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Articles 241 - 253 of 253
Full-Text Articles in Medicine and Health Sciences
Comparison Of Bactericidal And Fungicidal Efficacy Of Antiseptic Formulations According To En 13727 And En 13624 Standards, Asli Şahi̇ner, Ece Halat, Evren Alğin Yapar
Comparison Of Bactericidal And Fungicidal Efficacy Of Antiseptic Formulations According To En 13727 And En 13624 Standards, Asli Şahi̇ner, Ece Halat, Evren Alğin Yapar
Turkish Journal of Medical Sciences
Background/aim: In this study, the antibacterial and antifungal properties of the five most commonly used antiseptic formulations were evaluated in terms of different contact times and organic conditions. Materials and methods: Solutions of chlorhexidine digluconate, povidone iodine, isopropyl alcohol, hydrogen peroxide, and tincture of iodine were prepared and tested according to European standards EN 13727 and EN 13624 with different parameters.Results: The results showed that isopropyl alcohol (70% v/v) and tincture of iodine (2%) had greater bactericidal and fungicidal activity against the four tested bacteria and two fungi in all conditions.Conclusion: When the results of the five different active substances …
Mid-Dose Losartan Mitigates Diabetes-Induced Hepatic Damage By Regulating Inos, Enos, Vegf, And Nf-?B Expressions, Fati̇h Oltulu, Ayli̇n Buhur, Çevi̇k Gürel, Gökçe Ceren Kuşçu, Meli̇h Dağdevi̇ren, Nefi̇se Ülkü Karabay Yavaşoğlu, Ti̇mur Köse, Altuğ Yavaşoğlu
Mid-Dose Losartan Mitigates Diabetes-Induced Hepatic Damage By Regulating Inos, Enos, Vegf, And Nf-?B Expressions, Fati̇h Oltulu, Ayli̇n Buhur, Çevi̇k Gürel, Gökçe Ceren Kuşçu, Meli̇h Dağdevi̇ren, Nefi̇se Ülkü Karabay Yavaşoğlu, Ti̇mur Köse, Altuğ Yavaşoğlu
Turkish Journal of Medical Sciences
Background/aim: Losartan, an antihypertensive drug, is highly preferred in patients with diabetes mellitus (DM) and hypertension because of its retarding effect on diabetic nephropathy. In this study, we investigated the potential therapeutic effect of different doses of losartan on hepatic damage in a streptozotocin (STZ, 50 mg/kg)-induced DM model in rats.Materials and methods: In this study, five different groups were formed: control, DM, low-dose losartan (5 mg/kg), mid-dose losartan (20 mg/kg), and high-dose losartan (80 mg/kg). Liver tissues of experimental groups were evaluated immunohistochemically for TUNEL, iNOS, eNOS, VEGF, and NF-?B pathways. In addition to immunohistochemical analysis, analyses of SOD …
An Old Friend: Uric Acid And Its Association With Fractional Flow Reserve, Sali̇h Topal, Burak Sezenöz, Mustafa Candemi̇r, Eser Açikgöz, Sadik Kadri̇ Açikgöz, Nuri̇ Bülent Boyaci
An Old Friend: Uric Acid And Its Association With Fractional Flow Reserve, Sali̇h Topal, Burak Sezenöz, Mustafa Candemi̇r, Eser Açikgöz, Sadik Kadri̇ Açikgöz, Nuri̇ Bülent Boyaci
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography.Materials and methods: We retrospectively analyzed 293 patients who underwent FFR measurement to determine the significance of intermediate coronary stenosis detected by conventional coronary angiography. Patients were divided into 2 groups: Group 1 (n = 127) included patients with FFR of 0.80 (hemodynamically nonsignificant lesions). Uric acid levels were assessed in both groups with the enzymatic colorimetric method by clinical chemistry autoanalyzer.Results: The …
The Validity And Reliability Of The Turkish Version Of The Physical Activity Scale For Individuals With Physical Disabilities (Pasipd), Kardem Ulaş, Semra Topuz, Gönül Horasan
The Validity And Reliability Of The Turkish Version Of The Physical Activity Scale For Individuals With Physical Disabilities (Pasipd), Kardem Ulaş, Semra Topuz, Gönül Horasan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to assess the validity and reliability of Turkish translation of thePhysical Activity Scale for Individuals with Physical Disabilities (PASIPD) in a disabled Turkish population.Materials and methods: Following the translation protocol of the PASIPD, the Turkish version of the PASIPD, Short Form-36, and International Physical Activity Questionnaire were administered to 198 developmentally and physically disabled individuals.Results: The Turkish version of the PASIPD was found to be reliable. The domains of the Turkish version of the PASIPD were also found to be valid. Four factors were obtained from the questionnaire. The ICC was 1.0 since …
Assessment Of The Visual Pathways In Patients With Neurofibromatosis-1 By 3s-Space Technique With 3-Tesla Mri, Özge Saraç, Oktay Algin, Mehmet Beyazal, Fatma Banu Anlar, Ali̇ Varan, Adi̇le Tülay Kansu
Assessment Of The Visual Pathways In Patients With Neurofibromatosis-1 By 3s-Space Technique With 3-Tesla Mri, Özge Saraç, Oktay Algin, Mehmet Beyazal, Fatma Banu Anlar, Ali̇ Varan, Adi̇le Tülay Kansu
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the size/tortuosity of the optic nerve (ON) and the dilatation of the ON sheath (ONS) in neurofibromatosis type 1 (NF-1) patients with 3T-MRI, and to assess the usefulness of 3D-SPACE in imaging the optic pathway, ON, and ONS in NF-1 patients. Materials and methods: Twenty consecutive NF-1 patients without optic pathway glioma (OPG) (Group 1), 16 consecutive NF-1 patients with OPG (Group 2), and 19 controls were included in this study. The thickness and tortuosity of the ON and the diameter of the ONS were measured on STIR and 3D-SPACE images. Results: The thickness of …
Evaluation Of Medial Olivocochlear Efferent System And Hearing Loss In Patients With Primary Sjögren's Syndrome, Bülent Gündüz, Nuri̇ye Yildirim, Serdar Can Güven, Emre Orhan, Recep Karamert, Zafer Günendi̇
Evaluation Of Medial Olivocochlear Efferent System And Hearing Loss In Patients With Primary Sjögren's Syndrome, Bülent Gündüz, Nuri̇ye Yildirim, Serdar Can Güven, Emre Orhan, Recep Karamert, Zafer Günendi̇
Turkish Journal of Medical Sciences
Background/aim: Autoimmune diseases are a remarkable issue for researchers due to their adverse effects on the auditory system, but for primary Sjögren's syndrome (pSS) there is little research on the comprehensive audiological findings in literature. The main objective of this study was to investigate the medial olivocochlear efferent functions of subjects with pSS and to examine the audiological findings.Materials and methods: The study included 36 subjects with pSS and 36 healthy subjects. All the subjects underwent testing including pure tone, speech, and high frequency audiometry; tympanometry and acoustic reflexes; distortion product otoacoustic emissions (DPOAE); and suppression of DPOAE.Results: The hearing …
Radiographic Comparison Of Cervical Spine Motion Using Lma Fastrach, Lma Ctrach, And The Macintosh Laryngoscope, Gözde İnan, Nurdan Bedi̇rli̇, Zerri̇n Özköse Şatirlar
Radiographic Comparison Of Cervical Spine Motion Using Lma Fastrach, Lma Ctrach, And The Macintosh Laryngoscope, Gözde İnan, Nurdan Bedi̇rli̇, Zerri̇n Özköse Şatirlar
Turkish Journal of Medical Sciences
Background/aim: The optimal technique for airway management in patients with cervical pathology remains unclear. Intubating laryngeal mask airway devices such as LMA CTrach and LMA Fastrach have not been compared for cervical spine (C-spine) movements in the context of cervical pathology. The present study aimed to determine upper C-spine movements by radiography during intubation with different devices as well as comparing the duration and success of intubation in cervical surgery.Materials and methods: Sixty patients scheduled for elective cervical surgery were registered in this prospective, randomized study. Patients with cervical trauma/injury, previous neck surgery, and body mass index (BMI) of >35 …
The Effect Of Parathyroidectomy On Bone Mineral Density In Primary Hyperparathyroidism, Mustafa Çalişkan, Selvi̇han Beysel, Muhammed Kizilgül, Mustafa Özbek, Erman Çakal
The Effect Of Parathyroidectomy On Bone Mineral Density In Primary Hyperparathyroidism, Mustafa Çalişkan, Selvi̇han Beysel, Muhammed Kizilgül, Mustafa Özbek, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the change in bone mineral density (BMD) before and 1 year after parathyroidectomy in patients with primary hyperparathyroidism (PHPT). Materials and methods: The clinical and biochemical parameters and DEXA screening of patients with symptomatic PHPT (n = 28) and asymptomatic PHPT (n = 63) were investigated before and 1 year after parathyroidectomy. Results: Patients with symptomatic PHPT had a higher prevalence of nephrolithiasis (18.2% vs. 4.6%, P = 0.032) when compared to the prevalence in patients with asymptomatic PHPT. The prevalence of osteoporosis in the lumbar spine (63.0% vs. 37.5%, P = 0.026) and …
Does Transrectal Ultrasonography-Guided Biopsy Of The Prostate Lead To Possible Further Metastasis Via Circulating Tumor Cells?, Mustafa Kemal Ati̇lla, Bahatti̇n Avci, Lokman İrkilata, Mustafa Aydin, Alper Bi̇tki̇n, Mevlüt Keleş, İnci̇ Yücel, Mahmut Ulubay
Does Transrectal Ultrasonography-Guided Biopsy Of The Prostate Lead To Possible Further Metastasis Via Circulating Tumor Cells?, Mustafa Kemal Ati̇lla, Bahatti̇n Avci, Lokman İrkilata, Mustafa Aydin, Alper Bi̇tki̇n, Mevlüt Keleş, İnci̇ Yücel, Mahmut Ulubay
Turkish Journal of Medical Sciences
Background/aim: We evaluate whether transrectal ultrasonography (TRUS)-guided prostate biopsy might lead to spillage of tumor cells into peripheral blood as a result of disruption of the epithelial barrier and ultimately result in metastasis. Materials and methods: Eighty-eight patients underwent TRUS-guided prostate needle biopsy due to prostate-specific antigen (PSA) increase or abnormal digital rectal examination at the Samsun Research and Training Hospital (Samsun, Turkey) between April 2016 and September 2018. Approximately 10 mL of whole blood was collected from patients before, 1 week after, and 1 month after biopsy. Samples were analyzed for CD117 positivity and prostate-specific membrane antigen (PSMA) levels …
Neutrophil-To-Lymphocyte Ratio, Monocyte-To-Lymphocyte Ratio, And Platelet-To-Lymphocyte Ratio In Different Etiological Causes Of Thyrotoxicosis, Işilay Taşkaldiran, Tülay Omma, Çağatay Emi̇r Önder, Sevde Nur Firat, Gönül Koç, Mustafa Kemal Kiliç, Şeri̇fe Mehli̇ka Kuşkonmaz, Cavi̇t Çulha
Neutrophil-To-Lymphocyte Ratio, Monocyte-To-Lymphocyte Ratio, And Platelet-To-Lymphocyte Ratio In Different Etiological Causes Of Thyrotoxicosis, Işilay Taşkaldiran, Tülay Omma, Çağatay Emi̇r Önder, Sevde Nur Firat, Gönül Koç, Mustafa Kemal Kiliç, Şeri̇fe Mehli̇ka Kuşkonmaz, Cavi̇t Çulha
Turkish Journal of Medical Sciences
Background/aim: The most common causes of thyrotoxicosis include Graves' disease (GD), toxic multinodular goiter (TMNG), toxic adenoma (TA), and subacute granulomatous thyroiditis (SAT). In our study, we aimed to see whether neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) may be helpful in the differential diagnosis of these diseases.Materials and methods: We retrospectively analyzed the hospital records of the Endocrinology Clinic of our hospital between 2016 and 2019. We included data from 66 GD, 37 TA, and 35 SAT patients. We compared the data with those of 35 healthy subjects as controls.Results: NLR, MLR, …
Retrospective Evaluation Of Anesthetic Techniques In Pregnant Women With Renal Transplantation, Asuman Sargin, Semra Karaman, Şeyda Ceylan Ari, Ali̇ Akdemi̇r, İsmet Hortu
Retrospective Evaluation Of Anesthetic Techniques In Pregnant Women With Renal Transplantation, Asuman Sargin, Semra Karaman, Şeyda Ceylan Ari, Ali̇ Akdemi̇r, İsmet Hortu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate anesthesia management in cesarean operation of pregnant women who underwent renal transplantation and the effects on postoperative renal function, retrospectively.Materials and methods: After obtaining the approval of the ethics committee of our hospital, the records of pregnant women who underwent kidney transplantation and cesarean section between 2007 and 2017 were retrospectively analyzed. The patients' demographic data, concomitant disease history, the treatment received, and type of anesthesia were retrospectively evaluated and recorded in the follow-up form.Results: It was found that a total of 47 women who underwent renal transplantation had 47 live …
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Neck Outcome Score, Şeyda Candeni̇z, Seyi̇t Çitaker, Batuhan Bakirarar
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Neck Outcome Score, Şeyda Candeni̇z, Seyi̇t Çitaker, Batuhan Bakirarar
Turkish Journal of Medical Sciences
Background/aim: This study aims to determine the validity and reliability of the Turkish version of the Neck OutcOme Score (NOOS).Materials and methods: Two hundred eight patients suffering from nonspecific neck pain participated in the study. Test-retest reliability and internal consistency were assessed using intraclass correlation coefficients (2, 1) and Cronbach's alpha, respectively. The dimensionality was investigated with the factor analysis. The construct validity was determined by testing whether the hypothesis of correlations between NOOS subscales, Short Form-36 subscales, and the Neck Disability Index were met using Spearman's rank correlation coefficient. Ceiling/floor effects and measurement error were tested as well.Results: The …
The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay
The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay
Turkish Journal of Medical Sciences
Background/Aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration is associated with numerous side effects. Of those, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative stress and inflammation are probably the most important mechanisms that contribute to the nephrotoxicity. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent. In the present study, the effects of NAC on cisplatin-induced nephrotoxicity were investigated. Materials and methods: Rats were divided into four groups each including eight rats: CONT, NAC-250, CP, and CP+NAC. Rats in experimental …