Medicine and Health Sciences Commons^™

Role Of Endosialin/Cd248 And Cytoglobin In Liver Fibrosis, Mahmoud Abdallah Mansour, Khaled Abd Elazeme Eid, Ashraf Mohamed Elkabeer, Eglal Mohamed Kenawy, Bakheet Elkot Mostafa Elsadek

Al-Azhar International Medical Journal

Background - Chronic liver diseases are a major global health burden. CYGB, Human IV globin is abundantly expressed in Hepatic Stellate Cell(HSCs) between hepatocytes. CYGB can bind oxygen and nitric oxide and is said to protect HSCs from reactive oxygen species(ROS).

Aim - to estimate role of CD248 and Cygb in process of liver fibrosis.

Patients and Methods - This study was conducted on forty-four Egyptian patients with hepatic stenosis detected by ultrasound, and forty healthy volunteers as control group.

Results - Our results showed statistical significant (p-value < 0.001) increased CD248 in patients group (189.03 ± 66.6) when compared with control group (138.7 ± 36.5), decreased Cygb in patients group (1.62 ± 0.35) when compared with control group (1.93 ± 0.26)

Conclusion - Our study identified Cygb and CD248 …

Nash: Non-Alcoholic Steatohepatitis, Jennifer Heck

Nursing Student Class Projects (Formerly MSN)

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease which refers to the presence of hepatic steatosis without significant intake of alcohol. Non-alcoholic fatty liver disease develops in a variety of forms from reversible simple steatosis to non-alcoholic steatohepatitis (NASH), which if left unchecked can progress to liver fibrosis, cirrhosis and even develop into hepatocellular carcinoma (Mells et al., 2014). NAFLD is thought to be nonthreatening, but with progression over several years could lead to NASH. A strong link between obesity and NASH has been shown. In addition to obesity, insulin resistance (type II diabetes mellitus), and hyperlipidemia all …