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Role Of Interleukin-6 In Cd4 And Cd8 T Cell Effector Functions, Rui Yang
Role Of Interleukin-6 In Cd4 And Cd8 T Cell Effector Functions, Rui Yang
Graduate College Dissertations and Theses
IL-6 is an inflammatory cytokine that contributes to the pathogenesis of many immunological diseases including rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, allergic asthma, as well as the protection against infections caused by various pathogens. These are linked to its role in regulating CD4 T cell differentiation and effector function.
Most of these functions are dependent on the IL-6-mediated signaling through the transcription factor Stat3. In this thesis, we identify a novel molecular mechanism by which IL-6 regulates CD4 T cell effector function. We show that IL-6-dependent signal raises the levels of mitochondrial Ca2+ late during activation of CD4 T …