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Full-Text Articles in Medicine and Health Sciences
Can 3d Printers Create Viable Personalized Therapy In The Treatment Of Diabetes?, Lyla White
Can 3d Printers Create Viable Personalized Therapy In The Treatment Of Diabetes?, Lyla White
Holster Scholar Projects
This study aimed to use 3D printing techniques to create a drug tablet containing two commonly used active ingredients (metformin and glyburide) for treating diabetes in a single pill. The hypothesis was that both drugs can be given in doses not available commercially and that these pills will have appropriate hardness, and extended-release dissolution. I was able to create 48 tablets that contained evenly dispersed active ingredient powder and met the weight requirements with consistency between tablets. Unfortunately, we had to substitute the usual bulk excipient for another because it was incompatible with the metformin and the replacement (mannitol) may …
Development Of Abuse Deterrent Formulations Using Hot Melt Extrusion, Pavan Kumar Nukala
Development Of Abuse Deterrent Formulations Using Hot Melt Extrusion, Pavan Kumar Nukala
Theses and Dissertations
In recent years prescription drug diversion, misuse, abuse represent a growing problem for the United States. Oral ingestion, snorting, injection are most commonly employed routes of abuse. To circumvent this problem hot melt extrusion (HME) was employed to prepare abuse deterrent formulation (ADF). Abuse Deterrent Immediate Release Egg-Shaped Tablet Using 3D Printing Technology: Quality by Design to Optimize Drug Release and Extraction. In current work, we developed egg-shaped tablet (egglet) using fused deposition modeling (FDM) 3D printing. Drug-loaded polymeric filaments (1.5 mm) were prepared using HME followed by printing into egglets of different sizes and infill densities. Based on printability, …