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Articles 1 - 14 of 14
Full-Text Articles in Medicine and Health Sciences
Uji Toksisitas Akut Dan Efek Antiinflamasi Ekstrak Metanol Dan Ekstrak N-Heksana Daun Pepaya (Carica Papaya L), Tahara Dilla Santi
Uji Toksisitas Akut Dan Efek Antiinflamasi Ekstrak Metanol Dan Ekstrak N-Heksana Daun Pepaya (Carica Papaya L), Tahara Dilla Santi
Pharmaceutical Sciences and Research
The acute toxicity test and antiinflammatory effect of methanolic and n-hexane extracts Carica papaya L leaf have been studied. The results of phytochemical screening show that papaya leaf contains alkaloid, steroid, and flavonoid compound. Flavonoid and alkaloid extracted from methanolic extract of papaya leaf and steroid extracted from n-hexane extract of papaya leaf. The acute toxicity test of methanolic and n-hexane extracts Carica papaya L leaf have been studied on rat with giving a single dose of samples. The aim of this work was to investigate the behavioral responses (pharmacological profile), the development of body weight and mortality for 14 …
Skrining Fitokimia Dan Aktivitas Antioksidan Fraksi Etanol Alga Merah Eucheuma Spinosum, Bina Lohita Sari, Nurulia Susanti, Sutanto Sutanto
Skrining Fitokimia Dan Aktivitas Antioksidan Fraksi Etanol Alga Merah Eucheuma Spinosum, Bina Lohita Sari, Nurulia Susanti, Sutanto Sutanto
Pharmaceutical Sciences and Research
The red alga, Eucheuma spinosum from South Bangka Waters was shown to contain antioxidant activity. Natural antioxidants from algae are known to play an important role against various diseases and aging processes. The study objective was to investigate phytochemical screenings and antioxidant activity of ethanol fractions Euchema spinosum from south Bangka waters. Antioxidant activities of fresh algae (FA), dry algae (DA), and algae product (AP) were determined with DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. Extraction was conducted using 70% ethanol in acidic environment for 24 hours. Then, the extract was evaporated using rotary evaporator. Dry extract was fractionated with ethanol - n - …
Enzim Papain: Aspek Green Chemistry Pada Reaksi Knoevenagel, Laurentius Haryanto, Antonius Herry Cahyana
Enzim Papain: Aspek Green Chemistry Pada Reaksi Knoevenagel, Laurentius Haryanto, Antonius Herry Cahyana
Pharmaceutical Sciences and Research
Green chemistry aspect is the chemical approach that has been studied in the past two decade. One of the principles is the development of green synthesis process that is friendly for the environment. This research showed that papain can be used as catalyst for Knoevenagel reaction with 3 kinds of substituted-benzaldehyde and malononitrile as substrates in aqueous medium. The best reaction condition with 80% yield was reached by utilizing of 25 mg papain/mmol substrate. Reaction was conducted at ambient temperature and pressure for 30 min. Products were as yellowish to yellow needle crystals and successfully characterized by melting point, UV-Vis, …
Daun Jambu Biji (Psidium Guajava L.) Sebagai Antikanker Payudara, Dwitiyanti Dwitiyanti
Daun Jambu Biji (Psidium Guajava L.) Sebagai Antikanker Payudara, Dwitiyanti Dwitiyanti
Pharmaceutical Sciences and Research
Guava leaves are used as a cytotoxic. Previous research has demonstrated that guava leaves contained 61.71% of quersetin and has potential as an cytotoxic. The aim of this study was to determine the cytotoxic activity of 70% ethanol extract of guava leaves against cancer cells T47D. The method used direct counting (viable cell count) to obtained LC50 value. This study used a test solution with six concentrations that were 130.62; 67.98; 35.98; 18.43; 9.56 and 5 µg/ml. The LC50 value from the 70% ethanol extract of guava leaves was 27.54 µg/ml. The results suggested the extract of guava leaves has …
Pembentukan 8-Ohdg Dari Zat Toksik Pemicu Radikal Bebas, Intan Cahaya Dani, Budiawan Budiawan
Pembentukan 8-Ohdg Dari Zat Toksik Pemicu Radikal Bebas, Intan Cahaya Dani, Budiawan Budiawan
Pharmaceutical Sciences and Research
This study was conducted to observe the profile of DNA Adduct (8-OHdG) formation as DNA damage indicators, by using calf thymus DNA incubated with toxic and carcinogenic compounds. The compounds which could trigger free radicals in this research were PAH(Benzo[a]Pyrene), TiO2, and CuCl2. Calf thymus DNA was incubated with Benzo[a]Pyrene and CuCl2 compounds under pH and temperature variations. The incubation of calf thymus DNA with TiO2-UV radiation (254 nm) was used to induce the formation of reactive oxygen species (ROS) in the process of oxidative DNA damage. From this research, all of compounds have potency to trigger the formation of …
Evaluasi Aktivitas Antioksidan Senyawa 4-[(E)-2-(4-Okso-3-Fenilkuinazolin-2-Il)Etenil]-Benzensulfonamida Dan Analognya, Catur Jatmika, Baitha Palanggatan Maggadani, Hayun Hayun
Evaluasi Aktivitas Antioksidan Senyawa 4-[(E)-2-(4-Okso-3-Fenilkuinazolin-2-Il)Etenil]-Benzensulfonamida Dan Analognya, Catur Jatmika, Baitha Palanggatan Maggadani, Hayun Hayun
Pharmaceutical Sciences and Research
Quinazolinone derivative compounds exhibit a broad spectrum of biological activity, including antioxidant. Quinazolinone derivative compound 4-[(E)-2-(4-oxo-3-phenyl quinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs (2a-f) have been synthesized and demonstrated its activity as a selective inhibitor of cyclooxygenase-2. The aim of this research was to evaluate the antioxidant activity of compound 4-[(E) -2-(4-oxo-3-fenilkuinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs with DPPH radical scavenging method, ferric reducing activity potential (FRAP), and phosphomolybdenum method. The experiment revealed that the % inhibition and antioxidant capacity of compound 2c, 2e and 2f were higher compared to compound 2a, 2b and 2d. The DPPH radical scavenging analysis found that the % inhibition …
Aktivitas Antioksidan Ekstrak, Fraksi Dan Golongan Senyawakimia Daun Premna Oblongata Miq, Katrin Katrin, Atika Bendra
Aktivitas Antioksidan Ekstrak, Fraksi Dan Golongan Senyawakimia Daun Premna Oblongata Miq, Katrin Katrin, Atika Bendra
Pharmaceutical Sciences and Research
Indonesia has many kinds of plants which can be used as natural antioxidant sources. This study was focused on antioxidant activity of Cincau Perdu leaves extract (Premna oblongata Miq.) using 1-Diphenyl-2-picrylhydrazyl (DPPH) methods. P. oblongata leaves was extracted using n-hexane, ethylacetate and methanol. It was found that methanol extract has the highest activity with IC50 value 20.01 μg/mL. The extract with highest antioxidant activity were fractionated with accelerated column chromatography and were earned 6 combination fractions. The antioxidant activity of each combination fractions were tested by DPPH methods. Fraction-5 showed the highest activity as antioxidant with IC50 23.51 μg/mL. The …
Evaluasi Kadar Kurkumin Dalam Jamu Tradisional Kunir Asam Yang Dijual Di Pasar Kota Gede Bulan Februari 2015, Fitrilya Mustikahati Yusuf, Nurkhasanah Nurkhasanah
Evaluasi Kadar Kurkumin Dalam Jamu Tradisional Kunir Asam Yang Dijual Di Pasar Kota Gede Bulan Februari 2015, Fitrilya Mustikahati Yusuf, Nurkhasanah Nurkhasanah
Pharmaceutical Sciences and Research
Javanese women often consume kunir asam to relieve dysmenorrhea symptom. It is a traditional herbal medicine which is conventionally prepared from curcuma domestica. One of the active compound of curcuma domestica is curcumin. The purpose of this research is to determine the amount of curcumin available in kunir asam selling in daily market of Kota Gede. Curcumin level in daily batches consistency was also evaluated. Curcumin analysis was conducted by qualitative and quantitative tests by TLC densitometry method. A total of 50.0 ml kunir asam was extracted with 25.0 ml of chloroform, and then the mixture was dried by evaporation. …
Toksisitas Ekstrak Etanol Mangifera Foetida L. Sebagai Pengkelat Besi Ditinjau Dari Ld50 Dan Komponen Sel Darah, Tri Wahyuni, Santi Purna Sari, Ari Estuningtyas, Hj Freisleben
Toksisitas Ekstrak Etanol Mangifera Foetida L. Sebagai Pengkelat Besi Ditinjau Dari Ld50 Dan Komponen Sel Darah, Tri Wahyuni, Santi Purna Sari, Ari Estuningtyas, Hj Freisleben
Pharmaceutical Sciences and Research
Ethanolic extract of bacang mango leaves (Mangifera foetida L.) decreased iron concentration in blood Sprague dawley rats that had been induced iron overload. The aim of this experiment was to determine acute toxicity (LD50) value of ethanolic extract of M.foetida by weil method and its effect to blood component. This study was conducted by employing a complete random design using 25 male and 25 female mice of DDY strain which devided into 5 groups. The first group until fourth group were administered ethanolic extract of M.foetida with dose variation which suspension in aquadest orally. The fifth group was control that …
Penetapan Kadar Fenolik Dan Flavonoid Total Ekstrak Metanol Buah Dan Daun Patikala (Etlingera Elatior (Jack) R.M.Sm), Aktsar Roskiana Ahmad, Juwita Juwita, Siti Afrianty Daniya Ratulangi
Penetapan Kadar Fenolik Dan Flavonoid Total Ekstrak Metanol Buah Dan Daun Patikala (Etlingera Elatior (Jack) R.M.Sm), Aktsar Roskiana Ahmad, Juwita Juwita, Siti Afrianty Daniya Ratulangi
Pharmaceutical Sciences and Research
Fruit and leaves of patikala (Etlingera elatior (Jack) R.M.Sm), is a traditional medicinal plants used by people to treat various diseases. The purpose of this study was to determine the total phenolic and flavonoid compounds of E. elatior fruits and leaves extracts. We extracted dried fruits and leaves samples by maceration method using methanol. Qualitative analysis of chemical compounds with certain eluent was done using Thin Layer Chromatography (TLC) to determine the group of active compounds in the extract. The amount of phenolic compounds in the sample was determined by the colorimetric method at a maximum wavelength of 744.8 nm …
Losio Antioksidan Buah Naga Merah (Hylocereus Polyrhizusbritton And Rose), Amanda Angelina Sinaga, Sri Luliana, Andhi Fahrurroji
Losio Antioksidan Buah Naga Merah (Hylocereus Polyrhizusbritton And Rose), Amanda Angelina Sinaga, Sri Luliana, Andhi Fahrurroji
Pharmaceutical Sciences and Research
Hylocereus polyrhizus Britton and Rose (Red dragon fruit) has been shown to have antioxidant activity which contains vitamin C, polyphenol, and flavonoid. This research was aimed to investigate antioxidant activity from H. polyrhizus in form of lotion. Lotion were made with 5 concentration from H. polyrhizus methanol extract were 0.04, 0.08, 0.16, 0.32 and 0.64%. Lotion antioxidant activity was measured using DPPH method. The result showed that H. polyrhizus methanol extract had antioxidant activity with inhibition concentration were 19.99±0.33; 25.01±0.08; 39.14±0.04; 66.69±0.12 and 83.37±0.05. The result showed significant differences on antioxidant activity. The physical stability observation of five formula with …
Sintesis Ramah Lingkungan Senyawa Imina Turunan Vanilin Dan 2-Hidroksi Asetofenon Serta Uji Aktivitas Biologi Dan Antioksidan, Herry Cahyana, Putri Pratiwi
Sintesis Ramah Lingkungan Senyawa Imina Turunan Vanilin Dan 2-Hidroksi Asetofenon Serta Uji Aktivitas Biologi Dan Antioksidan, Herry Cahyana, Putri Pratiwi
Pharmaceutical Sciences and Research
Eco-friendly synthesis of imine derivative compound from 2-hydroxy acetophenone and vanillin had been conducted by using a method of stirring (with stirrer) in a water solvent. The whole experiment began with the synthesis of imine compounds, followed by purification and characterization of the synthesis products and finally analysis on their biological and antioxidant activities. The experiments showed that imine compounds could be synthesized by a chemical reaction of 4-amino antipirin aqueous solution with 2-hydroxy acetophenone and vanillin at magnetic stirrer speed of 250 and 450 rpm, respectively, which produced product A, (E)-4-(1-(2-hydroxyphenyl) ethylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H) -one and product B, (E)-4-(4-hydroxy-3-(vinyloxy) benzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one. Yield …
Pengaruh Kandungan Komponen Minor Dari Minyak Kelapa Sawit (Elaeis Guineensis Jacq.) Terhadap Aktivitas Antioksidan Pada Proses Pemurnian Karotenoid, Ahmad Gazali Sofwan Sinaga, Donald Siahaan
Pengaruh Kandungan Komponen Minor Dari Minyak Kelapa Sawit (Elaeis Guineensis Jacq.) Terhadap Aktivitas Antioksidan Pada Proses Pemurnian Karotenoid, Ahmad Gazali Sofwan Sinaga, Donald Siahaan
Pharmaceutical Sciences and Research
Palm oil contains carotenoid and vitamin E which possess antioxidant properties. A long exposure of heat and chemical substances during the purification process may lower antioxidant activity. This research was conducted to compare antioxidant activity of carotenoid and vitamin E obtained from each stage of three continuous purification process (transesterification, solvolytic micellization, and saponification). Total carotenoid concentration was analyzed by UV-visible spectrophotometer at λ 446 nm and total vitamin E concentration was analyzed by high-performance liquid chromatography, while ester and triglyceride concentration were analyzed by gas chromatography. Antioxidant activity was measured by DPPH assay with incubation time in 60 minutes. …
Sintesis Dan Karakterisasi Hidrogel Superabsorben Kitosan Poli(N-Vinilkaprolaktam) (Pnvcl) Dengan Metode Full Ipn (Interpenetrating Polymer Network), Nadhrah Wivanius, Emil Budianto
Sintesis Dan Karakterisasi Hidrogel Superabsorben Kitosan Poli(N-Vinilkaprolaktam) (Pnvcl) Dengan Metode Full Ipn (Interpenetrating Polymer Network), Nadhrah Wivanius, Emil Budianto
Pharmaceutical Sciences and Research
Polymer material used for hydrogel should have capability to swell and to keep water molecules in its structure without solubilised in water. Natural polymers has functional groups which can perform as active sites in modification to produce polymer with better characteristic. Chitosan is a natural polymer which has good swelling ability but lack of structural strength. Synthesis of chitosan hydrogel by interpenetrating polymer network (IPN) will increase its strength through crosslinking. In this research, the first step of modification was the synthesis of chitosan polymer network crosslinked by acetaldehyde. The next step was the synthesis of PNVCL polymer network crosslinked …