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Full-Text Articles in Medicine and Health Sciences
Microglial Iron Trafficking: New Player In Brain Injury, Elif Keles, Hasan Hüseyi̇n Kazan, Lati̇fe Arzu Aral, Hayrunni̇sa Bolay Belen
Microglial Iron Trafficking: New Player In Brain Injury, Elif Keles, Hasan Hüseyi̇n Kazan, Lati̇fe Arzu Aral, Hayrunni̇sa Bolay Belen
Turkish Journal of Medical Sciences
Neonatal brain injury is a significant reason of neurodevelopmental abnormalities and long-term neurological impairments. Hypoxic-ischemic encephalopathy and preterm brain injury, including intraventricular hemorrhage are the most common grounds of brain injury for full-term and preterm neonates. The prevalence of hypoxic ischemic encephalopathy varies globally, ranging from 1 to 3.5/1000 live births in high-resource countries and 26/1000 in low-resource countries. Preterm birth's global incidence is 15 million, a significant reason for infant mortality and morbidity, permanent neurologic problems, and the associated social and economic burden. The widespread neurodevelopmental effects of neonatal brain injury could have an unfavorable impact on a variety …
Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver
Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an …
Effects Of Ankaferd Bloodstopper On Dermal Healing In Diabetic Rats, Sertaç Aktop, Burcu Çevreli̇, Deni̇z Genç, Emel Serdaroğlu Kaşikçi, Ni̇l Çomunoğlu Üstündağ, Noushi̇n Zi̇bandeh, Eli̇f Merve Özcan, Gökhan Göçmen, Mehmet Kami̇l Göker, İsmai̇l Tayfun Uzbay, Tunç Akkoç
Effects Of Ankaferd Bloodstopper On Dermal Healing In Diabetic Rats, Sertaç Aktop, Burcu Çevreli̇, Deni̇z Genç, Emel Serdaroğlu Kaşikçi, Ni̇l Çomunoğlu Üstündağ, Noushi̇n Zi̇bandeh, Eli̇f Merve Özcan, Gökhan Göçmen, Mehmet Kami̇l Göker, İsmai̇l Tayfun Uzbay, Tunç Akkoç
Turkish Journal of Medical Sciences
Background/aim: Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to the development of chronic wounds. Ankaferd BloodStopper (ABS) is a new and promising local haemostatic agent. Although the mechanism of ABS-mediated haemostasis is well established, little is known about the associated histological and biochemical tissue reactions. The aim of this study was to evaluate the effects of this new-generation local haemostatic agent on short-term soft-tissue healing in streptozotocin (STZ)-treated rats. Materials and methods: The 24 Wistar albino rats used in this study were divided into STZ-treated (STZ, n = 12) and nontreated groups (control, n = …
Antioxidants Status In Type 2 Diabetic Patients In Morocco, Rachid Eljaoudi, Naoual Elomri, Meryem Laamarti, Yahia Cherrah, Taoufik Amezyane, Driss Ghafir, Azeddine Ibrahimi
Antioxidants Status In Type 2 Diabetic Patients In Morocco, Rachid Eljaoudi, Naoual Elomri, Meryem Laamarti, Yahia Cherrah, Taoufik Amezyane, Driss Ghafir, Azeddine Ibrahimi
Turkish Journal of Medical Sciences
Background/aim: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes. Materials and methods: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se). Results: CRP and triglycerides were higher in the diabetic group while high-density lipoprotein levels were significantly …
Prospects Of Curcumin As An Additive In Storage Solutions: A Study On Erythrocytes, Soumya Ravikumar, Carl Hsieh, Vani Rajashekharaiah
Prospects Of Curcumin As An Additive In Storage Solutions: A Study On Erythrocytes, Soumya Ravikumar, Carl Hsieh, Vani Rajashekharaiah
Turkish Journal of Medical Sciences
Background/aim: Curcumin, a naturally occurring antioxidant, shows a wide variety of medicinal properties. The possibility of utilizing curcumin as an additive in storage solutions of blood has not been explored. The purpose of this study was to analyze the effect of curcumin on erythrocytes during storage. Materials and methods: Blood obtained from rats was stored (4 °C) for 20 days in citrate-phosphate-dextrose-adenine-1 solution. Samples were divided into four groups: 1) Controls; 2) Curcumin 10 mM; 3) Curcumin 30 mM; and 4) Curcumin 60 mM. Every fifth day, hemoglobin, superoxide, antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase (GSH-Px)), lipid peroxidation …
Hepatoprotective And Antidiabetic Activities Of Fraxinus Angustifolia Vahl Extracts In Animal Models: Characterization By High Performance Liquid Chromatography Analysis, Zineb Medjahed, Dina Atman-Kilani, Marie-Laure Fauconnier, Gaetan Richard, Djebbar Atmani
Hepatoprotective And Antidiabetic Activities Of Fraxinus Angustifolia Vahl Extracts In Animal Models: Characterization By High Performance Liquid Chromatography Analysis, Zineb Medjahed, Dina Atman-Kilani, Marie-Laure Fauconnier, Gaetan Richard, Djebbar Atmani
Turkish Journal of Medical Sciences
Background/aim: The present study was designed to explore antidiabetic and hepatoprotective potentials of Fraxinus angustifolia leaf (FAL) and bark (FAB) extracts in vivo. Materials and methods: Streptozotocin (STZ)-induced diabetic rats, pretreated with the extracts (25 and 50 mg/kg), were monitored for fasting blood glucose (FBG) levels. Hepatoprotective potential was examined after injection of an excessive dose of paracetamol (10 g/60 kg) by analysis of biochemical parameters (transaminases, bilirubin), malondialdehyde (MDA) levels, and histological sections. high performance liquid chromatography analysis was also performed for partial characterization. Results: A considerable hypoglycemic effect was noticed 2 h after the STZ-induction, with a higher …
Hypolipidemic And Antioxidant Activity Of Aqueous Extract Of Monascus Purpureus Fermented Indian Rice In High Cholesterol Diet Fed Rats, Aiyalu Rajasekaran, Muthusamy Kalaivani
Hypolipidemic And Antioxidant Activity Of Aqueous Extract Of Monascus Purpureus Fermented Indian Rice In High Cholesterol Diet Fed Rats, Aiyalu Rajasekaran, Muthusamy Kalaivani
Turkish Journal of Medical Sciences
To evaluate hypolipidemic and anti-oxidant activities of Monascus purpureus fermented Indian variety of rice. Materials and methods: Indian rice variety IR-532-E-576 was fermented with Monascus purpureus MTCC 1090 (Monascaceae) and extracted with water by boiling. Experimentally induced hyperlipidemia was produced by feeding rats with 2% cholesterol enriched diet for 15 days. Afterwards hypercholesterolemic rats were orally administered with Monascus fermented Indian rice extract at the dose of 1.2 and 2.4 mg/kg bw along with high cholesterol diet for 30 successive days in order to evaluate their expected hypolipidemic activity. Plasma lipid parameters such as total cholesterol, triglycerides, LDL (low density …
The Relationship Between Carnitine Levels And Lipid Peroxidation In Glial Brain Tumors, Ni̇lüfer Bayraktar, Hati̇ce Paşaoğlu, Aydin Paşaoğlu, Memduh Kaymaz, Gürsel Bi̇beroğlu, Sevsen Kulaksizoğlu
The Relationship Between Carnitine Levels And Lipid Peroxidation In Glial Brain Tumors, Ni̇lüfer Bayraktar, Hati̇ce Paşaoğlu, Aydin Paşaoğlu, Memduh Kaymaz, Gürsel Bi̇beroğlu, Sevsen Kulaksizoğlu
Turkish Journal of Medical Sciences
Aim: It is assumed that reactive oxygen species and lipid peroxidation cause cell membrane damage and play a role in oncogenesis. Carnitine and acyl esters, which play a role in intracellular short-, medium-, and long-chain fatty acid metabolism, are one of the defense mechanisms against free radical toxicity. It is thought that the protective effects of carnitine are related with its role in lipid metabolism. In our study, we analyzed the relation between malondialdehyde (MDA) and free carnitine, and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 carnitine levels in glial tumors [glioblastoma …
The Effect Of Caffeic Acid Phenethyl Ester (Cape) Treatment On Levels Of Mda, No And Antioxidant Enzyme Activities In Retinas Of Streptozotocin-Induced Diabetic Rats, Mustafa Durmuş, H. Ramazan Yilmaz, Efkan Uz, Nurten Özçeli̇k
The Effect Of Caffeic Acid Phenethyl Ester (Cape) Treatment On Levels Of Mda, No And Antioxidant Enzyme Activities In Retinas Of Streptozotocin-Induced Diabetic Rats, Mustafa Durmuş, H. Ramazan Yilmaz, Efkan Uz, Nurten Özçeli̇k
Turkish Journal of Medical Sciences
Aim: This study was performed to determine the effect of caffeic acid phenethyl ester (CAPE) treatment on levels of malondialdehyde (MDA) and nitric oxide (NO) and activities of antioxidant enzymes in retinas of streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Twenty-seven rats were enrolled and divided into three groups: group 1: non-diabetic rats as control (n = 9); group 2: STZ-induced, untreated diabetic rats (n = 8); and group 3: STZ-induced, CAPE-treated diabetic rats (n = 10). Levels of MDA and NO and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in retinal tissues were analyzed. Results: In …
Reversal Of Endotoxin-Induced Hypotension By Inhibition Of Inducible Nitric Oxide Synthase Activity Is Associated With Improved Oxidative Status In Rat Heart, Aorta And Mesenteric Artery, Bahar Tunçtan, Belma Korkmaz, Hati̇ce Yildirim, Lülüfer Tamer, Uğur Ati̇k, C. Kemal Buharalioğlu
Reversal Of Endotoxin-Induced Hypotension By Inhibition Of Inducible Nitric Oxide Synthase Activity Is Associated With Improved Oxidative Status In Rat Heart, Aorta And Mesenteric Artery, Bahar Tunçtan, Belma Korkmaz, Hati̇ce Yildirim, Lülüfer Tamer, Uğur Ati̇k, C. Kemal Buharalioğlu
Turkish Journal of Medical Sciences
Overproduction of reactive oxygen and nitrogen species leads to oxidative stress and decreased total antioxidant capacity, which is responsible for high mortality from several diseases such as endotoxic shock. Nitric oxide (NO) produced by inducible NO synthase (iNOS) during endotoxemia is the major cause of vascular hyporeactivity, hypotension and multiple organ failure. We investigated whether NO-mediated oxidative stress in rat heart, aorta and mesenteric artery is involved in the attenuation of endotoxin-induced hypotension by inhibition of iNOS. In conscious male Wistar rats, injection of endotoxin (10 mg/kg, i.p.) caused a gradual fall in mean arterial pressure (MAP) for 4 hours …
Salivary Malondialdehyde Levels In Patients With Oral Leukoplakia, Yegane Güven, Meral Ünür, Kivanç Bektaş, Ezel Uslu, Ahmet Belce, Erdi̇nç Demi̇rez, Şule Can
Salivary Malondialdehyde Levels In Patients With Oral Leukoplakia, Yegane Güven, Meral Ünür, Kivanç Bektaş, Ezel Uslu, Ahmet Belce, Erdi̇nç Demi̇rez, Şule Can
Turkish Journal of Medical Sciences
Since leukoplakia is a premalignant condition, it is evident that an effective means of control would contribute to reducing the mortality and morbidity of oral cancer. The reactivity of free radicals and singlet oxygen is believed to be an important factor in the pathogenesis of many degenerative diseases including carcinogenesis. Reactive free radicals may damage cells by induction of lipid peroxidation of the polyunsaturated fatty acids. Buege and Aust's method was used for lipid peroxidation analysis. One way of estimating free radical activity and lipid peroxidation is to determine the concentration of malondialdehyde (MDA) in the body fluids. MDA concentration …
Lipid Peroxidation, Nitrate And Nitrite Levels In Eclamptic And Intrauterine Growth Retarded Pregnancies, Hati̇ce Paşaoğlu, Nesli̇han Bukan, Gülsen Bulduk, Şevki̇ Çelen
Lipid Peroxidation, Nitrate And Nitrite Levels In Eclamptic And Intrauterine Growth Retarded Pregnancies, Hati̇ce Paşaoğlu, Nesli̇han Bukan, Gülsen Bulduk, Şevki̇ Çelen
Turkish Journal of Medical Sciences
In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 µmol/L p < 0.001) and IUGR (24.3 ± 9.5 µmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 µmol /L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p < 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.
The Effects Of Fenthion On Lipid Peroxidation And Some Liver Enzymes: The Possible Protective Role Of Vitamins E And C, İrfan Altuntaş, Namik Deli̇baş
The Effects Of Fenthion On Lipid Peroxidation And Some Liver Enzymes: The Possible Protective Role Of Vitamins E And C, İrfan Altuntaş, Namik Deli̇baş
Turkish Journal of Medical Sciences
The effects of fenthion on the serum activities of cholinesterase (ChE), enzymes concerning liver damage and lipid peroxidation (LPO), and the ameliorating effects of a combination of vitamins E and C against fenthion toxicity were investigated. The results of the in vivo experiment showed that fenthion caused a significant increase in LPO and the activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and lactate dehydrogenase (LDH), and a significant decrease in the activities of ChE and alanine aminotransferase (ALT). In addition, treatment with a combination of vitamins E and C led to a significant decrease in LPO and …
Mao Inhibitors In Aging: Can They Serve As Protective Agents In Cardiac Tissue Against Oxidative Stress?, Ferhan Külahçioğlu Gi̇rgi̇n, Mert Özgönül, Güli̇nnaz Alper, Gülri̇z Menteş, Bi̇ltan Ersöz, Eser Yildirim Sözmen
Mao Inhibitors In Aging: Can They Serve As Protective Agents In Cardiac Tissue Against Oxidative Stress?, Ferhan Külahçioğlu Gi̇rgi̇n, Mert Özgönül, Güli̇nnaz Alper, Gülri̇z Menteş, Bi̇ltan Ersöz, Eser Yildirim Sözmen
Turkish Journal of Medical Sciences
Biological damage mediated by reactive oxygen species has been increasingly recognized in aging phenomena in recent decades. The increase in catecholamine metabolism is yet another physiological change in aging, predisposing the organism to supranormal hydrogen peroxide produc-tion as a by-product. This study was undertaken to investigate the alterations in oxidant- antioxidant status in rat cardiac tissue during aging. The effects of acute administration of monoamine oxidase (MAO) inhibitors on this status were also investigated to find possible preventive strategies in conjugate aging. MAO activities, malondialdehyde MDA and diene conjugate levels as well as superoxide dismutase and catalase activities were determined …
Effect Of Exercise On Blood Antioxidant Status And Erythrocyte Lipid Peroxidation: Role Of Dietary Supplementation Of Vitamin E, Mustafa Kelle, Hüda Di̇ken, Abdurrahman Şermet, Mukadder Atmaca, Cemi̇l Tümer
Effect Of Exercise On Blood Antioxidant Status And Erythrocyte Lipid Peroxidation: Role Of Dietary Supplementation Of Vitamin E, Mustafa Kelle, Hüda Di̇ken, Abdurrahman Şermet, Mukadder Atmaca, Cemi̇l Tümer
Turkish Journal of Medical Sciences
We tested the effects of moderate physical exercise on the blood antioxidant capacity and erythrocyte lipid peroxidation in 21 Wistar albino rats. Erythrocyte superoxide dismutase (SOD) activity increased significantly (p
Oxidative Damage In Erythrocytes During Cold Storage With Organ Preservation Solution, Aki̇f B. Memmedoğlu, Ahmet Özaydin, İsmai̇l Seçki̇n, Gönül Sultuybek
Oxidative Damage In Erythrocytes During Cold Storage With Organ Preservation Solution, Aki̇f B. Memmedoğlu, Ahmet Özaydin, İsmai̇l Seçki̇n, Gönül Sultuybek
Turkish Journal of Medical Sciences
It is known that erythrocyte aggregation in renal tissue during preserva-tion is cause of microcirculation defects in the reperfusion period. The aim of our study is to investigate oxidative damage in erythrocytes relative to the time of cold ischemia during organ preservation and relationship between lipid peroxidation and development of these damages. In experiments with a rabbit model, explanted kidneys were exposed to perfusion and 96 hours preservation with Euro-Collins (EC) in the 1st group, and University of Wisconsin (UW) solution in the 2nd group. Electron-microscopic examinations in renal tissueswere performed. Lipid peroxidation and glutathione levels in erythrocytes preserved in …
Lipid Peroxidation In Behçet's Disease In Activeand Remission Periods, Teoman Erdem, Necmetti̇n Akdeni̇z, İrfan Altuntaş, Fati̇h Akçay
Lipid Peroxidation In Behçet's Disease In Activeand Remission Periods, Teoman Erdem, Necmetti̇n Akdeni̇z, İrfan Altuntaş, Fati̇h Akçay
Turkish Journal of Medical Sciences
Recent few studies revealed that increased levels of oxygen free radicals might play a role in tissue damage. There are some studies in the literature proposing that increased levels of oxygen radicals might play a role in tissue damage, as also seen in Behçet's disease (BD). The aim of the present study was to measure plasma malondialde-hyde (MDA) (as an index of lipid peroxida-tion) levels in 23 patients with BD (13 men, 10 women with a mean age of 34.5 ± .2 years) both in active and in remission periods. Twenty-one healthy volunteers (11 men, 10 women) formed as the …
Alterations Of Erythrocyte And Plasma Lipid Peroxides As Well As Antioxidant Mechanism In Patients With Type Ii Diabetes Mellitus (Niddm), Yıldız Atamer, Yüksel Koçyi̇ği̇t, Aytaç Atamer, Nuriye Mete, Naime Canoruç, Gülten Toprak
Alterations Of Erythrocyte And Plasma Lipid Peroxides As Well As Antioxidant Mechanism In Patients With Type Ii Diabetes Mellitus (Niddm), Yıldız Atamer, Yüksel Koçyi̇ği̇t, Aytaç Atamer, Nuriye Mete, Naime Canoruç, Gülten Toprak
Turkish Journal of Medical Sciences
It has been maintained that free oxygen radicals (FOR) that occur in cell have important roles in the ethiopathogenesis of diabet, and that cell damage progressing as a result of their accumulation is responsible for the development of diabetic complications. In recent years, along with free oxygen radicals, antioxidant mechanisms and the substances influencing as free radical cleaner have been investigated in connection with diabet. With this respect, in a total of 30 patients with type II Diabetes Mellitus (NIDDM), 15 with diabetic retinopathy and 15 without diabetic retinopathy, and in 20 healthy subjects, we measured glutathione (GSH), catalase and …