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Sex-Related Differences In The Efficacy Of Dexamethasone Pretreatmentfor Postoperative Analgesia In Patients Undergoing Laparoscopiccholecystectomy: A Randomized Controlled Study, Choel Lee, Jae-Yoon Chung, Myeongjong Lee

Turkish Journal of Medical Sciences

Background/aim: Sex-related differences in response to pain have become a topic of increasing interest. However, sex-related differences in the efficacy of dexamethasone for postoperative analgesia have not been previously addressed. Materials and methods: The study included 196 men and 196 women, aged between 18 and 45 years, who were scheduled for laparoscopic cholecystectomy. The patients were randomly allocated into dexamethasone (M/F: 98/98) and control (normal saline; M/F: 98/98) groups. Patients in the study group received intravenous dexamethasone at 0.1 mg/kg (dexamethasone group) 1 h before induction of anesthesia. Patients in the control group received normal saline. Changes in cumulative morphine-containing, …