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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Characterization Of The Fast Axonally Transported Proteins In The Rat Optic Pathway, Surafel Mulugeta
Characterization Of The Fast Axonally Transported Proteins In The Rat Optic Pathway, Surafel Mulugeta
Theses and Dissertations in Biomedical Sciences
The fast axonally transported proteins represent a subset of neuronal proteins that are conveyed anterogradely as secretory vesicle constituents from the perikarya. Although fast transport displays properties consistent with the general secretory pathway, neuronal structure presents special problems which may require modifications of the general pathway. The elucidation of these special modifications is essential for a more complete understanding of neuronal function both in normal and pathological conditions. In order to characterize the fast transported (FT) proteins and to better understand fast transport trafficking, the FT of radiolabeled retinal ganglion cell (RGC) proteins in the adult rat optic pathway was …
Characterization Of Angiotensin Ii Receptor Subtypes In The Brain, David L. Saylor
Characterization Of Angiotensin Ii Receptor Subtypes In The Brain, David L. Saylor
Electronic Theses and Dissertations
The present studies explore binding, distribution, and function of angiotensin II (AII) receptors (AT$\sb1$ and AT$\sb2)$ in the brain. The discovery that sulfhydryl reducing agents masked some but not all AII receptors in the brain prompts an evaluation of commonly used binding assay buffer constituents. EDTA enhances binding (40%) at both AT$\sb1$ and AT$\sb2$ nuclei, while bacitracin did not alter binding at either receptor subtype. Phenanthroline and BSA differentially altered binding at AT1 (220% of control) and AT$\sb2$ (118% of control) receptors. The results indicate that phenanthroline and BSA would be poor buffer constituents for studies comparing binding at AT$\sb1$ …
Psychiatric Outcomes In Low Birthweight Children At Age Six: Relation To Neonatal Cranial Ultrasound Abnormalities, Agnes H. Whitaker, Ronan Van Rossem, Judy F. Feldman, Irvin Sam Schonfeld, Jennifer A. Pinto-Martin, Carolyn Torre, David Shaffer, Nigel Paneth
Psychiatric Outcomes In Low Birthweight Children At Age Six: Relation To Neonatal Cranial Ultrasound Abnormalities, Agnes H. Whitaker, Ronan Van Rossem, Judy F. Feldman, Irvin Sam Schonfeld, Jennifer A. Pinto-Martin, Carolyn Torre, David Shaffer, Nigel Paneth
Publications and Research
Examined the relation of neonatal cranial ultrasonography abnormalities to later psychiatric disorder in 564 low birth weight children (aged 5.2–8.7 yrs). Psychiatric diagnoses were assessed by means of the Diagnostic Interview Schedule for Children–Parent version, and detailed information was collected on other predictors and outcomes. Results show that 454 Ss had no cranial abnormalities, 78 had germinal matrix hemorrhage (GMH) and/or intraventricular hemorrhage (IVH), and 32 had a parenchymal lesion (PL) or ventricular enlargement (VE). 22% of the Ss had at least 1 psychiatric disorder, the most common being attention deficit hyperactivity disorder (ADHD). Isolated GMH/IVH did not increase …
Axotomy And Regeneration Of The Rat Facial Nerve: A Histomorphometric Study Of The Facial Nucleus, Nerve And Orbicularis Oculi Muscle In An Experimental Model Of Facial Paralysis, Peter Konstantinos Thanos
Axotomy And Regeneration Of The Rat Facial Nerve: A Histomorphometric Study Of The Facial Nucleus, Nerve And Orbicularis Oculi Muscle In An Experimental Model Of Facial Paralysis, Peter Konstantinos Thanos
Theses and Dissertations in Biomedical Sciences
One of the most unsettling sequela of facial paralysis (FP) is the loss of eye sphincter function and the blink response, leading to functional, psychological and aesthetic deficits. A medley of restorative microsurgery approaches have been employed in treating these deficits, however full recovery of function remains elusive. The present research utilized the rat model of facial paralysis, and consisted of three stages. Stage I examined the facial motor neuron (FMN) pool of the eye sphincter (orbicularis oculi muscle=OOM) and identified the facial nerve branch which provides the majority of innervation to the OOM. II. Examined the efficacy of the …