Medicine and Health Sciences Commons^™

Clinical Utility Of Neutrophil To Lymphocyte Ratio In Sickle Cell Disease With Vaso-Occlusive Crisis, Satish Maharaj, Simone Chang

Hematology/Oncology and Stem Cell Therapy

Background and objectives: The neutrophil-to-lymphocyte ratio represents a universally accessible value that correlates with inflammation and prognosis in several disease states; however, the role of this biomarker in sickle cell disease remains poorly explored. Hence, the objective of the present study was to determine its potential clinical utility in patients with sickle cell disease.

Patients: Herein, we retrospectively reviewed 143 patients with sickle cell disease who presented to the emergency department with fever and painful vaso-occlusive crisis.

Results: The examined cohort had a prevalence of 11% confirmed bacterial infection, with approximately two-thirds reporting the use of hydroxyurea. The neutrophil-to-lymphocyte ratio …

Evaluation Of Resistant Associated Variants / Substitutions (Ravs/Rass) Role In Management Of Compensated Naive And Experienced Chronic Hepatitis C Virus Infection, Gamal Mohammad Mohammad Soliman, Ashraf Taha Abd Elmouttaleb, Mostafa Abd Elaziz Ahmed Abd Elrahman, Mohamed Ghareb Mohamed Shikhroho, Amr Mohammed Mohsen Aly Badary

Al-Azhar International Medical Journal

Background: The success of DAA-based combination therapy for the treatment of HCV NS3 resistance-associated substitutions (RAS) is influenced by their occurrence. Objective: The main aim of this study were; 1) identifying the association of HCV relapse (post treatment with ani-NS5A DAAs Simeprevir or Daclatasvir) with occurrence of RAVs/RASs (Resistance associated substitutions) of nucleotide and specific amino acid replacement among Egyptian. Methods: This cross-sectional, case-control study was conducted. Patients were enlisted by Tropical Medicine. Department outpatient clinics at El-Hussein University (Al Azhar University Faculty of Medicine) and EL-Agouza Police hospital. 150 HCV patients in all were involved in the study.These three …

Retrospective Analysis Of Risk Factors And Management Of Infection After Lumbar Spine Implantation, Hussien Mohamed Mohamed, Hussein Abo El-Gheit, Mohamed Abulsoud

Al-Azhar International Medical Journal

Background: Wound infection still has a negative impact on patient outcomes after spine surgery, despite the discovery of preventative medicines as well as improvements in surgical approach and postoperative care. The risk of intraoperative/postoperative infection is increased by utilizing a posterior surgical approach, applying instrumentation, using an allograft, requiring a blood transfusion, and longer operations.

Aim of the study: To determine the prevalence and risk factors for post-operative instrumental lumbar spinal infection and evaluate functional outcomes after the management of the infections.

Patients and Methods: This study was conducted on diseased persons whom had an infection after lumbar spine instrumentation …