Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Pembentukan 8-Ohdg Dari Zat Toksik Pemicu Radikal Bebas, Intan Cahaya Dani, Budiawan Budiawan
Pembentukan 8-Ohdg Dari Zat Toksik Pemicu Radikal Bebas, Intan Cahaya Dani, Budiawan Budiawan
Pharmaceutical Sciences and Research
This study was conducted to observe the profile of DNA Adduct (8-OHdG) formation as DNA damage indicators, by using calf thymus DNA incubated with toxic and carcinogenic compounds. The compounds which could trigger free radicals in this research were PAH(Benzo[a]Pyrene), TiO2, and CuCl2. Calf thymus DNA was incubated with Benzo[a]Pyrene and CuCl2 compounds under pH and temperature variations. The incubation of calf thymus DNA with TiO2-UV radiation (254 nm) was used to induce the formation of reactive oxygen species (ROS) in the process of oxidative DNA damage. From this research, all of compounds have potency to trigger the formation of …