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Full-Text Articles in Medicine and Health Sciences
Total Antioxidant Capacity And C-Reactive Protein Levels In Patients With Community-Acquired Pneumonia, Ahmet Bi̇rcan, Recep Sütçü, Müni̇re Gökirmak, Hi̇cran Hi̇çyilmaz, Ahmet Akkaya, Önder Öztürk
Total Antioxidant Capacity And C-Reactive Protein Levels In Patients With Community-Acquired Pneumonia, Ahmet Bi̇rcan, Recep Sütçü, Müni̇re Gökirmak, Hi̇cran Hi̇çyilmaz, Ahmet Akkaya, Önder Öztürk
Turkish Journal of Medical Sciences
Aims: The aim of this study was to evaluate the oxidative stress measured by serum total antioxidant capacity (TAC) and malondialdehyde (MDA) in patients with community-acquired pneumonia (CAP), and to evaluate their possible correlation with the serum C-reactive protein (CRP) and pneumonia severity index (PSI). Materials and Methods: The PSI, chest X-ray (CXR) scores, and the serum TAC, MDA, and CRP levels were determined in 67 CAP patients on admission and compared to 45 healthy controls. Results: In the whole study population, the TAC level was inversely correlated with CRP levels and WBC counts (r=-0.648, P=0.0001; r=-0.626, P=0.0001, respectively). Lower …
Placental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress In Preeclampsia, Ekambaram Padmini, Bose Vijaya Geetha
Placental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress In Preeclampsia, Ekambaram Padmini, Bose Vijaya Geetha
Turkish Journal of Medical Sciences
Aims: Preeclampsia is a hypertensive disorder of human pregnancy and a leading cause of premature delivery and fetal growth retardation. The purpose of this study was to evaluate the expression of heat shock protein 70 (HSP70), both constitutive (HSC70) and induced (HSP70) forms, along with oxidative stress status in the placental tissues of normotensive (control group) and preeclamptic pregnancies. Materials and Methods: Placental samples were collected after delivery from normotensive pregnancies and preeclamptic patients (n = 20, each). Lipid peroxidation product malondialdehyde (MDA) and nitrite and nitrate levels, along with antioxidants such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) …
Serum Homocysteine Levels In Highway Toll Collectors And The Relationship With Intima-Media Thickness Of The Carotid Artery, Ramazan Memi̇şoğullari, Beşi̇r Erdoğmuş, Hami̇t Hakan Alp, Cahi̇t Bi̇lgi̇n, Peri̇ Meram Arbak, Özlem Yavuz
Serum Homocysteine Levels In Highway Toll Collectors And The Relationship With Intima-Media Thickness Of The Carotid Artery, Ramazan Memi̇şoğullari, Beşi̇r Erdoğmuş, Hami̇t Hakan Alp, Cahi̇t Bi̇lgi̇n, Peri̇ Meram Arbak, Özlem Yavuz
Turkish Journal of Medical Sciences
Aim: A relationship between air pollution and increased intima-media thickness (IMT) has been recently reported, but its etiology is not yet well understood. We aimed to determine whether exposure to exhaust particles, which are important air pollutants, is associated with increased serum homocysteine (Hcy) levels and whether elevated Hcy levels are associated with increased IMT. Materials and Methods: Serum Hcy levels were measured by fluorometric high performance liquid chromatography in 65 male highway toll collectors (HTCs) and 43 healthy male volunteers. IMT was measured with Doppler sonography by an experienced radiologist. Results: Serum Hcy levels (14.5 ± 4.9 mmol/L, P < 0.005) and IMT (0.757 ± 0.18 mm, P < 0.001) were higher in the HTC group than in controls (12.0 ± 2.8 mmol/L and 0.612 ± 0.11 mm, respectively). A positive correlation was found between Hcy level and IMT both in the HTC group (r = 0.36; P < 0.005) and in the control group (r = 0.36; P < 0.05). Conclusions: Exposure to exhaust particles may cause an increase in oxidative stress because of an increase in serum Hcy levels, which consequently may lead to an increase in IMT. Nevertheless, further studies on the subject are needed before drawing a firm conclusion.