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Full-Text Articles in Medicine and Health Sciences
Sex Differences In Angiotensin Signaling In Bulbospinal Neurons In The Rat Rostral Ventrolateral Medulla, Gang Wang, Teresa A. Milner, Robert C. Speth, Andrea C. Gore, Di Wu, Costantino Iadecola, Joseph P. Pierce
Sex Differences In Angiotensin Signaling In Bulbospinal Neurons In The Rat Rostral Ventrolateral Medulla, Gang Wang, Teresa A. Milner, Robert C. Speth, Andrea C. Gore, Di Wu, Costantino Iadecola, Joseph P. Pierce
HPD Articles
Sex differences may play a significant role in determining the risk of hypertension. Bulbospinal neurons in the rostral ventrolateral medulla (RVLM) are involved in the tonic regulation of arterial pressure and participate in the central mechanisms of hypertension. Angiotensin II (ANG II) acting on angiotensin type 1 (AT(1)) receptors in RVLM neurons is implicated in the development of hypertension by activating NADPH oxidase and producing reactive oxygen species (ROS). Therefore, we analyzed RVLM bulbospinal neurons to determine whether there are sex differences in: 1) immunolabeling for AT(1) receptors and the key NADPH oxidase subunit p47 using dual-label immunoelectron microscopy, and …
Human Brain Contains A Novel Non-At1, Non-At2 Binding Site For Active Angiotensin Peptides, Vardan T. Karamyan, Craig A. Stockmeier, Robert C. Speth
Human Brain Contains A Novel Non-At1, Non-At2 Binding Site For Active Angiotensin Peptides, Vardan T. Karamyan, Craig A. Stockmeier, Robert C. Speth
HPD Articles
AIMS: To determine whether the novel non-AT1, non-AT2 binding site for angiotensins recently discovered in rodent brains occurs in the human brain. MAIN METHODS: Radioligand binding assays of (125)I-sarcosine(1), isoleucine(8) angiotensin II binding were carried out in homogenates of the rostral pole of the temporal cortex of human brains containing 0.3 mM parachloromercuribenzoate (PCMB), 10 microM losartan to saturate AT1 receptors, 10 microM PD123319 to saturate AT2 receptors, with or without 10 microM angiotensin II to define specific binding. Competition binding assays employed a variety of angiotensin peptides, specific angiotensin receptor antagonists, several neuropeptides and an endopeptidase inhibitor to determine …
Cannabinoid Ester Constituents From High-Potency Cannabis Sativa, Safwat A. Ahmed, Samir A. Ross, Desmond Slade, Mohamed M. Radwan, Fazila Zulfiqar, Rae R. Matsumoto, Yan-Tong Xu, Eddy Viard, Robert C. Speth, Vardan T. Karamyan, M A. Elsohly
Cannabinoid Ester Constituents From High-Potency Cannabis Sativa, Safwat A. Ahmed, Samir A. Ross, Desmond Slade, Mohamed M. Radwan, Fazila Zulfiqar, Rae R. Matsumoto, Yan-Tong Xu, Eddy Viard, Robert C. Speth, Vardan T. Karamyan, M A. Elsohly
HPD Articles
Eleven new cannabinoid esters, together with three known cannabinoid acids and Delta9-tetrahydrocannabinol ( Delta9-THC ), were isolated from a high-potency variety of Cannabis sativa. The structures were determined by extensive spectroscopic analyses to be beta-fenchyl Delta9-tetrahydrocannabinolate ( 1), epi-bornyl Delta9-tetrahydrocannabinolate ( 2), alpha-terpenyl Delta9-tetrahydrocannabinolate ( 3), 4-terpenyl Delta 9-tetrahydrocannabinolate ( 4), alpha-cadinyl Delta9-tetrahydrocannabinolate ( 5), gamma-eudesmyl Delta9-tetrahydrocannabinolate ( 6), gamma-eudesmyl cannabigerolate ( 7), 4-terpenyl cannabinolate ( 8), bornyl Delta9-tetrahydrocannabinolate ( 9), alpha-fenchyl Delta9-tetrahydrocannabinolate ( 10), alpha-cadinyl cannabigerolate ( 11), Delta9-tetrahydrocannabinol ( Delta9-THC ), Delta9-tetrahydrocannabinolic acid A ( Delta9-THCA ), cannabinolic acid A ( CBNA), and cannabigerolic acid ( CBGA). Compound …
Health Professions Division Catalog 2008-2009, Nova Southeastern University
Health Professions Division Catalog 2008-2009, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
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