Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (1308)
- Western Michigan University (649)
- Old Dominion University (463)
- Walden University (427)
- University of Nevada, Las Vegas (409)
-
- University of Kentucky (391)
- Rowan University (291)
- Portland State University (266)
- California State University, San Bernardino (255)
- Aga Khan University (247)
- Lesley University (246)
- Universitas Negeri Malang (232)
- Chapman University (205)
- University of South Florida (204)
- City University of New York (CUNY) (197)
- Nova Southeastern University (187)
- Edith Cowan University (180)
- Antioch University (178)
- Universitas Indonesia (172)
- Georgia Southern University (163)
- SIT Graduate Institute/SIT Study Abroad (163)
- Children's Health Medical Center Dallas (155)
- Chulalongkorn University (152)
- University of Southern Maine (142)
- Minnesota State University, Mankato (140)
- University of Arkansas, Fayetteville (138)
- University of St Augustine for Health Sciences (136)
- Western Kentucky University (136)
- Dominican University of California (135)
- Loma Linda University (134)
- Keyword
-
- Mental health (1102)
- Humans (954)
- Depression (705)
- Female (456)
- Male (424)
-
- Anxiety (416)
- Mental Health (374)
- COVID-19 (353)
- Adult (324)
- Health (282)
- Stress (266)
- Adolescent (257)
- Middle Aged (198)
- Trauma (192)
- Suicide (187)
- Psychology (186)
- Adolescents (173)
- Child (168)
- Addiction (167)
- Art therapy (166)
- Health literacy (158)
- Activities (155)
- Children (155)
- Counseling (153)
- Stigma (153)
- Burnout (152)
- Mindfulness (152)
- Coloring book (151)
- Resilience (147)
- Alcohol (142)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (598)
- Faculty, Staff and Students Publications (549)
- Walden Dissertations and Doctoral Studies (395)
- Masters Theses (329)
- Dissertations (287)
-
- The Journal of Sociology & Social Welfare (236)
- Theses and Dissertations (216)
- Theses Digitization Project (205)
- Jurnal Kajian Bimbingan dan Konseling (201)
- Rowan-Virtua Research Day (183)
- Antioch University Dissertations & Theses (177)
- Electronic Theses and Dissertations (171)
- Independent Study Project (ISP) Collection (153)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (145)
- Expressive Therapies Capstone Theses (132)
- Jurnal Ilmu Kesejahteraan Sosial (130)
- Loma Linda University Electronic Theses, Dissertations & Projects (129)
- Dissertations and Theses (127)
- Digital Journal of Clinical Medicine (118)
- All Graduate Theses, Dissertations, and Other Capstone Projects (116)
- EVMS School of Health Professions Theses & Dissertations (113)
- FMHI Publications (100)
- International Conference on Gambling & Risk Taking (100)
- Staff and Researcher Publications (100)
- LMU Theses and Dissertations (94)
- Faculty Scholarship (92)
- Faculty Publications (88)
- Psychology Faculty Publications (87)
- Journal of Mind and Medical Sciences (85)
- Publications and Research (85)
- Publication Type
Articles 11971 - 12000 of 14564
Full-Text Articles in Medicine and Health Sciences
A Brief Content Analysis Of Attachment And Sexual Relationships In Sex Therapy And Research Journals, Kathryn Zambrano Devis
A Brief Content Analysis Of Attachment And Sexual Relationships In Sex Therapy And Research Journals, Kathryn Zambrano Devis
UNLV Theses, Dissertations, Professional Papers, and Capstones
A surge of scholarly publications on attachment within couple relationships prompted this content analysis of attachment articles published in six sex therapy and sex research journals. This study investigates the extent to which these journals attend to attachment in the context of adult sexual relationships. The researcher found 2257 articles published within these journals; 64 of which attend to attachment and 9 of which attend to attachment and sex. Implications for couples therapy in the field of sex therapy and future directions are discussed.
Teen Stress And Substance Use Problems In Coös: Survey Shows Strong Community Attachment Can Offset Risk, Karen T. Van Gundy, Meghan L. Mills
Teen Stress And Substance Use Problems In Coös: Survey Shows Strong Community Attachment Can Offset Risk, Karen T. Van Gundy, Meghan L. Mills
Carsey Publications
This brief explores how social stress and community attachment are related to problem alcohol and drug use for girls and boys in Coös County, New Hampshire. The brief uses survey data from the Coös Youth Study, which includes self-reported information from 564 Coös youth who were in seventh and eleventh grades in 2008, and who were surveyed again one year later (in 2009) when they were in eighth and twelfth grades. Nearly one-fourth of youth in Coös County (22 percent of boys and 23 percent of girls) reported at least one alcohol or drug use related problem. The authors note …
Treatment Of Anxiety Using Manualized Protocol: A Case Study, Deborah Stevenson
Treatment Of Anxiety Using Manualized Protocol: A Case Study, Deborah Stevenson
Theses and Dissertations
This case study evaluates the effectiveness of a manualized cognitive-behavioral therapy for the treatment of Generalized Anxiety Disorder in an adult female with comorbid Major Depressive Disorder and Social Phobia. The client voluntarily participated in outpatient individual psychotherapy offered in a private counseling facility. The client's psychosocial assessment is presented and the literature on empirical treatment and developing treatment models for Generalized Anxiety Disorder is reviewed. The client's progress in treatment and a comparison with what might be considered "best treatment" is presented. The client's Generalized Anxiety Disorder was treated using the manualized program Mastery of Your Anxiety and Worry …
Case Study In Optimal Dosing In Duodenal Ulcer, Karl E. Peace
Case Study In Optimal Dosing In Duodenal Ulcer, Karl E. Peace
Biostatistics: Faculty Publications
Georgia Southern University faculty member Karl E. Peace authored "Case Study in Optimal Dosing in Duodenal Eulcer" in Peptic Ulcer Disease.
The Consequences Of Early Onset Alcohol Experimentation: Adaptive Exploration On Downward Trajectory, Marjorie Grefer
The Consequences Of Early Onset Alcohol Experimentation: Adaptive Exploration On Downward Trajectory, Marjorie Grefer
Kaleidoscope
No abstract provided.
Behavioral Health Change In Appalachian Women With High Cardiovascular Disease Risk Report, Sarah Cole
Behavioral Health Change In Appalachian Women With High Cardiovascular Disease Risk Report, Sarah Cole
Kaleidoscope
No abstract provided.
Gender Roles And Their Influence On Life Prospects For Women In Urban Karachi, Pakistan: A Qualitative Study, Tazeen S. Ali, Gunilla Krantz, Raisa Gul, Nargis Asad, Eva Johansson, Ingrid Mogren
Gender Roles And Their Influence On Life Prospects For Women In Urban Karachi, Pakistan: A Qualitative Study, Tazeen S. Ali, Gunilla Krantz, Raisa Gul, Nargis Asad, Eva Johansson, Ingrid Mogren
School of Nursing & Midwifery
BACKGROUND: Pakistan is a patriarchal society where men are the primary authority figures and women are subordinate. This has serious implications on women's and men's life prospects.
OBJECTIVE: The aim was to explore current gender roles in urban Pakistan, how these are reproduced and maintained and influence men's and women's life circumstances.
DESIGN: Five focus group discussions were conducted, including 28 women representing employed, unemployed, educated and uneducated women from different socio-economic strata. Manifest and latent content analyses were applied.
FINDINGS: TWO MAJOR THEMES EMERGED DURING ANALYSIS: 'Reiteration of gender roles' and 'Agents of change'. The first theme included perceptions …
Marital Status And Mortality Among Middle Age And Elderly Men And Women In Urban Shanghai, Puthiery Va, Wan-Shui Yang, Sarah Nechuta, Wong-Ho Chow, Hui Cai, Gong Yang, Shan Gao, Yu-Tang Gao, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang
Marital Status And Mortality Among Middle Age And Elderly Men And Women In Urban Shanghai, Puthiery Va, Wan-Shui Yang, Sarah Nechuta, Wong-Ho Chow, Hui Cai, Gong Yang, Shan Gao, Yu-Tang Gao, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang
Peer Reviewed Articles
Background: Previous studies have suggested that marital status is associated with mortality, but few studies have been conducted in China where increasing aging population and divorce rates may have major impact on health and total mortality.
Methods: We examined the association of marital status with mortality using data from the Shanghai Women’s Health Study (1996–2009) and Shanghai Men’s Health Study (2002–2009), two population-based cohort studies of 74,942 women aged 40–70 years and 61,500 men aged 40–74 years at the study enrollment. Deaths were identified by biennial home visits and record linkage with the vital statistics registry. Marital status was categorized …
An Automated Internet Application To Help Patients With Bipolar Disorder Track Social Rhythm Stabilization., Daniel Z Lieberman, Susan Swayze, Frederick K Goodwin
An Automated Internet Application To Help Patients With Bipolar Disorder Track Social Rhythm Stabilization., Daniel Z Lieberman, Susan Swayze, Frederick K Goodwin
Psychiatry and Behavioral Sciences Faculty Publications
This column describes a pilot study of a fully automated, Internet-based program that provides a key element of interpersonal and social rhythm therapy, a form of psychotherapy shown to be effective in the treatment of bipolar disorder when combined with mood-stabilizing medication. Participants (N=64) recorded the time they completed activities of daily living and their mood at the time of each entry. After 90 days they demonstrated a 31% increase in social rhythm stability and a small, though statistically significant, decrease in symptoms of abnormal mood. Internet-based programs can enhance access to a best practice in the management of bipolar …
Association Between Mental Health Disorders And Juveniles' Detention For A Personal Crime, Patricia A. Stoddard Dare, Christopher A. Mallett, Craig Boitel
Association Between Mental Health Disorders And Juveniles' Detention For A Personal Crime, Patricia A. Stoddard Dare, Christopher A. Mallett, Craig Boitel
Social Work Faculty Publications
Background: Youth involved with juvenile courts often suffer from mental health difficulties and disorders, and these mental health disorders have often been a factor leading to the youth’s delinquent behaviours and activities.
Method: The present study of a sample population (N= 341), randomly drawn from one urban US county’s juvenile court delinquent population, investigated which specific mental health disorders predicted detention for committing a personal crime.
Results: Youth with attention-deficit hyperactivity disorder and conduct disorder diagnoses were significantly less likely to commit personal crimes and experience subsequent detention, while youth with bipolar diagnoses were significantly more likely.
Conclusion: Co-ordinated youth …
Colostrum Avoidance, Prelacteal Feeding And Late Breast-Feeding Initiation In Rural Northern Ethiopia, Nikki Lynn Rogers, Jemilla Abdi, Dennis Moore, Sarah Nd'iangui, Linda J. Smith, Andrew J. Carlson, Dennis Carlson
Colostrum Avoidance, Prelacteal Feeding And Late Breast-Feeding Initiation In Rural Northern Ethiopia, Nikki Lynn Rogers, Jemilla Abdi, Dennis Moore, Sarah Nd'iangui, Linda J. Smith, Andrew J. Carlson, Dennis Carlson
Population and Public Health Sciences Faculty Publications
Objective
To identify specific cultural and behavioural factors that might be influenced to increase colostrum feeding in a rural village in Northern Ethiopia to improve infant health.
Design
Background interviews were conducted with six community health workers and two traditional birth attendants. A semi-structured tape-recorded interview was conducted with twenty mothers, most with children under the age of 5 years. Variables were: parental age and education; mother's ethnicity; number of live births and children's age; breast-feeding from birth through to weaning; availability and use of formula; and descriptions of colostrum v. other stages of breast milk. Participant interviews were …
Advances In Information And Communication Technology (Ict): Issues, Challenges And Opportunities For Health Care Professionals, Waris Qidwai
Advances In Information And Communication Technology (Ict): Issues, Challenges And Opportunities For Health Care Professionals, Waris Qidwai
Department of Family Medicine
No abstract provided.
A Bayesian Model For Gene Family Evolution, Liang Liu, Lili Yu, Venugopal Kalavacharla, Zhanji Liu
A Bayesian Model For Gene Family Evolution, Liang Liu, Lili Yu, Venugopal Kalavacharla, Zhanji Liu
Biostatistics: Faculty Publications
Background
A birth and death process is frequently used for modeling the size of a gene family that may vary along the branches of a phylogenetic tree. Under the birth and death model, maximum likelihood methods have been developed to estimate the birth and death rate and the sizes of ancient gene families (numbers of gene copies at the internodes of the phylogenetic tree). This paper aims to provide a Bayesian approach for estimating parameters in the birth and death model.
Results
We develop a Bayesian approach for estimating the birth and death rate and other parameters in the birth …
The Effects Of Expert Witness Testimony On Juror Verdict: Psychiatry Versus Psychology, La Shonine Gandy-Smith
The Effects Of Expert Witness Testimony On Juror Verdict: Psychiatry Versus Psychology, La Shonine Gandy-Smith
Theses and Dissertations
The purpose of this study was to explore the effects of expert witness testimony on juror verdicts. We, further, assessed whether there would be a difference in the relative influence of MDs and PhD expert witnesses. Undergraduate and graduate students served as mock jurors and were presented with an insanity case which either (a) a PhD testified for the defense and a MD testified for the prosecution or (b) an MD testified for the defense and a PhD testified for the prosecution. After analysis of verdicts, an Insanity Defense Attitudes Survey, and specific witness credibility evaluations indicated no bias toward …
Differential Effects Of Accumbens Core Vs. Shell Lesions In A Rat Concurrent Conditioned Place Preference Paradigm For Cocaine Vs. Social Interaction, Michael Fritz, Rana El Rawas, Sabine Klement, Kai Kummer, Michael J. Mayr, Vincent Eggart, Ahmad Salti, Michael T. Bardo, Alois Saria, Gerald Zernig
Differential Effects Of Accumbens Core Vs. Shell Lesions In A Rat Concurrent Conditioned Place Preference Paradigm For Cocaine Vs. Social Interaction, Michael Fritz, Rana El Rawas, Sabine Klement, Kai Kummer, Michael J. Mayr, Vincent Eggart, Ahmad Salti, Michael T. Bardo, Alois Saria, Gerald Zernig
Center for Drug Abuse Research Translation Faculty Publications
BACKGROUND: A main challenge in the therapy of drug dependent individuals is to help them reactivate interest in non-drug-associated activities. Among these activities, social interaction is doubly important because treatment adherence itself depends on it. We previously developed a rat experimental model based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of social interaction with a gender- and weight-matched male conspecific (i) reversed CPP from cocaine to social interaction despite continuing cocaine training and (ii) prevented the reinstatement of cocaine CPP. In the present study, we investigated if the two subregions of the nucleus accumbens …
Smoking Cessation Outcomes Among Individuals With Substance Use And/Or Psychiatric Disorders, Milan Khara, Chizimuzo T.C. Okoli
Smoking Cessation Outcomes Among Individuals With Substance Use And/Or Psychiatric Disorders, Milan Khara, Chizimuzo T.C. Okoli
Nursing Faculty Publications
Objectives: The population of individuals with substance use (SUD) and/or psychiatric disorders (PD) has a high prevalence of smoking and a consequent increase in tobacco-related morbidity and mortality when compared to the general population. The aim of this study is to examine the outcomes of a program in a real-life setting which takes a tailored approach to smoking cessation among individuals with SUD and/or PD.
Methods: A retrospective chart review of tailored tobacco dependence treatment was performed on individuals with histories of SUD and/or PD attending a Tobacco Dependence Clinic (TDC) program in Vancouver, British Columbia, Canada. Participants of the …
Accuracy Of Educator Nominations In Identifying Students With Elevated Levels Of Anxiety And Depression, Jennifer Cunningham
Accuracy Of Educator Nominations In Identifying Students With Elevated Levels Of Anxiety And Depression, Jennifer Cunningham
USF Tampa Graduate Theses and Dissertations
Internalizing disorders, specifically depression and anxiety, affect up to 18% and 33% of youth, respectively (Costello, Egger, & Angold, 2005b). Schools have become a major provider of mental health services to children, primarily in attempts to overcome barriers to receiving community services (Farmer, Burns, Philip, Angold, & Costello, 2003). As such, it is important that schools have effective mechanisms in place to accurately identify students who may be in need of such services. The current study examined the accuracy of one such method, educator nominations (including from both teachers and school-based mental health professionals) in identifying students who self-report elevated …
Psychosocial Correlates Of Alexithymia In A Rural Adolescent Residential Population, Stephanie Powell, Kenneth M. Coll, Ann Trotter, Patti Thobro, Robin Haas
Psychosocial Correlates Of Alexithymia In A Rural Adolescent Residential Population, Stephanie Powell, Kenneth M. Coll, Ann Trotter, Patti Thobro, Robin Haas
Counselor Education Faculty Publications and Presentations
This study used a multimethod approach to evaluate the relationship of alexithymia (as measured by the 20-item Toronto Alexithymia Scale and the 30-item Emotion Awareness Questionnaire), psychosocial development (assessed with the Measure of Psychosocial Development), and risk behavior (as measured by the Youth Comprehensive Risk Assessment) in 67 adolescents (85% from rural communities) in a rural residential treatment facility. Results revealed that both measures of alexithymia demonstrated good internal consistency and convergent validity. The EAQ-30 demonstrated stronger convergent validity over the TAS-20 with psychosocial measures of shame, inferiority, and role confusion and was more robust in differentiating risk behavior among …
A New Face In The Crowd: An Examination On The Social Integration Of Children With Disabilities, Christen Maguire
A New Face In The Crowd: An Examination On The Social Integration Of Children With Disabilities, Christen Maguire
Independent Study Project (ISP) Collection
Historically in India people with disabilities have been pushed to the side and have not been given the attention which they need and deserve. As a result this population has become extremely marginalized and has not been included in making decisions with the rest of society. The main reason why this has become such a marginalized group is because of a negative stigma which has been associated with mental disabilities. Slowly this stigma is beginning to change, but it still affects the way people view and act towards the disabled. The integration of people with disabilities into the rest of …
Autism In Kenya: A Social, Educational And Political Perspective, Ariana Riccio
Autism In Kenya: A Social, Educational And Political Perspective, Ariana Riccio
Independent Study Project (ISP) Collection
Autism is a widely misunderstood developmental disability that is generally diagnosed in early childhood and has been the recent subject of much media and medical attention in developed nations worldwide. While there has been a noted improvement in diagnostic and therapeutic options for children and their families in developing nations, the attention placed on disability, particularly on autism, is considered underdeveloped and inadequate. This paper will attempt to address the current framework surrounding autism in the area of Nairobi, Kenya and discuss the social attitudes, diagnostic practices, educational opportunities, and government intervention programs available in the area. Given the lack …
Assessing Mental Health Care For Iraqi Refugees In Jordan Looking To New Solutions For The Future, Hannah B. Egan
Assessing Mental Health Care For Iraqi Refugees In Jordan Looking To New Solutions For The Future, Hannah B. Egan
Independent Study Project (ISP) Collection
Across the globe citizens flee their native countries in search of newfound safety and stability. These people are known as refugees. Since 2003 refugees from Iraq have entered Jordan in search of a better life. Unfortunately, the terrors that Iraqi refugees escape do not disappear after crossing country lines. These memories cause serious mental health conditions for Iraqi refugees. Such conditions are intensified by the living environment in Jordan where Iraqis are not granted legal status. While some refugees are wealthy and others are resettled to the United States or Europe, the majority remain “stuck” in Jordan.
This study seeks …
Perceived Self-Efficacy Of Licensed Counselors To Provide Substance Abuse Counseling, Nichelle Chandler, Michelle Perepiczka, Richard S. Balken
Perceived Self-Efficacy Of Licensed Counselors To Provide Substance Abuse Counseling, Nichelle Chandler, Michelle Perepiczka, Richard S. Balken
Walden Faculty and Staff Publications
This nationwide, quantitative study documented licensed counselors' perceived self-efficacy of adequately providing substance abuse services. Despite their lack of substance abuse training, counselors were highly confident in their ability to provide quality substance abuse services. Counselor training implications are discussed.
Depression And Its Associated Risk Factors In Medical And Surgical Post Graduate Trainees At A Teaching Hospital: A Cross Sectional Survey From A Developing Country, Aisha Yousuf, Sidra Ishaque, Waris Qidwai
Depression And Its Associated Risk Factors In Medical And Surgical Post Graduate Trainees At A Teaching Hospital: A Cross Sectional Survey From A Developing Country, Aisha Yousuf, Sidra Ishaque, Waris Qidwai
Department of Family Medicine
Objectives: To determine the frequency of depression among post graduate medical trainees in a teaching hospital of Pakistan and to explore the associated factors contributing to depression in them. Methods: It's a cross-sectional study at the Aga Khan University Hospital, Karachi. It was done in June 2008 till August 2008. Zung Self-Rating Depression Scale was administered among 172 post graduate trainees. Self administered questionnaires were used to assess the associated demographic and work related risk factors. Adjusted odds ratios (OR) were calculated by logistic regression. Results: The survey response rate was 172(82.69%). Depression in the overall sample was 103(59.88%), of …
A Silent Storm: Hepatitis C In Pakistan, Noureen Jiwani, Raisa B. Gul
A Silent Storm: Hepatitis C In Pakistan, Noureen Jiwani, Raisa B. Gul
School of Nursing & Midwifery
No abstract provided.
Diagnosing Liability : The Legal History Of Posttraumatic Stress Disorder, Deirdre M. Smith
Diagnosing Liability : The Legal History Of Posttraumatic Stress Disorder, Deirdre M. Smith
Faculty Publications
This Article examines the origins of the unique relationship between the psychiatric diagnosis Posttraumatic Stress Disorder (PTSD) and the law and considers the implications of that relationship for contemporary uses of the diagnosis in legal settings. PTSD stands apart from all other diagnoses in psychiatry 's standard classification system, the Diagnostic and Statistical Manual of Mental Disorders (DSM} , and is the focus of significant controversy within psychiatry, because its diagnostic criteria require a determination of causation. By diagnosing a person with PTSD, a clinician necessarily assigns responsibility to a specific event or agent for causing the person 's symptoms, …
Medical Education: Value Based Teaching, Haider Naqvi, Ather Hussain
Medical Education: Value Based Teaching, Haider Naqvi, Ather Hussain
Department of Psychiatry
No abstract provided.
The Social Nature Of Male Suicide: A New Analytic Model, Daniel Coleman, John T. Casey
The Social Nature Of Male Suicide: A New Analytic Model, Daniel Coleman, John T. Casey
School of Social Work Faculty Publications and Presentations
Suicide is one of the leading causes of male mortality. In nearly every country in the world, more males than females end their life by suicide. Previous research indicates male-specific risk factors include social factors such as being unmarried, low income, and unemployment. An analytic model of male suicide is developed, proposing that the traditional male gender role creates a culturally-conditioned narrowing of perceived options and cognitive rigidity when under stress that increases male suicide risk. Suicide prevention and intervention require recognition of the role of high traditional masculinity, situating individual explanations within a broader social context. Based on this …
The Effects Of Caffeine And Expectancy On Short Term Memory, Sara J. O'Brien
The Effects Of Caffeine And Expectancy On Short Term Memory, Sara J. O'Brien
Doctoral Dissertations and Master's Theses
Although caffeine is the most widely used drug in the world, research on the effects of caffeine on mental performance tasks (especially short term memory tasks) is inconclusive. One possible explanation for this limited understanding is the lack of studies accounting for participant expectancy surrounding caffeine. This study examined the effects of caffeine dosage (0mg, 200mg, and 400mg) and expectancy related to past caffeine use (positive, negative) on short term memory span task. A two-way Analysis of Variance showed that the two independent variables (caffeine dose and expectancy), did not significantly influence the short term memory span score. However, the …
Psychosocial Problems Of Refugees: Understanding And Addressing Needs, Catherine Doren
Psychosocial Problems Of Refugees: Understanding And Addressing Needs, Catherine Doren
Independent Study Project (ISP) Collection
Because all refugees have, by definition, left their country due to a “well-founded fear of persecution due to race, political opinion, ethnic origin, religion, or belonging to a particular social group,” it must be assumed that they have experienced trauma, making psychosocial problems ubiquitous among refugees (Bulbul, 2011; M. Carballo, personal communication, 29 September 2011). Research has shown that refugees often experience a range of psychosocial problems, yet research about the potential avenues for ameliorating these problems and their consequences is lacking and must be increased. Through a combination of interviews and a review of the field’s existing literature, it …
Prenatal Cocaine Exposure Increases Synaptic Localization Of A Neuronal Rasgef, Grasp-1 Via Hyperphosphorylation Of Ampar Anchoring Protein, Grip, Kalindi Bakshi, Mary Kosciuk, Robert G. Nagele, Eitan Friedman, Hoau-Yan Wang
Prenatal Cocaine Exposure Increases Synaptic Localization Of A Neuronal Rasgef, Grasp-1 Via Hyperphosphorylation Of Ampar Anchoring Protein, Grip, Kalindi Bakshi, Mary Kosciuk, Robert G. Nagele, Eitan Friedman, Hoau-Yan Wang
Publications and Research
Prenatal cocaine exposure causes sustained phosphorylation of the synaptic anchoring protein, glutamate receptor interacting protein (GRIP1/2), preventing synaptic targeting of the GluR2/3-containing alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid-type glutamate receptors (AMPARs; J. Neurosci. 29: 6308–6319, 2009). Because overexpression of GRIP-associated neuronal rasGEF protein (GRASP-1) specifically reduces the synaptic targeting of AMPARs, we hypothesized that prenatal cocaine exposure enhances GRASP-1 synaptic membrane localization leading to hyper-activation of ras family proteins and heightened actin polymerization. Our results show a markedly increased GRIP1-associated GRASP-1 content with approximately 40% reduction in its rasGEF activity in frontal cortices (FCX) of 21-day-old (P21) prenatal cocaineexposed rats. This cocaine effect …