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Full-Text Articles in Medicine and Health Sciences
The Effect Of Sulfur Dioxide On T-Butyl Hydroperoxide Induced Oxidative Stress In Lung Tissues Of Rats, Saadet Gümüşlü, Di̇jle Ki̇pmen Korgun, Süreyya Bi̇lmen, Gülteki̇n Yücel, Pi̇raye Yargiçoğlu, Aysel Ağar
The Effect Of Sulfur Dioxide On T-Butyl Hydroperoxide Induced Oxidative Stress In Lung Tissues Of Rats, Saadet Gümüşlü, Di̇jle Ki̇pmen Korgun, Süreyya Bi̇lmen, Gülteki̇n Yücel, Pi̇raye Yargiçoğlu, Aysel Ağar
Turkish Journal of Medical Sciences
In this study, the effects of sulfur dioxide (SO_2) ,a common pollutant in urban air, on t-butyl hydroperoxide-induced oxidative stress in rat lung tissues were examined. Ten young rats and 10 adult rats were exposed to SO_2 while another 10 young rats and 10 adult rats made up the control groups. Ten ppm SO_2 was administered to the animals of the SO_2 groups in an exposure chamber for one hour a day every day for 6 weeks. The control groups were exposed to filtered air in the same chamber for the same period. At the end of the experimental period, …
The Effects Of Benzo(A) Pyrene Doxorubicin And Paclitaxel On P170 Glycoprotein, Di̇dem Turgut Coşan, Ayşe Başaran
The Effects Of Benzo(A) Pyrene Doxorubicin And Paclitaxel On P170 Glycoprotein, Di̇dem Turgut Coşan, Ayşe Başaran
Turkish Journal of Medical Sciences
B(a)P is a mutagenic, carcinogenic and teratogenic substance. Paclitaxel and doxorubicin are antineoplastic drugs widely used in cancer treatment. The purpose of this study is to observe the effects of doxorubicin and paclitaxel on p170 glycoprotein in rat liver and kidney tissue after administration of B(a)P. As is well known, p170 glycoprotein is an indicator of drug resistance. We hypothesized that a combination of these antineoplastic drugs would cause lower p170 levels and thus would have a stronger effect than single drug administration. For confirmation, a combination of drugs was used to prevent the development of drug resistance. In this …
Effect Of Low-Intensity Microwave Radiation On Rat Kidney: An Ultrastructural Study, Yusuf Nergi̇z, M. Aydin Ketani̇, Zülküf Akdağ, Ahmet Reşi̇t Ersay, M. Sali̇h Çeli̇k
Effect Of Low-Intensity Microwave Radiation On Rat Kidney: An Ultrastructural Study, Yusuf Nergi̇z, M. Aydin Ketani̇, Zülküf Akdağ, Ahmet Reşi̇t Ersay, M. Sali̇h Çeli̇k
Turkish Journal of Medical Sciences
Exposure to low-intensity microwave radiation for prolonged periods is known to be a potential factor inducing visceral damage. There are several studies in the literature demonstrating the harmful effects of such radiation on the kidney of laboratory animals. Our aim was to determine the effect of low intensity microwave radiation on rat kidney at the light and electron microscopic level. Animals (28 rats) in the experiment group were exposed to 2.65 mW/cm 2 radition (9450 MHz) for 1 h per day during 26 and 52 days respectively and tissue samples of these animals were examined and compared with those of …
Action Of Aspirin On Acetylcholine-Stimulatedtear Secretion In Rats, Zerri̇n Kapicioğlu, Gamze Çan, I. Nuri̇ Kalyoncu
Action Of Aspirin On Acetylcholine-Stimulatedtear Secretion In Rats, Zerri̇n Kapicioğlu, Gamze Çan, I. Nuri̇ Kalyoncu
Turkish Journal of Medical Sciences
In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were anesthetized intraperitoneally (ip) with urethane (1,2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60mg/kg of ASA, group 3 received 50mg/kg of Acetylcholine (Ach), and group 4 received 60mg/kg of ASA and 30 min …
The Effects Of Constant Darkness And Constantlight On The Pineal Gland And Thymusmorphology In The Rats, Nihal İçten, Filiz Karagöz, K. Ali Güneç
The Effects Of Constant Darkness And Constantlight On The Pineal Gland And Thymusmorphology In The Rats, Nihal İçten, Filiz Karagöz, K. Ali Güneç
Turkish Journal of Medical Sciences
It is known that periods of constant darkness and constant light cause stim-ulation and inhibition of melatonin secretion from the pineal gland. It is also suggested that neuroendocrine responses to environmental stimuli, such as light, can influence immune responses through the pineal gland. For these reasons, in this study the effects of the alterations in the photoperiod rhythm on the pineal gland and thymus morphology were experimentally investigated. 30 Swiss albino rats, aged 4 wk, were divided into 3 groups. Group I rats were kept in a dark room, group II in a room under a bright artificial light and …
Neuronal Differentiation In The Cerebral Cortexof The Rat: A Golgi-Cox Study, Necdet Demi̇r, Ramazan Demi̇r
Neuronal Differentiation In The Cerebral Cortexof The Rat: A Golgi-Cox Study, Necdet Demi̇r, Ramazan Demi̇r
Turkish Journal of Medical Sciences
The development of cerebral cortex neurons has been studied in different stages of pre- and postnatal periods of rats. In order to show the neuronal processes, the Golgi-Cox impregnation technique was used. The first neuronal process development was observed in the cranial and caudal poles of the cerebral cortex during the 15th prenatal day and continued spreading from the lateral regions and poles towards the dorsocentral regions of the hemispheres. The cells which showed the first impregnation in the cerebral cortex, were bipolar cells and their bodies were located in the deep regions of the hemisphere wall. Primitive multipolar cells, …
The Effects Of Shock Waves On The Rat Fetus, Orhan Yalçin, Lütfi Tahmaz, Zuhal Yumbul, İdris Bi̇lgi̇ç
The Effects Of Shock Waves On The Rat Fetus, Orhan Yalçin, Lütfi Tahmaz, Zuhal Yumbul, İdris Bi̇lgi̇ç
Turkish Journal of Medical Sciences
There is an ongoing controversy regarding shock wave lithotripsy (SWL) contraindicated during pregnancy (1, 2). While the effects of shock waves on a variety of cells in both clinical and experimental studies are well documented, their effects on the fetus remain to be clarified. In this study, we investigated the effects of SWL on the rat fetus. On the 8th, 11th, 14th and 17th days of pregnancy, 100, 250 or 500 shock waves were produced with a Multimed 2001 ELMED Systems Lithotriptor. In ongoing pregnancy, the effects of SWL on fetuses ranged from mild in early pregnancy to moderate and …
Renal Ultrastructural Alterations Followingadministration Of Diethylstilbestrol, Bilge Onarlioğlu, Yasemin Günay, İsmihan Göze, Emel Koptagel
Renal Ultrastructural Alterations Followingadministration Of Diethylstilbestrol, Bilge Onarlioğlu, Yasemin Günay, İsmihan Göze, Emel Koptagel
Turkish Journal of Medical Sciences
Diethylstilbestrol (DES), nonsteroid in structure, is an artificial estrogen derivative and is used as an anabolic agent. It is known that diethylstilbestrol causes genetic disorders and toxic effects leading up to carcinoma even in amounts below its residual levels. For this purpose, a dose of 60µm/kg/day of DES dissolved in 0,1 ml corn oil has been administered to rats by oral gavage for varying periods of 20, 50 and 100 days periods. Rat renal tissue samples, following routine electron microscopical procedure, have been examined by transmission electron microscopy. Following diethylstilbestrol administration, glomerular capilleries seemed dilated along with occasional basement membrane …