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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Circadian Clock-Specific Roles For The Light Response Protein White Collar-2, Michael A. Collett, Jay C. Dunlap, Jennifer J. Loros
Circadian Clock-Specific Roles For The Light Response Protein White Collar-2, Michael A. Collett, Jay C. Dunlap, Jennifer J. Loros
Dartmouth Scholarship
To understand the role of white collar-2 in theNeurospora circadian clock, we examined alleles ofwc-2 thought to encode partially functional proteins. We found that wc-2 allele ER24 contained a conservative mutation in the zinc finger. This mutation results in reduced levels of circadian rhythm-critical clock gene products, frq mRNA and FRQ protein, and in a lengthened period of the circadian clock. In addition, this mutation altered a second canonical property of the clock, temperature compensation: as temperature increased, period length decreased substantially. This temperature compensation defect correlated with a temperature-dependent increase in overall FRQ protein levels, with the …
Ups And Downs Of Mucosal Cellular Immunity Against Protozoan Parasites, Lloyd H. Kasper, Dominique Buzoni-Gatel
Ups And Downs Of Mucosal Cellular Immunity Against Protozoan Parasites, Lloyd H. Kasper, Dominique Buzoni-Gatel
Dartmouth Scholarship
No abstract provided.
Central Chemosensitivity, Sleep, And Wakefulness, E. E. Nattie, A Li
Central Chemosensitivity, Sleep, And Wakefulness, E. E. Nattie, A Li
Dartmouth Scholarship
No abstract provided.
Electrolytic Lesion Of The Anterior Cingulate Cortex Decreases Inflammatory, But Not Neuropathic Nociceptive Behavior In Rats, Renee R. Donahue, Perry N. Fuchs, Stacey C. Lagraize
Electrolytic Lesion Of The Anterior Cingulate Cortex Decreases Inflammatory, But Not Neuropathic Nociceptive Behavior In Rats, Renee R. Donahue, Perry N. Fuchs, Stacey C. Lagraize
Renee R. Donahue
The present study investigated the effect of lesions of the anterior cingulate cortex (ACC) on mechanical allodynia / hyperalgesia after L5 ligation or on inflammatory nociceptive responses following formalin injection in the rat. For both the neuropathic and inflammatory pain models, three groups of animals were used. The control groups consisted of a group of sham lesioned animals and a group of animals that had unilateral damage to the ACC or unilateral / bilateral damage to surrounding cortical tissue. The third group consisted of animals that had at least 75% bilateral damage of the ACC. Subjects received L5 ligation or …
Enhanced Formalin Nociceptive Responses Following L5 Nerve Ligation In The Rat Reveals Neuropathy-Induced Inflammatory Hyperalgesia, Renee R. Donahue, Perry N. Fuchs
Enhanced Formalin Nociceptive Responses Following L5 Nerve Ligation In The Rat Reveals Neuropathy-Induced Inflammatory Hyperalgesia, Renee R. Donahue, Perry N. Fuchs
Renee R. Donahue
The development of mechanical and thermal hypersensitivity following peripheral nerve injury is well known and a great deal of research has been directed towards understanding the mechanisms underlying these phenomena. However, there has been very little research examining if hypersensitivity to an inflammatory condition following nerve injury also develops. Therefore, the purpose of the present study was to determine if hypersensitivity to an inflammatory condition produced in the formalin test develops following ligation of the L5 spinal nerve. Male Sprague–Dawley rats received tight ligation of the L5 spinal nerve or were given sham surgery. Following a 14-day recovery period, the …