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Full-Text Articles in Medicine and Health Sciences
In Vitro Analysis Of Tobramycin-Treated Pseudomonas Aeruginosa Biofilms On Cystic Fibrosis-Derived Airway Epithelial Cells, Gregory G. Anderson, Sophie Moreau-Marquis, Bruce A. Stanton, George A. O'Toole
In Vitro Analysis Of Tobramycin-Treated Pseudomonas Aeruginosa Biofilms On Cystic Fibrosis-Derived Airway Epithelial Cells, Gregory G. Anderson, Sophie Moreau-Marquis, Bruce A. Stanton, George A. O'Toole
Dartmouth Scholarship
P. aeruginosa forms biofilms in the lungs of individuals with cystic fibrosis (CF); however, there have been no effective model systems for studying biofilm formation in the CF lung. We have developed a tissue culture system for growth of P. aeruginosa biofilms on CF-derived human airway cells that promotes the formation of highly antibiotic-resistant microcolonies, which produce an extracellular polysaccharide matrix and require the known abiotic biofilm formation genes flgK and pilB. Treatment of P. aeruginosa biofilms with tobramycin reduced the virulence of the biofilms both by reducing bacterial numbers and by altering virulence gene expression. We performed microarray analysis …
In Vitro Activity Of Tigecycline Against Acinetobacter Baumannii Strains Isolated From Nosocomial Infections, Esragül Akinci, İpek Mumcuoğlu, Pinar Öngürü, F. Nurhayat Bayazit, Sevi̇nç Ersoy Şen, Ayşe Erbay, Neri̇man Balaban, Hürrem Bodur
In Vitro Activity Of Tigecycline Against Acinetobacter Baumannii Strains Isolated From Nosocomial Infections, Esragül Akinci, İpek Mumcuoğlu, Pinar Öngürü, F. Nurhayat Bayazit, Sevi̇nç Ersoy Şen, Ayşe Erbay, Neri̇man Balaban, Hürrem Bodur
Turkish Journal of Medical Sciences
Aims: Acinetobacter species usually affect hospitalized patients and are involved in many infections associated with a high mortality rate. Management of infections caused by these strains is very difficult, as the strains often display multiple drug resistance, including carbapenem resistance. Tigecycline is the most recently developed semi-synthetic broad spectrum glycylcycline antibiotic. The present study was conducted to evaluate the in vitro susceptibility of Acinetobacter baumannii strains isolated from the hospitalized patients to tigecycline. Materials and Methods: Acinetobacter isolates were collected from hospitalized patients with documented nosocomial infections between June 2005 and October 2006. Only one isolate per patient was accepted. …