Medicine and Health Sciences | Open Access Articles

Week Of June 15, 2020, New York Medical College

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Week Of June 8, 2020, New York Medical College

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Week Of May 26, 2020, New York Medical College

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The Apicomplexan-Specific Fikk Kinase Is Crucial For Cyst Formation In Toxoplasma Gondii, Corey Gaylets

NYMC Student Theses and Dissertations

Toxoplasma gondii is an obligate intracellular pathogen. It is considered the second deadliest foodborne pathogen in the world with up to 1/3 of the human population estimated to be currently infected. The majority of immune competent people may exhibit mild symptoms following T gondii infection. The acute stage of infection is often well controlled by cellular immunity in healthy individuals. However sterilizing immunity does not occur as the tachyzoite stage of the parasite responsible for acute infection differentiates to a slow growing bradyzoite stage contained in tissues cysts that can persist for the life of the host. However, if the …

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Endothelial Progenitor Cell-Breast Cancer Interaction, Ghada Ben Rahoma

NYMC Student Theses and Dissertations

Breast cancer remains the second leading cause of cancer death among women in the U.S. Although organ-confined disease is curable, metastatic disease remains incurable and an unmet clinical need. Hence, the development of new therapeutic targets and further understanding of the genesis of malignant progression is needed and to this end analysis of the tumor microenvironment is imperative for novel therapeutic targets in breast cancer. We and others have demonstrated that bone marrow derived endothelial progenitor cells (EPCs) incorporate in the neovasculature around implanted tumors supporting their growth and metastasis. The incorporation of EPCs from the marrow to the tumor …

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Cell Surface Regulatory Immune Targets In Anaplastic Thyroid Cancer, Sanjukta Chakraborty

NYMC Student Theses and Dissertations

Thyroid cancer incidence is increasing at an alarming rate almost trebling every decade. 52,070 new cases of thyroid cancer (14,260 in men and 37,810 in women) were diagnosed in 2019 with an estimated death toll of 2170. Although most thyroid tumors are treatable and has good prognosis, anaplastic thyroid cancer (ATC) is extremely aggressive with a grim poor prognosis of 6-9 months post diagnosis. ATC is completely refractory to mainstream therapies. In our study, immunohistochemical analyses of ATC tissues confirmed a T cell inflamed “hot” tumor immune microenvironment (TIME) as evidenced by presence of CD3+ and CD8+ T cells. This …

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Intranasal Administration Of Pcrv Conjugated To A Tobacco Mosaic Virus Delivery Platform Protects Against P. Aeruginosa In A Murine Model Of Acute Pneumonia, Eman Barahim

NYMC Student Theses and Dissertations

Pseudomonas aeruginosa is a facultative anaerobic bacterium that is the most common type of Gram-negative bacteria causing nosocomial pneumonia in the United States. P. aeruginosa is an opportunistic pathogen ubiquitously found in the atmosphere that can colonize both plants and animals. It is known to cause a wide range of severe, persistent, and fatal infections ranging from acute and chronic pneumonia, skin and soft tissue infections to urinary tract infections, especially in immune-compromised individuals. Patients with cystic fibrosis are at high risk because of deficiencies in mucosal immunity and phagocytosis. Ultimately, Pseudomonas infections can be lethal. There is a very …

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