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Full-Text Articles in Medicine and Health Sciences
Activation Of Toll-Like Receptor 3 Translates To Long-Term Post-Viral Lung Disease, Xinyu Wang
Activation Of Toll-Like Receptor 3 Translates To Long-Term Post-Viral Lung Disease, Xinyu Wang
Arts & Sciences Electronic Theses and Dissertations
Chronic obstructive lung disease (COPD) causes substantial human and economic costs both in the US and worldwide. To identify the molecular mechanisms to allow for targeted therapies for COPD, we developed a high-fidelity mouse model of chronic lung inflammation using the natural rodent pathogen Sendai virus (SeV). While nucleic acid-sensing pattern recognition receptors are important for innate immune responses to viral pathogens, there have been few studies investigating their role in the context of chronic disease. Here we show that Toll-like receptor 3 (Tlr3) signaling is required for the development of chronic lung disease in a postviral mouse model. Activation …
The Relationship Between Serum Levels Of Surfactant Protein D In Copd Exacerbation Severity And Mortality, Fatma Esra Günaydin, Nurdan Kalkan, Gülşah Günlüoğlu, Esma Nur Aktepe, Bariş Demi̇rkol, Sedat Altin
The Relationship Between Serum Levels Of Surfactant Protein D In Copd Exacerbation Severity And Mortality, Fatma Esra Günaydin, Nurdan Kalkan, Gülşah Günlüoğlu, Esma Nur Aktepe, Bariş Demi̇rkol, Sedat Altin
Turkish Journal of Medical Sciences
Background/aim: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. In COPD patients, various inflammatory markers such as cytokines and acute phase proteins, which show systemic inflammation in the circulation, increase during exacerbations. In our study, we aimed to determine the relationship between serum SP-D levels and exacerbation severity, clinical course of the disease, and early mortality after discharge.Materials and methods: Fifty hospitalized patients with COPD acute exacerbation (46 male and 4 female) were recruited in this study. Thirty-three of the subjects (31 male and 2 female) were reevaluated after discharge. Venous blood samples were taken …