Medicine and Health Sciences Commons^™

Improving The Inference Of Some Experiemtal Studies By Using Ranked Auxiliary Covariates, Rajai Jabrah

Electronic Theses and Dissertations

In many studies, the measurement of sampling units according to the response variable is costly or time consuming, however, it is possible to rank sampling units according to baseline auxiliary covariates, which are available, easily obtainable, and cost efficient. In these cases, when estimating the population mean, Ranked Set Sampling (RSS) can be a more efficient sampling method than the Simple Random Sampling (SRS) method. In this dissertation, we propose a modified approach of the RSS method to allocate units into an experimental study, aimed to compare two or more groups.

Ranked auxiliary covariates, which are typically correlated with the …

The Effects Of Alpha Stimulation On Induced Anxiety, Nolan Thomas Hill

Electronic Theses and Dissertations

Anxiety is defined as an emotional and physical reaction that prepares us to confront a feared stimulus. Among the many measureable changes induced by anxiety are changes in facial electromyography (EMG), heart rate (HR), and sweat gland activity (EDG). At a pathological level anxiety interferes with cognitive processes. Currently, when anxiety crosses into the pathological level, it is treated with a variety of therapies that share in their use of periods of exposure to anxiety-inducing stimuli. Several devices have been developed to alter brain activity by transcranial electrical stimulation (TCES). One such device, Alpha-Stim^®, has been shown to …

Exploring The Relationship Between Early Childhood Attentional Control And Language Ability, Jaima S. Price

Electronic Theses and Dissertations

Relatively few studies have investigated the relationship between early childhood attentional control and later cognitive outcomes, especially language development. The current study is an investigation of the relationship between the executive functioning (EF) component of attentional control and language ability in the second year of life. More specifically, the predictive nature of two aspects of attentional control, attentional focus and resistance to distraction, was be the primary focus of the proposed study. Although it was expected that children both high in attentional focus and resistance to distraction would have significantly superior language development than infants with lower attentional capacities, analyses …

Youth With Type 1 Diabetes Mellitus: An Examination Of Adolescents’ Illness Perceptions And Associated Impact On Health-Related Quality Of Life, Zainab Shahpurwala

Electronic Theses and Dissertations

Objectives: To examine the impact of various psychosocial factors (perceived stress, diabetes-specific parental involvement, self-efficacy for diabetes management, and perceived peer support) on adolescents’ self-reported health-related quality of life (HRQoL) and assess the association between these factors and their self-reported HRQoL. To determine if differences in perceptions exist between diabetes camp and non-camp adolescent attendees on the various aforementioned psychosocial factors and their impact on their HRQoL. Methods: The study employed a cross-sectional, non-experimental, quantitative design to address the aforementioned objectives. Adolescents were recruited from multiple sites including diabetes summer camps and university-based and community-based private clinics. Self-administered paper-based surveys …

The Emotions, Coping And Social Support Perceived By Ncaa Division I Athletes During Concussion Recovery: A Qualitative Study, Paige Wells

Electronic Theses and Dissertations

Context: Concussed patients require an individualized assessment and treatment plan in order to improve the outcomes associated with their overall recovery. A new model has been created to explain the psychological response to sport concussion injury and rehabilitation process. This model highlights pre-injury and post-injury factors affecting the recovery process including emotions, coping and social support. Understanding the emotional disturbances, coping behaviors and social support available to concussed athletes may provide valuable information for the healthcare team in management and care for the concussed athlete.

Purpose: To identify and describe the emotions, coping mechanisms and social support perceived by Division …

Sleep-Related Arousal And Spontaneous Movement Properties In Methadone-Exposed Neonates: A Videographic Assessment On The First Or Second Postnatal Night, Hira Shrestha

Electronic Theses and Dissertations

Prenatal substance exposure such as alcohol, nicotine, and opiates is known to modulate autonomic regulatory function during sleep, and to decrease arousability and spontaneous movements (SM). SM during sleep may reflect a protective mechanism for immature patterns of arousals. Neurodevelopmental compromise in sleep and arousal systems may underlie sudden infant death syndrome (SIDS) risk in which infants expire during sleep. Previous studies from our laboratory found abnormal patterns of neonatal arousal, sleep fragmentation, and deficits in sleep-related SM in infants with prenatal alcohol exposure. In this study, prenatal exposure to methadone was hypothesized to disrupt the development of sleep and …

Mental Health Referral In Primary Care: Influence Of A Screening Instrument And A Brief Educational Intervention, Michael T. Miesner

Electronic Theses and Dissertations

Although less than half of all patients with mental disorders seek mental health treatment per se, approximately 80% of all people will visit their primary care physician (PCPs) within a year (Strosahl, 1998). However, it is not well understood how to best handle patients presenting with mental health issues in primary care practices. The purpose of this project was to implement an intervention involving a screening measure for anxiety and mood disorders in a primary care setting to increase the volume of anxiety and mood disorder screening, to increase the accuracy of disorder detection, and to also enhance PCPs patterns …

A Study Of Fetal Tissue Implantation For The Treatment Of Parkinson's Disease: Can Self-Efficacy And Social Support Predict Physical Functioning And Perceived Treatment?, Bethany L. Fiebelkorn

Electronic Theses and Dissertations

Few studies have comprehensively explored the benefit of fetal tissue implantation in Parkinson's disease (PD) patients. This type of investigation is necessary to better understand how and why some participants in a double-blind investigation of fetal tissue implantation for PD improved following the surgical procedure while others did not (Freed et al., 2001). Data for the present study were collected during a quality of life (QoL) study conducted by McRae et al. (2004) that sampled PD patients who participated in Freed et al.'s (2001) double-blind investigation of fetal tissue implantation. Several aspects of QoL were examined in McRae et al.'s …

Exercise Behavior Patterns In Emerging Adulthood: An Exploration Of Predictor Variables From Self-Determination Theory And Transtheoretical Model, Chad R. Johnson

Electronic Theses and Dissertations

During the transition from childhood to adulthood, young people establish patterns of behavior and make lifestyle choices that affect both their current and future health (NCHS, 2010). Emerging adulthood – a new conception of development for the period from the late teens through the twenties – focuses on individuals ages 18-25 who did not have a child, own a home, or have sufficient income to be fully independent (Arnett, 2000). Very little is known about social influence, motivational mediators, and motivation on exercise behavior within this developmental period. Therefore, the purpose of this study was to determine the influence of …

Anxiety In Children With Williams Syndrome : Association With Negative Reactivity, Self-Regulation, And Sensory Modulation., Nicole A. Crawford-Zelli

Electronic Theses and Dissertations

Williams syndrome (WS) is a neurodevelopmental disorder caused by a submicroscopic deletion of approximately 25 genes on chromosome 7q11.23 (Hillier et al., 2003). This genotype is associated with a characteristic set of phenotypic features including mild to moderate intellectual disability, a distinctive cognitive profile, facial dysmorphology, common personality traits, cardiovascular problems, and connective tissue disorders (Morris, 2010). In addition, behavioral difficulties such as anxiety symptoms (e.g., Leyfer, Woodruff-Borden, & Mervis, 2009), negative reactivity (e.g., Davies, Udwin, & Howlin, 1998), problems with self-regulation (e.g., Woodruff-Borden, Kistler, Henderson, Crawford, & Mervis, 2010), and sensory modulation difficulties (e.g., John & Mervis, 2010) are …

Genome-Wide Association Analysis Of Major Depressive Disorder And Its Related Phenotypes., Nagesh Ramarao Aragam

Electronic Theses and Dissertations

Major Depressive Disorder (MDD) is a complex and chronic disease that ranks fourth as cause of disability worldwide. Thirteen to 14 million adults in the U.S. are believed to have MDD and an estimated 75% attempt suicide making MDD a major public health problem. Recently several genome-wide association (GWA) studies of MDD have been reported; however, few GWA studies focus on the analysis for MDD related phenotypes such as neuroticism and age at onset of MDD. The purpose of this study is to determine risk factors for MDD, identify genome-wide genetic variants affecting neuroticism and age at onset as quantitative …

Introversion And Autism: A Conceptual Exploration Of The Placement Of Introversion On The Autism Spectrum, Jennifer Grimes

Electronic Theses and Dissertations

The conceptualization of the personality construct of introversion has been problematic since the term's inception due to the complexity and seemingly self-contradictory nature of the collection of attributes of which it is comprised. To advance the understanding of introversion, I propose that it is a continuous segment of the non-clinical part of the autism spectrum, and that it is not the same as the inverse of extraversion. When introversion and autism are placed on the same continuum, the nature of the relationship of the traits becomes more apparent, and new possibilities are available for exploration of both autism and introversion. …

A Longitudinal Study Of Fetal Tissue Transplantation Surgery: The Effects On Quality Of Life And Personality For Individuals With Parkinson's Disease, Cynthia C. Cole

Electronic Theses and Dissertations

Parkinson's disease (PD) is a chronic and progressive condition that affects the physical, emotional, and social functioning of individuals. Freed et al. (2001) conducted a double-blind sham-controlled trial to investigate the effectiveness of fetal tissue transplantation of those with PD. The authors investigated the effects of the surgery across the dimensions of physical and neurological functioning. A quality of life (QoL) study was conducted to determine if there were differences in QoL when comparing those who received the fetal tissue transplantation to those who received the sham surgery (McRae et al., 2004).

While there is little research on the effectiveness …

Elucidating The Role Of The Α7 Nicotinic Receptor In The Etiology Of Schizophrenia., Michelle Johnson Chandley

Electronic Theses and Dissertations

The α7 subunit of the nicotinic receptor, a ligand gated ion channel with an affinity for nicotine, has long been implicated in the pathophysiology of schizophrenia due to the extremely high rate of smoking within the patient population. However, the exact role of the receptor has never fully been determined. In the following studies, various functions the receptor may assume in disease state are evaluated. There is a strong relationship between the immune system and schizophrenia, with the α7 subunit possibly serving as the link between the two. One of the following studies looks at the possibility of the receptor …

An Epidemiological Study Of Maternal Depression: Findings From The National Institute Of Child Health And Human Development Study Of Early Child Care And Youth Development., Liang Wang

Electronic Theses and Dissertations

This study examined maternal depression status from month 1 to 36 after birth using data from the NICHD Study of Early Child Care and Youth Development. Maternal depression was assessed with the Center of Epidemiological Studies Depression Scale. The prevalence of maternal depression was highest at 1 month, decreased at 6 months, and then kept fairly stable to 36 months. The prevalence was higher in blacks than other races, in 18-24 than 25-46 years old, and in single mothers than non-single mothers. Mothers with better physical health, social support, or employed had a lower prevalence than their counterparts. Mothers in …

The Effects Of Nicotine Conditioned Place Preference In D2 Primed Adolescent Rats: Age-Related And Gender Effects., Yoko Emily Ogawa

Electronic Theses and Dissertations

This study investigated nicotine conditioned place preference (CPP) in two different ages of adolescence using a rodent model of schizophrenia. Both 2- and 3-chambered CPP apparatuses were used to test whether the CPP was due to an aversion to the white chamber. Animals were neontally treated with the dopamine D₂/D₃ agonist, quinpirole, or saline and raised to either early postweanling age (P 22) or adolescence (P 29). Rats were conditioned to prefer the white chamber using nicotine. Results showed that nicotine induced CPP and appeared to alleviate an increased stress response in D₂ primed animals, which …

An Analysis Of Nicotine Exacerbation Of Reductions In Ppi In A Rodent Model Of Schizophrenia., Amanda Marie Maple

Electronic Theses and Dissertations

Prepulse inhibition (PPI) is an operational measure of sensorimotor gating and is known to be reduced when the dopamine D² receptor is activated. We used a rodent model of psychosis in which increases in dopamine D_{2 receptor sensitivity are produced through neonatal quinpirole (a dopamine D2 / D3 agonist) treatment to rats. Rats were administered quinpirole (1mg/kg) or saline from postnatal day (P) 1-21. Rats were raised to adulthood and tested on PPI. Results showed that neonatal quinpirole treatment produced a significant reduction in PPI, and nicotine exacerbated this reduction. This reduction was partially blocked by …}

Nicotine Sensitization In A Rodent Model Of Schizophrenia: A Comparison Of Adolescents, Adults, And Neurotrophic Factors., Marla Kay Perna

Electronic Theses and Dissertations

The behavioral effects of nicotine on locomotor activity in a rodent model of psychosis were analyzed. This model is based on neonatal quinpriole treatment (a dopamine D2/D3 agonist) which causes increased D2 receptor sensitivity, a phenomenon known as D2 priming that is common in schizophrenia. D2-primed adolescent rats did not demonstrate nicotine-induced hypoactivity early in training, and males demonstrated more rapid sensitization to nicotine as compared to controls administered nicotine. D2-primed females administered nicotine demonstrated increased stereotypic behavior. D2-primed adult rats given nicotine demonstrated significantly more robust sensitization to nicotine than controls given nicotine. Brain-derived neurotrophic factor (BDNF) was analyzed …

The Psychiatric Treatment Of A Group Of Delinquents., Bernard Finkelstein

Electronic Theses and Dissertations

No abstract provided.