-body therapies may be appropriate to integrate into the treatment of depression, studies consistently lack methodological sophistication particularly in the area of control groups. In order to better understand the relationship between control group selection and methodological rigor, we provide a brief review of the literature on control group design in yoga and tai chi studies for depression, and we discuss challenges we have faced in the design of control groups for our recent clinical trials of these mind-body complementary therapies for women with depression. To address the multiple challenges of research …

An Exploration Of Comorbid Symptoms And Clinical Correlates Of Clinically Significant Hoarding Symptoms, Brian J. Hall, David F. Tolin, Randy O. Frost, Gail Steketee

Psychology: Faculty Publications

Background Hoarding disorder (HD) is currently being considered for inclusion in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), yet remains poorly understood. Consensus is building that hoarding may constitute a separate disorder, although comorbidity remains high and complicates the diagnostic picture. The purpose of this investigation was to explore patterns of comorbidity among people who engage in hoarding behavior in order to better understand its clinical presentation and phenomenology. Methods Data were collected from a large internet sample (N = 363) of people who self-identified as having hoarding problems, met criteria for clinically significant hoarding, and …

Food Groups And Fatty Acids Associated With Self-Reported Depression: An Analysis From The Australian National Nutrition And Health Surveys, Barbara J. Meyer, Nithin Kolanu, David A. Griffiths, Ben Grounds, Peter R. C Howe, Irene A. Kreis

Faculty of Science, Medicine and Health - Papers: part A

Objective The aim of this study was to explore the associations between incidence of depression and dietary intakes of foods and fatty acids in adult Australians. Methods Data from the 1995 Australian National Nutrition Survey (NNS), the 1995 Australian National Health Survey (NHS) and an updated fatty acid database were merged and the 24-h fatty acid intakes were calculated for the 10 986 adult participants ages 18 to 79 y in the 1995 NNS. The merged data set was used to run a logistic regression with depression as the response variable and the food groups and calculated fatty acid values, …