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Full-Text Articles in Medicine and Health Sciences
Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu
Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu
Research outputs 2022 to 2026
Background: Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the association between systemic inflammation assessed by joint cumulative high-sensitivity C-reactive protein (CumCRP) and monocyte to high-density lipoprotein ratio (CumMHR) and incident type 2 diabetes (T2D) and their predictive value for T2D in a general population. Methods: A total of 40,813 nondiabetic participants from a prospective real-life cohort (Kailuan Study, China) were followed biennially from 2010/2011 until December 31, 2020. Multivariable Cox regression analyses were conducted to evaluate the adjusted hazard ratios (aHRs) of …
Arterial Stiffness And Obesity As Predictors Of Diabetes: Longitudinal Cohort Study, Cancan Cui, Zhiyuan Wu, Jia Zheng, Jiaqi Chu, Jiajing Zhu, Yitian Qi, Zhenming Zhang, Zhijia Wang, Mengchao Zhang, Zhanhao Mo, Liangkai Cheng, Lei Ding, Xiaoping Kang, Lin Liu, Te Zhang
Arterial Stiffness And Obesity As Predictors Of Diabetes: Longitudinal Cohort Study, Cancan Cui, Zhiyuan Wu, Jia Zheng, Jiaqi Chu, Jiajing Zhu, Yitian Qi, Zhenming Zhang, Zhijia Wang, Mengchao Zhang, Zhanhao Mo, Liangkai Cheng, Lei Ding, Xiaoping Kang, Lin Liu, Te Zhang
Research outputs 2022 to 2026
BACKGROUND: Previous studies have confirmed the separate effect of arterial stiffness and obesity on type 2 diabetes; however, the joint effect of arterial stiffness and obesity on diabetes onset remains unclear. OBJECTIVE: This study aimed to propose the concept of arterial stiffness obesity phenotype and explore the risk stratification capacity for diabetes. METHODS: This longitudinal cohort study used baseline data of 12,298 participants from Beijing Xiaotangshan Examination Center between 2008 and 2013 and then annually followed them until incident diabetes or 2019. BMI (waist circumference) and brachial-ankle pulse wave velocity were measured to define arterial stiffness abdominal obesity phenotype. The …
Combined Effect Of Adiposity And Elevated Inflammation On Incident Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Yulong Lan, Shuohua Chen, Xiong Ding, Guanzhi Chen, Chutao Wu, Lois Balmer, Wencan Xu, Shouling Wu, Wei Wang
Combined Effect Of Adiposity And Elevated Inflammation On Incident Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Yulong Lan, Shuohua Chen, Xiong Ding, Guanzhi Chen, Chutao Wu, Lois Balmer, Wencan Xu, Shouling Wu, Wei Wang
Research outputs 2022 to 2026
Background: Adiposity and elevated inflammation are two hallmarks of hyperglycemia. However, it is unknown whether clustering of elevated inflammation and adiposity interact act on diabetogenesis and lead to a greater risk for incident type 2 diabetes (T2D). Methods: Adiposity was indicated by body mass index, waist circumference and ultrasonography-measured fatty liver degrees. Elevated inflammation was indicated as high-sensitivity C-reactive protein levels ≥ 2 mg/L. Time-to-event survival analyses were conducted to investigate the joint effect of adiposity and inflammation on incident T2D on both multiplicative and additive scales. Results: Among 82,172 non-diabetic participants from a prospective cohort in China, 14,278 T2D …
Leveraging Igg N-Glycosylation To Infer The Causality Between T2d And Hypertension, Haotian Wang, Yuan Li, Weijie Cao, Jie Zhang, Mingyang Cao, Xiaoni Meng, Di Liu, Youxin Wang
Leveraging Igg N-Glycosylation To Infer The Causality Between T2d And Hypertension, Haotian Wang, Yuan Li, Weijie Cao, Jie Zhang, Mingyang Cao, Xiaoni Meng, Di Liu, Youxin Wang
Research outputs 2022 to 2026
Background: Observational studies demonstrated a bidirectional association between type 2 diabetes (T2D) and hypertension, whereas Mendelian randomization (MR) analyses supported the causality from T2D to hypertension but not causal from hypertension to T2D. We previously found that IgG N-glycosylation is associated with both T2D and hypertension, and thus IgG N-glycosylation might link the causality between them. Methods: We carried out a genome-wide association study (GWAS) to identify IgG N-glycosylation-quantitative-trait loci (QTLs) integrating GWAS for T2D and hypertension and then performed bidirectional univariable and multivariable MR analyses to infer the causal association among them. The inverse-variance-weighted (IVW) analysis was performed as …
Supra-Additive Effect Of Chronic Inflammation And Atherogenic Dyslipidemia On Developing Type 2 Diabetes Among Young Adults: A Prospective Cohort Study, Yulong Lan, Dan Wu, Zhiwei Cai, Yuancheng Xu, Xiong Ding, Weiqiang Wu, Shaocong Lan, Lan Chen, Zheng Guo, Lois Balmer, Xingang Li, Manshu Song, Shouling Wu, Jingli Gao, Wei Wang, Youren Chen
Supra-Additive Effect Of Chronic Inflammation And Atherogenic Dyslipidemia On Developing Type 2 Diabetes Among Young Adults: A Prospective Cohort Study, Yulong Lan, Dan Wu, Zhiwei Cai, Yuancheng Xu, Xiong Ding, Weiqiang Wu, Shaocong Lan, Lan Chen, Zheng Guo, Lois Balmer, Xingang Li, Manshu Song, Shouling Wu, Jingli Gao, Wei Wang, Youren Chen
Research outputs 2022 to 2026
Background: Both elevated inflammation and atherogenic dyslipidemia are prominent in young-onset diabetes and are increasingly identified as biologically intertwined processes that contribute to diabetogenesis. We aimed to investigate the age-specific risks of type 2 diabetes (T2D) upon concomitant chronic inflammation and atherogenic dyslipidemia. Methods: Age-stratified Cox regression analysis of the risk of incident diabetes upon co-exposure to time-averaged cumulative high-sensitivity C-reactive protein (CumCRP) and atherogenic index of plasma (CumAIP) among 42,925 nondiabetic participants from a real-world, prospective cohort (Kailuan Study). Results: During a median 6.41 years of follow-up, 3987 T2D developed. Isolated CumAIP and CumCRP were significantly associated with incident …
Temporal Relationship Between Atherogenic Dyslipidemia And Inflammation And Their Joint Cumulative Effect On Type 2 Diabetes Onset: A Longitudinal Cohort Study, Yulong Lan, Guanzhi Chen, Dan Wu, Xiong Ding, Zegui Huang, Xianxuan Wang, Lois Balmer, Xingang Li, Manshu Song, Wei Wang, Shouling Wu, Youren Chen
Temporal Relationship Between Atherogenic Dyslipidemia And Inflammation And Their Joint Cumulative Effect On Type 2 Diabetes Onset: A Longitudinal Cohort Study, Yulong Lan, Guanzhi Chen, Dan Wu, Xiong Ding, Zegui Huang, Xianxuan Wang, Lois Balmer, Xingang Li, Manshu Song, Wei Wang, Shouling Wu, Youren Chen
Research outputs 2022 to 2026
Background: Concurrent atherogenic dyslipidemia and elevated inflammation are commonly observed in overt hyperglycemia and have long been proposed to contribute to diabetogenesis. However, the temporal relationship between them and the effect of their cumulative co-exposure on future incident type 2 diabetes (T2D) remains unclear. Methods: Longitudinal analysis of data on 52,224 participants from a real-world, prospective cohort study (Kailuan Study) was performed to address the temporal relationship between high-sensitivity C-reactive protein (hsCRP) and the atherogenic index of plasma (AIP, calculated as triglyceride/high-density lipoprotein) in an approximately 4-year exposure period (2006/2007 to 2010/2011). After excluding 8824 participants with known diabetes, 43,360 …
Thyroid Dysfunction And Glycaemic Control Among Type 2 Diabetes Mellitus Patients In Ghana: A Comparative Cross-Sectional Study, Samuel Asamoah Sakyi, Bright Ameyaw, Edwin Ferguson Laing, Richard Anthony, Richard K.Dadzie Ephraim, Alfred Effah, Afia Agyapomaa Kwayie, Ebenezer Senu, Enoch Odame Anto, Emmanuel Acheampong, Bright Oppong Afranie, Benjamin Amoani, Stephen Opoku
Thyroid Dysfunction And Glycaemic Control Among Type 2 Diabetes Mellitus Patients In Ghana: A Comparative Cross-Sectional Study, Samuel Asamoah Sakyi, Bright Ameyaw, Edwin Ferguson Laing, Richard Anthony, Richard K.Dadzie Ephraim, Alfred Effah, Afia Agyapomaa Kwayie, Ebenezer Senu, Enoch Odame Anto, Emmanuel Acheampong, Bright Oppong Afranie, Benjamin Amoani, Stephen Opoku
Research outputs 2022 to 2026
Introduction: Thyroid disorders and diabetes mellitus coexist and are prevalent endocrinopathies among adult population. Thyroid dysfunction contributes to metabolic imbalances, increase beta-cell apoptosis and glucose intolerance. There is paucity of data and contradicting findings on how thyroid dysfunction influence glycaemic control. Therefore, we evaluated thyroid dysfunction and glycaemic control among Type 2 diabetes mellitus (T2DM) patients in Ghana. Methods: A comparative cross-sectional study was conducted among 192 T2DM patients from Effia Nkwanta Regional Hospital. Three consecutive monthly fasting plasma glucose (FBG) and glycated haemoglobin (HbA1c) were analysed and the results were classified as, moderate hyperglycaemia (MH) (FBG = 6.1–12.0 mmol/L, …
Vitamin K1 Intake And Incident Diabetes In The Danish Diet Cancer And Health Study: Supplemental Information, Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua Lewis, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schulz, Nicola P. Bondonno
Vitamin K1 Intake And Incident Diabetes In The Danish Diet Cancer And Health Study: Supplemental Information, Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua Lewis, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schulz, Nicola P. Bondonno
Research outputs 2022 to 2026
No abstract provided.
Association Of Cumulative Monocyte To High-Density Lipoprotein Ratio With The Risk Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Yulong Lan, Yuancheng Xu, Songna Xu, Yuejun Huang, Lois Balmer, Gehendra Maharra, Wencan Xu, Wei Wang, Shouling Wu
Association Of Cumulative Monocyte To High-Density Lipoprotein Ratio With The Risk Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Yulong Lan, Yuancheng Xu, Songna Xu, Yuejun Huang, Lois Balmer, Gehendra Maharra, Wencan Xu, Wei Wang, Shouling Wu
Research outputs 2022 to 2026
Background: Recent studies have established that monocyte-derived inflammation plays a central role in the pathogenesis of type 2 diabetes mellitus (T2DM). It is unclear whether chronic metabolic inflammation, reflected by the cumulative monocyte to high-density lipoprotein ratio (CumMHR), predisposes the general population to T2DM. Methods: This study included 40,813 participants without diabetes from a real-life, community-based cohort (the Kailuan Study) attending a 2-year cycle of health survey since 2006. Cumulative exposure was obtained from 2006/2007 to 2010/2011. Follow-up started at 2010/2011 and through 2020. Multivariable-adjusted Cox regression models were used to calculate the CumMHR-associated risk of incident T2DM. Results: Over …
Immunoglobulin G N-Glycan, Inflammation And Type 2 Diabetes In East Asian And European Populations: A Mendelian Randomization Study, Biyan Wang, Di Liu, Manshu Song, Wei Wang, Bo Guo, Youxin Wang
Immunoglobulin G N-Glycan, Inflammation And Type 2 Diabetes In East Asian And European Populations: A Mendelian Randomization Study, Biyan Wang, Di Liu, Manshu Song, Wei Wang, Bo Guo, Youxin Wang
Research outputs 2022 to 2026
Background: Immunoglobulin G (IgG) N-glycans have been shown to be associated with the risk of type 2 diabetes (T2D) and its risk factors. However, whether these associations reflect causal effects remain unclear. Furthermore, the associations of IgG N-glycans and inflammation are not fully understood. Methods: We examined the causal associations of IgG N-glycans with inflammation (C-reactive protein (CRP) and fibrinogen) and T2D using two-sample Mendelian randomization (MR) analysis in East Asian and European populations. Genetic variants from IgG N-glycan quantitative trait loci (QTL) data were used as instrumental variables. Two-sample MR was conducted for IgG N-glycans with inflammation (75,391 and …
Combined Evaluation Of Arterial Stiffness, Glycemic Control And Hypertension For Macrovascular Complications In Type 2 Diabetes, Zhiyuan Wu, Siqi Yu, Haiping Zhang, Zheng Guo, Yulu Zheng, Zongkai Xu, Zhiwei Li, Xiangtong Liu, Xia Li, Shuo Chen, Jingbo Zhang, Lixin Tao, Xiuhua Guo
Combined Evaluation Of Arterial Stiffness, Glycemic Control And Hypertension For Macrovascular Complications In Type 2 Diabetes, Zhiyuan Wu, Siqi Yu, Haiping Zhang, Zheng Guo, Yulu Zheng, Zongkai Xu, Zhiwei Li, Xiangtong Liu, Xia Li, Shuo Chen, Jingbo Zhang, Lixin Tao, Xiuhua Guo
Research outputs 2022 to 2026
Background: Arterial stiffness, glycemic control and blood pressure are risk factors of macrovascular complications in type 2 diabetes. This study aimed to investigate the combined association of arterial stiffness, glycemic control and hypertension status with the occurrence of diabetic macrovascular complication. Methods: A total of 1870 patients of diabetes were enrolled from Beijing Health Management Cohort between 2008 and 2018 as baseline, and then followed for macrovascular complication onset. We proposed a composite risk score (0 – 4) by arterial stiffness severity, pool glycemic control and hypertension status. Cox model was used to estimate the hazard ratio (HR) and 95 …
Association Of Plasma Neurofilament Light Chain With Glycaemic Control And Insulin Resistance In Middle-Aged Adults, Rohith N. Thota, Pratishtha Chatterjee, Steve Pedrini, Eugene Hone, Jessica J. A. Ferguson, Manohar L. Garg, Ralph N. Martins
Association Of Plasma Neurofilament Light Chain With Glycaemic Control And Insulin Resistance In Middle-Aged Adults, Rohith N. Thota, Pratishtha Chatterjee, Steve Pedrini, Eugene Hone, Jessica J. A. Ferguson, Manohar L. Garg, Ralph N. Martins
Research outputs 2022 to 2026
Aims: This study aimed to determine the association of plasma neurofilament light (NfL), a marker of neurodegeneration, with diabetes status and glycaemic parameters in people with normal glycaemia (NG), pre-diabetes (PD) and type 2 diabetes (T2D). Methods: Clinical and descriptive data for the diagnostic groups, NG (n=30), PD (n=48) and T2D (n=29), aged between 40 and 75 years were included in this cross-sectional analysis. Plasma NfL levels were analyzed using the ultra-sensitive single-molecule array (Simoa) platform. Results: A positive correlation was evident between plasma NfL and fasting glucose (r = 0.2824; p = 0.0032). Plasma NfL levels were not correlated …
Association Between Non-Tea Flavonoid Intake And Risk Of Type 2 Diabetes: The Australian Diabetes, Obesity And Lifestyle Study, Mary D. Adu, Catherine P. Bondonno, Benjamin H. Parmenter, Marc Sim, Raymond J. Davey, Kevin Murray, Simone Radavelli Bagatini, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson, Nicola P. Bondonno
Association Between Non-Tea Flavonoid Intake And Risk Of Type 2 Diabetes: The Australian Diabetes, Obesity And Lifestyle Study, Mary D. Adu, Catherine P. Bondonno, Benjamin H. Parmenter, Marc Sim, Raymond J. Davey, Kevin Murray, Simone Radavelli Bagatini, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson, Nicola P. Bondonno
Research outputs 2022 to 2026
Studies examining the association between flavonoid intake and measures of insulin resistance and β-cell dysfunction, as markers of type 2 diabetes (T2DM) across the adult lifespan, may provide insights into how flavonoids influence T2DM risk. This study examined the cross-sectional associations between flavonoid intakes, from dietary sources other than tea, and biomarkers of glucose tolerance and insulin sensitivity in adults aged 25 years and older participating in the Australian diabetes, obesity and lifestyle (AusDiab) study. Additionally, longitudinal associations between non-tea flavonoid intakes and incident T2DM over 12 years were explored. Eligible participants (n = 7675) had no previous history of …
Temporal Trends In Renal Replacement Therapy In Community-Based People With Or Without Type 2 Diabetes: The Fremantle Diabetes Study, Wendy A. Davis, Aron Chakera, Edward Gregg, Daniel Mcaullay, Timothy M.E. Davis
Temporal Trends In Renal Replacement Therapy In Community-Based People With Or Without Type 2 Diabetes: The Fremantle Diabetes Study, Wendy A. Davis, Aron Chakera, Edward Gregg, Daniel Mcaullay, Timothy M.E. Davis
Research outputs 2022 to 2026
Background: Although rates of cardiovascular disease complicating type 2 diabetes are declining, equivalent data for renal replacement therapy (RRT) are conflicting. The aim of this study was to characterize temporal changes in RRT incidence rates (IRs) in Australians with or without type 2 diabetes. Methods: Participants with type 2 diabetes from the Fremantle Diabetes Study Phases I (FDS1; n = 1291 recruited 1993–1996) and II (FDS2; n = 1509 recruited 2008–2011) were age-, sex-and postcode-matched 1:4 to people without diabetes and followed for first hospitalization for/with RRT. Five-year IRs, IR ratios (IRRs) for those with versus without diabetes in FDS1 …