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Full-Text Articles in Medicine and Health Sciences
Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu
Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu
Research outputs 2022 to 2026
Background: Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the association between systemic inflammation assessed by joint cumulative high-sensitivity C-reactive protein (CumCRP) and monocyte to high-density lipoprotein ratio (CumMHR) and incident type 2 diabetes (T2D) and their predictive value for T2D in a general population. Methods: A total of 40,813 nondiabetic participants from a prospective real-life cohort (Kailuan Study, China) were followed biennially from 2010/2011 until December 31, 2020. Multivariable Cox regression analyses were conducted to evaluate the adjusted hazard ratios (aHRs) of …
Arterial Stiffness And Obesity As Predictors Of Diabetes: Longitudinal Cohort Study, Cancan Cui, Zhiyuan Wu, Jia Zheng, Jiaqi Chu, Jiajing Zhu, Yitian Qi, Zhenming Zhang, Zhijia Wang, Mengchao Zhang, Zhanhao Mo, Liangkai Cheng, Lei Ding, Xiaoping Kang, Lin Liu, Te Zhang
Arterial Stiffness And Obesity As Predictors Of Diabetes: Longitudinal Cohort Study, Cancan Cui, Zhiyuan Wu, Jia Zheng, Jiaqi Chu, Jiajing Zhu, Yitian Qi, Zhenming Zhang, Zhijia Wang, Mengchao Zhang, Zhanhao Mo, Liangkai Cheng, Lei Ding, Xiaoping Kang, Lin Liu, Te Zhang
Research outputs 2022 to 2026
BACKGROUND: Previous studies have confirmed the separate effect of arterial stiffness and obesity on type 2 diabetes; however, the joint effect of arterial stiffness and obesity on diabetes onset remains unclear. OBJECTIVE: This study aimed to propose the concept of arterial stiffness obesity phenotype and explore the risk stratification capacity for diabetes. METHODS: This longitudinal cohort study used baseline data of 12,298 participants from Beijing Xiaotangshan Examination Center between 2008 and 2013 and then annually followed them until incident diabetes or 2019. BMI (waist circumference) and brachial-ankle pulse wave velocity were measured to define arterial stiffness abdominal obesity phenotype. The …
Combined Effect Of Adiposity And Elevated Inflammation On Incident Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Yulong Lan, Shuohua Chen, Xiong Ding, Guanzhi Chen, Chutao Wu, Lois Balmer, Wencan Xu, Shouling Wu, Wei Wang
Combined Effect Of Adiposity And Elevated Inflammation On Incident Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Yulong Lan, Shuohua Chen, Xiong Ding, Guanzhi Chen, Chutao Wu, Lois Balmer, Wencan Xu, Shouling Wu, Wei Wang
Research outputs 2022 to 2026
Background: Adiposity and elevated inflammation are two hallmarks of hyperglycemia. However, it is unknown whether clustering of elevated inflammation and adiposity interact act on diabetogenesis and lead to a greater risk for incident type 2 diabetes (T2D). Methods: Adiposity was indicated by body mass index, waist circumference and ultrasonography-measured fatty liver degrees. Elevated inflammation was indicated as high-sensitivity C-reactive protein levels ≥ 2 mg/L. Time-to-event survival analyses were conducted to investigate the joint effect of adiposity and inflammation on incident T2D on both multiplicative and additive scales. Results: Among 82,172 non-diabetic participants from a prospective cohort in China, 14,278 T2D …
Supra-Additive Effect Of Chronic Inflammation And Atherogenic Dyslipidemia On Developing Type 2 Diabetes Among Young Adults: A Prospective Cohort Study, Yulong Lan, Dan Wu, Zhiwei Cai, Yuancheng Xu, Xiong Ding, Weiqiang Wu, Shaocong Lan, Lan Chen, Zheng Guo, Lois Balmer, Xingang Li, Manshu Song, Shouling Wu, Jingli Gao, Wei Wang, Youren Chen
Supra-Additive Effect Of Chronic Inflammation And Atherogenic Dyslipidemia On Developing Type 2 Diabetes Among Young Adults: A Prospective Cohort Study, Yulong Lan, Dan Wu, Zhiwei Cai, Yuancheng Xu, Xiong Ding, Weiqiang Wu, Shaocong Lan, Lan Chen, Zheng Guo, Lois Balmer, Xingang Li, Manshu Song, Shouling Wu, Jingli Gao, Wei Wang, Youren Chen
Research outputs 2022 to 2026
Background: Both elevated inflammation and atherogenic dyslipidemia are prominent in young-onset diabetes and are increasingly identified as biologically intertwined processes that contribute to diabetogenesis. We aimed to investigate the age-specific risks of type 2 diabetes (T2D) upon concomitant chronic inflammation and atherogenic dyslipidemia. Methods: Age-stratified Cox regression analysis of the risk of incident diabetes upon co-exposure to time-averaged cumulative high-sensitivity C-reactive protein (CumCRP) and atherogenic index of plasma (CumAIP) among 42,925 nondiabetic participants from a real-world, prospective cohort (Kailuan Study). Results: During a median 6.41 years of follow-up, 3987 T2D developed. Isolated CumAIP and CumCRP were significantly associated with incident …
Association Of Plasma Neurofilament Light Chain With Glycaemic Control And Insulin Resistance In Middle-Aged Adults, Rohith N. Thota, Pratishtha Chatterjee, Steve Pedrini, Eugene Hone, Jessica J. A. Ferguson, Manohar L. Garg, Ralph N. Martins
Association Of Plasma Neurofilament Light Chain With Glycaemic Control And Insulin Resistance In Middle-Aged Adults, Rohith N. Thota, Pratishtha Chatterjee, Steve Pedrini, Eugene Hone, Jessica J. A. Ferguson, Manohar L. Garg, Ralph N. Martins
Research outputs 2022 to 2026
Aims: This study aimed to determine the association of plasma neurofilament light (NfL), a marker of neurodegeneration, with diabetes status and glycaemic parameters in people with normal glycaemia (NG), pre-diabetes (PD) and type 2 diabetes (T2D). Methods: Clinical and descriptive data for the diagnostic groups, NG (n=30), PD (n=48) and T2D (n=29), aged between 40 and 75 years were included in this cross-sectional analysis. Plasma NfL levels were analyzed using the ultra-sensitive single-molecule array (Simoa) platform. Results: A positive correlation was evident between plasma NfL and fasting glucose (r = 0.2824; p = 0.0032). Plasma NfL levels were not correlated …