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Levamisole-Induced Leukocytoclastic Vasculitis And Neutropenia In A Patient With Cocaine Use: An Extensive Case With Necrosis Of Skin, Soft Tissue, And Cartilage, Natasha Arora, Tania Jain, Ravinder Bhanot, Suganthini Natesan

Wayne State University Associated BioMed Central Scholarship

Abstract

Levamisole-induced vasculitis is a relatively new entity in people who use cocaine. We describe a 44-year-old woman with a history of cocaine use who presented with a complaint of a painful rash of 2-3 month’s duration on her extremities, cheeks, nose, and earlobes. She had not experienced fever, weight loss, alopecia, dry eyes, oral ulcers, photosensitivity, or arthralgia. Examination revealed tender purpuric eruptions with central necrosis on her nose, cheeks, earlobes, and extremities. Laboratory investigations revealed neutropenia, an elevated erythrocyte sedimentation rate (ESR), presence of lupus anticoagulant, low complement component 3 (C3), and presence of perinuclear anti-neutrophil cytoplasmic antibody …