Medicine and Health Sciences Commons^™

Endogenous Interleukin-10 Contributes To Wound Healing And Regulates Tissue Repair, Walker D Short, Meredith Rae, Thomas Lu, Benjamin Padon, Tanuj J Prajapati, Fayiz Faruk, Oluyinka O Olutoye, Ling Yu, Paul Bollyky, Sundeep G Keswani, Swathi Balaji

Faculty, Staff and Students Publications

INTRODUCTION: Interleukin-10 (IL-10) is essential in fetal regenerative wound healing and likewise promotes a regenerative phenotype in adult dermal wounds. However, the role of endogenous IL-10 in postnatal dermal wound healing is not well-established. We sought to determine the function of endogenous IL-10 in murine full thickness excisional wounds that are splinted to prevent contracture and mimic human patterns of wound closure.

METHODS: Full-thickness excisional wounds were made in wildtype (WT) and IL-10

RESULTS: We observed no difference in wound healing rate between WT and IL-10

CONCLUSIONS: These data suggest that endogenous IL-10 expression does not alter closure of full …

Surgical Reconstruction Of Stage 3 And 4 Pressure Injuries: A Literature Review And Proposed Algorithm From An Interprofessional Working Group, Samir S Awad, James D Stern, Cathy T Milne, Shane G Dowling, Ron Sotomayor, Elizabeth A Ayello, Leandro J Feo Aguirre, Basil Z Khalaf, Lisa J Gould, Michael N Desvigne, Abigail E Chaffin

Faculty, Staff and Students Publications

OBJECTIVE: Stage 3 and 4 pressure injuries (PIs) present an enormous societal burden with no clearly defined interventions for surgical reconstruction. The authors sought to assess, via literature review and a reflection/evaluation of their own clinical practice experience (where applicable), the current limitations to the surgical intervention of stage 3 or 4 PIs and propose an algorithm for surgical reconstruction.

METHODS: An interprofessional working group convened to review and assess the scientific literature and propose an algorithm for clinical practice. Data compiled from the literature and a comparison of institutional management were used to develop an algorithm for the surgical …

Comparison Of Neurocognitive And Quality-Of-Life Outcomes In Pediatric Craniopharyngioma Patients Treated With Partial Resection And Radiotherapy Versus Gross-Total Resection Only, Guillermo Aldave, M Fatih Okcu, Murali Chintagumpala, Lucia Ruggieri, Charles G Minard, Fatema Malbari, Lisa E Mash, Arnold C Paulino, Susan Mcgovern, Uma Ramaswamy, William Whitehead, Lisa S Kahalley

Faculty, Staff and Students Publications

OBJECTIVE: The optimal management of pediatric craniopharyngioma patients remains controversial, shifting from radical resection (gross-total resection [GTR]) to a more conservative approach with partial resection/biopsy followed by radiotherapy (PR+RT). To the authors' knowledge, no previous studies have compared neurocognitive and quality-of-life (QOL) outcomes between the two main treatments. In this study, the authors compared changes in intellectual, adaptive, and QOL scores in children treated for craniopharyngioma with GTR and those treated with PR+RT.

METHODS: Patients underwent annual neurocognitive and QOL evaluations for up to 10 years posttreatment, including the Full-Scale IQ, Verbal Comprehension Index (VCI), Perceptual Reasoning Index (PRI), Working …

Middle Meningeal Artery Embolization For Chronic Subdural Hematoma: Predictors Of Clinical And Radiographic Failure From 636 Embolizations, Mohamed M Salem, Okkes Kuybu, Alex Nguyen Hoang, Ammad A Baig, Mirhojjat Khorasanizadeh, Cordell Baker, Joshua C Hunsaker, Aldo A Mendez, Gustavo Cortez, Jason M Davies, Sandra Narayanan, C Michael Cawley, Howard A Riina, Justin M Moore, Alejandro M Spiotta, Alexander A Khalessi, Brian M Howard, Ricardo Hanel, Omar Tanweer, Elad I Levy, Ramesh Grandhi, Michael J Lang, Adnan H Siddiqui, Peter Kan, Christopher S Ogilvy, Bradley A Gross, Ajith J Thomas, Brian T Jankowitz, Jan-Karl Burkhardt

Faculty, Staff and Students Publications

Background

Knowledge regarding predictors of clinical and radiographic failures of middle meningeal artery (MMA) embolization (MMAE) treatment for chronic subdural hematoma (CSDH) is limited.

Purpose

To identify predictors of MMAE treatment failure for CSDH.

Materials and Methods

In this retrospective study, consecutive patients who underwent MMAE for CSDH from February 2018 to April 2022 at 13 U.S. centers were included. Clinical failure was defined as hematoma reaccumulation and/or neurologic deterioration requiring rescue surgery. Radiographic failure was defined as a maximal hematoma thickness reduction less than 50% at last imaging (minimum 2 weeks of head CT follow-up). Multivariable logistic regression models …

Inhibitory Input Directs Astrocyte Morphogenesis Through Glial Gababr, Yi-Ting Cheng, Estefania Luna-Figueroa, Junsung Woo, Hsiao-Chi Chen, Zhung-Fu Lee, Akdes Serin Harmanci, Benjamin Deneen

Faculty, Staff and Students Publications

Communication between neurons and glia plays an important role in establishing and maintaining higher order brain function1. Astrocytes are endowed with complex morphologies which places their peripheral processes in close proximity to neuronal synapses and directly contributes to their regulation of brain circuits2–4. Recent studies have shown that excitatory neuronal activity promotes oligodendrocyte differentiation5–7; whether inhibitory neurotransmission regulates astrocyte morphogenesis during development is unknown. Here we show that inhibitory neuron activity is necessary and sufficient for astrocyte morphogenesis. We found that input from inhibitory neurons functions through astrocytic GABABR and …

Reducing Readmission Rates Among Patients Who Have A Dual Diagnosis Of Both Mental And Physical Illnesses, Hannah M. Shahan

Electronic Theses and Dissertations

Readmission rates are a primary indicator used by acute care hospitals to determine the effectiveness of healthcare treatments and interventions. High readmission rates indicate the existence of a gap in the continuum of care. Acute care hospitals focus on the treatment of the immediately urgent physical health condition. Once the immediate presenting illness is treated or stabilized, the patient is discharged. This focus largely leaves mental illness undiagnosed and untreated. However, chronic, untreated mental illnesses are often comorbid with physical illnesses. In studies comparing patients with comorbid physical and mental illness to patients with only a physical illness, comorbidity was …

Mental Confidence In Alzheimer's Disease, Harrison Adams

Electronic Theses and Dissertations

A simple symptom like forgetfulness can lead to a gradual, subtle decline in the individual’s sense of identity. In dementia, self-efficacy is the foundation that allow individual to prolong their capacity of independence and identity. Alzheimer’s disease (AD) is the most prominent form of dementia with tens of millions in the world currently living with Alzheimer’s disease. AD is most often associated with impaired memory, confusion, language impairment, and unpredictable, agitated, aggressive, and paranoid behavior. While there are many studies examining the quality of life in individuals with AD, there are fewer investigating the psychological effects of AD on the …

The Effectiveness Of Targeted Education On Improving Nurses’ Self-Efficacy In Caring For Psychiatric Patients On Medical Surgical Units, Rachel Shirey

Doctor of Nursing Practice Scholarly Projects

Individuals with mental illness are occasionally hospitalized on medical units, specifically medical-surgical units. Nurses working on medical-surgical units may find patients with mental illness more challenging due to the complexity of care they sometimes require. Nurses’ perceived ability to provide quality care for these patients is reduced in comparison to their perceived ability to care for patients without mental illness. Consequently, low self-efficacy can result in the provision of a lower quality of care for this population. The purpose of this quality improvement project was to improve the care that patients with mental illness receive while hospitalized on medical-surgical units. …

A Model To Integrate Mental Health Services With Gynecological Care, Simerjeet Singh, Theresa A. Moore, Hannah White

Undergraduate Research Symposium

Half of the world’s population experiences changes in life relating to gynecological health which may involve stigmatized conditions. Stigma is defined as unfavorable societal beliefs about a topic which impacts healthcare significantly. Menopause is a stage 12 months after a woman’s last menstrual cycle and the menopausal transition (MT) is the years leading up to this stage. Symptoms of MT may include night sweats and hot flashes accompanied by psychological changes. Postpartum depression (PPD) is a mental health condition that one in seven women experience after having a baby. PPD may occur during the first six months after delivery when …

Interaction Between Fluoxetine And Risperidone And Its Association With Clinical Outcomes In Schizophrenic Patients, Fitri Rachmaini, Dian Ayu Juwita, Rahmad Abdillah, Rezy Dwi Afrianti, Fatma Sri Wahyuni

Pharmaceutical Sciences and Research

The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at the time of hospital discharge, the length of hospitalisation and the Positive and Negative Syndrome Scale- Excitement Component (PANSS-EC). This study was conducted prospectively in psychiatric ward of HB Saanin Mental Hospital from May to October 2021 and study subjects were selected using consecutive sampling technique with inclusion criteria. Forty-three patients were eligible for this study. Research data …

Rural Social Work Practice: Trauma-Focused Interventions Social Workers Use, Jose Carbajal

Journal of Human Services: Training, Research, and Practice

This research study examines rural social workers’ level of trauma knowledge and trauma treatment self-efficacy and the use of evidence-based interventions (CBT, TF-CBT, CPT, EMDR and PE). A retrospective design was used to examine Texas rural social workers’ use of evidence-based interventions. The Texas rural social worker sample (N=19) was extrapolated from a larger study (N=1007) conducted in 2014 examining Texas social workers’ trauma treatment and their use of evidence-based interventions. Descriptive and correlation statistical procedures were implemented to analyze the data for the current study. The results show social workers’ knowledge of trauma and treatment self-efficacy scores are above …

Genetic Loci Of Beta-Aminoisobutyric Acid Are Associated With Aging-Related Mild Cognitive Impairment, Einat Granot-Hershkovitz, Brian Spitzer, Yunju Yang, Wassim Tarraf, Bing Yu, Eric Boerwinkle, Myriam Fornage, Thomas H Mosley, Charles Decarli, Bruce S Kristal, Hector M González, Tamar Sofer

Faculty, Staff and Student Publications

We studied the genetic associations of a previously developed Metabolomic Risk Score (MRS) for Mild Cognitive Impairment (MCI) and beta-aminoisobutyric acid metabolite (BAIBA)-the metabolite highlighted by results from a genome-wide association study (GWAS) of the MCI-MRS, and assessed their association with MCI in datasets of diverse race/ethnicities. We first performed a GWAS for the MCI-MRS and BAIBA, in Hispanic/Latino adults (n = 3890) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We identified ten independent genome-wide significant (p value <5 × 10-8) variants associated with MCI-MRS or BAIBA. Variants associated with the MCI-MRS are located in the Alanine-Glyoxylate Aminotransferase 2 (AGXT2 gene), which is known to be associated with BAIBA metabolism. Variants associated with BAIBA are located in the AGXT2 gene and in the SLC6A13 gene. Next, we tested the variants' association with MCI in independent datasets of n = 3178 HCHS/SOL older individuals, n = 3775 European Americans, and n = 1032 African Americans from the Atherosclerosis Risk In Communities (ARIC) study. Variants were considered associated with MCI if their p value <0.05 in the meta-analysis of the three datasets and their direction of association was consistent with expectation. Rs16899972 and rs37369 from the AGXT2 region were associated with MCI. Mediation analysis supported the mediation effect of BAIBA between the two genetic variants and MCI (p value = 0.004 for causal mediated effect). In summary, genetic variants in the AGXT2 region are associated with MCI in Hispanic/Latino, African, and European American populations in the USA, and their effect is likely mediated by changes in BAIBA levels.

A Retrospective Comparison Of The Effectiveness Of Buprenorphine Versus Baclofen For Acute Opioid Withdrawal, Matthew Hermenau, Benton Stamper, Kitty Leung, Raymond Pomm, Christina Guerrier, Joseph Cammilleri, Brittany Johnson

HCA Healthcare Journal of Medicine

Background

A significant impediment to opioid cessation or dose reduction is mitigating withdrawal severity that has been shown to affect the course of opioid dependence. Current guidelines recommend the use of buprenorphine and methadone over alpha-2 adrenergic agonists. Baclofen, a GABA-B agonist, has promising results as an adjunct agent for opioid withdrawal but has not been compared to buprenorphine. This study compared the ability of buprenorphine and baclofen to mitigate acute opioid withdrawal.

Methods

This was a single-center, retrospective chart review of 63 patients with diagnosed opioid use disorder that received scheduled buprenorphine or baclofen for 3 days, in addition …

The Impact Of Nutrition On The Mental And Physical Health Of Young Adults, Dareena El-Far

WRIT: Journal of First-Year Writing

Upon close examination by nutritional professionals, concern has arisen regarding the typical contents of a young adult diet. In terms of the rate at which young adults choose to consume nutritionally-dense food items, the rate at which nutrition-deficient junk food items are chosen over the former is significantly higher. Among further examinations of this issue by researchers, it has become evident that the nutritional decisions made by young adults are increasingly associated with several social, commercial, mental, educational, and economic influences. As a consequence of these factors, research has uncovered a connection between the consumption of a poor diet and …

Suicide Screening Among Adolescents With A History Of Mental Or Physical Abuse- Evaluating The Effectiveness Of Suicide Screening: A Scoping Review, Tiffany Nicole Jackson Bsn, Rn, Cody Tyler Cottrell Bsn, Rn, Allison Tucker Mcculley Bsn, Rn, Cen, Sharon Little Dnp, Aprn, Fnp-Bc

Doctor of Nursing Practice Projects

Purpose The purpose of this scoping review is to gather evidence on best practice for the administration of pediatric suicide screening in a variety of healthcare settings.

Career Self-Efficacy And Future Career Anxiety On Indonesian Fresh Graduates During Pandemic, May Lia Elfina, Devina Andriany

Jurnal Kajian Bimbingan dan Konseling

The uncertain job vacancy presents substantial influence on job seekers during the Covid-19 pandemic. The anxiety concerning their future career emerges as a new and deteriorating issue for fresh graduates. On the other hand, self-efficacy serves as a crucial element in facing a shift in the situation. The self-efficacy being adopted in overcoming career anxiety is known as career self-efficacy. Therefore, this study aims to identify the correlation between career self-efficacy and future career anxiety in Indonesian fresh graduate. This study used a quantitative method with a correlational study approach. For the research sample, the final-year students participated in this …

Contributive Factors Of Tolerance Among Senior High School Students, Muhammad Rezza Septian, Mamat Supriatna, Juntika Nurihsan, Nandang Budiman

Jurnal Kajian Bimbingan dan Konseling

This article aims to explore the contributing factors of tolerance in senior high school students. This research covers the concept of tolerance theory and aspects that contribute to tolerance. The study was carried out using a cross-sectional survey method with a quantitative approach. The population in this study were high school students in the city of Bandung, Indonesia. The research sample was taken using a random sampling technique. The research sample consisted of 300 high school, vocational high school, and Madrasah Aliyah students in the city of Bandung. Data collection was completed using tolerance instruments, and data analysis used confirmatory …

Career Pocketbook: A Media To Improve Primary School Students’ Career Understanding, Maryam Rahim, Wenny Hulukati, Nurul Maulida Alwi

Jurnal Kajian Bimbingan dan Konseling

This study develops a career pocketbook as a career information media to accelerate career understanding among primary school students. This research and development study was completed in a number of stages, including (1) preliminary study, (2) product design, (3) product development following the design, (4) limited tryout, and (5) product revision. For the limited tryout, we conducted a number of tryouts. In the first limited tryout, we involved the experts (from the guidance and counseling field, career guidance and counseling field, and Indonesian language), followed by an individual tryout involving nine students and three counselors, then a small group tryout …

Need For Career Guidance In The Almajiri School System In Nigeria: Implication For In-School Adolescents, Foluke Nike Bolu-Steve, Falilat Anike Okesina

Jurnal Kajian Bimbingan dan Konseling

The study investigated the need for career guidance in the Almajiri school system as perceived by teachers in Kebbi State, Nigeria. The population consisted of all teachers within the state. The researchers purposively selected six large schools in Brinin Kebbi which is the state capital, and another six large secondary schools in Argungu. Fifty teachers were picked in each of the schools using simple random sampling technique. Thus, a total of six hundred respondents partook in this study. Need for Career Guidance in Almajiri schools (NCGASQ) was the instrument used in this study. The questionnaire was the major instrument used …

How To Prevent Student Mental Health Problems In Metaverse Era?, Muslihati Muslihati, Yuliati Hotifah, Wahyu Nur Hidayat, Ahmad Yusuf Sobri, Anabelie V. Valdez, Achmad Miftahul Ilmi, Nur Mega Aris Saputra

Jurnal Kajian Bimbingan dan Konseling

Metaverse, a combination of social media, gaming, and virtual reality technology innovation, is a new concept that has attracted the attention of various groups. This concept has also aided numerous groups of people, including the academician. As Metaverse offers various means to innovate, it is projected to change human lives and patterns of interaction. However, Metaverse also presents a number of negative impacts on mental health, even greater than the impacts of online games. This literature review aims to examine the impacts of the Metaverse on adolescents. Then, it develops the relevant preventive strategy through school guidance and counseling programs. …

Sexual Abuse And Interpersonal Difficulties In Youth, Priscilla Herrera, Kinsey Ellis

Undergraduate Research Symposium Posters

Researchers have found childhood sexual abuse victimization to be associated with impairments in trust, social comfort, and quality of interpersonal relationships1,2,3. Research which investigates the unique relationship between sexual abuse and interpersonal difficulties among youth with a history of child maltreatment is limited. The present study aimed to investigate interpersonal functioning differences in maltreated youth who have and have not experienced sexual abuse.

Self-Compassion Based On Gender And Student Academic Achievement, Ismarini Bekti Setiani, Dwitias Titi

Jurnal Kajian Bimbingan dan Konseling

This study aims to determine the effect of gender on the level of students’ self-compassion and determine the effect of students’ level of self-compassion on their academic achievement. This study uses a quantitative approach, with the type of ex-post facto research and ordinal regression analysis. The data were collected using the Self-Compassion Scale (SWD) with alternative answers from one to five of scale. The sample in this study was students at Universitas Negeri Yogyakarta. Our analysis results showed no significant effect of gender on the students’ level of self-compassion and no significant effect of students’ level of self-compassion on their …

E-Module Behavior Counseling Practicum Based On Case Study, Henny Indreswari, Lutfi Fauzan, Devy Probowati, Rizka Apriani

Jurnal Kajian Bimbingan dan Konseling

One of the mandatory courses for students majoring in guidance and counseling is a behavior counseling practicum. The purpose of this research is to develop the behavior counseling e-module based on case studies that can be applied to students of guidance and counseling. The research and development design used in this study is the ADDIE model. The instrument used is a module assessment scale. The assessors are experts in guidance and counseling, media, language, and prospective users. Index agreement result of the product by the guidance and counseling expert validator is 1 (very high), the media expert is 0.93 (very …

Isolation Of Human Cutaneous Immune Cells For Single-Cell Rna Sequencing, Ashley A Hailer, David Wu, Abdullah El Kurdi, Michelle Yuan, Raymond J Cho, Jeffrey B Cheng

Staff and Researcher Publications

Single-cell RNA sequencing (scRNA-seq) allows for high-resolution analysis of transcriptionally dysregulated cell subpopulations in inflammatory diseases. However, it can be challenging to properly isolate viable immune cells from human skin for scRNA-seq due to its barrier properties. Here, we present a protocol to isolate high-viability human cutaneous immune cells. We describe steps for obtaining and enzymatically dissociating a skin biopsy specimen and isolating immune cells using flow cytometry. We then provide an overview of downstream computational techniques to analyze sequencing data. For complete details on the use and execution of this protocol, please refer to Cook et al. (2022)

Experiencing Moral Distress Within The Intimate Partner Violence & Sexual Assault Workforce, Rachel J Voth Schrag, Sophia Fantus, Sarah Leat, Saltanat Childress, Leila Wood

Faculty, Staff and Student Publications

PURPOSE: Moral distress (MD) refers to the psychological disequilibrium that emerges when institutional policies and/or practices conflict with an individual's professional values and ethics. MD has been interrogated frequently in health care and ancillary medical settings, and has been identified as a critical barrier to enhanced organizational climate and patient care. However, little work has investigated experiences of MD among members of the intimate partner violence (IPV) and sexual violence (SV) workforce.

METHODS: This study investigates MD in a sample of IPV and SV service providers via secondary analysis of 33 qualitative interviews conducted with service providers in the summer …

Elementary Classroom Views Of Nature Are Associated With Lower Child Externalizing Behavior Problems, Amber L. Pearson, Catherine D. Brown, Aaron Reuben, Natalie Nicholls, Karin A. Pfeiffer, Kimberly A. Clevenger

Kinesiology and Health Science Faculty Publications

Exposure to nature views has been associated with diverse mental health and cognitive capacity benefits. Yet, much of this evidence was derived in adult samples and typically only involves residential views of nature. Findings from studies with children suggest that when more greenness is available at home or school, children have higher academic performance and have expedited attention restoration, although most studies utilize coarse or subjective assessments of exposure to nature and largely neglect investigation among young children. Here, we investigated associations between objectively measured visible nature at school and children's behavior problems (attention and externalizing behaviors using the Brief …

Mental Health In M*A*S*H: An Analysis Of The Changing Portrayal Of Mental Health Topics In The 1970s And Early 1980s, Lyndsey Clark

Departmental Honors & Graduate Capstone Projects

This paper studies all eleven seasons of the hit television show M*A*S*H (1972-1973) and examines how the portrayal of mental health changed in the show’s plotlines in response to changing guidelines and mental health policy in the 1970s and early 1980s. This study focuses on the association of mental illness with homosexuality, the changes made to the American Psychological Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM) in the 1970s and early 1980s, the rise and fall of mental health policies from the Kennedy Administration to the Reagan Administration, and the portrayal of several pertinent mental conditions, such as …

Wellness Review 2022, Part 2, Martin Huecker, Brian A. Ferguson, Jacob Shreffler

Journal of Wellness

Introduction: Similar to prior reviews, the Journal of Wellness editors searched the literature from the second half of 2022 for an interesting and impactful selection of publications on wellness in healthcare professionals.

Methods: Editors conducted a standard keyword search in Pubmed, focusing chiefly on large journals, interventional trials, and other prospective research. We included papers published between July 1, 2022 and December 31, 2022.

Literature in Review: Finding several hundred publications, we excluded editorials, reviews, and some smaller, less generalizable papers. A final 25 significant studies focusing on wellness in medical professionals were sorted into the following categories: logistics, creativity …

Recurrent Pregnancy Loss - A Life Changing Condition For Women, Denisa Oana Balalau, Fernanda-Ecaterina Augustin, Delia-Maria Bogheanu, Alin-Gabriel Negulescu, Romina-Marina Sima, Anca Silvia Dumitriu, Stana Paunica, Liana Ples

Journal of Mind and Medical Sciences

Recurrent pregnancy loss (RPL) is estimated to occur in 2.5% of women trying to conceive. Definition of RPL varies depending on used guideline. In Europe, RPL is defined as two or more lost pregnancies before 24 weeks’ gestation. Although many factors have been associated with a higher risk of recurrent miscarriage, the aetiology is unknown in about half of cases. Several factors have been related to recurrent pregnancy loss, such as: environmental, behavioral, genetic, endocrine, metabolic, autoimmune, anatomic, thrombophilia and male factor. Given the multitude of etiopathogenic factors, RPL frequently requires an interdisciplinary approach for diagnosis and treatment. By its …

The Relationship Between Quality Of Life And Functionality In Patients With Schizophrenia – A Preliminary Report, Vlad Dionisie, Mihnea Costin Manea, Manea Mirela, Lavinia Steluta Bonciu, Sorin Riga, Maria Gabriela Puiu

Journal of Mind and Medical Sciences

This research aimed to investigate the relationship between quality of life and level of functioning in a group of Romanian patients with schizophrenia. A cross-sectional, observational, prospective study on 47 patients with schizophrenia was conducted. Socio-demographic and clinical data were documented and WHOQOL-BREF and Life Skills Profile-16 instruments were further administered. To examine the correlation between variables, Person correlation test was employed. The mean age of the sample was 38.32±12.32 years and 66% of the patients were males. Significant correlations were found between all aspects of the quality of life (physical health, psychological, social relationships and environmental health) and total …