Medicine and Health Sciences Commons^™

A Retrospective Study Of Drug Interactions And Their Clinical Significance In 100 Hospitalized Patients, Michael Ray Alexander

University of the Pacific Theses and Dissertations

Within the past several years, a great deal of attention has been focused on the phenomena of drug-drug interactions and their importance in the therapeutic regimen of patients for whom multiple therapeutic agents might be indicated. The rather sudden concern for this aspect of medical and pharmaceutical practice is evidenced by the proliferation of literature devoted to the topic for both professions. While iatrogenic disease has long been recognized as one of the hazards inherent in prescribing practices, only isolated reports of specific interactions were found until recently. Although it cannot be said with certainty when the first interaction of …

A Pharmacologic Investigation Of The Antiinflammatory Activity Of Cryogenine, Donald Saadia Kosersky

University of the Pacific Theses and Dissertations

This study was conducted in an attempt to define the anti inflammatory efficacy of cryogenine, the major alkaloid of Heimia salicifolia Link and Otto. The anti inflammatory effects produced by cryogenine, phenylbutazone, indomethacin, mefenamic acid, paramethasone, hydrocortisone and 6-mercaptopurine were compared considering the sequential changes in various motameters during the course of adjuvant-induced polyarthritis in rats. Polyarthritis was induced by the subplantar injection of a suspension of heat-killed Mycobacterium butyricus in mineral oil into the right hind paw of Sprague-Dawley rats. The manifestations of the diseases were monitored in terms of hind paw swelling, subjective appearance of secondary lesions, impairment …

In Vitro Resorption Characteristics Of Selected Diuretic Compounds By Thedesaga Resomat, Donald Gene Floriddia

University of the Pacific Theses and Dissertations

An in vitro method was tested whereby the processes of dissolution and distribution of active ingredient into a lipoid solvent were combined in one model and evaluated.

The objectives of this research project were: (1) to evaluate the efficacy of the in vitro model known as the Desaga Resomat, in the testing of gastrointestinal absorption; (2) to apply the procedure and instrument to a group of therapeutically important products in determining their absorption characteristics; (3) to graphically illustrate the absorption profile of a specific drug as per cent absorbed vs. time, simulating in vivo absorption; (4) to compare the profile …

The Effects Of Indomethacin On A Strain Of Fibroblasts Cultivated In Vitro, John Thomas Mccloskey

University of the Pacific Theses and Dissertations

Man has always searched for greater understanding of himself and his environment. As a result, much scientific investigation has been directed towards the understanding of the life process. In recent years, such scientific inquiry has become increasingly focused on the fundamental biochemical events taking place at the cellular, subcellular, and molecular levels. In the course of investigation into the nature of living things, research has often necessitated the development of new techniques and investigational tools to serve as experimental systems. Very often such new methods have made possible the discovery of previously unknown processes. One very interesting and useful investigational …

The Dialysis Of Caffeine Through Selected Semi-Permeable Membranes, Paul James Perry

University of the Pacific Theses and Dissertations

Until the past few years, cellulose derivatives, (e.g., cellophane, collodion, and parchment) and animal membranes (e.g., goldbeater’s skin) have been the only dialysis membranes employed commercially. Cellophane has been used as the dialysis membrane in the artificial kidney since the machine’s inception in 1914. It continues to serve in this capacity, even though, in the last few years, attempts have been made to develop better films.

An appreciation of both the “solution theory” and the “pore theory” is in order for this discussion. By incorporating the dynamics of these theories in the techniques of membram formulation, improved membrane performance can …

The Development Of An Oral Inhalation Dosage Form Antinauseant, Kit Michael Mills

University of the Pacific Theses and Dissertations

It would seem appropriate that studies be conducted on the development of an oral inhalation dosage form antinauseant. The present project will consist of developing and testing a series of aerosol formulations to determine their feasibility in antinauseant therapy. In vitro pressure, valve release, spray pattern, particle size, and aging studies will be performed. The present work will also include an in vivo evaluation of promising formulations.

Observations Related To The Mechanisms Of Tetracycline-Induced Lipid Accumulation In A Strain Of Mouse Fibroblasts Cultivated In Vitro, Dale William James

University of the Pacific Theses and Dissertations

Intravenous administration of tetracycline has been known to result in fatty degeneration of the liver. This study was undertaken in order to elucidate some of the actions of tetracycline on mammalian cells in culture and to attempt to relate these findings to the clinical condition of fatty degeneration of the liver mentioned above.

It is suggested that lipid accumulation occurring after tetracycline administration is possible the result of a decrease in B-lipoprotein synthesis and enzyme inhibition. These factors could result from the high blood levels of tetracycline seen after large and rapid intravenous injections of the drugs into normal patients …

The Pharmacology Of Rodenticides, S. A. Peoples

Proceedings of the 4th Vertebrate Pest Conference (1970)

The compounds used as rodenticides are tremendously varied in their chemical structure and mechanism of action. With a few exceptions, these agents are generally poisonous to all animals, including man, and a great deal of study has been directed to their toxicity in animals other than rodents. However, the development of new compounds as Norbormide and certain antifertility drugs which are highly selective in their action may justify the hope that the ideal rodenticide free of secondary toxic hazards will soon be available. Until this happy announcement is made, a review of the pharmacology of the older compounds is in …

Interactions Of Sodium Ethacrynate In Intravenous Admixture With Selected Cardiovascular And Psychotherapeutic Agents, Patrick N. Catania

University of the Pacific Theses and Dissertations

The possibility of drug incompatibilities is a matter of serious concern when administering two or more therapeutic agents. This is especially true in the case of parenteral administration when one must be aware not only of therapeutic interactions but also chemical and physical reactions that might occur.

In order to avoid incompatibilities, drug manufacturers have suggested that parenteral solutions be used immediately after reconstitution and that admixtures of parenteral products not be administered wherever possible (1,2). Physicians have also stressed the importance in avoiding multiple drug therapy (3,4). In spite of these suggestions, the practice of multiple drug therapy is …

Differential Spectrophotometric Analysis Of Intravenous Admixtures Containing Metaraminol With Selected Corticosteroids, Frederick Erin Turner

University of the Pacific Theses and Dissertations

Intravenous admixtures consisting of one or more drug formulations, diluted in a large volume of intravenous solution, are used extensively in current medical practice. Development of reliable methods to predict the compatibility of the admixture components is essential as a guide for their selection.

Because the majority of the reports published, to date, have used a visible change as the criterion for judging compatibility, it was the purpose of this study to demonstrate the use of spectrophotometric analysis to detect the occurrence of chemical interactions between two components of an intravenous admixture.

1970 Apothecary, Southwestern Oklahoma State University

Apothecary

The end of the academic year heralds the arrival of the 1970 APOTHECARY. It has been a fast-paced, hectic time for all. For some, this ends the formal pharmacy curriculum and thus many new situations lie ahead. The 1970 APOTHECARY would like to take this opportunity to wish all the Seniors the best of luck in the future and hearty congratulations on their achievements.

We are very proud of this edition of the APOTHECARY and we want to thank everyone involved in its completion. Certainly, the most "credit" goes to Dr. Ulrich, faculty sponsor. He made most of the …

The Southwestern Pharmacist Vol. 1, No. 4, Southwestern Oklahoma State University

The Southwestern Pharmacist

Summer has not stopped the Pharmacy Wives organization. Two summer get-togethers have been held inviting all student pharmacy wives and faculty wo­ men and wives.

The Chemistry Of Pesticides, Walter R. Benson

Food and Drug Administration Papers

INTRODUCTION This review is limited to the structures and a few reactions of the pesticides mainly insecticides-that affect mammalian systems and that are the subject of papers by other authors in this monograph. There is no attempt to give a complete review of the chemistry of pesticides. It is intended only to show the breadth and depth of pesticide chemistry through the use of examples. With proper use of the references, and of the papers by Crosby, Freed and Montgomery, and Owens in this monograph, the reader will be able to find information for other chemicals.

NOMENCLATURE Pesticides or economic …

The Southwestern Pharmacist Vol. 1, No. 3, Southwestern Oklahoma State University

The Southwestern Pharmacist

If you have ever needed help in any way, then you have pro­bably met Mrs. Leroy Thomas (more affectionately known as Johnnie Faye). She is the guard­ian angel of the pharmacy faculty and student body; nothing would be organized without her.

Inhibition Of Cell Division, Protein Synthesis And Nucleic Acid Synthesis In Escherichia Coli W By Tetracycline Antibiotics, George Henry Miller

Theses and Dissertations

Tetracyclines, originally isolated in the late 1940's and early 1950's from the mycelium of Streptomyces, have achieved major importance as therapeutic and prophylactic agents against a wide range of infections in human and veterinary medicine. They have also achieved great importance in agriculture where they are widely used to promote weight gain in livestock. Commercial production, during 1958 in the United States alone was 120 tons with a value of approximately $1 million per ton.

The clinical importance of these compounds has stimulated efforts to define their mode of action as inhibitors of bacterial reproduction. Antibiotics having as many functional …

An Investigation Of The Release Of 5-Fluorouracil From Ointment Bases, Vance Leroy Grainger

University of the Pacific Theses and Dissertations

During the several years in which this therapy has been developed and evaluated, as standard dermatological preparation has not been available. The objective of the present work was to study the release of 5-FU from various ointment bases and to attempt to determine the type of base which would release the compound most satisfactorily.

The methods chosen were designed to determine the release and penetration of 5-FU both by in vitro and in vivo methods. A modified agar plate method was chosen as the in vitro test for measuring release and subsequent diffusion into the agar. The penetration of the …

A Comparison Of The Fluidized Bed Drying Technique With Conventional Methods Of Drying Tablet Granulations, Kit Michael Mills

University of the Pacific Theses and Dissertations

Drying procedures, like other important unit operations in pharmacy, have received little attention in pharmaceutical literature. Within recent years, however, growing interest in these pharmaceutical engineering areas has become apparent.

Fluidization operations, although relatively unexplored in pharmacy, have been firmly established on a broad scale in other industries. Fluidization may be defined as the suspension and agitation of a bed of particulate solids by a vertically rising stream of gas. Each suspended particle is surrounded by the gas. This relative velocity of the gas and solid particles is high, although the gas velocity itself is relatively low. Heat is transferred …

Studies On The Localization And Retention Of Tetracycline Hydrochloride In Ehrlich Ascites Cells, Dale William James

University of the Pacific Theses and Dissertations

The antibiotics have become so widely and successfully used in the practice of medicine that they are now considered to be essential. Among the antibiotics, the tetracycline group has achieved an enviable reputation for dependable medication, In spite of this, there remain several unanswered questions, One of these pertains to the interesting phenomenon for almost selective localization of tetracycline in certain tumor cells or masses, Although there have been numerous publications dealing with this phenomenon, as the following paragraphs will indicate, there is little agreement as to the factors involved. Indeed, there are some sharply conflicting opinions.

The investigations described …

1969 Apothecary, Southwestern Oklahoma State University

Apothecary

As we come to the close of another academic year, so ends this edition of THE APOTHECARY. For many of us, this is our last year of formal education at dear ole Southwestern. As well as rejoicing, we can look at this as a sad moment for in the future lies the inevitable visit with Uncle Sam (for the males) and facing the hard cruel world; also, we will be separated from our friends and acquaintances whom we've known for five years. We wish to congratulate all the Seniors and wish them the best of luck for a great and …

Syntheses And Antimicrobial Activities Of Some 4-Aza-Sitostane Derivatives, Hassan Y. Aboul-Enein

Electronic Theses and Dissertations

Research into the chemical and pharmacological properties of aza­steroids has become of interest because of their potential value as pharmacodynamic and chemotherapeutic agents. A nitrogen atom, for example, would be able to interact, unlike carbon, with a variety of sites in enzymes by means of ionic-ionic, ionic-dipole, dipole-dipole and hydrogen.bonds. Azasteroids having a nitrogen, atom might be adsorbed more strongly or in a different orientation to a given enzyme, and also may produce.a different biologic effect with a new spectrum of biological activities. The pharmacological.activities of a number of synthetic azasteroids, have been reported.

This investigation is concerned with the …

Studies On The Effects Of Dopamine, Tyramine, And Ephedrine On The Intestine, Richard D. Heilman

Dissertations (1934 -)

No abstract provided.

The Southwestern Pharmacist Vol. 1, No. 2, Southwestern Oklahoma State University

The Southwestern Pharmacist

The public has come to expect to use drugs in almost every instance of therapy today. They expect to buy and use drugs for self-medication, and they have a wide variety of drugs from which to choose.

The Southwestern Pharmacist Vol. 1, No. 1, Southwestern Oklahoma State University

The Southwestern Pharmacist

Work began this summer on the 42,000 - square - foot addition to the Chemistry-Pharmacy-Physics Building. The J. J. Bol­linger Construction Company of Oklahoma City received the con­tract.

1968 Apothecary, Southwestern Oklahoma State University

Apothecary

About the Cover

The cover depicts the proposed addition to the present facilities to the School of Pharmacy. When completed at an estimated cost in excess of $1 million, the addition will double our laboratory and classroom space. The School of Pharmacy will occupy the entire third floor and a portion of the second floor in the proposed addition.

1967 Apothecary, Southwestern Oklahoma State University

Apothecary

We, as seniors, are now rapidly approaching graduation and are beginning to plan our future lives and endeavors after receiving our degrees. Several are planning to continue their education in pharmacy or related fields, but the majority will enter the profession at the retail level. In whatever direction we decide to embark, let us hope we can remember the many things which our professors have tried to teach us. Probably the most important ideal set forth by the faculty is the ethical standards we all must follow, for without ethics we cannot truly call pharmacy a profession. It is up …

A Study Of Several Factors Incident To The Absorption Of Choline From The Small Intestine Of The Albino Rat, Ralph E. Purdy

University of the Pacific Theses and Dissertations

The substance choline, one of the quaternary nitrogen bases, has been the subject of a number of reviews and investigations. It has been described as a cholinergic agent, an inotropic agent, a vitamin, and perhaps in other ways. In spite of the interest shown in its action and uses, there is as yet very little information available as to the mechanism by which it is absorbed by the intestinal mucosa.

The studies referred to thus far leave the field open for additional investigation. No mention was found in the literature of studies on selective areas of absorption of choline in …

A Synthesis Of A Homologous Series Of Aryl Mono- And Diboronic Acids, Larry Milton Allen

University of the Pacific Theses and Dissertations

Many attempts have been made to prepare aryl boronic acids and their esters which show a preferential affinity for tumor tissues for use in radiation therapy of neoplatic disorders (1,2). The data of Soloway, as extended and refined by Hansch and his coworkers, successfully correlates the low lipid solubility and electron releasing substituents of phyenl boronic acid derivatives with increased tumor concentration (3,4,5). However, most of these organoboron compounds do not produce a sufficiently high tumor-to-normal tissue boron concentration ratio for practical use in human cancer chemotherapy by the neutron capture technique. The knowledge that several chemical substances are preferentially …

Studies On The Metabolism And Excretion Of Chlorine Chloride, John Thomas Mccloskey

University of the Pacific Theses and Dissertations

The organic base choline is of considerable interest to the physiologist because of its role in normal metabolic function, and to the pharmacologist because of its possible application in the treatment of several human diseases.

The overall function of choline in the biologic system must be seen as an equilibrium between its lipotropic activity as a whole molecule and its function as a source of methyl groups in biochemical reactions.

IV. Investigation Undertaken in This Study

Due to the long-standing and as yet unresolved question dealing with the relative merits of the path by which choline leaves the intestine, these …

Studies On The Essential Oil Of Anemopsis Californica, Ramesh Narmadashanker Acharya

University of the Pacific Theses and Dissertations

The roots and rhizomes of Anemopsis Californica (Nutt.) Hook and Arn. (family Saururaceae) have been used by the early Spanish Americans and Indians to treat a variety of ailments. The plant is commonly known as Yerba del Mansa, Yerba Mansa, or Manza.

We decided to investigate the essential oil of Anemopsis Californica in greater detail. The results of our investigation to date are included and described in this thesis.

Quantitative Calculation Of Gas Chromatographic Peaks In Pesticide Residue Analyses, Jean A. Gaul

Food and Drug Administration Papers

Comparison of five methods for calculating gas chromatographic peaks (disc integration, triangulation, peak height X width at half height, R_t X peak height, and peak height) shows no significant difference in the calculated results when aldrin, heptachlor epoxide, and dieldrin are injected into a gas chromatograph equipped with electron capture detector.

Problems are associated with the calculation of toxaphene, chlordane, DDT, and BHC. The author makes suggestions for calculating these four residues when present individually and in combinations with other pesticides. Use of the last four toxaphene peaks compares favorably with results obtained by using the entire toxaphene curve. …