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Articles 1 - 30 of 219
Full-Text Articles in Medicine and Health Sciences
Evaluation Of Children Presenting To The Emergency Room After Electrical Injury, Aslihan Arasli Yilmaz, Ali̇ Osman Köksal, Osman Özdemi̇r, Mehtap Acar, Gülten Küçükkonyali, Yasemi̇n İnan, Si̇bel Çeli̇k, Mi̇ne Güveloğlu, Nesi̇be Andiran, Saci̇t Günbey
Evaluation Of Children Presenting To The Emergency Room After Electrical Injury, Aslihan Arasli Yilmaz, Ali̇ Osman Köksal, Osman Özdemi̇r, Mehtap Acar, Gülten Küçükkonyali, Yasemi̇n İnan, Si̇bel Çeli̇k, Mi̇ne Güveloğlu, Nesi̇be Andiran, Saci̇t Günbey
Turkish Journal of Medical Sciences
Background/aim: To evaluate children who presented to the Pediatric Emergency Department with electrical injury and to discuss the follow-up of these cases and potential precautions that can be taken. Materials and methods: A total of 36 patients presented to the Pediatric Emergency Department with electrical injury between May 2010 and May 2013, and these cases were investigated retrospectively. The patients? age and sex, location and form of exposure to electric current, seasonal distribution, length of hospital stay, musculoskeletal and cardiovascular system complications, renal damage, and treatments were recorded. Results: The majority of the patients were exposed to low-voltage electrical current …
The Effects Of Atorvastatin On Antioxidant/Antiinflammatory Propertiesof Hdls In Hypercholesterolemics, Gülşen Akalin Çi̇ftçi̇, İpek Ertorun, Aysen Akalin, İbrahi̇m Özkan Alataş, Ahmet Musmul
The Effects Of Atorvastatin On Antioxidant/Antiinflammatory Propertiesof Hdls In Hypercholesterolemics, Gülşen Akalin Çi̇ftçi̇, İpek Ertorun, Aysen Akalin, İbrahi̇m Özkan Alataş, Ahmet Musmul
Turkish Journal of Medical Sciences
Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in hypercholesterolemic subjects treated with atorvastatin. In this study, we aimed to evaluate effects of atorvastatin treatment on functionality of HDL, oxidative stress, and endothelial functions in hypercholesterolemic subjects. Materials and methods: Thirty patients (20 females, 10 males) aged from 40 to 60 years and diagnosed as hypercholesterolemic were included. Patients were treated with 10 mg/day atorvastatin for 3 months. Markers of endothelial functions, namely asymmetric dimethylarginine (ADMA), homocysteine, and nitric oxide (NO), and …
The Impact Of One Fraction Of 8 Gy Radiotherapy In Palliative Treatmentof Multiple Myeloma Patients With Painful Bone Destructions, Milda Rudzianskiene, Arturas Inciura, Elona Juozaityte, Rolandas Gerbutavicius, Renata Simoliuniene, Viktoras Rudzianskas, Greta Emilia Kiavialaitis
The Impact Of One Fraction Of 8 Gy Radiotherapy In Palliative Treatmentof Multiple Myeloma Patients With Painful Bone Destructions, Milda Rudzianskiene, Arturas Inciura, Elona Juozaityte, Rolandas Gerbutavicius, Renata Simoliuniene, Viktoras Rudzianskas, Greta Emilia Kiavialaitis
Turkish Journal of Medical Sciences
Background/aim: Radiotherapy is required to overcome pain and to promote recalcification in multiple myeloma (MM) patients. The aim of our prospective study was to evaluate the impact of one fraction of 8 Gy regimen in palliative treatment of MM. Materials and methods: Forty-six patients with MM and painful bone destructions were treated by 8 Gy single fraction regimen. The visual analog scale was used for evaluation of pain. Analgesic use was measured prior to and after radiotherapy (4, 12, and 24 weeks). Recalcification was evaluated with radiographs before and after radiotherapy at 1 and 3 months. Quality of life questionnaires …
Pandemic H1n1 Igg Levels In Healthcare Workers, Viroj Wiwanitkit
Pandemic H1n1 Igg Levels In Healthcare Workers, Viroj Wiwanitkit
Turkish Journal of Medical Sciences
No abstract provided.
Is Alzheimer Disease Related To Age-Related Macular Degeneration?, Seden Demi̇rci̇, Ali̇me Güneş, Kadi̇r Demi̇rci̇, Serpi̇l Demi̇rci̇, Levent Tök, Özlem Tök
Is Alzheimer Disease Related To Age-Related Macular Degeneration?, Seden Demi̇rci̇, Ali̇me Güneş, Kadi̇r Demi̇rci̇, Serpi̇l Demi̇rci̇, Levent Tök, Özlem Tök
Turkish Journal of Medical Sciences
Background/aim: To compare the cognitive functions and define the frequency of Alzheimer disease (AD) between participants with and without age-related macular degeneration (AMD). Materials and methods: Fifty-nine patients with late-stage AMD (74.3 ± 7.3 years) and 49 age-, sex-, and education-matched control subjects were compared for the presence of AD according to the guidelines of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Detailed neuropsychological tests were performed for all subjects. Results: Neuropsychiatric tests scores were lower in the AMD group than the control group. The frequency of AD …
The Connection Between Mci And Alzheimer Disease: Neurocognitive Clues, Kübra Batum, Ni̇lgün Çinar, Şevki̇ Şahi̇n, Mi̇raç Ayşen Çakmak, Si̇bel Karşidağ
The Connection Between Mci And Alzheimer Disease: Neurocognitive Clues, Kübra Batum, Ni̇lgün Çinar, Şevki̇ Şahi̇n, Mi̇raç Ayşen Çakmak, Si̇bel Karşidağ
Turkish Journal of Medical Sciences
Background/aim: Mild cognitive impairment (MCI) is defined as a pathological stage between 'healthy aging' and 'dementia'. In this study, cases of MCI were compared with early-stage Alzheimer disease (AD) and age-related cognitive decline (ARCD) in terms of cognitive profiles in order to find a connection between MCI and AD. Materials and methods: Patients who were comparable in terms of age and sex and who met the criteria of MCI, ARCD, or early-stage AD were included in the study retrospectively. Wechsler memory scale, executive function, visuospatial, language, and memory tests were applied to all subjects. Additionally, all patients completed a mini-mental …
Cognitive Problems Related To Vertebro-Basilar Circulation, Abdulkadi̇r Koçer
Cognitive Problems Related To Vertebro-Basilar Circulation, Abdulkadi̇r Koçer
Turkish Journal of Medical Sciences
Neurodegenerative disorders are characterized by decreased regional cerebral blood flow. Supporting this concept, both cognitive training exercises and physical activity promote blood flow increase and correlate with healthy cognitive aging. The terminal branches of the posterior circulation supply blood to areas of the brain, such as the thalamus, hippocampus, occipital lobe, and cerebellum, involved with important intellectual functions, particularly recent memory, visual-spatial functioning, and visuomotor adaptations. Amnesia and visual agnosia may be a complication of not only posterior circulation infarctions but also vertebrobasilar insufficiency (VBI) without accompanying structural infarcts. The cognitive impairment may be a manifestation of transient attacks and …
The Risk Of Tumor Cell Dissemination In Mediastinoscopy: A Cytological Study, Yasemi̇n Bi̇lgi̇n Büyükkarabacak, Ayşen Taslak Şengül, Bi̇lge Can Meydan, Burçi̇n Çeli̇k, Mehmet Gökhan Pi̇rzi̇renli̇, Selçuk Gürz, Zeynep Peli̇n Sürücü, Ahmet Başoğlu
The Risk Of Tumor Cell Dissemination In Mediastinoscopy: A Cytological Study, Yasemi̇n Bi̇lgi̇n Büyükkarabacak, Ayşen Taslak Şengül, Bi̇lge Can Meydan, Burçi̇n Çeli̇k, Mehmet Gökhan Pi̇rzi̇renli̇, Selçuk Gürz, Zeynep Peli̇n Sürücü, Ahmet Başoğlu
Turkish Journal of Medical Sciences
Background/aim: Mediastinoscopy is an invasive procedure that is used in the diagnosis of mediastinal diseases and in staging lung cancer. Tumor cell seeding during mediastinoscopy along the mediastinum and the incision line is a very rare complication. This study aimed to test the safety of mediastinoscopy in terms of tumor seeding by cytological evaluation of mediastinal lavage samples taken before and after biopsy. Materials and methods: The patients who underwent mediastinoscopy in our hospital between 2011 and 2014 were studied prospectively. Seventy-three patients with a diagnosis of lung or mediastinal malignancy were included in the study. All patients underwent classical …
Vkorc1 And Cyp2c9 Genotypic Data-Based Dose Prediction Alone Does Not Accurately Predict Warfarin Dose Requirements In Some Malaysian Patients, Yung An Chua, Wan Zaidah Abdullah, Zurkurnai Yusof, Siew Hua Gan
Vkorc1 And Cyp2c9 Genotypic Data-Based Dose Prediction Alone Does Not Accurately Predict Warfarin Dose Requirements In Some Malaysian Patients, Yung An Chua, Wan Zaidah Abdullah, Zurkurnai Yusof, Siew Hua Gan
Turkish Journal of Medical Sciences
Background/aim: VKORC1 and CYP2C9 genetic polymorphisms may not accurately predict warfarin dose requirements. We evaluated an existing warfarin dosing algorithm developed for Malaysian patients that was based only on VKORC1 and CYP2C9 genes. Materials and methods: Five Malay patients receiving warfarin maintenance therapy were investigated for their CYP2C9*2, CYP2C9*3, and VKORC1-1639G>A genotypes and their vitamin K-dependent (VKD) clotting factor activities. The records of their daily warfarin doses and international normalized ratio (INR) 2 years prior to and after the measurement of VKD clotting factors activities were acquired. The mean warfarin doses were compared with predicted warfarin doses calculated from …
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most common progressive neurodegenerative disorder causing increased morbidity and mortality. It is characterized by accumulation of amyloid-β in neurons. As there is no known definitive treatment of this disorder, studies trying to determine its exact pathogenetic pathways and target therapies for these specific pathways are being rapidly conducted. Autophagy is one of the areas of interest in studies on the pathogenesis of AD. It is a process of self-digestion that is thought to be a response to stressors and allows cells to adapt to environmental changes. There is accumulating evidence showing an association between autophagy …
Age-Related Macular Degeneration And Alzheimer Disease, Eren Çerman, Muhsi̇n Eraslan, Osman Çeki̇ç
Age-Related Macular Degeneration And Alzheimer Disease, Eren Çerman, Muhsi̇n Eraslan, Osman Çeki̇ç
Turkish Journal of Medical Sciences
This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.
Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik
Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β …
Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger
Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Dementia is an inevitable disease of aging, leading not only to diminished cognitive ability but also behavioral changes, malnutrition, pressure sores, and infections. Acknowledging common problems and their solutions is essential for any health service worker who deals with demented geriatric patients.
Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar
Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is one of the most common neurodegenerative diseases and the most prevalent form of dementia. Some factors in the development of AD, age being the best-known one, have been suggested; however, no causes have been found yet. The pathophysiology of the disease is highly complex, current therapies are palliative, and a cure is still lacking. Adverse effects of anesthetics in the elderly have been reported since the 1950s; however, awareness of this old problem has recently gained importance again. Whether exposure to surgery and general anesthesia (GA) is associated with the development of AD has been questioned. …
Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul
Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul
Turkish Journal of Medical Sciences
Background/aim: Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. A growing amount of evidence indicates that resistin has hallmark regulatory functions such as inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers such as hs-CRP and TNF-α. Materials and methods: In this cross-sectional study, 38 AD patients and 32 control subjects with normal cognitive function aged 65 years and over were included. The diagnosis of AD was made according to DSM-IV …
Vitamin D Status And Its Association With Gradual Decline In Cognitive Function, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Özgür Kara, Burçi̇n Halaçli, Sezgi̇n Etgül, Muhammet Cemal Kizilarslanoğlu, Burcu Balam Yavuz, Münevver Özcan, Meltem Gülhan Hali̇l, Eylem Şahi̇n Cankurtaran, Mustafa Cankurtaran, Servet Arioğul
Vitamin D Status And Its Association With Gradual Decline In Cognitive Function, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Özgür Kara, Burçi̇n Halaçli, Sezgi̇n Etgül, Muhammet Cemal Kizilarslanoğlu, Burcu Balam Yavuz, Münevver Özcan, Meltem Gülhan Hali̇l, Eylem Şahi̇n Cankurtaran, Mustafa Cankurtaran, Servet Arioğul
Turkish Journal of Medical Sciences
Background/aim: To compare plasma vitamin D concentrations among patients with normal cognitive function (control group), mild cognitive impairment (MCI), and Alzheimer disease (AD). Materials and methods: In total, 158 patients with AD, 228 patients with MCI, and 603 control subjects were included. Plasma levels of 25-hydroxyvitamin D were measured after comprehensive geriatric assessment and compared among groups. SPSS 15.0 was used for statistical analysis. Results: Mean levels of 25-hydroxyvitamin D were significantly different among the 3 groups of AD patients, MCI patients, and controls (P < 0.001). Post hoc analysis revealed that the levels were significantly lower in the MCI group than the control group (P = 0.002) and significantly lower in the AD group than the control group (P = 0.003). Multivariate analysis showed that age (OR: 1.070, 95% CI: 1.025-1.116, P = 0.002), instrumental activities of daily living score (OR: 0.920, 95% CI: 0.850-0.995, P = 0.037), 25-hydroxyvitamin D level (OR: 0.959, 95% CI: 0.932-0.987, P = 0.004), and diabetes mellitus (OR: 2.476, 95% CI: 1.153-5.319, P = 0.020) were factors independently associated with AD. Conclusion: This study demonstrated that there is a correlation between plasma 25-hydroxyvitamin D levels and cognitive functions.
Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi
Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi
Turkish Journal of Medical Sciences
Background/aim: Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids. The aim of this pilot study was to determine urine TNGFR levels in patients with dementia and to verify whether TNGFR can be used as a biomarker of dementia. Materials and methods: Twelve patients with dementia and 12 healthy individuals were asked to voluntarily participate in this study. Ages, sexes, and weights were matched. The first morning urine samples were collected …
Prevalence Of Cognitive Impairment And Related Risk Factors Incommunity-Dwelling Elderly In Kayseri, Turkey, Si̇bel Arguvanli, Si̇bel Akin, Eli̇f Deni̇z Şafak, Sali̇me Mucuk, Ahmet Öztürk, Mustafa Mümtaz Mazicioğlu, Hati̇ce Duygu Kizilçay, Şemsi̇nnur Göçer
Prevalence Of Cognitive Impairment And Related Risk Factors Incommunity-Dwelling Elderly In Kayseri, Turkey, Si̇bel Arguvanli, Si̇bel Akin, Eli̇f Deni̇z Şafak, Sali̇me Mucuk, Ahmet Öztürk, Mustafa Mümtaz Mazicioğlu, Hati̇ce Duygu Kizilçay, Şemsi̇nnur Göçer
Turkish Journal of Medical Sciences
Background/aim: The increased rate of elderly individuals in the general population leads to functional decline because of cognitive impairment (CImp). We aimed to detect the prevalence of CImp and related risk factors in community-dwelling elders living in an urban area (Kayseri, Turkey). Materials and methods: This is a cross-sectional, population-based study conducted in a sample of 900 community-dwelling elders aged 60 years and older. Cognitive status and depressive symptoms were assessed by standardized Mini Mental State Examination (MMSE) and the Geriatric Depression Scale (GDS), respectively. Results: The mean age of the participants was 71.6 ± 0.18 years, of whom 47.9% …
Bioimpedance For Assessing Volume Status In Children With Nephrotic Syndrome, Kadri̇ye Özdemi̇r, Makbule Sevgi̇ Mi̇r, Ni̇da Di̇nçel, Si̇bel Bozabali, İpek Kaplan Bulut, Ebru Yilmaz, Betül Sözeri̇
Bioimpedance For Assessing Volume Status In Children With Nephrotic Syndrome, Kadri̇ye Özdemi̇r, Makbule Sevgi̇ Mi̇r, Ni̇da Di̇nçel, Si̇bel Bozabali, İpek Kaplan Bulut, Ebru Yilmaz, Betül Sözeri̇
Turkish Journal of Medical Sciences
Background/aim: The effectiveness of assessing volume load via bioimpedance in pediatric patients with nephrotic syndrome (NS) was investigated. Materials and methods: Patients with NS (n = 34) were compared with healthy controls (n = 20). The inferior vena cava index and inferior vena cava collapsibility index (IVCCI) scores were determined for all subjects. Bioimpedance measurements were used to directly determine volume load. Clinical findings, relative fluid load, and echocardiographic measurements were determined and compared with bioimpedance in calculating volume load. Results: The sensitivity and specificity of bioimpedance in determining volume load were found to be 65% and 90%, respectively. IVCCI …
Toxic Potentials Of Ten Herbs Commonly Used For Aphrodisiac Effect In Turkey, Mahmoud Abudayyak, Ebru Özdemi̇r Nath, Gül Özhan
Toxic Potentials Of Ten Herbs Commonly Used For Aphrodisiac Effect In Turkey, Mahmoud Abudayyak, Ebru Özdemi̇r Nath, Gül Özhan
Turkish Journal of Medical Sciences
Background/aim: Sexual dysfunction is a serious problem worldwide. In Turkey, herbal products are used by some people suffering from sexual dysfunction. Despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. Therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in Turkey. Materials and methods: Ten herbs (Anethum graveolens, Carthamus tinctorius, Citrus aurantium, Cocos nucifera, Glycyrrhiza glabra, Melissa officinalis, Nigella arvensis, Pinus pinea, Prunus mahaleb, and Zingiber officinale) …
Evaluation Of Patency Following Revision Technique Ofhigh-Velocity Arteriovenous Fistula, Ümi̇t Halici, Mehmet Ali̇ Kaygin, Özgür Dağ, Ahmet Aydin, Hüsnü Kami̇l Li̇mandal, Ümi̇t Arslan, Eyüp Serhat Çalik, Bi̇lgehan Erkut
Evaluation Of Patency Following Revision Technique Ofhigh-Velocity Arteriovenous Fistula, Ümi̇t Halici, Mehmet Ali̇ Kaygin, Özgür Dağ, Ahmet Aydin, Hüsnü Kami̇l Li̇mandal, Ümi̇t Arslan, Eyüp Serhat Çalik, Bi̇lgehan Erkut
Turkish Journal of Medical Sciences
Background/aim: The objective of this study is to report our experience with surgical revision of dialysis access-induced ischemia syndrome. Materials and methods: Between January 2005 and July 2013, 1254 patients underwent arteriovenous fistula operation, and 86 of them [53 males, mean age: 55 ± 25 (range: 25 to 75) years; 33 females, mean age: 50 ± 20 (range: 30 to 70) years] subsequently developed steal syndrome. These patients were treated with arterial pressure-controlled polytetrafluoroethylene banding or constriction with polypropylene suturing technique. Patients were followed in the outpatient clinic at regular intervals. Results: Symptoms were not relieved during the first 15 …
Investigation Of The Effect Of Changes In Muscle Strength In Gestational Ageupon Fear Of Falling And Quality Of Life, Emrah Atay, Fatma Başalan İz
Investigation Of The Effect Of Changes In Muscle Strength In Gestational Ageupon Fear Of Falling And Quality Of Life, Emrah Atay, Fatma Başalan İz
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is the investigation of the effect of changes in muscle strength in gestational age upon fear of falling and quality of life. Materials and methods: This longitudinal, descriptive study included a sample of 37 pregnant women who volunteered to participate. The research data were collected at 20 and 32 weeks of gestation. Data collection instruments included a newly developed questionnaire form, the Tinetti Falls Efficacy Scale, a visual analog scale, and the Turkish language version of the WHO Quality of Life Scale. Upper body flexibility was measured by the back scratch test, while muscle …
Evaluation Of Retinal Nerve Fiber Layer Thickness In Alzheimer Disease Usingspectral-Domain Optical Coherence Tomography, Ali̇me Güneş, Seden Demi̇rci̇, Levent Tök, Özlem Tök, Serpi̇l Demi̇rci̇
Evaluation Of Retinal Nerve Fiber Layer Thickness In Alzheimer Disease Usingspectral-Domain Optical Coherence Tomography, Ali̇me Güneş, Seden Demi̇rci̇, Levent Tök, Özlem Tök, Serpi̇l Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) and to compare the results with those of healthy controls. Materials and methods: Forty patients (mean age: 75.02 ± 6.34 years; 23 women) with untreated AD and 40 age-, sex-, and education-matched healthy patients were examined in this case-control prospective study. All patients underwent detailed ophthalmic and neurological examination. The Mini Mental State Examination (MMSE) was performed and RNFL thickness was measured using spectral-domain optical coherence tomography. The association between RNFL and MMSE score was also assessed. Results: The average RNFL thickness was 84 …
Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci
Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci
Turkish Journal of Medical Sciences
Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. Materials and methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients. Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG …
Ebola Viral Disease: What Should Be Done To Combat The Epidemic In 2014?, Ali̇ye Baştuğ, Hürrem Bodur
Ebola Viral Disease: What Should Be Done To Combat The Epidemic In 2014?, Ali̇ye Baştuğ, Hürrem Bodur
Turkish Journal of Medical Sciences
Ebola virus disease (EVD) was defined first in 1976. Since then, more than 24 epidemics have been reported from Africa, predominantly with the Zaire species. On 21 March 2014, the current West Africa outbreak was reported by the World Health Organization, the largest one ever recorded. The Congo epidemic was reported in July 2014. It was considered that the two epidemics had unrelated origins with 96.8% identical genomic sequence of the virus. EVD outbreaks occurred in areas with limited resources but it has a potentially global effect due to the possibility of imported infection and the potential misuse of the …
Utility Of M30, An Apoptotic Serum Marker, In Liver Diseases, Aki̇f Altinbaş, Şahi̇n Çoban, Ömer Başar, Osman Yüksel
Utility Of M30, An Apoptotic Serum Marker, In Liver Diseases, Aki̇f Altinbaş, Şahi̇n Çoban, Ömer Başar, Osman Yüksel
Turkish Journal of Medical Sciences
The aim of this paper is to evaluate the role of apoptosis in some common liver diseases, and the utility of M30, an apoptotic serum marker, in the diagnosis of the severity of underlying hepatic injury. As is widely known, apoptosis is programmed cell death, and its deregulation results in an uncontrolled inflammatory process leading to upregulation of liver fibrogenesis. Both extrinsic and intrinsic pathways are crucial in apoptosis, and caspase cleavage of cytokeratin proteins occurs in both. Therefore, the measurement of caspase-cleaved cytokeratin fragments could be a novel method to assess the intensity of apoptotic cell numbers in epithelial …
Protective Effects Of Erdosteine, Vitamin E, And Vitamin C On Renal Injury Induced By The Ischemia-Reperfusion Of The Hind Limbs In Rats, Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbaş, Soner Dönmez, Haci Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali
Protective Effects Of Erdosteine, Vitamin E, And Vitamin C On Renal Injury Induced By The Ischemia-Reperfusion Of The Hind Limbs In Rats, Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbaş, Soner Dönmez, Haci Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali
Turkish Journal of Medical Sciences
To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined. Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II …
Analysis Of Vaca/Caga Genotypes/Status In Helicobacter Pylori Isolates From Iranian Children And Their Association With Clinical Outcome, Tahereh Falsafi, Afsaneh Khani, Fatemeh Mahjoub, Ezat Asgarani, Nazli Sotoudeh
Analysis Of Vaca/Caga Genotypes/Status In Helicobacter Pylori Isolates From Iranian Children And Their Association With Clinical Outcome, Tahereh Falsafi, Afsaneh Khani, Fatemeh Mahjoub, Ezat Asgarani, Nazli Sotoudeh
Turkish Journal of Medical Sciences
More than 50% of Iranian children are infected with Helicobacter pylori; however, no data exist about the association of vacA/cagA genotype/status with disease outcomes in them. We analyzed association of vacA/cagA genotypes/status of children's isolates with gastric inflammation status as the first step in H. pylori pathogenesis. Materials and methods: Antral biopsies for culture and histopathology were taken from 328 children in 1997-2009. vacA (s, m) alleles and cagA statuses of the isolates were determined by PCR. Histopathology was performed according to the Sydney system; gastritis was scored as normal, mild, moderate, severe, and follicular. Results: A total of 159 …
Hypo- And Hypervolemic Edema In Children With Steroid Sensitive Nephrotic Syndrome, Mehmet Aki̇f Büyükavci, Mahmut Çi̇vi̇li̇bal, Murat Elevli̇, Hati̇ce Ni̇lgün Selçuk Duru
Hypo- And Hypervolemic Edema In Children With Steroid Sensitive Nephrotic Syndrome, Mehmet Aki̇f Büyükavci, Mahmut Çi̇vi̇li̇bal, Murat Elevli̇, Hati̇ce Ni̇lgün Selçuk Duru
Turkish Journal of Medical Sciences
The mechanism of edema formation in nephrotic syndrome is still poorly understood. We aimed to evaluate the volume status in children with steroid-sensitive nephrotic syndrome (SSNS) and to emphasize the importance of echocardiography in demonstrating of volume changes. Materials and methods: Thirty-two SSNS patients and 30 healthy children were enrolled in this study. The volume statuses of patients were evaluated by clinical and laboratory features, including fractional sodium excretion (FENa) and distal sodium/potassium exchange (UK/UNa+K ratio). Inferior vena cava collapsibility index (IVCCI), left atrial diameter (LAD), aortic diameter (AD), and left ventricular mass index (LVMI) were measured using conventional echocardiographic …
Is There An Association Between Histopathological Changes In The Lower Ureter And Renal Functions? Evaluation Of Patients Who Underwent Ureteroneocystostomy For Ureterovesical Obstruction Or Vesicoureteral Reflux, Müjdem Nur Azili, Doğuş Güney, Ayper Kaçar, Hüseyi̇n Tuğrul Ti̇ryaki̇
Is There An Association Between Histopathological Changes In The Lower Ureter And Renal Functions? Evaluation Of Patients Who Underwent Ureteroneocystostomy For Ureterovesical Obstruction Or Vesicoureteral Reflux, Müjdem Nur Azili, Doğuş Güney, Ayper Kaçar, Hüseyi̇n Tuğrul Ti̇ryaki̇
Turkish Journal of Medical Sciences
We aimed to assess the relationship between the histological changes of the ureterovesical junction (UVJ) and renal functions. Therefore, we evaluated histological changes of the lower ureter and renal scintigraphy findings of patients for whom ureteroneocystostomy was performed because of vesicoureteral reflux (VUR) or ureterovesical junction obstruction (UVO). Materials and methods: UVJ specimens were obtained from 18 children. We investigated the changes in neuronal innervation, muscular morphology, extracellular matrix, and apoptosis rate with renal scintigraphy findings. Results: Seven UVO and 11 VUR patients were treated. Alpha-actin expression in smooth muscle cells was found to be lower (P < 0.001) while neuronal defect was more prominent in the UVO group (P = 0.002). The renal functions decreased as the smooth muscle structural defect increased in the VUR group (P < 0.05). Conclusion: Neuronal tissue and muscle tissue were more defective in the UVO group. The decrease in neuronal fibers and muscle cells explains the pathogenesis of the obstructive group, but no difference was observed regarding the accumulation of collagen type 3 and cellular apoptosis between the VUR and UVO groups. In the VUR group, renal functions decreased while the smooth muscle defect at the distal end of the ureter increased.