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Articles 1 - 10 of 10
Full-Text Articles in Medicine and Health Sciences
Novel Method Of Administering Aspirin And Dosage Forms Containing Same, Anwar A. Hussain, Lewis W. Dittert, Thomas S. Foster
Novel Method Of Administering Aspirin And Dosage Forms Containing Same, Anwar A. Hussain, Lewis W. Dittert, Thomas S. Foster
Pharmaceutical Sciences Faculty Patents
The invention relates to a novel method of administering aspirin to achieve improved delivery thereof. The invention further relates to novel dosage forms of neutralized aspirin adapted for nasal administration, such as solutions, suspensions, gels and ointments. These dosage forms find utility in the treatment of conditions known to respond to the administration of aspirin, particularly in the treatment of migraine and in the mitigation of cardiovascular damage resulting from heart attack.
Fall 1989, Southwestern Oklahoma State University
Fall 1989, Southwestern Oklahoma State University
The Sig
The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Fall 1989
Effect Of Inhibitors Of Arachidonic Acid Metabolism On Corneal Neovascularization In The Rat, W. L. Haynes, A. D. Proia, G. K. Klintworth
Effect Of Inhibitors Of Arachidonic Acid Metabolism On Corneal Neovascularization In The Rat, W. L. Haynes, A. D. Proia, G. K. Klintworth
Osteopathic Medicine, Jerry M. Wallace School of
No abstract provided.
Porous Microspheres For Drug Delivery And Methods For Making Same, Patrick P. Deluca, Motoko Kanke, Toyomi Sato, Hans G. Schroeder
Porous Microspheres For Drug Delivery And Methods For Making Same, Patrick P. Deluca, Motoko Kanke, Toyomi Sato, Hans G. Schroeder
Pharmaceutical Sciences Faculty Patents
Controlled release drug delivery systems comprised of spherical microporous polymeric network of interconnecting channels containing pore incorporated drugs or other agents wherein the drugs or agents are confined within the pore channel are described. Also disclosed are processing parameters in connection with the novel method of the invention for obtaining drug delivery systems especially suited for parenteral as well as oral administration.
50 Years Of Excellence: A Commemorative History Honoring The 50th Anniversary Of The Southwestern Oklahoma State University School Of Pharmacy 1939-1989, Southwestern Oklahoma State University
50 Years Of Excellence: A Commemorative History Honoring The 50th Anniversary Of The Southwestern Oklahoma State University School Of Pharmacy 1939-1989, Southwestern Oklahoma State University
Pharmacy
A Commemorative History Honoring the 50th Anniversary of the School of Pharmacy Southwestern Oklahoma State University 1939-1989
Pharmacokinetics Of Gentamicin In Neonates On Extracorporeal Membrane Oxygenation., W. Michael Southgate, Joseph T. Dipiro, Alex F. Robertson
Pharmacokinetics Of Gentamicin In Neonates On Extracorporeal Membrane Oxygenation., W. Michael Southgate, Joseph T. Dipiro, Alex F. Robertson
Publications from the Office of the Dean
Extracorporeal membrane oxygenation (ECMO) has been used in more than 1,000 infants in 50 centers in the United States. The extracorporeal circuit contains approximately 400 ml of blood, an amount exceeding the blood volume of most full-term neonates. The effect of this additional blood volume on drug disposition is unknown. In this study, we determined the pharmacokinetic parameters of gentamicin in 10 infants on ECMO. Gentamicin concentrations were determined by a fluorescence polarization immunoassay. Pharmacokinetic parameters were determined from these concentrations by using a two-compartment model. Our study demonstrated a mean steady-state volume of distribution of 0.51 +/- 0.11 liters/kg, …
Structure And Function Of Human Hemoglobin Covalently Labeled With Periodate-Oxidized Adenosine Triphosphate, Michael Kavanaugh, Max F. Perutz, Giulio Fermi, Daniel T. Shih, Richard T. Jones
Structure And Function Of Human Hemoglobin Covalently Labeled With Periodate-Oxidized Adenosine Triphosphate, Michael Kavanaugh, Max F. Perutz, Giulio Fermi, Daniel T. Shih, Richard T. Jones
Biomedical and Pharmaceutical Sciences Faculty Publications
Periodate-oxidized adenosine triphosphate (o-ATP), a ribose ring-opened dialdehyde derivative of ATP, reacts specifically with human deoxyhemoglobin to give a single major covalently modified product after reduction with sodium borohydride. This product, designated di-ATP Hb, was isolated using ion-exchange chromatography and shown to have incorporated two molecules of o-ATP/tetramer. Peptide mapping and x-ray crystallography at 2.8-A resolution indicate that a covalent adduct is formed between the ligand and residues Lys-82 EF6 of each beta chain in the organic phosphate-binding site of the molecule. di-ATP Hb exhibits a significantly decreased oxygen affinity (P50 = 20.8 mm Hg versus 5.8 mm Hg control; …
Aldosterone Stimulates K Secretion Across Mammalian Colon Independent Of Na Absorption, Gerhard Rechkemmer, Dan R. Halm
Aldosterone Stimulates K Secretion Across Mammalian Colon Independent Of Na Absorption, Gerhard Rechkemmer, Dan R. Halm
Neuroscience, Cell Biology & Physiology Faculty Publications
K transport across guinea pig (Cavia porcellus) distal colon was measured in vitro using isotopically determined unidirectional fluxes. Aldosterone stimulated electrogenic Na absorption, as measured by amiloride-sensitive short-circuit current (Isc), and reduced net K absorption from +2.5 ± 0.2 µEq/cm2 per hr to +0.8 ± 0.3 µEq/cm2 per hr (mean ± SEM). Amiloride addition to the mucosal solution did not enhance net K absorption, as expected if inhibiting active Na absorption would reduce active K secretion as in the distal nephron. The amiloride-insensitive Isc was -1.0 ± 0.2 µEq/cm2 per hr (mean ± SEM) …
Southeastern University Of Health Sciences Catalog 1989-1991, Southeastern University
Southeastern University Of Health Sciences Catalog 1989-1991, Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
1989 Apothecary, Southwestern Oklahoma State University
1989 Apothecary, Southwestern Oklahoma State University
Apothecary
The Apothecary staff would like to take this opportunity to congratulate the seniors who successfully completed their three years of professional training at Southwestern Oklahoma State University School of Pharmacy. We trust that they will strive for excellence in all of their endeavors and that they will use the knowledge that they have gained at Southwestern to make further advances in the Pharmacy profession.