Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Mechanisms Of Action Of Antiseizure Drugs And The Ketogenic Diet., Michael Rogawski, Jong Rho, Wolfgang Löscher
Mechanisms Of Action Of Antiseizure Drugs And The Ketogenic Diet., Michael Rogawski, Jong Rho, Wolfgang Löscher
Michael A. Rogawski
Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic treatment for people with epilepsy, but not all patients become free of seizures. The ketogenic diet is one treatment option for drug-resistant patients. Both types of therapy exert their clinical effects through interactions with one or more of a diverse set of molecular targets in the brain. ASDs act by modulation of voltage-gated ion channels, including sodium, calcium, and potassium channels; by enhancement of gamma-aminobutyric acid (GABA)-mediated inhibition through effects on GABA-A receptors, the GABA transporter 1 (GAT1) GABA uptake transporter, or GABA transaminase; through interactions with …