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Hemodynamic Effects Of Atrial Natriuretic Peptide In Ischemia-Reperfusioninjury That Occurs After Exercise, Selma Arzu Vardar, Orki̇de Palabiyik, Ruhan Deni̇z Topuz, Eli̇f Ezgi̇ Gürel, Semra Çalişkan, Serap Topcu Özen, Necdet Süt, Çeti̇n Hakan Karadağ

Turkish Journal of Medical Sciences

Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes. We compared the hemodynamic effects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed by reperfusion in exercised rat hearts with nonexercised ones. Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups after a running protocol for 5 days and 4 nonexercised (NE) groups. In the first protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the second protocol, different doses of isatin (0.1, 10, 100 µM/L) were …